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Correcting distortions of thin-walled machined parts by machine hammer peening

Chinese Journal of Aeronautics 2024年第6期37卷 439-453页

作者： Aitor MADARIAGA Mikel CUESTA Gorka ORTIZ-DE-ZARATE Eneko SAENZ-DE-ARGANDONA Denis SORIANO Michael B.PRIME pedro jose arrazola Department of Materials University of ManchesterOxford RoadManchester M139PLUnited Kingdom Mechanical and Industrial Production Department Faculty of EngineeringMondragon UnibertsitateaArrasate 20500Spain Los Alamos National Laboratory Los AlamosNew MexicoUSA

Thin-walled aerostructural components frequently get distorted after the machining *** to correct distortions or eventually rejecting parts significantly increases the *** paper proposes a new approach to correct distortions in thin-walled components by strategically applying hammer peening on target surfaces of a machined *** alloy 7475-T7351 was chosen for this *** study was divided in two ***,the residual stresses(RS)induced by four different pneumatic hammer peening conditions(modifying the stepover distance and initial offset)were characterised in a test coupon,and one of the conditions was selected for the next *** the second stage,a FEM model was used to predict distortions caused by machining in a representative ***,the RS induced by hammer peening were included in an FEM model to define two hammer peening strategies(varying the coverage area)to analyse the capability to reduce *** workpieces were machined and then treated with the simulated hammer peening strategies for experimental *** in the test coupon showed that pneumatic hammer peening can generate high compressive RS(-50 to350 MPa)up to 800 lm depth,with their magnitude increasing with a reduced stepover *** of hammer peening over 4% of the surface of the representative workpiece reduced the machininginduced distortions by 37%,and a coverage area of 100% led to and overcorrection by a factor of *** confirms that hammer peening can be strategically applied(in target areas and changing the percentage of coverage)to correct low or severe distortions.

关键词： Aeronautics Machining,Hammer Peening Aluminium alloy Distortions Residual Stress

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Improving surface integrity when drilling CFRPs and Ti-6Al-4V using sustainable lubricated liquid carbon dioxide

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Chinese Journal of Aeronautics 2023年第7期36卷 129-146页

作者： In˜igo RODRIGUEZ pedro jose´arrazola Mikel CUESTA Luka STERLE Franci PUSˇAVEC Faculty of Engineering Mondragon UnibertsitateaArrasate-Mondragon 20500Spain Faculty of Mechanical Engineering University of LjubljanaLjubljana 1000Slovenia

In the quest for decreasing fuel consumption and resulting gas emissions in the aeronautic sector,lightweight materials such as Carbon Fiber Reinforced Polymers(CFRPs)and Ti-6Al-4V alloys are being *** materials,with excellent weight-to-strength ratios,are widely used for structural applications in aircraft *** date,several studies have been published showing that the use of metalworking fluids(MWFs),special tool geometries,or advanced machining techniques is required to ensure a surface quality that meets aerospace component *** MWFs pose a number of environmental and worker health hazards and also degrade the mechanical properties of CFRPs due to water absorption in the ***,a transition to more environmentally friendly cooling/lubrication techniques that prevent moisture problems in the composite is *** research shows that lubricated LCO_(2) is a viable option to improve the quality of drilled CFRP and titanium aerospace components compared to dry machining,while maintaining clean work *** results show that the best combination of tool geometry and cooling conditions for machining both materials is drilling with Brad point drills and lubricated LCO_(2).Drilling under these conditions resulted in a 90%improvement in fiber pullout volume compared to dry machined CFRP *** addition,a 33% reduction in burr height and a 15% improvement in surface roughness were observed compared to dry drilling of titanium.

关键词： Carbon fibers Cryogenics Green manufacturing Machining Solid lubricants Surface morphology Titanium alloys

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CONSTANS alters the circadian clock in Arabidopsis thaliana

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Molecular Plant 2024年第8期17卷 1204-1220页

作者： pedro de los Reyes Gloria Serrano-Bueno Francisco J.Romero-Campero He Gao jose M.Romero Federico Valverde Plant Development Group-Institute for Plant Biochemistry and Photosynthesis Consejo Superior de Investigaciones CientificasUniversidad de SevillaSevilleSpain Department of Computer Science and Artificial Intelligence Universidad de SevillaSevilleSpain Department of Plant Developmental Biology Max Planck Institute for Plant Breeding ResearchCologneGermany Department of Plant Biochemistry and Molecular Biology Universidad de SevillaSevilleSpain

