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Prognostic significance of heart rate in hospitalized patients presenting with myocardial infarction

World Journal of Cardiology 2012年第1期4卷 15-19页

作者： Lorenzo Fácila pedro Morillas Juan Quiles Federico Soria Alberto Cordero Pilar Mazón manuel Anguita Cándido Martín-Luengo Jose Ramón Gonzalez-Juanatey Vicente Bertomeu Department of Cardiology Consorcio Hospitalario General de Valencia Department of Cardiology Hospital Universitario de San Juan Department of Cardiology Hospital Virgen de la Arrixaca Department of Cardiology Hospital Clínico Universitario Santiago de Compostela Department of Cardiology Hospital Reina Sofía Department of Cardiology Hospital Universitario de Salamanca

AIM: To investigate the prognostic significance of resting heart rate in patients with acute coronary syndrome (ACS), independent of other known factors. METHODS: Patients 40 years of age or older who had been admitted with acute coronary syndrome (ACS) to one of the 94 hospitals participating in the Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome (PAMISCA) study were included. Patients were divided into two groups based on their resting heart rate (HR ≥ or < 70 bpm). Complications were recording during a follow-up period of 1 year. RESULTS: There were 1054 ACS patients analyzed (43.5% with ST segment elevation and 56.5% without elevation). Mean age was 66.6 ± 11.7 years, 70.6% were male and 29.4% of subjects were female. During follow-up, more patients in the HR ≥ 70 bpm group were hospitalized for heart failure and they also had a higher mortality rate. In the multivariate analysis, a heart rate of ≥ 70 bpm was independently related to overall mortality during the follow-up period (hazard ratio 2.5; 95% confidence interval, 1.26-4.97, P = 0.009). CONCLUSION: A resting heart rate ≥ 70 bpm in patients who survive an ACS is an indicator of a high risk of suffering cardiovascular events during follow-up.

关键词： Heart rate Myocardial infarction Prognosis

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Community‑based screening of Chagas disease among Latin American migrants in a non‑endemic country: an observational study

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Infectious Diseases of Poverty 2021年第5期10卷 14-27页

作者： Violeta Ramos‑Sesma Miriam Navarro Jara Llenas‑García Concepción Gil‑Anguita Diego Torrus‑Tendero Philip Wikman‑Jorgensen María García‑López Concepción Amador‑Prous María‑Paz Ventero‑Martín pedro Guevara‑Hernández Ana Garijo‑Saiz Ares Sanchez‑Sanchez Cristina Bernal‑Alcaraz Ana‑Isabel Pujades‑Tarraga Roser Muñoz‑Perez María Flores‑Chávez José‑manuel Ramos‑Rincón Internal Medicine Service HLA Inmaculada HospitalGranadaSpain Public Health Science History and Gynecology DepartmentUniversidad Miguel Hernández de ElcheAlicanteSpain Epidemiology Unit Public Health Center of Elche AlicanteSpain Internal Medicine Department Hospital Vega Baja de Orihuela(AlicanteSpain)-Foundation for the Promotion of Health and Biomedical Research of the Valencia Region(FISABIO)AlicanteSpain Clinical Medicine Department University Miguel Hernández of ElcheSant Joan d’AlacantSpain Internal Medicine Department Hospital Marina BaixaLa Vila Joiosa(AlicanteSpain)-FISABIOAlicanteSpain Internal Medicine Department General University Hospital of Alicante–Biomedical and Health Research Institute of Alicante(ISABIAL)AlicanteSpain Parasitology Area University Miguel Hernández of ElcheSant Joan d’AlacantSpain Internal Medicine Department University Hospital of Sant Joan(Sant Joan d’AlacantSpain)–FISABIOAlicanteSpain Microbiology Service General University Hospital of Alicante–ISABIALAlicanteSpain Pediatric Department General University Hospital of Alicante–ISABIALAlicanteSpain Digestive Service General University Hospital of Alicante–ISABIALAlicanteSpain Reference and Research Laboratory in Parasitology National Center of Microbiology/Mundo Sano FoundationMadridSpain

