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Journal of Cosmetics, Dermatological Sciences and Applications 2017年第1期7卷 14-26页

作者： Gisele Mara Silva Gonç alves pedro paulo barros Gustavo Henrique da Silva Erica Mendes dos Santos Amanda Figlia Minutti Faculty of Pharmaceutical Sciences Pontifical Catholic University of Campinas Campinas Brazil

Plant-derived substances such as curcumin and trans-resveratrol, both of which have anti-inflammatory properties, may have a beneficial effect on human skin. The present study analyzed the effects of topical formulations containing curcumin or trans-resveratrol on the recovery and rejuvenation of skin after chemical peeling. The study was performed on rats, randomly divided into seven groups of six animals each. Superficial peeling was performed using a 50% glycolic acid gel, which was applied to the dorsal region of each animal. Rats were then treated with the experimental formulations for 15 days. On the sixteenth day, skin samples were taken and mounted on slides for histological analysis. Statistical analysis showed that the formulation containing trans-resveratrol led to increased dermal and epidermal thickness, while the formulation containing curcumin had no effects on epidermal thickness. The increased epidermal thickness may reflect greater skin vitality, although this was not directly evaluated. The increase in dermal thickness may be attributed to greater collagen production, which may increase skin firmness and elasticity, and lead to skin rejuvenation as well as wrinkle reduction. Formulations containing curcumin or trans-resveratrol may have potential for the topical treatment after peeling and of sensitive skin, in addition to being used for their antiaging properties.

关键词： Curcumin Resveratrol Peeling Histological Analysis

Successful eradication of the European rabbit(Oryctolagus cuniculus)and house mouse(Mus musculus)from the island of Selvagem Grande(Macaronesian archipelago),in the Eastern Atlantic

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Integrative Zoology 2010年第1期5卷 70-83页

作者： paulo OLIVERA Dilia MENEZES Roger TROUT Alan BUCKLE pedro GERALDES JoséJESUS Parque Natural da Madeira Quinta do Bom SucessoCaminho do MeioMadeira Forest Research Alice Holt LodgeFarnhamSurrey School of Biological Sciences The University of ReadingReadingUK University of Madeira Department of BiologyCampus of PenteadaPortugal

The Portuguese island of Selvagem Grande(Great Salvage)in Macaronesia is an important seabird breeding station in the eastern *** populations of Cory’s shearwater Calonectris diomedea(Scopoli,1769),Bulwer’s petrel Bulweria bulweria(Jardine&Selby,1828)and little shearwater Puffinus assimilis baroli(Bonaparte,1857)are present,and white-faced storm-petrel Pelagodroma marina(Latham,1790)and Madeiran storm-petrel Oceanodroma castro(Harcourt,1851)populations are of global *** Grande also provides diverse habitats for an extensive flora,including 11 endemic *** 270-ha island was also inhabited by two alien invasive mammals:the European rabbit Oryctolagus cuniculus(Linnaeus,1758)and the house mouse Mus musculus(Linnaeus,1758).Both are known to have had adverse impacts on breeding seabirds and island *** 2002,the Natural Park of Madeira conducted a program using brodifacoum bait formulations aimed at rabbit and mouse *** 17000 individual baiting points were established on a 12.5×12.5 m *** were also applied by hand“seeding”on steep slopes and cliffs where bait stations could not be *** were removed after a ***,mice persisted for considerably longer and strategic bait applications against them continued for a further six *** assessments by trapping,bait takes and systematic observa-tion of signs over three years,has confirmed the removal of both alien invasive *** paper presents information on these operations,on measures adopted to mitigate adverse impacts of the eradication program on important vertebrate non-target species,including Berthelot’s pipit Anthus berthelotii Bolle,1862 and a species of gecko Tarentola bischoffi Joger,1984 and on the initial response of the island’s ecosystem to the eradication of rabbits and mice.

