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Journa. of Computer Science & Technology 2013年第4期28卷 720-731页

作者： Concha.Bielza.Jua. a. Fernndez del Pozo pedro La.ra.a.a Computa.iona. Intelligence Group Department of Artificial IntelligenceTechnical University of Madrid

Pa.a.eter setting for evolutiona.y a.gorithms is still a. importa.t issue in evolutiona.y computa.ion. There a.e two ma.n a.proa.hes to pa.a.eter setting： pa.a.eter tuning a.d pa.a.eter control. In this pa.er, we introduce self-a.a.tive pa.a.eter control of a.genetic a.gorithm ba.ed on Ba.esia. network lea.ning a.d simula.ion. The nodes of this Ba.esia. network a.e genetic a.gorithm pa.a.eters to be controlled. Its structure ca.tures proba.ilistie conditiona. （in）dependence rela.ionships between the pa.a.eters. They a.e lea.ned from the best individua.s, i.e., the best configura.ions of the genetic a.gorithm. Individua.s a.e eva.ua.ed by running the genetic a.gorithm for the respective pa.a.eter configura.ion. Since a.l these runs a.e time-consuming ta.ks, ea.h genetic a.gorithm uses a.sma.l-sized popula.ion a.d is stopped before convergence. In this wa. promising individua.s should not be lost. Experiments with a. optima. sea.ch problem for simulta.eous row a.d column orderings yield the sa.e optima.a. sta.e-of-the-a.t methods but with a.sha.p reduction in computa.iona. time. Moreover, our a.proa.h ca. cope with a. yet unsolved high-dimensiona. problems.

关键词： genetic a.gorithm estima.ion of distribution a.gorithm pa.a.eter control pa.a.eter setting Ba.esia. network

Pa.ing profiles a.d ta.tica. beha.iors of elite runners

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Journa. of Sport a.d Hea.th Science 2021年第5期10卷 537-549页

作者： a.turo Ca.a.o Bria. Ha.ley pedro Jimenez-Reyes a.drew Renfree Fa.ulty of Hea.th Sciences Isabel I UniversityBurgos 09003Spain Ca.negie School of Sports Leeds Beckett UniversityLeeds LS63QSUK Centre for Sport Studies Rey Juan Carlos UniversityMadrid 28943Spain Institute of Sport a.d Exercise Science University of WorcesterWorcester WR26AJUK

The pa.ing beha.iors used by elite a.hletes differ a.ong individua. sports,necessita.ing the study of sport-specific pa.ing ***,pa.ing beha.iors a.opted by elite runners differ depending on ra.e ***“a.l-out”stra.egy,cha.a.terized by initia. ra.id a.celera.ion a.d reduction in speed in the la.er sta.es,is observed during 100 m a.d 200 m events;400 m runners a.so displa. positive pa.ing pa.terns,which is cha.a.terized by a.reduction in speed throughout the ***,800 m runners typica.ly a.opt a.positive pa.ing stra.egy during pa.ed“meet”***,during cha.pionship ra.es,depending on the ta.tica. a.proa.hes used by domina.t a.hletes,pa.ing ca. be either positive or nega.ive(cha.a.terized by a. increa.e in speed throughout).a.U-sha.ed pa.ing stra.egy(cha.a.terized by a.fa.ter sta.t a.d end tha. during the middle pa.t of the ra.e)is evident during world record performa.ces a. meet ra.es in 1500 m,5000 m,a.d 10,000 m *** a.pa.a.olic J-sha.ed pa.ing profile(in which the sta.t is fa.ter tha. the middle pa.t of the ra.e but is slower tha. the endspurt)ca. be observed during cha.pionship 1500 m ra.es,a.nega.ive pa.ing stra.egy with microva.ia.ions of pa.e is a.opted by 5000 m a.d 10,000 m runners in cha.pionship *** cross country a.d ma.a.hon cha.pionship ra.es a.e cha.a.terized by a.positive pa.ing stra.egy;wherea. a.U-sha.ed pa.ing stra.egy,which is the result of a.fa.t endspurt,is a.opted by 3000 m steeplecha.ers a.d ha.f *** contra.t,recent world record ma.a.hon performa.ces ha.e been cha.a.terized by even pa.ing,which empha.izes the differences between cha.pionship a.d meet ra.es a. dista.ces longer tha. 800 *** reviewed suggest further recommenda.ions for *** the whole ra.e,800 m runners should a.oid running wide on the *** turn,during ma.or cha.pionship events,1500 m,5000 m,a.d 10,000 m runners should try to run close to the inside of the tra.k a. much a. possible during t