Background:Chagas disease is a parasitic disease endemic to Latin America,but it has become a disease of global concern due to migration *** carriers may host the parasite for years,without knowing they are *** aim of this study is to assess prevalence of Chagas disease and evaluate the participants’level of knowl‑edge between Latin American migrants attending a community-based screening ***:Three community-based campaigns were performed in Alicante(Spain)in 2016,2017 and 2018,including educational chats and blood tests for Trypanosoma cruzi *** completed a questionnaire assessing knowledge about the mechanisms of transmission,disease presentation,diagnosis,and *** seroposi‑tive for *** underwent diagnostic confrmation by two diferent *** were analyzed by multivariable logistic regression and expressed as adjusted odds ratios(aORs),adjusting for age,sex,and time in ***:A total of 596 participants were included in the study;17%were aged under 18 *** in adults was 11%[54/496;95%confdence interval(CI):8.3–14.5%]versus 0%among *** but one case were in *** was independently associated with having been born in Bolivia(aOR:102,95%CI:13–781)and a primary school-level education(aOR:2.40,95%CI:1.14–5.06).Of 54 people diagnosed with Chagas disease(most of whom were asymptomatic),42(77.7%)returned to the clinic at least once,and 24(44.4%)received *** analysis showed that coming from Argentina(aOR:13,95%CI:1.61–1188)or Bolivia(aOR:1.90,95%CI:1.19–3.39)and having received information about Chagas disease in Spain(aOR:4.63,95%CI:2.54–8.97)were associ‑ated with a good level of knowledge on the *** primary level studies(aOR:0.59,95%CI:0.34–0.98)and coming from Ecuador(aOR:4.63,95%CI:2.52–847)were independently associated with a lower level of ***:Community-based interventions are a good strategy for diagnosi

关键词： Chagas disease Trypanosoma cruzi Knowledge Community-based intervention Migrant Early diagnosis Screening

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Protective and Regenerative Effect of the Extract of Kombucha and the Fungus Ganoderma sichuanense on the Islets of Langerhans of Diabetic Rats

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Open Journal of Veterinary Medicine 2023年第10期13卷 173-185页

作者： pedro Hinojosa-Gómez Sergio Fausto-Guerra Guillermo Nolasco-Rodríguez Lucia García-Delgado Víctor Barragán-Cano manuel Rosales-Cortés Esther Albarrán-Rodríguez José Ricardo Cuéllar-Pérez Department of Veterinary Medicine University Center for Agricultural Biological Sciences University of Guadalajara Jalisco Mexico Doctorate of Sciences in Ecophysiology and Genetic Resources University Center for Agricultural Biological Sciences University of Guadalajara Jalisco Mexico Department of Botany and Zoology University Center for Agricultural Biological Sciences University of Guadalajara Jalisco Mexico

Objective: The present study consisted of challenging the extract of kombucha and the fungus Ganoderma reported as hypoglycemic and used as alternative treatments against diabetes on the number and morphology of islets of Langerhans. Material and Methods: 64 Wistar rats were used in 4 groups: one control, three experimental, streptozotocin, Kombucha y Ganoderma induced diabetes with streptozotocin. Divided into four post-induction stages at 2, 15, 30 and 45 days of treatment, sacrificing 4 rats at each stage, to perform the morphological analysis of the pancreas. Results: A decrease in the islets of Langerhans in size, volume and the number of cells within them was identified for the streptozotocin group from the second stage until almost disappearing due to diabetes, in the groups of Kombucha y Ganoderma the same was observed but they were recovered with the extract treatments and the average number of islets was similar in these groups, the group of Ganoderma. Conclusion: Under the conditions of this work, a protective and regenerative effect of both extracts is identified.

关键词： Rats Diabetes Streptozotocin Ganoderma Kombucha Pancreas

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Synthesis of Solid Acid Catalysts Based on TiO2- SO42-and Pt/TiO2- SO42-Applied in n-Hexane Isomerization

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Open Journal of Metal 2013年第3期3卷 34-44页

作者： Juan manuel Hernández Enríquez Luz Aracely Cortez Lajas Ricardo García Alamilla Estefanía ángeles San Martín pedro García Alamilla Edward Brent Handy Guadalupe Cárdenas Galindo Luz Arcelia García Serrano CIEP Facultad de Ciencias Químicas Universidad Autónoma de San Luis Potosí Av. Dr. Manuel Nava #6 Zona Universitaria 78210 San Luis Potosí San Luis Potosí México Instituto Politécnico Nacional Centro Interdisciplinario de Investigaciones y Estudios sobre Medio Ambiente y Desarrollo 30 de Junio #1520 Barrio La Laguna Ticomán 07340 México D.F. México Instituto Tecnológico de Cd. Madero División de Estudios de Posgrado e Investigación Juventino Rosas y Jesús Urueta S/N Col. Los Mangos 89440 Cd. Madero Tamaulipas México Universidad Juárez Autónoma de Tabasco División Académica de Ciencias Agropecuarias Avenida Universidad S/N Zona Cultura Colonia Magisterial 86040 Villahermosa Tabasco México