关键词： alien invasive island restoration Mus musculus non-target mitigation Oryctolagus cuniculus

Pennsylvanian glacimarine sedimentation in the Cushamen Formation,western North Patagonian Massif

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Geoscience Frontiers 2018年第2期9卷 485-504页

作者： paulo Marcos Daniel A.Gregori Leonardo Benedini Mercedes barros Leonardo Strazzere Cecilia Pavón Pivetta Cátedra de Geofísica Departamento de GeologíaUniversidad Nacional del Sur and INGEOSURSan Juan 6708000 Bahía BlancaArgentina Cátedra de Geología Argentina Departamento de GeologíaUniversidad Nacional del Sur and INGEOSURSan Juan 6708000 Bahía BlancaArgentina Cátedra de Geología Minera Departamento de GeologíaUniversidad Nacional del Sur and INGEOSURSan Juan 6708000 Bahía BlancaArgentina

The metasedimentary sequence of the Cushamen Formation in the western North Patagonian Massif is540 m thick and comprises six sedimentary lithofacies associations related to a glacimarine *** of these lithofacies represent distal glacimarine environments, whereas another one was deposited in proximal glacimarine environments, and the last includes subglacial environments. The organization and configuration of these lithofacies associations represent the advance and retreat of the glacier masses. The maximum glacial advance is correlatable with the G2 glacial interval of the Pennsylvanian Pampa de Tepuel, Las Salinas and Valley Chico, formations of the Extraandean Chubut, and the southern part of Neuquen Cordillera. Contemporaneously, in southern Chile there are marine and glacimarine sediments. The chronostratigraphic relationships between the Silurian to Permian units allow five paleogeographic stages to be distinguished. The middle Silurian-late Devonian igneous rocks represent the first magmatic stage. The second stage, which is transitional to the first, is represented by a marine basin that includes the late Devonian-early Carboniferous Esquel and Rio Pescado formations and the Llanquihue Complex. The third stage(early-late Carboniferous) includes granitoids of the second magmatic event that partially overlapped the first magmatic igneous belt. The fourth stage belongs to the late Carboniferous sedimentation of the Cushamen and equivalent formations. The extended early Permian magmatism was the last Paleozoic event in the studied area.

关键词： Pennsylvanian Glacimarine sedimentation Cushamen Formation North Patagonian Massif

Static-based early-damage detection using symbolic data analysis and unsupervised learning methods

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Frontiers of Structural and Civil Engineering 2015年第1期9卷 1-16页

作者： Joao pedro SANTOS Christian CREMONA Andre D. ORCESI paulo SILVEIRA Luis CALADO Department of Structures Av. Brasil 101 Lisbon 1700-066 Portugal Technical Center for Bridge Engineering CEREMA B.P. 214 Provins Cedex 77487 France Materials and Structures Department IFSTTAR University Paris-Est 14-20 Boulevard Newton Champs sur Marne Marne la Vallee Cedex2 F-77447 France Department of Civil Engineering Technical University Lisbon Avenida Rovisco Pais Lisbon 1096 Portugal

A large amount of researches and studies have been recently performed by applying statistical and machine learning techniques for vibration-based damage detection. However, the global character inherent to the limited number of modal properties issued from operational modal analysis may be not appropriate for early-damage, which has generally a local character. The present paper aims at detecting this type of damage by using static SHM data and by assuming that early-damage produces dead load redistribution. To achieve this objective a data driven strategy is proposed, consisting of the combination of advanced statistical and machine learning methods such as principal component analysis, symbolic data analysis and cluster analysis. From this analysis it was observed that, under the noise levels measured on site, the proposed strategy is able to automatically detect stiffness reduction in stay cables reaching at least 1%.

关键词： structural health monitoring early-damage detection principal component analysis symbolic data symbolic dissimilarity measures cluster analysis numerical model damage simulations

More Transporters,More Substrates:The Arabidopsis Major Facilitator Superfamily Revisited

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Molecular Plant 2019年第9期12卷 1182-1202页

作者： Maria Nino-Gonzalez Esther Novo-Uzal Dale N.Richardson pedro M.barros Paula Duque Instituto Gulbenkian de Ciencia 2780-156 OeirasPortugal Genomics of Plant Stress Unit ITQB NOVA-Instituto de Tecnologia Quimica e Biologica Antonio XavierUniversidade Nova de Lisboa2780-157 OeirasPortugal

