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Journa. of Ma.eria.s Science a.d Chemica. Engineering 2018年第9期6卷 1-5页

作者： pedro a. martínez Jua. C. Orozco a.eja.dro a.onso Rosa.M. Luna.Miguel a. Ba.ron Dulce Y. Medina.Eliza.eth Ga.fia.-Ga.cía División de Ciencia. Básica. e Ingeniería Universidad Autónoma Metropolitana Reynosa Tamaulipas México

The present work proposes a.mea. for recovery of meta.s used in current ion-lithium ba.teries, like lithium, coba.t a.d nickel, using orga.ic a.ents a.d ultra.ound instea. of the more a.gressive a.d less environment friendly method with sulfuric a.id. This is especia.ly useful in those countries tha. doesn’t ha.e lithium deposits a.d ha.e a.growing dema.d of such ba.teries, reducing the economic loss this represents. During the process, va.ia.les such a. tempera.ure, lea.hing a.ent concentra.ion a.d ultra.ound frequency were modified, using concentra.ions of 0.5 M (mola.), 1 M a.d 1.5 M of sodium citra.e, tempera.ures of 25°C, 55°C a.d 60°C a.d a.so ultra.ound frequencies of 20 KHz, 30 KHz a.d 40 KHz. It wa. found tha. the best combina.ion of these va.ia.les tha. yielded the most qua.tity of the desired meta. wa. 0.5 M concentra.ion for both lithium a.d nickel, while using 60°C a.d no ultra.ound with Li a.d 55°C a.d 40 KHz for Ni. For Co the best va.ia.les discovered were 1.5 mola. concentra.ion, 60°C a.d 40 KHz.

关键词： Lithium Lea.hing Orga.ic a.ents Ion-Lithium Ba.teries Ultra.ound Lea.hing Sodium Citra.e

Functions of nuclea. fa.tor Y in nervous system development,function a.d hea.th

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2887-2894页

作者： pedro Moreira.Roger Pocock Development a.d Stem Cells Progra. Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Nuclea. fa.tor Y is a.ubiquitous heterotrimeric tra.scription fa.tor complex conserved a.ross euka.yotes tha. binds to CCa.T boxes,one of the most common motifs found in gene promoters a.d *** the la.t 30 yea.s,resea.ch ha. revea.ed tha. the nuclea. fa.tor Y complex controls ma.y a.pects of bra.n development,including differentia.ion,a.on guida.ce,homeosta.is,disea.e,a.d most recently ***,a.complete understa.ding of tra.scriptiona. regula.ory networks,including how the nuclea. fa.tor Y complex binds to specific CCa.T boxes to perform its function rema.ns *** this review,we explore the nuclea. fa.tor Y complex’s role a.d mode of a.tion during bra.n development,a. well a. how genomic technologies ma. expa.d understa.ding of this key regula.or of gene expression.

关键词： a.on guida.ce CCa.T boxes neurona. degenera.ion neurona. differentia.ion neurona. regenera.ion nuclea. fa.tor Y complex tra.scription fa.tor tra.scriptiona. regula.ion

Bra.n sca.ring in infa.ts:immunologica. insights from a.neona.a. hypoxic-ischemic encepha.opa.hy model

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Neura. Regenera.ion Resea.ch 2025年第10期20卷 2909-2910页

作者： pedro Moreno Pimentel-Coelho Ca.los Cha.a. Filho Biophysics Institute Federal University of Rio de JaneiroRio de JaneiroBrazil

Neona.a. hypoxic-ischemic encepha.opa.hy(HIE)is a.significa.t ca.se of disa.ility in *** bra.n function a.d a.celera.ing neurologica. recovery ma. require a.combina.ion of neuroprotective a.d pro-regenera.ive trea.ments a. different sta.es of *** the first hours a.ter the neona.a. insult a.e the most critica. period for neuroprotection,the existence of seconda.y a.d tertia.y mecha.isms of bra.n injury offers the possibility of preventing dela.ed neurodegenera.ion in the subsequent da.s,weeks,or months(Levison et a..,2022).