The physicochemical properties and catalytic activity of pure and sulfated titanium oxide (TiO2 and ) is described in this work. Titanium hydroxide synthesized by the sol-gel method was impregnated with a 1 N H2SO4 solution, varying amount of sulfate ions () in the range from 10 to 20 wt%. Pure and modified hydroxides were calcined at 500°C for 3 h and then characterized by TGA-DTG, XRD, BET, FT-IR, potentiometric titration with n-butylamine and 2-propanol dehydration. Catalytic activity of materials was tested in the n-hexane isomerization at 350°C. The results showed that TiO2 and mainly developed anatase phase. All have acceptable specific surface area (95-105 m2/g). Potentiometric titration with n-butylamine revealed that showed higher acidity (430-530 mV) than compared to pure TiO2 (﹣15 mV), indicating that this oxide only has weak acidity. The results showed good relationship between acidity determined by potentiometric titration with n-butylamine and the catalytic activity evaluated by 2-propanol dehydration and n-hexane isomerization. Titanium oxide with 20 wt% ofions was the material that demonstrated the highest catalytic activity for both reactions.

关键词： Acid Catalysts Sulfated Titanium Oxide Physico-Chemical Properties n-Hexane Isomerization

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Ag, Hg and Cr Precipitation for Recycling Derived of Hazardous Liquid Waste

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Green and Sustainable Chemistry 2013年第2期3卷 37-42页

作者： Silvia C. Gutiérrez-Gutiérrez Genoveva Rosano-Ortega Carlos Vega-Lebrún Juan manuel López pedro ávila-Pérez Sonia M. Martínez Gallegos Daniel Cruz González Chemical Engineering Faculty Benemérita Universidad Autónoma de Puebla Puebla México Division of Graduate Studies and Research Instituto Tecnológico de Toluca Toluca México Research Department Universidad Popular Autónoma del Estado de Puebla (UPAEP) Puebla México Technological Research División Instituto Nacional de Investigaciones Nucleares Ocoyoacac México

Production of different compounds can generate large amounts of hazardous wastes which are dangerous to the environment and human health. The disposal or treatment of hazardous liquid waste rich in heavy metals like silver (Ag), mercury (Hg) and chromium (Cr) is difficult due to the strong acidity and toxicity which usually present in these contaminants. For this study, several research works were reviewed in order to obtain an efficient and viable treatment in time and removal efficiency. A series of chemical precipitations were evaluated for efficiency in the reduction of heavy metals in liquid waste. The precipitation of all three metals lasted 30 minutes and after treatment the wastewater presented concentrations of 0.064 mg·L-1 Ag, 0.010 mg·L-1 Hg and 0.048 mg·L-1 Cr, with a standard pH (7.5-8.5);with removal efficiencies of 94.31% for Ag, 99.99% for Hg and 98.17% for Cr.

关键词： Hazardous Liquid Waste Treatment for Recycling Silver Mercury Chromium

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First radiative shock experiments on the SG-Ⅱ laser

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High Power Laser Science and Engineering 2021年第2期9卷 198-205页

作者： Francisco Suzuki-Vidal Thomas Clayson Chantal Stehlé Uddhab Chaulagain Jack W.D.Halliday Mingying Sun Lei Ren Ning Kang Huiya Liu Baoqiang Zhu Jianqiang Zhu Carolina De Almeida Rossi Teodora Mihailescu pedro Velarde manuel Cotelo John M.Foster Colin N.Danson Christopher Spindloe Jeremy P.Chittenden Carolyn Kuranz Blackett Laboratory Imperial College London First Light Fusion Ltd 3. Magdrive Ltd LERMA Sorbonne-Université ELI Beamlines Center Institute of Physics Czech Academy of Sciences Shanghai Institute of Optics and Fine Mechanics Chinese Academy of Sciences Instituto de Fusión Nuclear Guillermo Velarde Universidad Politécnica de Madrid AWE plc. Aldermaston Science and Technology Facilities Council Rutherford Appleton LaboratoryHarwell Campus University of Michigan

We report on the design and first results from experiments looking at the formation of radiative shocks on the Shenguang-Ⅱ(SG-Ⅱ) laser at the Shanghai Institute of Optics and Fine Mechanics in ***-heating of a two-layer CH/CH-Br foil drives a～40 km/s shock inside a gas cell filled with argon at an initial pressure of 1 *** use of gas-cell targets with large(several millimetres) lateral and axial extent allows the shock to propagate freely without any wall interactions,and permits a large field of view to image single and colliding counter-propagating shocks with time-resolved,pointprojection X-ray backlighting(～20 μm source size,4.3 keV photon energy).Single shocks were imaged up to 100 ns after the onset of the laser drive,allowing to probe the growth of spatial nonuniformities in the shock *** results are compared with experiments looking at counter-propagating shocks,showing a symmetric drive that leads to a collision and stagnation from～40 ns *** present a preliminary comparison with numerical simulations with the radiation hydrodynamics code ARWEN,which provides expected plasma parameters for the design of future experiments in this facility.