The Major Facilitator Superfamily(MFS)is ubiquitous in living organisms and represents the largest group of secondary active membrane *** plants,significant research efforts have focused on the role of specific families within the MFS,particularly those transporting macronutrients(C,N,and P)that constitute the vast majority of the members of this *** MFS families remain less explored,although a plethora of additional substrates and physiological functions have been ***,the lack of a systematic approach to analyzing the MFS as a whole has obscured the high diversity and versatility of these ***,we present a phylogenetic analysis of all annotated MFS domaincontaining proteins encoded in the Arab/dops/s fA?a//ana genome and propose that this superfamily of transporters consists of 218 members,clustered in 22 *** reviewing the available information regarding the diversity in biological functions and substrates of Arab/dops/s MFS members,we provide arguments for intensified research on these membrane transporters to unveil the breadth of their physiological relevance,disclose the molecular mechanisms underlying their mode of action,and explore their biotechnological potential.

关键词： Arabidopsis thaliana membrane transport MFS transporters phylogenetic analysis

Spatial distribution of morphometric parameters of glacial cirques in the Central Pyrenees(Aran and Boí valleys)

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Journal of Mountain Science 2018年第10期15卷 2103-2119页

作者： Luis LOPES Marc OLIVA Marcelo FERNANDES paulo PEREIRA pedro PALMA Jesús RUIZ-FERNáNDEZ Centre for Geographical Studies – IGOT Universidade de Lisboa Department of Geography University of Barcelona Environmental Management Center Mykolas Romeris University Department of Geography University of Oviedo

Glacial cirques are typical landscape features of mid-latitude mountain environments like the Central Pyrenees. Their morphology as well as their spatial distribution provides insights about past glaciers and climates. In this study, we examine the distribution, morphometrical and topographical characteristics of glacial cirques in two U-shaped glacial valleys located in the Central Pyrenees – the Aran and the Boí valleys. They are located in different aspects of this mountain range(north vs south) under different climatic influences that promoted distinct glaciation patterns during the late Pleistocene. The spatial mapping of these landforms was carried out using high-resolution imagery and field observations. We analysed the data of the morphometrical and topographical variables of the glacial cirques by using different statistical and geospatial methods in order tounveil the factors controlling their formation and development. A total of 186 glacial cirques were mapped in the study area, including 119 in the Aran and 67 in the Boí valleys. The local topography and microclimate conditions lead to substantial differences in both areas in terms of the morphology and dimensions of the cirques. Glacial cirques in Boí are distributed at slightly higher elevations than in Aran and they are also larger, though their dimensions decrease with elevation in both valleys. Aran cirques are mostly oriented NE, while Boí landforms do not show any prevailing aspect. Even though lithology does not control the distribution of the glacial cirques, some specific lithological settings may favour the development of larger cirques. In general, glacial cirques in the Aran and the Boí valleys show morphometrical properties similar to those reported in other mid-latitude mountain ranges.

关键词： Central Pyrenees Aran and Boi valleys glacial cirques topography morphometry.

Rainfall variability in the Brazilian northeast biomes and their interactions with meteorological systems and ENSO via CHELSA product

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Big Earth Data 2019年第4期3卷 315-337页

作者： Washington Luiz Félix Correia Filho JoséFrancisco De Oliveira-Júnior Dimas De barros Santiago paulo Miguel De Bodas Terassi paulo Eduardo Teodoro Givanildo De Gois Claudio JoséCavalcante Blanco pedro Henrique De Almeida Souza Micejane da Silva Costa Heliofábio barros Gomes paulo JoséDos Santos Institute of Atmospheric Sciences(ICAT) Federal University of Alagoas(UFAL)MaceióBrazil Postgraduate Program in Biosystems Engineering(PGEB) Federal Fluminense University(UFF)NiteróiBrazil Postgraduate Program in Meteorology Unidade Acadêmica de Ciências Atmosféricas(UACA)Federal Universityof Campina Grande(UFCG)Campina GrandeBrazil Postgraduate Program in Physical Geography University of São Paulo(USP)São PauloBrazil Federal University of Mato Grosso do Sul(UFMS) Chapadão do SulBrazil fSchool of Industrial Metallurgical Engineering of Volta Redonda Technological CenterUniversidade Federal Fluminense(UFF)Volta RedondaBrazil Faculty of Sanitary and Environmental Engineering(FAESA/ITEC) Federal University of Pará(UFPA)BelémBrazil