关键词： neona.a. protective hypoxic

Insights into induction of the immune response by the hepa.itis B va.cine

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World Journa. of Ga.troenterology 2022年第31期28卷 4249-4262页

作者： Federico a.eja.dro Di Lello a.fredo pedro martínez Diego martín Flichma. Microbiology Universidad de Buenos Aires.Facultad de Farmacia y Bioquímica.Instituto de Investigaciones en Bacteriología y Virología MolecularBuenos Aires C1113AADArgentina Consejo Na.iona. de Investiga.iones Científica. y Técnica. Buenos Aires C1425FQBArgentina Virology Section Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno“CEMIC”Buenos Aires C1431FWOArgentina Microbiology Universidad de Buenos AiresInstituto de Investigaciones Biomédicas en Retrovirus y Síndrome de Inmunodeficiencia AdquiridaBuenos Aires C1121ABGArgentina

a.ter more tha. four deca.es of hepa.itis B virus(HBV)va.cine implementa.ion,its sa.ety a.d effica.y in preventing HBV infection ha.e been proven a.d severa. milestones ha.e been *** countries ha.e included HBV immuniza.ion schedules in their hea.th policies a.d progress ha. been ma.e rega.ding universa.iza.ion of the first HBV va.cine dose a. *** of these a.tions ha.e significa.tly contributed to reducing both the incidence of HBV infection a.d its rela.ed ***,there a.e still ma.y dra.ba.ks to *** ma.n concerns a.e the deficient covera.e ra.e of the dose a. birth a.d the la.ge a.ult popula.ion tha. ha. not been rea.hed timely by universa. ***,the current most widely used second-genera.ion va.cines do not induce protective immunity in 5%to 10%of the popula.ion,pa.ticula.ly in people over 40-yea.s-old,obese(body ma.s index>25 kg/m2),hea.y smokers,a.d pa.ients undergoing dia.ysis or infection with huma. immunodeficiency *** developed a.d a.proved novel va.cine formula.ions using more potent a.juva.ts or multiple a.tigens ha.e shown better performa.ce,pa.ticula.ly in difficult *** a.va.ces re-la.nch the expecta.ions of a.hieving the World Hea.th Orga.iza.ion’s objective of completing hepa.itis control by 2030.

关键词： Hepa.itis B virus Va.cine Immune response a.tibodies Neutra.izing

Effects of feeding yea.t(Sa.cha.omyces cerevisia.), orga.ic selenium a.d chromium mixed on growth performa.ce a.d ca.ca.s tra.ts of ha.r la.bs

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Journa. of Integra.ive a.riculture 2015年第3期14卷 575-582页

作者： pedro a.Hernández-Ga.cía.a.eja.dro La.a.Bueno Germán D Mendoza.martínez José R Bárcena.Ga.a.Ferna.do X Pla.a.Pérez Rufino López-Orda. José a.martínez-Ga.cía Fa.ulty of Veterina.y a.d Livestock (University Center) Autonomous University of the State of Mexico Depa.tment of a.ima. Production Chapingo Autonomous University Depa.tment of a.riculture a.d Livestock Metropolitan Autonomous University (Xochimilco Unit) Institute of Genetic a.d Productivity (Livestock Center) Postgraduate College

Yea.ts a.d orga.ic minera.s a.e used in diets to improve hea.th, productive performa.ce a.d some ca.ca.s cha.a.teristics of rumina.ts a.d non-rumina.ts. Thirty-two la.bs（Pelibuey×Ka.a.din; BW=（30.55±1.67） kg; n=8） were used in a.56-d feeding experiment to study the effects of different levels of live yea.t（Sa.cha.omyces cerevisia.; yea.t）, selenium（Se） a.d chromium（Cr） mixed（Se-Cr）, a.d a.mixture of yea.t-Se-Cr on growth performa.ce a.d ca.ca.s tra.ts. a.ima.s were stra.ified by body weight（BW） a.d ra.domly a.signed to one of four trea.ments： 1） control group（0.0 g kg–1 yea.t）; 2） yea.t（1.50 g kg–1 dry ma.ter inta.e（DMI） d–1）; 3） Se-Cr premix（1.5 mg kg–1 DMI d–1 for ea.h minera.）; a.d 4） yea.t-Se-Cr mixture. There were no trea.ment effects on fina. BW; wherea. la.bs fed Se-Cr or yea.t-Se-Cr ha. higher（P〈0.05） DMI tha. a.ima.s supplemented with only yea.t. a.era.e da.ly ga.n（a.G）, ga.n：feed ra.io, chop a.ea. dorsa. fa. a.d ca.ca.s yield were simila.（P〉0.05） a.ong trea.ment groups. In conclusion, supplementa.ion with yea.t, Se-Cr mixed or yea.t-Se-Cr did not improve a.G, fina. BW, ba.k fa. content a.d ca.ca.s yield of growing of Pelibuey×Ka.a.din la.bs. Supplementa.ion with Se-Cr a.d yea.t-Se-Cr increa.ed DMI, a.d a.proxima.ely 250 g a.G a.ima.–1 d–1 wa. produced with no nega.ive effects on growth a.d hea.th of the a.ima.s.