Plants are sessile organisms that have acquired highly plastic developmental strategies to adapt to the *** these processes,the floral transition is essential to ensure reproductive success and is finelyregulated by several internal andexternal genetic *** photoperiodic pathway,which controls plant response to day length,is one of the most important pathways controlling *** Arabidopsis photoperiodic flowering,CONSTANS(CO)is the central gene activating the expression of the florigen FLOWERING LOCUS T(FT)in the leaves at the end of a long *** circadian clock strongly regulates Co ***,to date,no evidence has been reported regarding a feedbackloop from the photoperiod pathway back to the circadian *** transcriptional networks,we have identified relevant network motifs regulating the interplay between the circadian clock and the photoperiod *** expression,chromatin immunoprecipitation experiments,and phenotypic analysis allowed us to elucidate the role of Co over the circadian *** with altered cO expression showed a different internal clock period,measured by daily leaf rhythmic *** showed that co upregulates the expression of key genes related to the circadian clock,such as CCA1,LHY,PRR5,and Gl,at the end of a long day by bindingto specific sites on their ***,a high numberof PRR5-repressed target genes are upregulated by CO,and this could explain the phase transition promoted by *** CO-PRR5 complex interacts with the bZiP transcriptionfactor HY5andhelps to localize the complex in the promoters of clock *** together,our results indicate that there may be a feedback loop in which co communicates back to the circadian clock,providing seasonal information to the circadian system.

关键词： CONSTANS circadian clock photoperiod

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A new oxidative pathway of nitric oxide production from oximes in plants

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Molecular Plant 2024年第1期17卷 178-198页

作者： pedro Lopez-Gomez Javier Buezo Marina Urra Alfonso Cornejo Raquel Esteban Jorge Fernandez de los Reyes Estibaliz Urarte Estefania Rodriguez-Dobreva Alejandro Chamizo-Ampudia Alejandro Eguaras Sebastian Wolf Daniel Marino Victor Martinez-Merino jose F.Moran Institute for Multidisciplinary Research in Applied Biology(IMAB) Department of SciencesPublic University of Navarre(UPNA)Avda.de Pamplona 12331192 MutilvaSpain Institute for Advanced Materials and Mathematics(INAMAT2) Department of SciencesPublic University of Navarre(UPNA)Campus de Arosadia31006 PamplonaSpain Department of Plant Biology and Ecology University of the Basque Country(UPV/EHU)Sarriena s/nApdo.64448080 BilbaoSpain Center for Plant Molecular Biology(ZMBP) University of TubingenGeschwister-Scholl-Platz72074 TubingenGermany Institute of Natural Resources and Agrobiology of Salamanca(IRNASA) Department of Plant-Microorganism InteractionsSpanish National Research Council(CSIC)Cordel de Merinas40-5237008SalamancaSpain Department of Biochemistry Area of Molecular BiologyVeterinary FacultyUniversity of LeonCampus de Vegazanas/n.24071 LeonSpain

Nitric oxide(NO)is an essential reactive oxygen species and a signal molecule in *** several studies have proposed the occurrence of oxidative NO production,only reductive routes for NO production,such as the nitrate(NO_(3)^(-))-upper-reductase pathway,have been evidenced to date in land ***,plants grown axenically with ammonium as the sole source of nitrogen exhibit contents of nitrite and NO3−,evidencing the existence of a metabolic pathway for oxidative production of *** hypothesized that oximes,such as indole-3-acetaldoxime(IAOx),a precursor to indole-3-acetic acid,are intermediate oxidation products in NO *** detected the production of NO from IAOx and other oximes catalyzed by peroxidase(POD)enzyme using both 4-amino-5-methylamino-2′,7′-difluorescein fluorescence and *** stimulated the reaction,while superoxide dismutase inhibited ***,mouse NO synthase can also use IAOx to produce NO at a lower rate than *** provided a full mechanism for POD-dependent NO production from IAOx consistent with the experimental data and supported by density functional theory *** showed that the addition of IAOx to extracts from Medicago truncatula increased the in vitro production of NO,while in vivo supplementation of IAOx and other oximes increased the number of lateral roots,as shown for NO donors,and a more than 10-fold increase in IAOx dehydratase ***,we found that in vivo supplementation of IAOx increased NO production in Arabidopsis thaliana wild-type plants,while prx33-34 mutant plants,defective in POD33-34,had reduced *** data show that the release of NO by IAOx,as well as its auxinic effect,explain the superroot ***,our study reveals that plants produce NO utilizing diverse molecules such as oximes,POD,and flavins,which are widely distributed in the plant kingdom,thus introducing a long-awaited oxidative pathway to NO production in plants.T

