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New perspectives in iron chelation therapy for the treatment of Parkinson’s disease

Neural Regeneration Research 2019年第11期14卷 1905-1906页

作者： Marco T. Nunez pedro Chana-cuevas Faculty of Sciences Universidad de ChileSantiagoChile Movement Disorders Center Universidad de Santiago de ChileSantiagoChile

Neurodegenerative diseases with an iron accumulation component: A wide variety of neurological diseases are characterized by the accumulation of iron in different areas of the central nervous system, include Parkinson’s disease, Huntington disease, Alzheimer’s disease, Friedreich’s ataxia, amyotrophic lateral sclerosis, pantothenate kinase-associated neurodegeneration and other neuropathologies associated with brain iron accumulation (Hayflick et al., 2018).

关键词： Parkinson Huntington Friedreich Alzheimer

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Dobesilate for dry age-related macular degeneration

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Journal of Biomedical Science and Engineering 2013年第10期6卷 8-14页

作者： pedro cuevas Luis A.Outeirino Carlos Azanza Javier Angulo Guillermo Giménez-Gallego Departamento de Investigación IRYCISHospital Universitario Ramón y CajalMadridSpain Departamento de Oftalmología Hospital de Día Pío XIIMadridSpain Departamento de Estructura y Función de Proteínas Centro de Investigaciones BiológicasCSICMadridSpain

We have evaluated the effects of intravitreal dobesilate, a synthetic fibroblast growth factor inhibitor, in patients with dry age-related macular degeneration, an inflammatory-related retinal disease without available treatment up to date. 36 eyes from 36 patients with dry age-related macular degeneration were treated with a single intravitreal dobesilate injection. The end points were the improvement from baseline visual acuity and normalization of retinal histology at one month. Intravitreal dobesilate injection resulted in a significant improvement in functional and anatomical outcomes at one month after injection. Our results suggest that intravitreal dobesilate may increase the chance of visual acuity gain in dry age-related macular degeneration, even in cases with initial low vision. This study supports the findings of previously published case reports, regarding the short-term improvement in visual acuity by intravitreal dobesilate injection in different degenerative retinal diseases.

关键词： Dry Age-Related Macular Degeneration Fibroblast Growth Factor Inhibition Intravitreal Dobesilate

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Dramatic resolution of vitreous hemorrhage after an intravitreal injection of dobesilate

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Military Medical Research 2015年第3期3卷 163-165页

作者： pedro cuevas Luis Antonio Outeirino Carlos Azanza Javier Angulo Guillermo Giménez-Gallego Facultad de Medicina Universidad Alfonso X Departamento de Oftalmología Hospital de Día Pío XII Servicio de Histología Departamento de Investigación IRYCISHospital Universitario Ramón y Cajal Departamento de Estructura y Función de Proteínas Centro de Investigaciones Biológicas CSIC

Vitreous hemorrhages are important clinical manifestations of proliferative diabetic retinopathy. Non-cleared vitreous hemorrhages could lead to hemosiderosis bulbi and glaucoma. Here, we describe the case of a type 2 diabetic patient presenting anterior segment and vitreous hemorrhages that resolved three days after treatment with a single intravitreal injection of dobesilate.

关键词： Proliferative diabetic retinopathy Vitreous hemorrhage Dobesilate

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Improvement in the signs and symptoms of dry eye disease with dobesilate eye drops

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Journal of Medical Colleges of PLA(China) 2016年第1期31卷 51-55页

作者： pedro cuevas Luis Antonio Outeiriño Carlos Azanza Javier Angulo Guillermo Giménez-Gallego Facultad de Medicina Universidad Alfonso Ⅹ Madrid Spain Departamento de Oftalmología Hospital de Día Pío Ⅻ Madrid Spain Servicio de Histología.Departamento de Investigación IRYCIS Hospital Universitario Ramón y Cajal Madrid Spain Departamento de Estructura y Función de Proteínas Centro de Investigaciones Biológicas.CSIC Madrid Spain

Background:Dry eye is a multifactor disease of the tear film and ocular surface that substantially affects quality of *** presentation:Dobesilate administered as eye drops was well tolerated and effective in treating both the objective signs and subjective symptoms of dry eye disease in this 2-week ***:To the best of our knowledge,this is the first clinical report of using dobesilate in eye *** may provide a novel approach to treating drying diseases of the eye.

关键词： Dry eye disease Dobesilate eye drops Fibroblast growth factor Vascular endothelial growth factor

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Watch out for Abdominal Pain in HIV-AIDS Patients: Abdominal Tuberculosis

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Case Reports in Clinical Medicine 2020年第12期9卷 392-398页

作者： María Rodríguez-Santiago Luis Alvarez-Pérez José Gaudier-Díaz pedro Gil-De Rubio Natalia Hernández-cuevas José Colón-Márquez Department of Internal Medicine University of Puerto Rico School of Medicine San Juan Puerto Rico

Extrapulmonary Tuberculosis (EPTB) is the TB involving organs other than lungs. The diagnosis of EPTB can be difficult, as suspicion is challenging, because it presents with nonspecific clinical features and atypical presentation. Furthermore, patients with HIV may present with fever of unknown origin (FUO) as the only symptom. We present a clinical case of a 49 years old Puertorrican female with HIV-AIDS and no high-risk behavior with an abdominal pain and fever. The investigation confirmed an Abdominal Tuberculosis. This case emphasizes the need to add Abdominal tuberculosis (ATB) within the differential diagnosis and discuss the diagnostic process.

关键词： Abdominal Pain Abdominal Tuberculosis (ATB) Diagnosing ATB HIV/AIDS

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