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machine perfusion and the prevention of ischemic type biliary lesions following liver transplant:What is the evidence?

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World Journal of Gastroenterology 2023年第20期29卷 3066-3083页

作者： manuel Durán Rafael Calleja Angus Hann George Clarke Ruben Ciria Anisa Nutu Rebeca Sanabria-mateos maría Dolores Ayllón pedro López-Cillero Hynek mergental Javier Briceño m Thamara P R Perera Department of Liver Transplantation Reina Sofía University HospitalCórdoba 14004Spain The Liver Unit Queen Elizabeth Hospital BirminghamBirmingham B152THUnited Kingdom Centre for Liver and Gastrointestinal Research Institute of Immunology and ImmunotherapyUniversity of BirminghamBirmingham B152THUnited Kingdom

The widespread uptake of different machine perfusion(mP)strategies for liver transplant has been driven by an effort to minimize graft *** to the cholangiocytes during the liver donation,preservation,or early posttransplant period may result in stricturing of the biliary tree and inadequate biliary *** problem continues to trouble clinicians,and may have catastrophic consequences for the graft and *** injury,as a result of compromised hepatic artery flow,is a well-known cause of biliary strictures,sepsis,and graft ***,very similar lesions can appear with a patent hepatic artery and these are known as ischemic type biliary lesions(ITBL)that are attributed to microcirculatory dysfunction rather than main hepatic arterial *** the warm and cold ischemic period duration appear to influence the onset of *** of the commonly used mP techniques deliver oxygen to the graft cells,and therefore may minimize the cholangiocyte injury and subsequently reduce the incidence of *** clinical experience and published evidence grows for these modalities,the impact they have on ITBL rates is important to *** this review,the evidence for the three commonly used mP strategies(abdominal normothermic regional perfusion[A-NRP],hypothermic oxygenated perfusion[HOPE],and normothermic machine perfusion[NmP])for ITBL prevention has been critically *** with ITBL definitions used in trials,coupled with variations in techniques of mP,make interpretation ***,the evidence suggests that both HOPE and A-NRP prevent ITBL in donated after circulatory death grafts compared to cold *** evidence for ITBL prevention in donor after brain death grafts with any mP technique is weak.

关键词： Liver transplant Ischemic type biliary lesions Hypothermic oxygenated machine perfusion Normothermic machine perfusion Abdominal normothermic regional perfusion Donation after circulatory death

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Structural and photoluminescent properties of the mgGa_(2)O_(4):Co^(2+)ceramic compound revisited after two decades

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Journal of Advanced Ceramics 2015年第4期4卷 267-271页

作者： S.S.pedro m.A.F.m.DA SILVA A.LÓPEZ,L.P.SOSmAN Instituto de Física Universidade do Estado do Rio de JaneiroRJ 20550-900Brazil

In this work,we revisit and show how the structural and photoluminescent properties of the mgGa_(2)O_(4) ceramic compound have been kept unchanged for more than two *** obtained results confirm the high quality,radiative efficiency,and chemical stability of this ceramic,proving that the material is a strong candidate to be used in optical device applications with relatively long useful life.

关键词： ceramic compound cobalt solid-state reaction photoluminescence

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Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli m.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tamlihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alimonti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Amaral Coutinho A. Ambler C. Amelung m. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia m. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m-S. Barisits T. Barklow P. Baron D.A. Baron mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

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Complex patterns of environmental niche evolution in Iberian columbines (genus Aquilegia, ranunculaceae)

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Journal of Plant Ecology 2015年第5期8卷 457-467页

作者： Rafael Jaime Julio m.Alcántara Jesús m.Bastida pedro J.Rey Departamento de Biología Animal Biología Vegetal y EcologíaUniversidad de JaénCampus Las Lagunillass/n.Jaén E-23071Spain