关键词： ammonium oxidation auxin nitric oxide oxime peroxidase root phenotype

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Unveiling Plant mTERF Functions

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Molecular Plant 2012年第2期5卷 294-296页

作者： pedro Robles jose Luis Micol Victor Quesada Instituto de Bioingenieria Universidad Miguel Hernandez Campus de Elche 03202 Elche Spain

Chloroplasts and mitochondria genomes contain a few dozen genes required for gene expression, photosynthesis, and the electron transport chain. However, proteomic and bioinformatic studies suggest that approximately 2000 and 2600 proteins are located in plant mitochondria and chloroplasts, respectively; most of them are encoded by nuclear genes, synthesized in the cytoplasm, and targeted to organelles. Despite the simplicity of organelle genomes, their transcriptional regulation is complex and can only be partially explained by currently known transcriptional machinery components, suggesting that additional unidentified regulatory factors exist （Liere et al., 2011）.

关键词： Unveiling Plant

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Macular atrophy after combined intravitreal triamcinolone and photodynamic therapy to treat choroidal neovascularization

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 161-163页

作者： jose M Ruiz-Moreno Javier A Montero pedro Amat Francisco Lugo Department of Ophthalmology Albacete Medical SchoolUniversity of Castilla La ManchaSpain Alicante Institute of Ophthalmology Vitreo-Retinal Unit.Spain Pio del Rio Hortega University Hospital Ophthalmology UnitValladolidSpain

AIMTo report the appearance of choriocapillaris atrophy after combined high dose intravitreal triamcinolone acetonide (TA) and photodynamic therapy (PDT) to treat choroidal neovascularization (CNV) associated with age... 详细信息

关键词： age related macular degeneration choriocapillaris atrophy intravitreous triamcinolone photodynamic therapy retinal pigment epithelium atrophy

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Biotinylated polyurethane-urea nanoparticles for targeted theranostics in human hepatocellular carcinoma

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Nano Research 2015年第5期8卷 1729-1745页

作者： Genoveva MorraI-Ruiz pedro Melgar-Lesmes Andrea Lopez-Vicente Conxita Solans Maria jose Garcia-Celma Department of Pharmacy and Pharmaceutical Technology Faculty of Pharmacy University of Barcelona Av Joan XXIII s/n 08028 Barcelona Spain Institute of Advanced Chemistry of Catalonia (IQAC) CS/C Jordi Girona 18-26 08034 Barcelona Spain Networking Research Center on Bioengineering Biomaterials and Nanomedicine CIBER-BBN Spain

Over the past years, significant efforts have been devoted to explore novel drug delivery and detection strategies for simultaneous therapy and diagnostics. The development of biotinylated polyurethane-urea nanoparticles as theranostic nanocarriers for targeted drug and plasmid delivery, for fluorescence detection of human hepatocellular carcinoma cells, is described herein. These targeted nanoparticles are specifically designed to incorporate biotin into the polymeric matrix, since many tumor types overexpress receptors for biotin as a mechanism to boost uncontrolled cell growth. The obtained nanoparticles were spherical, exhibited an average diameter ranging 110-145 nm, and showed no cytotoxicity in healthy endothelial cells. Biotinylated nanoparticles are selectively incorporated into the perinuclear and nuclear area of the human hepatocellular carcinoma cell line, HepG2, in division, but not into growing, healthy, human endothelial cells. Indeed, the simultaneous incorporation of the anticancer drugs, phenoxodiol or sunitinib, together with plasmid DNA encoding green fluorescent protein, into these nanoparticles allows a targeted pharmacological antitumor effect and furthermore, selective transfection of a reporter gene, to detect these cancer cells. The combined targeted therapy and detection strategy described here could be exploited for liver cancer therapy and diagnostics, with a moderate safety profile, and may also be a potential tool for other types of cancer.

关键词： cancer therapy DNA nanoparticles polyurethane theranostics

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Pupil apodization for increasing data storage density

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Chinese Optics Letters 2009年第8期7卷 720-723页

作者： Vidal F.Canales pedro J.Valle jose E.Oti Manuel P.Cagigal Department of Física Aplicada University of CantabriaLos Castros S/NSantander 39005Spain AOTEK S.COOP. Bo San Andrés 19Arrasate-Mondragón 20500Spain

We introduce a technique for increasing density in optical data storage systems. This technique is based on the use of a superresolving filter at the pupil of a confocal readout system. The main characteristic of this confocal readout system is that the light beam traverses twice through the pupil filter. We describe how to analyze the system performance for general filters, but we focus the study on filters with no focus displacement. Although the storage density attainable depends on the filter characteristics, we show that the storage density can be easily duplicated.