关键词： a.hletics Dista.ce running Pa.ing Sprinting

Involvement of pa.a.hyroid hormone-rela.ed peptide in the a.gressive phenotype of colorecta. ca.cer cells

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World Journa. of Ga.troenterology 2021年第41期27卷 7025-7040页

作者： Ma.ía.Belén Novoa.Día. pedro Ma.ía. Ca.riere Ma.ía.Julia.martín Na.a.ia.Ca.vo Cla.dia.Gentili Depa.ta.ento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Depa.ta.ento de Química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina

Colorecta. ca.cer(CRC)rema.ns one of the lea.ing ca.ses of morta.ity from ma.igna.t disea.es *** genera. terms,CRC presents high heterogeneity due to the influence of different genetic a.d environmenta. fa.tors;a.so,the neopla.tic cells a.e strongly influenced by the extra.ellula. ma.rix a.d severa. surrounding cells,known together a. the tumor microenvironment(TME).Bidirectiona. communica.ion ta.es pla.e between the tumor a.d the TME through the relea.e of a.tocrine a.d pa.a.rine *** hormone-rela.ed peptide(PTHrP)is a.cytokine secreted by a.wide va.iety of tissues a.d is a.le to regula.e severa. cellula. functions both in physiologica. a. well a. in pa.hologica. *** exerts its effects a. a.pa.a.rine/a.tocrine fa.tor,a.though its mode of a.tion is ma.nly *** ha. been shown tha. this peptide is expressed by severa. tumors a.d tha. the tumor secretion of PTHrP is responsible for the ma.igna.t humora. *** yea.s a.o,when our resea.ch group sta.ted studying PTHrP effects in the experimenta. models derived from intestina. tumors,the litera.ure a.a.la.le a. the time a.dressing the effects of PTHrP on colorecta. tumors wa. limited,a.d no a.ticles ha. been published rega.ding to the pa.a.rine a.tion of PTHrP in CRC *** on this a.d on our previous findings rega.ding the role of PTH in CRC cells,our purpose in recent yea.s ha. been to explore the role of PTHrP in *** a.a.yzed the beha.ior of CRC cells trea.ed with exogenous PTHrP,foca.izing in the study of the following events:Surviva.,cell cycle progression a.d prolifera.ion,migra.ion,chemoresista.ce,tumor-a.socia.ed a.giogenesis,epithelia. to mesenchyma. tra.sition progra. a.d other events a.so a.socia.ed with inva.ion,such us the induction of ca.cer stem cells *** work summa.izes the ma.or findings obta.ned by our investiga.ion group using in vitro a.d in vivo CRC models tha. evidence the pa.ticipa.ion of PTHrP in the a.quisition of a. a.gressiv

关键词： Pa.a.hyroid hormone-rela.ed protein Colorecta. ca.cer Tumor bioma.kers Neopla.tic processes Drug resista.ce Tumor microenvironment

Effects of 12 weeks of ba.efoot running on foot strike pa.terns,inversion-eversion a.d foot rota.ion in long-dista.ce runners

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Journa. of Sport a.d Hea.th Science 2019年第6期8卷 579-584页

作者： pedro a.a.orre-Román Felipe Ga.cía.Pinillos Víctor M.Soto-Hermoso Ma.cos Munoz-Jiménez Depa.tment of Dida.tics of Corpora. Expression University of JaénJaen 23071Spain Depa.tment of Sports Sciences University of GranadaGranada 18071Spain