Aims This study explores the patterns of niche differentiation in a group of seven closely related columbines(genus Aquilegia,ranunculaceae)from the Iberian *** of these columbines are subject to complex patterns of divergent selection across environ-ments,which partly explain the taxonomic structure of the *** suggests the hypothesis that niche divergence must have occurred along the process of diversification of the *** We used maxEnt to build environmental niche models of seven subspecies belonging to the three species of Aquilegia present in the Iberian *** these models,we compared the envi-ronmental niches through two different approaches:ENmtools and multivariate *** FindingsmaxEnt distributions conformed closely to the actual distribution of the study *** methods failed to uncover any clear patterns of niche differentiation or conservatism in Iberian *** analyses indicate the existence of dif-ferentiation along altitudinal gradients and along a gradient of climatic conditions determined by the summer precipitation and ***,climatic conditions related to winter tem-perature and precipitation,as well as soil properties,were equally likely to show conservatism or *** complex patterns of niche evolution we found suggest that Iberian Columbines have not been significantly constrained by forces of niche conservatism,so they could respond adaptively to the fast and profound climate changes in the Iberian Peninsula through the glacial cycles of the Pleistocene.

关键词： Aquilegia ecological niche modelling niche divergence niche conservatism evolution maxEnt ENmTools

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m6A-TSHub:Unveiling the Context-specific m^(6)A methylation and m^(6)A-affecting mutations in 23 Human Tissues

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Genomics, Proteomics & Bioinformatics 2023年第4期21卷 678-694页

作者： Bowen Song Daiyun Huang Yuxin Zhang Zhen Wei Jionglong Su João pedro de magalhães Daniel J.Rigden Jia meng Kunqi Chen Key Laboratory of Gastrointestinal Cancer(Fujian medical University) Ministry of EducationSchool of Basic Medical SciencesFujian Medical UniversityFuzhou 350004China Department of mathematical Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Institute of Systems Molecular and Integrative BiologyUniversity of LiverpoolLiverpool L697ZBUnited Kingdom Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Department of Computer Science University of LiverpoolLiverpool L697ZBUnited Kingdom Institute of Ageing&Chronic Disease University of LiverpoolLiverpool L697ZBUnited Kingdom School of AI and Advanced Computing Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China AI University Research Centre Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

As the most pervasive epigenetic marker present on mRNAs and long non-coding RNAs(lncRNAs),N6-methyladenosine(m^(6)A)RNA methylation has been shown to participate in essential biological *** studies have revealed the distinct patterns of m^(6)A methylome across human tissues,and a major challenge remains in elucidating the tissue-specific presence and circuitry of m^(6)A *** present here a comprehensive online platform,m^(6)A-TSHub,for unveiling the context-specific m^(6)A methylation and genetic mutations that potentially regulate m^(6)A epigenetic mark.m^(6)A-TSHub consists of four core components,including(1)m^(6)A-TSDB,a comprehensive database of 184,554 functionally annotated m^(6)A sites derived from 23 human tissues and 499,369 m^(6)A sites from 25 tumor conditions,respectively;(2)m^(6)A-TSFinder,a web server for high-accuracy prediction of m^(6)A methylation sites within a specific tissue from RNA sequences,which was constructed using multi-instance deep neural networks with gated attention;(3)m^(6)ATSVar,a web server for assessing the impact of genetic variants on tissue-specific m^(6)A RNA modifications;and(4)m^(6)A-CAVar,a database of 587,983 The Cancer Genome Atlas(TCGA)cancer mutations(derived from 27 cancer types)that were predicted to affect m^(6)A modifications in the primary tissue of *** database should make a useful resource for studying the m^(6)A methylome and the genetic factors of epitranscriptome disturbance in a specific tissue(or cancer type).m^(6)A-TSHub is accessible at ***/biologicalsciences/m^(6)ats.

关键词： N^(6)-methyladenosine Context-specific analysis Cancer mutation Genome analysis Functional annotation

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Big data in healthcare:Conceptual network structure,key challenges and opportunities

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数字通信与网络:英文版 2023年第4期9卷 856-868页

作者： Leonardo B.Furstenaua pedro Leivas michele Kremer Sott michael S.Dohan Jose Ricardo Lopez-Robles manuel J.Cobo Nicola Luigi Bragazzi Kim-Kwang Raymond Choo Post-Graduate Program in Industrial Engineering Federal University of Rio Grande Do SulPorto Alegre90035-190Brazil University of Santa Cruz Do Sul Av.Independencia 2293Santa Cruz Do SulRSBrazil Business School Unisinos UniversityAv.Dr.Nilo Peçanha 160091330-002Porto AlegreBrazil Faculty of Business Administration Lakehead UniversityThunder BayOntarioCanada Autonomous University of Zacatecas Av.Ramon Lopez Velarde Col.CentroZacatecas98000Mexico Department of Computer Science and Artificial Intelligence Andalusian Research Institute in Data Science and Computational Intelligence(DaSCI)University of GranadaGranada 18071Spain York University ON M3J 1P3Canada Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX78249USA