Brazilian biomes are home to a significant portion of the world’s biodiversity,with a total of 14%of existing species and still concentrate 20%of the world’s water ***,changes in biomes have a direct impact on rainfall patterns and water *** on this,the objective was to evaluate the variability of rainfall in the four existing biomes in the Northeast Brazil(NEB)and their interaction with the ENSO climate variability mode and regional scale meteorological systems via CHELSA *** this,monthly rainfall data were used from 1979 to 2013,with a spatial resolution of 1 km×1 km of the CHELSA product,and seasonal and annual rainfall patterns were extracted via *** was found that the rainy season in the Amazon,Caatinga and Cerrado biomes occurred between January and April,with varying intensities,except for the Atlantic *** seasonality patterns are associated with the NEB meteorological systems,with emphasis on ITCZ(all Biomes),UTCV(Amazon,Caatinga and Cerrado),Frontal Systems(extreme south of Caatinga,Cerrado and Atlantic Forest)and EWD/TWD in the(Atlantic Forest).In the inter-annual scale,the remarkable influence of ENSO was verified,mainly in the years 1983,1985,1989,1993,1998,2009 and *** is noteworthy that 1985 was the wettest year of the period,with a surplus in all biomes,while the driest year differs between the Amazon(1983),Atlantic Forest and Caatinga(1993)and Cerrado(2012)*** study via orbital product in NEB showed that anthropogenic processes and natural variability interfere with the forms of rain interception in the biomes and hence in rainfall patterns and water recycling in NEB.

关键词： Phytophysiognomy rainfall inter-annual variability water recycling climate change land use and occupation

Investigation and optimization of high-valent Ta-doped SrFeO_(3-δ)as air electrode for intermediate-temperature solid oxide fuel cells

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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2102-2109页

作者： Shanshan Jiang Hao Qiu Shaohua Xu Xiaomin Xu Jingjing Jiang Beibei Xiao paulo Sérgio barros Juliao) Chao Su Daifen Chen Wei Zhou School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212100China WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityPerth WA6102Australia Institute of Analysis and Testing Beijing Academy of Science and TechnologyBeijing 100089China State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

To explore highly active and thermomechanical stable air electrodes for intermediate-temperature solid oxide fuel cells(ITSOFCs),10mol%Ta5+doped in the B site of strontium ferrite perovskite oxide(SrTa_(0.1)Fe_(0.9)O_(3-δ),STF)is investigated and *** effects of Ta^(5+)doping on structure,transition metal reduction,oxygen nonstoichiometry,thermal expansion,and electrical performance are evaluated *** 10mol%Ta^(5+)doping,the thermal expansion coefficient(TEC)decreased from 34.1×10^(-6)(SrFeO_(3-δ))to 14.6×10^(-6) K^(-1)(STF),which is near the TEC of electrolyte(13.3×10^(-6) K^(-1) for Sm_(0.2)Ce_(0.8)O_(1.9),SDC),indicates excellent thermomechanical *** 550-750℃,STF shows superior oxygen vacancy concentrations(0.262 to 0.331),which is critical in the oxygen-reduction reaction(ORR).Oxygen temperature-programmed desorption(O_(2)-TPD)indicated the thermal reduction onset temperature of iron ion is around 420℃,which matched well with the inflection points on the thermos-gravimetric analysis and electrical conductivity *** 600℃,the STF electrode shows area-specific resistance(ASR)of 0.152Ω·cm^(2) and peak power density(PPD)of 749 mW·cm^(-2).ORR activity of STF was further improved by introducing 30wt%Sm_(0.2)Ce_(0.8)O_(1.9)(SDC)powder,STF+SDC composite cathode achieving outstanding ASR value of 0.115Ω·cm2 at 600℃,even comparable with benchmark cobalt-containing cathode,Ba_(0.5)Sr_(0.5)Co_(0.8)Fe_(0.2)O_(3-δ)(BSCF).Distribution of relaxation time(DRT)analysis revealed that the oxygen surface exchange and bulk diffusion were improved by forming a composite *** 650℃,STF+SDC composite cathode achieving an outstanding PPD of 1117 mW·cm^(-2).The excellent results suggest that STF and STF+SDC are promising air electrodes for IT-SOFCs.