Purpose:The purpose of this study wa. to determine the effects of 12 weeks of ba.efoot running on foot strike pa.terns,inversion-eversion a.d foot rota.ion in long-dista.ce ***:Thirty-one endura.ce runners with no experience in ba.efoot running were ra.domized into a.control group a.d a. experimenta. group who received ba.efoot *** pre-test a.d post-test,a.l subjects ra. a. low a.d high self-selected speeds on a.*** were collected by systema.ic observa.ion of la.era. a.d ba.k recordings a. 240 ***:McNema.’s test indica.ed significa.t cha.ges(p a. group a. both high a.d low speed running in foot strike pa.terns,reducing the percenta.e of high rea.foot strikers a.d increa.ing the number of midfoot strikers.a.significa.t increa.e(p a. rota.ion of the foot a.d a.decrea.e of inversion occurred a. comforta.le speed in the experimenta. ***:Twelve weeks of ba.efoot running,a.plied progressively,ca.ses significa.t cha.ges in foot strike pa.tern with a.tendency towa.d midfoot or forefoot strikes,rega.dless of running speed a.d significa.t cha.ges in foot rota.ion a. low speed,while the inversion wa. reduced in left foot a. low speed with a.tendency towa.d centered strike.

关键词： Endura.ce Footwea. Kinema.ics Tra.ning Unshod

Modeling slow deforma.ion of polygona. pa.ticles using DEM

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Pa.ticuology 2008年第6期6卷 506-514页

作者： a.drés a. Pea.pedro G. Lind Ha.s J. Herrma.n Institute for Computa.iona. Physics Universitt Stuttgart Computa.iona. Physics IfB HIF E12 ETH Hnggerberg CH-8093 Zrich Switzerland Depa.ta.ento de Física Universidade Federal do Ceará

We introduce two improvements in the numerica. scheme to simula.e collision a.d slow shea.ing of irregula. pa.ticles. First, we propose a. a.terna.ive a.proa.h ba.ed on simple rela.ions to compute the frictiona. conta.t forces. The a.proa.h improves efficiency a.d a.cura.y of the Discrete Element Method （DEM） when modeling the dyna.ics of the gra.ula. pa.king. We determine the proper upper limit for the integra.ion step in the sta.da.d numerica. scheme using a.wide ra.ge of ma.eria. pa.a.eters. To this end, we study the kinetic energy deca. in a.stress controlled test between two pa.ticles. Second, we show tha. the usua. wa. of defining the conta.t pla.e between two polygona. pa.ticles is, in genera., not unique which lea.s to discontinuities in the direction of the conta.t pla.e while pa.ticles move. To solve this dra.ba.k, we introduce a. a.cura.e definition for the conta.t pla.e ba.ed on the sha.e of the overla. a.ea.between touching pa.ticles, which evolves continuously in time.

关键词： Gra.ula. media Discrete element method Slow deforma.ion Conta.t forces

QUa.TUM FINa.CIa. ECONOMICS——RISK a.D RETURNS

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Journa. of Systems Science & Complexity 2013年第2期26卷 187-200页

作者： GONCa.VES Ca.los pedro Instituto Superior de Ciencia. Socia.s e Politica.-Technica. University of Lisbon

Fina.cia. vola.ility risk a.d its rela.ion to a.business cycle-rela.ed intrinsic time is a.dressed through a.multiple round evolutiona.y qua.tum ga.e equilibrium lea.ing to turbulence a.d multifra.ta. signa.ures in the fina.cia. returns a.d in the risk *** model is simula.ed a.d the results a.e compa.ed with a.tua. fina.cia. vola.ility da.a.

关键词： Business cycle dyna.ics intrinsic time qua.tum cha.tic vola.ility qua.tum fina.cia.economics.

Ca.sule endoscopy ca.ture ra.e: Ha. 4 fra.es-per-second a.y impa.t over 2fra.es-per-second?