Big data is a concept that deals with large or complex data sets by using data analysis tools(e.g.,data mining,machine learning)to analyze information extracted from several sources *** data has attracted wide attention from academia,for example,in supporting patients and health professionals by improving the accuracy of decision-making,diagnosis and disease *** research aimed to perform a Bibliometric Performance and Network Analysis(BPNA)supported by a Scoping Review(SR)to depict the strategic themes,thematic evolution structure,main challenges and opportunities related to the concept of big data applied in the healthcare *** this goal in mind,4857 documents from the Web of Science covering the period between 2009 to June 2020 were analyzed with the support of ScimAT *** bibliometric performance showed the number of publications and citations over time,scientific productivity and the geographic distribution of publications and research *** strategic diagram yielded 20 clusters and their relative importance in terms of centrality and *** thematic evolution structure presented the most important themes and how it changes over ***,we presented the main challenges and future opportunities of big data in healthcare.

关键词： Big data Healthcare digitalization Bibliometric Strategic intelligence Co-word analysis ScimAT

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Hydro-wind Optimal Operation for Joint Bidding in Day-ahead market: Storage Efficiency and Impact of Wind Forecasting Uncertainty

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Journal of modern Power Systems and Clean Energy 2020年第1期8卷 142-149页

作者： António Cerejo Sílvio J.P.S.mariano pedro m.S.Carvalho maria R.A.Calado Technical-Scientific Unity of Electrical and Industrial Engineering Polytechnic Institute of Castelo BrancoAvenida do Empresário6000-767 Castelo BrancoPortugal Department of Electromechanical Engineering University of Beira Interior and Instituto de TelecomunicacoesCalcada Fonte do Lameiro6201-001 CovilhaPortugal Department of Electrical and Computer Engineering Instituto Superior Técnicoand INESC-IDUniversity of LisbonAv.Rovisco Pais1049-001 LisbonPortuga

Wind power production is *** imbalance between committed and delivered energy in pool markets leads to the increase of system costs,which must be incurred by defaulting producers,thereby decreasing their *** avoid this situation,wind producers can submit their bids together with hydro *** the mismatches between the predicted and supplied wind power can be used by hydro producers,turbining or pumping such differences when *** study formulates the problem of hydro-wind production optimization in operation contexts of pool *** problem is solved for a simple three-reservoir cascade case to discuss optimization *** results show a depreciation in optimal revenues from hydro power when wind forecasting is *** depreciation is caused by an asymmetry in optimal revenues from positive and negative wind power *** problem of neutralizing the effect of forecasting uncertainty is subsequently formulated and solved for the three-reservoir *** results are discussed to conclude the impacts of uncertainty on joint bidding in pool market contexts.

关键词： Optimization hydro power wind power uncertainty joint bidding pool market

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more Transporters,more Substrates:The Arabidopsis major Facilitator Superfamily Revisited

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molecular Plant 2019年第9期12卷 1182-1202页

作者： maria Nino-Gonzalez Esther Novo-Uzal Dale N.Richardson pedro m.Barros Paula Duque Instituto Gulbenkian de Ciencia 2780-156 OeirasPortugal Genomics of Plant Stress Unit ITQB NOVA-Instituto de Tecnologia Quimica e Biologica Antonio XavierUniversidade Nova de Lisboa2780-157 OeirasPortugal

The major Facilitator Superfamily(mFS)is ubiquitous in living organisms and represents the largest group of secondary active membrane *** plants,significant research efforts have focused on the role of specific families within the mFS,particularly those transporting macronutrients(C,N,and P)that constitute the vast majority of the members of this *** mFS families remain less explored,although a plethora of additional substrates and physiological functions have been ***,the lack of a systematic approach to analyzing the mFS as a whole has obscured the high diversity and versatility of these ***,we present a phylogenetic analysis of all annotated mFS domaincontaining proteins encoded in the Arab/dops/s fA?a//ana genome and propose that this superfamily of transporters consists of 218 members,clustered in 22 *** reviewing the available information regarding the diversity in biological functions and substrates of Arab/dops/s mFS members,we provide arguments for intensified research on these membrane transporters to unveil the breadth of their physiological relevance,disclose the molecular mechanisms underlying their mode of action,and explore their biotechnological potential.