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αKLOTHO and sTGFβR2 treatment counteract the osteoarthritic phenotype developed in a rat model

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Protein & Cell 2020年第3期11卷 219-226页

作者： Paloma Martinez-Redondo Isabel Guillen-Guillen Noah Davidsohn Chao Wang Javier Prieto Masakazu Kurita Fumiyuki Hatanaka Cuiqing Zhong Reyna Hernandez-Benitez Tomoaki Hishida Takashi Lezaki Akihisa Sakamoto Amy NNemeth Yuriko Hishida Concepcion Rodriguez Esteban Kensaku Shojima Ling Huang Maxim Shokhirev Estrella Nunez-Delicado Josep MCampistol Isabel Guillen-Vicente Elena Rodriguez-Inigo Juan manuel Lopez-Alcorocho Marta Guillen-Vicente George Church Pradeep Reddy pedro Guillen-Garcia Guang-Hui Liu Juan Carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityCambridgeMA 02115USA Department of Genetics Harvard Medical SchoolBostonMA 02115USA Integrative Genomics and Bioinformatics Core Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 92037USA Universidad Catolica San Antonio de Murcia(UCAM) Campus de los JeronimosNo 1351230107 GuadalupeSpain Hospital Clinic of Barcelona Career Villarroel17008036 BarcelonaSpain Department of Traumatology and Research Unit Clinica CEMTRO28035 MadridSpain National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem cell and Regeneration Chinese Academy of SciencesBeijing 100101China Translational Medical Center for Stem Cell Therapy Shanghai East HospitalTongji University School of MedicineShanghai 200120China

Dear Editor,Homeostasis and repair are critical biological processes that allow for tissue and organ preservation and function in multicellular *** regulation and extension vary drastically across the animal kingdom,and mammals show limited tissue-specific regenerative capacity that declines with *** aging,articular cartilage is one of the tissues that undergo substantial changes in the matrix structure,molecular composition,metabolic activity,and mechanical properties(Loeser et al.2016).

关键词： aging treatment critical

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Skin models of cutaneous toxicity,transdermal transport and wound repair

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Burns & Trauma 2023年第1期11卷 393-407页

作者： Inês Vilela de Sousa Miguel J.S.Ferreira Luís B.Bebiano Sandra Simões Ana Filipa Matos Rúben F.Pereira pedro L.Granja i3S-Instituto de Investigação e Inovação em Saúde Universidade do PortoRua Dr.Manuel Pereira da Silva4200-393 PortoPortugal INEB-Instituto de Engenharia Biomédica Universidade do PortoRua do Campo Alegre8234150-180 PortoPortugal ICBAS-Instituto de Ciências Biomédicas Abel Salazar Universidade do PortoRua de Jorge Viterbo Ferreira 2284050-313 PortoPortugal FEUP-Faculdade de Engenharia da Universidade do Porto Rua Dr.Roberto Frias4200-465 PortoPortugal Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringFaculty of Science and Engineering&Henry Royce InstituteEngineering Building AThe University of ManchesterOxford RoadManchester M139PLUK ISEP-Instituto Superior de Engenharia do Porto Universidade do PortoRua Dr.António Bernardino de Almeida 4314200-072 PortoPortugal iMed.ULisboa Faculty of PharmacyUniversidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal Faculty of Pharmacy Universidade de LisboaAv.Prof.Gama Pinto1649-003 LisboaPortugal

Skin is widely used as a drug delivery route due to its easy access and the possibility of using relatively painless methods for the administration of bioactive ***,the barrier properties of the skin,along with its multilayer structure,impose severe restrictions on drug transport and ***,bioengineered models aimed at emulating the skin have been developed not only for optimizing the transdermal transport of different drugs and testing the safety and toxicity of substances but also for understanding the biological processes behind skin *** though in vivo research is often preferred to study biological processes involving the skin,in vitro and ex vivo strategies have been gaining increasing relevance in recent ***,there is a noticeably increasing adoption of in vitro and ex vivo methods by internationally accepted ***,microfluidic organ-on-a-chip devices are nowadays emerging as valuable tools for functional and behavioural skin *** in miniaturization,automation and reliability still need to be addressed in order to create skin models that can predict skin behaviour in a robust,high-throughput manner,while being compliant with regulatory issues,standards and *** this review,skin models for transdermal transport,wound repair and cutaneous toxicity will be discussed with a focus on high-throughput *** microfluidic strategies driven by advancements in microfabrication technologies will also be revised as a way to improve the efficiency of existing models,both in terms of complexity and throughput.