关键词： Pupil apodization for increasing data storage density PSF data

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Performance Parameters:Demobilization Antibiotic Resistant Bacteria(ARB)and Carrying Genes(ARG)in Wastewater Disinfection

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Journal of Environmental Science and Engineering(B) 2024年第1期13卷 1-8页

作者： Solange Kazue Utimura Denise Crocce Romano Espinosa Marcio Luís Busi da Silva Elisabete de Santis Braga pedro jose Alvarez Department of Chemical Engineering USPR.do LagoSão Paulo 25005508-080Brazil Department of Physical Chemical and Geological OceanographyUSPPraça do Oceanográfico 191SPBrazil Department of Civil and Environmental Engineering Rice University6100 Main St.HoustonTexas 77005USA

The UV irradiation is used for removing Antibiotic Resistant Bacteria(ARB)and Antibiotic Resistance Genes(ARG)from wastewater *** are viruses that infect within bacteria,are recognized for bacterial *** influence of some parameters in quantification and performance influencing of pathogen demobilization could be considered in disinfection of *** comparison of Polyvalent phage(NE1)versus Coliphage(NE4)in suppressing a bacterium Escherichia coli(NDM-1:b-lactam-resistant)with UV irradiation was observed the efficacy in reduction of cells in the disinfection and parameter *** results with the effect of UV-C irradiation on NDM-1 infected with 1%of NE4 showed a decrease of cells from 8×10^(6)to 2×10^(5)in 60 min with UV-C *** NDM1(***)was infected with 1%of NE4(Polyvalent Phage)under magnetic stirring for 1 h,the cells count was 8×10^(6).After 1 h in UV-C e×posure,the cells number reached 3×10^(5).The NDM1 that was e×posed in 1 h of UV-C irradiation and then was infected with 1%of *** counting were done 24 h after this *** cells were e×posed in UV-C and showed a reduction in the number of cells from 1×10^(8)to 4×10^(5)after 60 *** results indicate that bacteriophages can mitigate bacteria species,and combined the conventional water disinfection technologies that can support the microbial safety control strategies.

关键词： Antibiotic Resistant Bacteria(ARB) Antibiotic Resistance Genes(ARG) wastewater treatment disinfection Escherichia coli(E.coli).

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A Feature Selection Strategy to Optimize Retinal Vasculature Segmentation

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Computers, Materials & Continua 2022年第2期70卷 2971-2989页

作者： jose Escorcia-Gutierrez Jordina Torrents-Barrena Margarita Gamarra Natasha Madera pedro Romero-Aroca Aida Valls Domenec Puig Electronic and Telecommunications Engineering Program Universidad Autónoma del CaribeBarranquilla080001Colombia Department of Computational Science and Electronic Universidad de la CostaCUCBarranquilla080001Colombia Ophthalmology Service Universitari Hospital Sant JoanInstitut de Investigacio Sanitaria Pere VirgiliReus43201Spain Departament d’Enginyeria Informàtica i Matemàtiques Escola Tècnica Superior d’EnginyeriaUniversitat Rovira i VirgiliTarragona43007Spain

Diabetic retinopathy (DR) is a complication of diabetesmellitus thatappears in the retina. Clinitians use retina images to detect DR pathologicalsigns related to the occlusion of tiny blood vessels. Such occlusion brings adegenerative cycle between the breaking off and the new generation of thinnerand weaker blood vessels. This research aims to develop a suitable retinalvasculature segmentation method for improving retinal screening proceduresby means of computer-aided diagnosis systems. The blood vessel segmentationmethodology relies on an effective feature selection based on SequentialForward Selection, using the error rate of a decision tree classifier in theevaluation function. Subsequently, the classification process is performed bythree alternative approaches: artificial neural networks, decision trees andsupport vector machines. The proposed methodology is validated on threepublicly accessible datasets and a private one provided by Hospital Sant Joanof Reus. In all cases we obtain an average accuracy above 96% with a sensitivityof 72% in the blood vessel segmentation process. Compared with the state-ofthe-art, our approach achieves the same performance as other methods thatneed more computational *** method significantly reduces the numberof features used in the segmentation process from 20 to 5 dimensions. Theimplementation of the three classifiers confirmed that the five selected featureshave a good effectiveness, independently of the classification algorithm.

关键词： Diabetic retinopathy artificial neural networks decision trees support vector machines feature selection retinal vasculature segmentation

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