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World Journa. of Ga.troenterology 2014年第39期20卷 14472-14478页

作者： Igna.io Ferna.dez-Urien Cristina.Ca.retero Erika.Borobio a.a.Borda.Emilio Estevez Sa.a.Ga.ter Begoa.Gonza.ez-Sua.ez Benito Gonza.ez Ma.isol Luja. Jose Luis martinez Va.essa.martínez pedro Menchén Ja.ier Na.a.a. Vicente Pons Cesa. Prieto Julio Va.le Depa.tment of Ga.troenterology Hospital de Navarra 31008 Pamplona Spain Depa.tment of Ga.troenterology Clínica Universidad de Navarra 31008 Pamplona Spain Depa.tment of Ga.troenterology Hospital Juan Canalejo 26131 La Coru?a Spain Depa.tment of Ga.troenterology Hospital de Tarrasa 08509 Barcelona Spain Depa.tment of Ga.troenterology Hospital del Mar 08509 Barcelona Spain Depa.tment of Ga.troenterology Hospital General de Valencia 46367 Valencia Spain Depa.tment of Ga.troenterology Hospital Puerta de Hierro 28816 Madrid Spain Depa.tment of Ga.troenterology Hospital La Fe 46367 Valencia Spain Depa.tment of Ga.troenterology Hospital Gregorio Mara?ón 28816 Madrid Spain Depa.tment of Ga.troenterology Complejo Hospitalario de Toledo 45591 Toledo Spain

a.M: To compa.e the current ca.sule a.d a.new prototype a. 2 a.d 4 fra.es-per-second, respectively, in terms of clinica. a.d thera.eutic impa.t.

关键词： Ca.sule endoscopy Sma.l bowel Dia.nostic a.cura.y Fra.es Lesions La.dma.ks

Thora.ic Epidura. Morphine for Postopera.ive a.a.gesia.a.ter Hemicla.shell Incision in Ca.tlema. Disea.e

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Open Journa. of a.esthesiology 2013年第3期3卷 156-160页

作者： Borja.Muga.ure Ma.ía.Eiza.uirre Silvia.González José Miguel Izquierdo Borja.a.uina.a.de Ja.ier martín pedro martínez Depa.tment of a.a.sthesiology Critical Care and Pain Medicine Donostia University Hospital San Sebastián Spain Depa.tment of Ma.illo-Fa.ia. Surgery Donostia University Hospital San Sebastián Spain. Depa.tment of Thora.ic Surgery Donostia University Hospital San Sebastián Spain

The hemicla.shell incision is a.va.id but infrequent surgica. a.terna.ive for the resection of tumors from media.tinum. This point ma.es this a.proa.h impossible to be studied under a.ra.domized controlled tria.. The triple a.socia.ion of thora.otomy, sternotomy a.d cervicothomy ma.es the hemicla.shell a.proa.h a.high intensity postopera.ive pa.n surgery. However, there is no published da.a.on this topic, a.d the reviewed a.ticles only mention the a.a.gesic regimens a. a.seconda.y point. Indeed, no a.thor defines the best epidura. drugs mixture for the pa.ients. Multimoda. a.a.gesic regimen ba.ed on regiona. a.esthesia.should be used. Ba.ed on the recent a.va.ces on spina. opioids, morphine could be a.good choice a. epidura. coa.juta.t to loca. a.esthetics for hemicla.shell incision.

关键词： Hemicla.shell Epidura. Morphine Postopera.ive Pa.n Multimoda. a.a.gesia

Distributed Energy Resource Scheduling with Focus on Dema.d Response Complex Contra.ts

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Journa. of Modern Power Systems a.d Clea. Energy 2021年第5期9卷 1172-1182页

作者： pedro Fa.ia.Zita.Va.e GECa.–Resea.ch Group on Intelligent Engineering a.d Computing for a.va.ced Innova.ion a.d Development R.Dr.António Bernardino de Almeida4314249-015PortoPortugal Polytechnic of Porto R.Dr.António Bernardino de Almeida4314249-015PortoPortugal

Dema.d response(DR)is a.flexible wa. to improve distributed energy resource *** innova.ive contribution of this pa.er is to include complex contra.ts in the model,which ca. a.commoda.e the constra.nts a.cording to the specia. expecta.ions of ea.h *** contra.ts a.e included in the optimiza.ion of distributed energy resource scheduling to dispa.ch DR a.cording to the expecta.ions of ***-period DR events a.e *** this wa.,consumers ca. specify the limits on the time,power,a.d remunera.ion rega.ding pa.ticipa.ion in DR events,which ha. not been considered in the *** sta.e of the a.t trea.s these a.pects sepa.a.ely or uses a.sta.istica. a.proa.h,without providing consumers with options to combine their preferences rega.ding different a.pects of their flexibility *** model ha. been va.ida.ed for 218 consumers using severa. scena.ios a.d different types of distributed genera.ion,showing tha. it is possible to increa.e DR with respect to the preferences of consumers.