关键词： yea.t orga.ic selenium a.d chromium Pelibuey×Ka.a.din sheep

Pretrea.ment infla.ma.ory indices predict Beva.izuma. response in recurrent Glioma

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Ca.cer Drug Resista.ce 2020年第3期3卷 623-635页

作者： a.icia.martínez-González Ra.uel Ca.rera.marta.Lloret pedro C.La.a Depa.tment de Ma.emática. Universidad de Castilla-La ManchaETSI IndustrialesAvdaCiudad Real 13071Spain. Oncología.Ra.ioterápica.Hospita. Universita.io de Gra. Ca.a.ia.Dr Negrin Barranco de la Ballena s/nLas Palmas de Gran CanariaLas Palmas 35010Spain. Fa.ulta. de Ciencia. de la.Sa.ud Universidad de Las Palmas de Gran CanariaPaseo de Blas Cabrera Felipes/nLas Palmas de Gran CanariaLas Palmas 35016Spain. Funda.ión Ca.a.ia.del Instituto Ca.a.io de Investiga.ión del Cáncer Avda de la Trinidad 61 Torre Agustín Arevalo 7 planta La LagunaSanta Cruz de Tenerife 38204Spain. Sa. Roque University Hospita.s Dolores de la Rocha5Las Palmas de Gran CanariaLas Palmas 35001Spain. Ferna.do Pessoa.Ca.a.ia. University Dolores dela Rocha 14Las Palmas de Gran CanariaLas Palmas 35016Spain.

a.m:It rema.ns unclea. wha. the best thera.eutic option for recurrent glioma.pa.ients a.ter Stupp trea.ment ***(BVZ)is commonly a.ministered in progression,but it a.pea.s tha. only some pa.ients *** would be useful to find bioma.kers tha. determine beforeha.d who these pa.ients ***:The protocol included 31 high-risk progressing glioma.pa.ients a.ter Stupp trea.ment who received BVZ 5-10 mg/kg every 14 da.s a.d temozolomide(3-19 cycles,150-200 mg five da.s ea.h 28-da. cycle)during a.mea. of eight cycles of BVZ or until tumor progression or una.cepta.le *** a.a.yzed the clinica. outcome va.ues of infla.ma.ory indices mea.ured before BVZ ***:Lymphocyte level before BVZ a.ministra.ion wa. the best independent predictor of overa.l surviva.(HR=0.34;95%CI:0.145-0.81;P=0.015).The a.ea.under the receiver opera.ing cha.a.teristic(ROC)curve wa. 0.823,with 1.645 being the optima. cut-off va.ue,a.d 0.80 a.d 0.85 the sensitivity a.d specificity va.ues,*** a.d non-responder surviva. curves were a.so significa.tly different,considering the first a.d second tertiles a. cut-off *** number of BVZ cycles wa. not rela.ed to *** neutrophil pla.elet levels,pla.elet-to-lymphocyte ra.io(PLR),a.d neutrophil-to-lymphocyte ra.io(NLR)did not ha.e independent predictive *** va.ia.les were not correla.ed with ea.h ***,pa.ients with high NLR a.d PLR simulta.eously(double positive PLR-NLR)showed a.worse clinica. outcome tha. the rest(P=0.043).Conclusion:Pretrea.ment lymphocyte levels a.d double positive PLR-NLR could be used a. non-inva.ive hema.ologica. prognostic ma.kers for recurrent glioma. trea.ed with beva.izuma..a.close rela.ionship emerged between infla.ma.ion a.d a.giogenesis.

关键词： Recurrent glioma beva.izuma. predictive bioma.ker infla.ma.ory indices lymphocytes

Full-term pregna.cy in brea.t ca.cer survivor with fertility preserva.ion: a.ca.e report a.d review of litera.ure

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World Journa. of Clinica. Ca.es 2019年第1期7卷 58-68页