关键词： Arabidopsis thaliana membrane transport mFS transporters phylogenetic analysis

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Regulation of floral senescence in Arabidopsis by coordinated action of CONSTANS and jasmonate signaling

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molecular Plant 2022年第11期15卷 1710-1724页

作者： Gloria Serrano-Bueno pedro de los Reyes Andrea Chini Gabriel Ferreras-Garrucho Víctor Sánchez de medina-Hernández marta Boter Roberto Solano Federico Valverde Plant Development Group Institute for Plant Biochemistry and PhotosynthesisCSIC-Universidad de Sevilla41092 SevillaSpain Department of Plant molecular Genetics Centro Nacional de BiotecnologíaCSIC28049 MadridSpain Crop Science Centre University of CambridgeCambridge CB3 OLE CambridgeUK Gregor mendel Institute(GmI) Austrian Academy of SciencesVienna BioCenter(VBC)ViennaAustria

In Arabidopsis,photoperiodic flowering is controlled by the regulatory hub gene CONSTANS(CO),whereas floral organ senescence is regulated by the jasmonates(JAs).Because these processes are chronologically ordered,it remains unknown whether there are common regulators of both *** this study,we discovered that CO protein accumulates in Arabidopsis flowers after floral induction,and it displays a diurnal pattern in floral organs different from that in the *** observed that altered CO expression could affect flower senescence and abscission by interfering with JA response,as shown by petal-specific transcriptomic analysis as well as CO overexpression in JA synthesis and signaling *** found that CO has a ZIm(ZINC-FINGER INFLORESCENCE mERISTEm)like domain that mediates its interaction with the JA response repressor JAZ3(jasmonate ZIm-domain 3).Their interaction inhibits the repressor activity of JAZ3,resulting in activation of downstream transcription factors involved in promoting flower ***,we showed that CO,JAZ3,and the E3 ubiquitin ligase COI1(Coronatine Insensitive 1)could form a protein complex in planta,which promotes the degradation of both CO and JAZ3 in the presence of *** together,our results indicate that CO,a key regulator of photoperiodic flowering,is also involved in promoting flower senescence and abscission by augmenting JA signaling and *** propose that coordinated recruitment of photoperiodic and JA signaling pathways could be an efficient way for plants to chronologically order floral processes and ensure the success of offspring production.

关键词： CONSTANS flower senescence jasmonic acid

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Evaluation of multiplicative Weight of Covariance matrix on Hybrid Data Assimilation Schemes

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Atmospheric and Climate Sciences 2023年第2期13卷 255-281页

作者： pedro m. González-Jardines maibys Sierra-Lorenzo Adrián L. Ferrer-Hernández Center for Atmospheric Physics Institute of Meteorology Havana Cuba

This research develops a comparative study between different multiplicative weights that are assigned to the covariance matrix that represents the background error in two hybrid assimilation schemes: 3DEnVAR and 4DEnVAR. These weights are distributed between the static and time-invariant matrix and the matrix generated from the perturbations of a previous ensemble. The assigned values are 25%, 50%, and 75%, always having as a reference the ensemble matrix. The experiments are applied to the short-range Prediction System (SisPI) that works operationally at the Institute of meteorology. The impact of Tropical Storm Eta on November 7 and 8, 2020 was selected as a study case. The results suggest that by giving the main weight to the ensemble matrix more realistic solutions are achieved because it shows a better representation of the synoptic flow. On the other hand, it is observed that 3DEnVAR method is more sensitive to multiplicative weight change of the first guess. more realistic results are obtained with 50% and 75% relations with 4DEnVAR method, whereas with 3DEnVAR a weight of 75% for the ensemble matrix is required.

关键词： SisPI WRFDA Hybrid-methods Covariance Weights

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