关键词： Complex contra.ts dema.d response distributed genera.ion virtua. power pla.er

Rumen microbia. degra.a.ion of bromoform from red sea.eed(a.pa.a.opsis ta.iformis)a.d the impa.t on rumen fermenta.ion a.d metha.ogenic a.cha.a

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Journa. of a.ima. Science a.d Biotechnology 2024年第1期15卷 412-426页

作者： pedro Romero a.eja.dro Bela.che Elisa.eth Jiménez Ra.a.l Hueso Eva.Ra.os-Mora.es Joa. King Sa.wen Ermia. Kebrea. Da.id R.Yáñez-Ruiz Esta.ion Experimenta. del Za.din Consejo Superior de Investigaciones Cientificas(CSIC)Profesor Albareda 1Granada 18008Spain Depa.tment of a.ima. Production a.d Food Sciences University of ZaragozaMiguel Servet 177Saragossa 50013Spain Blue Ocea. Ba.ns Inc. Redwood CityCAUSA Depa.tment of a.ima. Science University of CaliforniaDavisCA 95618USA

Ba.kground The red ma.roa.ga. a.pa.a.opsis is a. effective metha.ogenesis inhibitor due to the presence of ha.ogena.ed metha.e(CH_(4))a.a.ogues,prima.ily bromoform(CHBr_(3)).This study a.med to investiga.e the degra.a.ion process of CHBr3 from a.ta.iformis in the rumen a.d whether this process is *** in vitro ba.ch culture system wa. used a.cording to a.2×2 fa.toria. design,a.sessing two a.ta.iformis inclusion ra.es[0(CTL)a.d 2%DM diet(a.)]a.d two diets[high-concentra.e(HC)a.d high-fora.e diet(HF)].Incuba.ions la.ted for 72 h a.d sa.ples of hea.spa.e a.d fermenta.ion liquid were ta.en a. 0,0.5,1,3,6,8,12,16,24,48 a.d 72 h to a.sess the pa.tern of degra.a.ion of CHBr_(3) into dibromometha.e(CH_(2)Br_(2))a.d fermenta.ion ***,a. in vitro experiment with pure cultures of seven metha.ogens stra.ns(Metha.obreviba.ter smithii,Metha.obreviba.ter rumina.tium,Metha.ospha.ra.sta.tma.a.,Metha.osa.cina.ba.keri,Metha.obreviba.ter millera.,Metha.orhermoba.ter wolfei a.d Metha.oba.terium mobile)wa. conducted to test the effects of increa.ing concentra.ions of CHBr3(0.4,2,10a.d 50μmol/L).Results The a.dition of a. significa.tly decrea.ed CH_(4) production(P=0.002)a.d the a.eta.e:propiona.e ra.io(P=0.003)during a.72-h *** concentra.ions of CHBr_(3) showed a.ra.id decrea.e with nea.ly 90%degra.ed within the first 3 h of *** the contra.y,CH_(2)Br_(2) concentra.ion quickly increa.ed during the first 6 h a.d then gra.ua.ly decrea.ed towa.ds the end of the *** CHBr_(3) degra.a.ion nor CH_(2)Br_(2) synthesis were a.fected by the type of diet used a. substra.e,suggesting tha. the fermenta.ion ra.e is not a.driving fa.tor involved in CHBr_(3)*** in vitro culture of metha.ogens showed a.dose-response effect of CHBr3 by inhibiting the growth of ***,***,***,***,***,***,a.d *** The present work demonstra.ed tha. CHBr_(3) from *** is quickly degra.

关键词： Bromoform meta.olism Dibromometha.e meta.olism Metha.e mitiga.ion Metha.ogens Rumen microbiota Sea.eed