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Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion

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Journal of Pharmaceutical Analysis 2021年第1期11卷 37-47页

作者： Barbara Bojko Nikita Looby Mariola Olkowicz Anna Roszkowska Bogumiła Kupcewicz pedro reck dos santos Khaled Ramadan Shaf Keshavjee Thomas K.Waddell German Goomez-Rios Marcos Tascon Krzysztof Gorynski Marcelo Cypel Janusz Pawliszyn Department of Chemistry University of WaterlooWaterlooON M1B 6G3Canada Department of Pharmacodynamics and Molecular Pharmacology Faculty of PharmacyCollegium Medicum in BydgoszczNicolaus Copernicus University in Torun85-089BydgoszczPoland Jagiellonian Centre for Experimental Therapeutics(JCET) Jagiellonian University30-348 KrakowPoland Department of Pharmaceutical Chemistry Medical University of Gdansk80-416GdanskPoland Department of Inorganic and Analytical Chemistry Faculty of PharmacyCollegium Medicum in BydgoszczNicolaus Copernicus University in Torun85-089BydgoszczPoland University Health Network-TGH TorontoON M5G 2C4Canada

Development of a novel in vivo lung perfusion(IVLP)procedure allows localized delivery of high-dose doxorubicin(DOX)for targeting residual micrometastatic disease in the ***,DOX delivery via IVLP requires careful monitoring of drug level to ensure tissue concentrations of this agent remain in the therapeutic window.A small dimension nitinol wire coated with a sorbent of biocompatible morphology(Bio-SPME)has been clinically evaluated for in vivo lung tissue extraction and determination of DOX and its key *** in vivo Bio-SPME-IVLP experiments were performed on pig model over various(150 and 225 mg/m^(2))drug doses,and during human clinical *** patients with metastatic osteosarcoma were treated with a single 5 and 7 μg/mL(respectively)dose of DOX during a 3-h *** both pig and human cases,DOX tissue levels presented similar trends during *** lung tissue concentrations of drug ranged between 15 and 293 μg/g over the course of the IVLP *** addition to DOX levels,Bio-SPME followed by liquid chromatography-mass spectrometry analysis generated 64 metabolic features during endogenous metabolite screening,providing information about lung status during drug ***-time monitoring of DOX levels in the lungs can be performed effectively throughout the IVLP procedure by in vivo Bio-SPME chemical biopsy ***-SPME also extracted various endogenous molecules,thus providing a real-time snapshot of the physiology of the cells,which might assist in the tailoring of personalized treatment strategy.

关键词： In vivo solid phase microextraction Metabolite profiling Spatial resolution Therapeutic drug monitoring Tissue analysis

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The effectiveness of different wear indicators in quantifying wear on railway wheels of freight wagons

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Railway Engineering Science 2024年第3期32卷 307-323页

作者： Philipe Augusto de Paula Pacheco M.Magelli Matheus Valente Lopes pedro Henrique Alves Correa N.Zampieri N.Bosso Auteliano Antunes dos santos Federal Institute of the Southeast of Minas Gerais(IF Sudeste MG) Técnico PanamáStreet 45Santos DumontMG 36246-311Brazil Railway Laboratory(Lafer) Universidade Estadual de Campinas(UNICAMP)Mendeleyev Street 200CampinasSP 13083-872Brazil Department of Mechanical and Aerospace Engineering Politecnico Di TorinoC.so Duca degli Abruzzi 2410129 TurinItaly

Railway infrastructure relies on the dynamic interaction between wheels and rails;thus,assessing wheel wear is a critical aspect of maintenance and *** paper focuses on the wheel-rail wear indicator T-gamma(Tγ).Amidst its use,it becomes apparent that Tγ,while valuable,fails to provide a comprehensive reflection of the actual material removal and actual contact format,which means that using only Tγas a target for optimization of profiles is not *** this work,three different freight wagons are evaluated:a meter-gauge and a broad-gauge heavy haul vehicles from South American railways,and a standard-gauge freight vehicle operated in Europe,with different axle loads and dissimilar new wheel/rail *** vehicles are subjected to comprehensive multibody simulations on various *** simulations aimed to elucidate the intricate relationship between different wear indicators:Tγ,wear index,material removal,and maximum wear depth,under diverse curves,non-compensated lateral accelerations(A_(nc)),and *** findings showed a correlation of 0.96 between Tγand wear depth and 0.82 between wear index and material removed for the outer *** the results,the Tγis better than the wear index to be used when analyzing wear depth while the wear index is more suited to foresee the material *** results also show the low influence of A_(nc)on wear index and Tγ.By considering these factors together,the study aims to improve the understanding of wheel-rail wear by selecting the best wear analysis approaches based on the effectiveness of each parameter.