作者： marta.Ga.rido-Ma.ín pedro Ma.ia.a.ga.ha.Luís Fernández Florencia.Molfino Fina.martínez-Soler a.elina.Tortosa.Pepita.Gimenez-Bona.é Depa.tment of Physiologica. Sciences Physiology Unit Faculty of Medicine and Health Sciences Bellvitge Campus Universitat de BarcelonaIDIBELL L’Hospitalet del Llobregat Hospita. Universita.i Genera. de Ca.a.unya Servicio de Oncología.Médica Consorcio Corporación Sanitaria Parc Taulí Instituto de Reproducción Cefer Depa.tment of Ba.ic Nursing Faculty of Medicine and Health Sciences Universitat de Barcelona IDIBELL L’Hospitalet del Llobregat

a.43-yea.-old woma. with a. a.socia.ed history of gynecologica. pa.hology a.d brea.t ca.cer with only one cryopreserved embryo wished to be a.*** fa.tors tha. influenced the success of the pregna.cy in this ca.e were a.a.yzed. Fa.ora.le fa.tors included: triple positive brea.t ca.cer [positive hormone receptors a.d positive huma. epiderma. growth fa.tor receptor 2],which is more hormosensitive a.d chemosensitive; a.sence of meta.ta.is; correct endometrium prepa.a.ion; a.d the pa.ient's optimistic a.titude a.d strict hea.th ha.its. In contra.t, the fa.tors a.a.nst success were: brea.t ca.cer; a.juva.t brea.t ca.cer thera.y gona.otoxicity; the a.e of the pa.ient(> 40-yea.-old);endometriosis; ova.ia. cyst; hydrosa.pinx; submucosa. fibroids a.d the respective a.socia.ed surgery done for the a.ove-mentioned pa.hology(a.l resolved prior to the embryo tra.sfer); a.d a.low qua.tity of ovules(low ova.ia. reserve) a.ter ova.ia. stimula.ion. This is a.very specia. clinica. ca.e of a.pa.ient with theoretica.ly low pregna.cy success proba.ility due to the consecutive a.cumula.ion of gynecologica. a.d oncologica. pa.hologies, who nonetheless beca.e pregna.t a.d delivered a.full-term infa.t a.d wa. a.le to provide a.equa.e brea.tfeeding.

关键词： Brea.t ca.cer Fertility preserva.ion Gona.otoxicity Pregna.cy In vitro fertiliza.ion Hydrosa.pinx Endometriosis Ca.e report

Chemothera.y induces cell pla.ticity;controlling pla.ticity increa.es thera.eutic response

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Signa. Tra.sduction a.d Ta.geted Thera.y 2023年第8期8卷 3563-3566页

作者： Fra.cisco J.Iborra.Cristina.martí Virtu Ca.a.uig-Na.a.ro Petros Pa.a.opoulos Sa.va.or Meseguer pedro M.Iborra.Fra.cisco Ga.cía.a.tonio martínez-Lorente Ferna.do a.ma.án Jua.a.Ca.a.uig Centro de Investiga.ión Príncipe Felípe(a.socia.ed Unit to Instituto de Biomedicína.de Va.encia. ValenciaSpain Pa.hology a.d Molecula. Thera.y Depa.tment Instituto de Biomedicína de Valencia(IBV)CSICValenciaSpain Molecula. a.d Cellula. Biology Depa.tment Centro Nacional de Biotecnología(CNB)CSICMadridSpain Hema.ology Depa.tment Hospital Clínico San CarlosMadridSpain Medica. Systems Biology Faculty of MedicineUniversity of HelsinkiHelsinkiFinland IC Biomed AlicanteSpain Vina.opóHospita.s Elcheand Biotechnology DepartmentUniversidad de AlicanteAlicanteSpain

Dea. Editor,One of the most serious issues in modern oncology is the ineffectiveness of trea.ments in destroying tumours,which lea.s to tumour recurrence a.d,ultima.ely,pa.ient *** phenomenon is ca.sed by conventiona. thera.ies’fra.tiona. killing of tumour cells,which ca. a.so ca.se resista.t cells to sprea..1 We a.a.ysed chemothera.y-resista.t cells a.d discovered tha. they a.e sma.ler tha. untrea.ed cells(Fig.1a..The fa.t tha. this phenomenon occurs in a.l tested cell types(Hela.a.49,Huh7,a.d MCF7)a.d rega.dless of the chemothera.y regimen(TRa.L,Ca.ptothecin,Doxorubicin)suggests tha. it is a.widesprea. phenomenon(Fig.1a.Supplementa.y Fig.S1).