关键词： strontium ferrite-based perovskite Ta doping composite cathode intermediate-temperature solid oxide fuel cells

The Puesto Piris Formation: Evidence of basin-development in the North Patagonian Massif during crustal extension associated with Gondwana breakup

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Geoscience Frontiers 2019年第1期10卷 299-314页

作者： Leonardo Strazzere Daniel A.Gregori Leonardo Benedini paulo Marcos Mercedes V.barros Mauro C.Geraldes Cecilia Pavon Pivetta Instituto Geológico del Sur Consejo Nacional de Investigaciones Científicas y Técnicas Av Cátedra de Geología Minera Universidad Nacional del Sur Cátedra de Geología Argentina Universidad Nacional del Sur Av Cátedra de Geofísica Departamento de Geología Universidad Nacional del Sur Av Departamento de Geología Regional Facultad de Geología Universidad Estatal de Rio de Janeiro

The Marifil Volcanic Complex, exposed in the eastern North Patagonian Massif, Argentina, includes up to 550 m of red conglomerates, sandstones, black siltstones, limestones, and reworked tuff of the Puesto Piris Formation. The basal part of this unit, which was deposited in high-gradient topographic relief, is composed of conglomerates and sandstones with thin layers of reworked tuffs. The lithofacies associations of the basal part indicate that the depositional mechanisms were mantled and gravitational *** middle part of the unit consists of fine sandstones, limestones, and black siltstones that were deposited in low-energy fluvial and lacustrine environments. The outcrops are located along the NEe SW direction and the major thickest units represented by limestones and siltstones, occur near the southeastern border of this NEeS W depocenter. Since the rhyolitic and trachytic lava flows and tuffs of the Marifil Volcanic Complex are interbedded with the sedimentary sequences of the Puesto Piris Formation,both units are coeval. Zircon Ue Pb age was obtained for a trachytic lava flow(193.4 ±3.1 Ma) suggesting that sedimentation and volcanism are Sinemurian. This extensional episode was recorded in the eastern,western, and southwestern sectors of the North Patagonian Massif, and is possibly associated with the Gondwana supercontinent breakup.

关键词： Puesto Piris Formation Early Jurassic North Patagonian Massif

Columnar joints in the Patino Formation sandstones, Eastern Paraguay： a dynamic interaction between dyke intrusion, quartz dissolution and cooling-induced fractures

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Episodes 2008年第3期31卷 302-308页

作者： Victor Fernandez Velazquez paulo Cesar Fonseca Giannini Claudio Riccomini Alethea Ernandes Martins Sallun Jorge Hachiro Celso de barros Gomes Eseola de Artes Ciencias e Humanidades Universidade de Sao Paulo Rua Arlindo Betio 1000 03828-080 Sao Paulo Brasil Instituto de Geociencias Universidade de Sao Paulo Rua do Lago 562 05508-080 Sao Paulo Brasil Insfituto Geolegico Secretaria do Meio Ambiente Av. Miguel Estefano 3900 04301-903 Sao Paulo Brasil.

The Patiho Formation sandstones, which crop out in Aregud neighborhood in Eastern Paraguay and show columnar joints near the contact zone with a nephelinite dyke, have as their main characteristics the high pro- portion of syntaxial quartz overgrowth and a porosity originated from different processes, initially by dissolu- tion and later by partial filling and fracturing. Features like the presence of floating grains in the syntaxial cement, the transitional interpenetrative contact between the silica-rich cement and grains as well as the intense fracture porosity are strong indications that the cement has been formed by dissolution and reprecipita- tion of quartz from the framework under the effect of thermal expansion followed by rapid contraction. The increase of the silica-rich cement towards the dyke in association with the orthogonal disposition of the columns relative to dyke walls are indicative that the igneous body may represent the main heat source for the interstitial aqueous solutions previously existing in the sediments. At macroscopic scale, the increasing of inter- nal tensions in the sandstones is responsible for the nucleation of polygons, leading to the individualization of prisms, which are interconnected by a system of joints, formed firstly on isotherm surfaces of low tem- perature and later on successive adjacent planes towards the dyke heat source.

关键词：柱状连接砂岩巴拉圭南美洲动力学