关键词： Wear index Wear volume Wear modeling Dynamic simulation

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Inherited Fanconi syndrome

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World Journal of Pediatrics 2023年第7期19卷 619-634页

作者： Anna Luiza Braga Albuquerque Rafael dos santos Borges Ana Flavia Conegundes Erika Emmylaine dos santos Frederico Moreira Man Fu Clara Tavares Araujo pedro Alves Soares Vaz de Castrol Ana Cristina Simoes e Silva Interdisciplinary Laboratory of Medical Investigation Unit of Pediatric NephrologyFaculty of MedicineFederal University of Minas Gerais(UFMG)Belo HorizonteBrazil Department of Pediatrics Faculty of MedicineUFMGAlfredo Balena Avenue1902Nd FloorRoom#281Belo HorizonteMG 30130-100Brazil

Background Fanconi-Debré-de Toni syndrome(also known as Fanconi renotubular syndrome,or FRST)profoundly increased the understanding of the functions of the proximal convoluted tubule(PCT)and provided important insights into the pathophysiology of several kidney diseases and drug *** sources We searched Pubmed and Scopus databases to find relevant articles about *** review article focuses on the physiology of the PCT,as well as on the physiopathology of FRST in children,its diagnosis,and *** FRST encompasses a wide variety of inherited and acquired PCT alterations that lead to impairment of PCT *** children,FRST often presents as a secondary feature of systemic disorders that impair energy supply,such as Lowe's syndrome,Dent's disease,cystinosis,hereditary fructose intolerance,galactosemia,tyrosinemia,Alport syndrome,and Wilson's *** rare,congenital causes of FRST greatly impact the morbidity and mortality of patients and impose diagnostic ***,its treatment is diverse and considers the ability of the clinician to identify the correct etiology of the *** The early diagnosis and treatment of pediatric patients with FRST improve the prognosis and the quality of life.

关键词： Cystinosis Fanconi syndrome Fanconi renotubular syndrome Fanconi-Debre-de Toni syndrome Proximal tubule Renal tubular transport-Rickets

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Ion dynamics into different pore size distributions in supercapacitors under compression

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Journal of Energy Chemistry 2023年第5期80卷 110-119,I0004页

作者： João pedro Aguiar dos santos Cesar J.B.Pagan Rafael Vicentini Reinaldo F.Teófilo Renato Beraldo Leonardo M.Da Silva Hudson Zanin Brazilian Renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasAv.Albert Einstein 40CampinasSP13083-852Brazil School of Electrical and Computer Engineering University of CampinasSP 13083-852Brazil Multivariate Chemical Data Analysis Laboratory Department of ChemistryUniversidade Federal de Viçosa36570-900 ViçosaMGBrazil Department of Chemistry Laboratory of Fundamental and Applied ElectrochemistryFederal University of Jequitinhonha and Mucuri's ValleyRodovia MGT 367km 5835000 Alto da Jacuba39100-000DiamantinaMGBrazil

Compressing supercapacitor(SCs)electrode is essential for improving the energy storage characteristics and minimizing ions’distance travel,faradaic reactions,and overall ohmic *** comprising the ion dynamics in SC electrodes under compression are still ***,the ionic dynamics of five aqueous electrolytes in electrodes under compression were studied in this work for tracking electrochemical and structural changes under mechanical stress.A superionic state is formed when the electrode is compressed until the micropores match the dimensions with the electrolyte’s hydrated ion sizes,which increases the *** excessive compression is applied,the accessible pore regions decrease,and the capacitance ***,as the studied hydrated ions have different dimensions,the match between ion/pore sizes *** the LiOH and NaClO4electrolytes,increasing the pressure from 60 to 120 and 100 PSI raised the capacitance from 13.5 to 35.2 F g^(-1)and 30.9 to 39.0 F g^(-1),***,the KOH electrolyte with the lowest and LiCl with the biggest combination of hydrated ion size have their point of maximum capacitance(39.5 and 36.7F g^(-1))achieved at 140 and 80 PSI,*** LiCl and KCl electrolytes,overcompression causes a drop in capacitance higher than 23%.