关键词： chemothera.y tumour pla.ticity

Using lysosoma. membra.e sta.ility of ha.mocytes in Rudita.es philippina.um a. a.bioma.ker of cellula. stress to a.sess conta.ina.ion by ca.feine, ibuprofen, ca.ba.a.epine a.d novobiocin

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Journa. of Environmenta. Sciences 2013年第7期25卷 1408-1418页

作者： Ga.riela.V. a.uirre-martínez Sa.a.Bura.ti Elena.Fa.bri a.gel T. DelVa.ls M. La.ra.martín-Día. Unitwin/Unesco/WiCoP Physical Chemistry Department University of Cdiz Faculty of Marine and Environmental SciencesPolígono Río San Pedro s/n 11510 Puerto Real Cdiz Spain a.da.usia. Center for Ma.ine Science a.d Technology (Ca.YTMa.) Campus Universitariode Puerto Real11510 Puerto Real Cdiz Spain University of Bologna Interdepartment Centre for Research in Environmental Sciences (CIRSA)via S. Alberto 16348123 Ravenna Italy

a.though pha.ma.eutica.s ha.e beendetected in the environment only in the ra.ge from ng/L to μg/L, it ha. beendemonstra.ed tha. they ca. a.versely a.fect the hea.th sta.us of a.ua.ic orga.isms. Lysosoma. membra.e sta.ility （LMS） ha. previously been a.plied a. a. indica.or of cellula.well-being todetermine hea.th sta.us in biva.ve mussels. The objective of this study is to eva.ua.e LMS in Rudita.es philippina.um ha.molymph using the neutra. red retention a.sa. （NRRa.. Cla.swere exposed in la.ora.ory conditions to ca.feine （0.1, 5, 15, 50 μg/L）, ibuprofen （0.1, 5, 10, 50 μg/L）, ca.ba.a.epine a.d novobiocin （both a. 0.1, 1, 10, 50 μg/L） for35da.s. Results show a.ose-dependent effect of the pha.ma.eutica.s. The neutra. red retention time mea.ured a. the end of the bioa.sa.wa. significa.tly reduced by 50% a.ter exposure to environmenta. concentra.ions （p 〈 0.05）（ca.feine = 15 μg/L; ibuprofen = 10 μg/L; ca.ba.a.epine = 1 μg/L a.d novobiocin = 1 μg/L）, compa.ed to controls. Cla.s exposed to these pha.ma.eutica.swere considered to present a.iminished hea.th sta.us （retention time 〈45 min）, significa.tlyworse tha. controls （96 min）（p 〈 0.05）. The predicted no environmenta. effect concentra.ion （PNEC） results showed tha. these pha.ma.eutica.s a.e very toxic a. the environmenta. concentra.ions tested. Mea.urement of the a.tera.ion of LMS ha. been found to be a.sensitive technique tha. ena.les eva.ua.ion of the hea.th sta.us of cla.s a.ter exposure to pha.ma.eutica.s under la.ora.ory conditions, thus representing a.robust Tier-1 screening bioma.ker.

关键词： neutra. red pha.ma.eutica.s bioa.sa. ha.molymph biva.ves hea.th sta.us Ma.ila.cla.

Security-constra.ned model for integra.ed power a.d na.ura.-ga. system

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Journa. of Modern Power Systems a.d Clea. Energy 2017年第3期5卷 326-336页

作者： Ca.los M.CORREa.POSa.a.pedro SáNCHEZ-martíN Sa.a.LUMBRERa. XM Compania de Expertos en MercadosMedellı´nColombia Technologica. Resea.ch Institute(IIT) ICAI School of EngineeringComillas Pontifical UniversityMadridSpain

One of the ma.n fa.tors impa.ting the relia.ility of energy systems nowa.a.s is the growing interdependence between electricity a.d ga. networks due to the increa.e in the insta.la.ion of ga.-fired units. Securityconstra.ned unit commitment(SCUC) models a.e used to economica.ly schedule genera.ing units without compromising the system relia.ility. This pa.er proposes a.novel SCUC formula.ion tha. includes dyna.ic ga. constra.nts,such a. the line pa.k, a.d tra.smission contingencies in power a.d ga. networks for studying the integra.ed system relia.ility. a.Benders’ decomposition with linea. progra.ming techniques is developed to be a.le to study la.ge systems. By including dyna.ic ga. constra.nts into the SCUC, the proposed model a.counts for the flexibility a.d relia.ility tha. power systems require from ga. systems in the short term. Ca.e studies of different size a.d complexity a.e employed to illustra.e how the relia.ility of one system is a.fected by the relia.ility of the other. These experiments show how both systems opera.e in a.secure wa.(by including contingencies) increa.es opera.ing costs by a.proxima.ely 9% a.d a.so show how these costs ca. va.y by 24% depending on the line pa.k scheduling.

关键词： Benders’decomposition Na.ura. ga. Relia.ility Security-constra.ned unit commitment