关键词： Skin In vitro models Ex vivo models Transdermal transport assays Wound healing assays Toxicity assays Microfluidic chip Skin-on-a-chip

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Characterization and Comparison of Microbial Soil Diversity in Two Andean Peatlands in Different States of Conservation-Vega Tocorpuri

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Journal of Geoscience and Environment Protection 2018年第4期6卷 194-210页

作者： Carolina Belfiore Ana Fernandez Ana Paula Santos manuel Contreras María Eugenia Farías Laboratorio de Investigaciones Microbiològicas de Lagunas Andinas (LIMLA) Planta Piloto de Procesos Industriales Microbiol&#242gicos (PROIMI-CONICET) Tucuma&#225n Argentina Centro de Ecologiía Aplicada (CEA) Suecia Chile

Cerro Tocorpuri, belongs to the II region of Chile, in San pedro de Atacama, on the border of Chile-Bolivia. The presence of a more or less constant supply of water conditions the existence of characteristic vegetation systems known as bogs (bofedales, vegas and marshes). These wetlands have a cultural, environmental and economic social importance. As a result of the exploitation of aquatic rights, peatlands began to dry up with the consequent loss of natural resources and damage to ancestral rights, and natural resources. The activities of microorganisms in wetlands play an important role in biogeochemical processes. The interaction between microbial diversity and soil, influences to the ability of the ecosystem to recover from stress (resilience). In the present work, the soil characteristics and the associated microbial biodiversity were studied, comparing samples of active and deteriorated peatland. It was seen that the loss of water causes great changes in the physical-chemical characteristics of the soil, which leads to a modification of the microbiota Proteobacteria decreased by 18% in deteriorated peatlands, which are evident more sensible to extreme conditions while Acidobacteria, Actinobacteria increased in these sample showing a better adaptation to the change of conditions. In view of the fact that high Andean Peatlands are exposed to increasing environmental impact, this preliminary comparative study of pristine and altered soil could guide the research directed to recovery of dead peatlands strategies.

关键词： Peatland Microbial Diversity Altered Soil

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First radiative shock experiments on the SG-II laser

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High Power Laser Science and Engineering 2021年第2期9卷 193-200页

作者： Francisco Suzuki-Vidal Thomas Clayson Chantal Stehlé Uddhab Chaulagain Jack W.D.Halliday Mingying Sun Lei Ren Ning Kang Huiya Liu Baoqiang Zhu Jianqiang Zhu Carolina De Almeida Rossi Teodora Mihailescu pedro Velarde manuel Cotelo John M.Foster Colin N.Danson Christopher Spindloe Jeremy P.Chittenden Carolyn Kuranz Blackett Laboratory Imperial College LondonLondonUK First Light Fusion Ltd YarntonUK LERMA Sorbonne-UniversitéObservatoire de ParisCNRSFrance ELI Beamlines Center Institute of PhysicsCzech Academy of SciencesDolni BrezanyCzech Republic Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghaiChina Instituto de Fusión Nuclear Guillermo Velarde Universidad Politécnica de MadridMadridSpain AWE plc. AldermastonReadingUK Science and Technology Facilities Council Rutherford Appleton LaboratoryHarwell CampusChiltonDidcotUK University of Michigan Ann ArborMIUSA Current affiliation:Magdrive Ltd HarwellUK

We report on the design and first results from experiments looking at the formation of radiative shocks on the ShenguangII(SG-II)laser at the Shanghai Institute of Optics and Fine Mechanics in ***-heating of a two-layer CH/CH–Br foil drives a∼40 km/s shock inside a gas cell filled with argon at an initial pressure of 1 *** use of gas-cell targets with large(several millimetres)lateral and axial extent allows the shock to propagate freely without any wall interactions,and permits a large field of view to image single and colliding counter-propagating shocks with time-resolved,pointprojection X-ray backlighting(∼20µm source size,4.3 keV photon energy).Single shocks were imaged up to 100 ns after the onset of the laser drive,allowing to probe the growth of spatial nonuniformities in the shock *** results are compared with experiments looking at counter-propagating shocks,showing a symmetric drive that leads to a collision and stagnation from∼40 ns *** present a preliminary comparison with numerical simulations with the radiation hydrodynamics code ARWEN,which provides expected plasma parameters for the design of future experiments in this facility.

关键词： high energy density physics laboratory astrophysics plasma physics high-power laser laser-driven shocks experiments X-ray backlighting X-ray radiography

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