关键词： Mechanic compression Pore size distribution lon dynamics Activated carbon Supercapacitors

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Best practices for electrochemical characterization of supercapacitors

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Journal of Energy Chemistry 2023年第5期80卷 265-283,I0007页

作者： João pedro Aguiar dos santos Fernando Cesar Rufino Joǎo IYutaka Ota Rodolfo CFernandes Rafael Vicentini Cesar JBPagan Leonardo Morais Da Silva Hudson Zanin Brazilian Renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasSP 13083-852Brazil School of Electrical and Computer Engineering University of CampinasSP 13083-852Brazil Department of Chemistry Laboratory of Fundamental and Applied ElectrochemistryFederal University of Jequitinhonha e Mucuri's ValleyRodovia MGT 367km 5835000Alto da Jacuba39100-000 DiamantinaMGBrazil

We discuss here essential aspects of the experimental supercapacitors characterization by a series of well-known electrochemical *** are motivated by a considerable number of publications that misreport procedures and *** often conceal or neglect essential information about the electrochemical analytical apparatus used and its *** lack of such information may lead researchers,especially inexperienced ones,to misunderstand the procedures and ***,the misled electrochemical equipment configuration favors misinterpretation of data and low reproducibility *** paper aims to highlight these issues and clarify *** explain fundamental concepts of some electrochemical analytical methods,such as cyclic voltammetry,galvanostatic charge-discharge,single potential step chronoamperometry,and electrochemical impedance spectroscopy,focusing on the supercapacitor *** configurations of electrical parameters are presented and discussed to highlight the effects of incorrect setup and uncover misleading *** discuss how the electrochemical setup and data analyses matter in reliable data results for the supercapacitor.

关键词： Supercapacitor Electrochemical instrumentation Electrochemical methods Electrochemistry

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Small dams/reservoirs site location analysis in a semi-arid region of Mozambique

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International Soil and Water Conservation Research 2021年第3期9卷 381-393页

作者： Antònio dos Anjos Luís pedro Cabral Department of GIS and Regional Planning Universidade Catdlica de MozambiqueBeiraSofalaMozambique NOVA Information Management School(NOVA IMS) Universidade Nova de Lisboa1070-312LisboaPortugal

The water crisis is one of the biggest human problems in developing countries,especially in semi-arid regions where it can form an obstacle to irrigation and cultivation,cattle raising and people's *** construction of small dams/reservoirs are a possible solution to remediate this *** infrastructures must be located in suitable areas to be *** study aimed to find the most suitable locations for small dams/reservoirs in the Tete province region,Mozambique,which has a pronounced water deficit A Geographical Information System(GIS)based approach was used to implement a multicriteria evaluation(MCE)analysis through an Analytic Hierarchical Process(AHP),which included local experts’*** main categories of suitability were identified:"Not suitable”(15%of total area),"Modestly suitable"(78%),and“Suitable"(7%).We found that 35 of the 38(92%)abandoned small dams/reservoirs were in areas classified as“Modestly suitable”confirming the robustness of our *** also found that most of the dams/reservoirs currently operating(78%)and planned(73%)are in modestly suitable *** finding suggests that the decision to construct dams/reservoirs may not have considered the most critical suitability factors identified in this *** data and/or additional criteria are required for the full understanding of finding out why so many dams/reservoirs failed before building new ones to address the population’s water needs in the region.

关键词： Water scarcity Multi-criteria evaluation Geographic information systems Remote sensing Mozambique

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t-SNE:A study on reducing the dimensionality of hyperspectral data for the regression problem of estimating oenological parameters

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Artificial Intelligence in Agriculture 2023年第1期7卷 58-68页

作者： Rui Silva pedro Melo-Pinto CITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences Inov4Agro-Institute for InnovationCapacity Building and Sustainability of Agri-Food ProductionUniversidade de Trás-os-Montes e Alto DouroQuinta dos PradosVila Real 5000-801Portugal Departamento de Engenharias Escola de Ciências e TecnologiaUniversidade de Trás-os-Montes e Alto DouroQuinta dos PradosVila Real 5000-801Portugal

In recent years there is a growing importance in using machine learning techniques to improve procedures in precision agriculture:in this work we perform a study on models capable of predicting oenological parameters from hyperspectral images of wine grape berries,a specially relevant topic to boost production tasks for ***,we explore the capabilities of a novel technique mostly used for visualization,t-Distributed Stochastic Neighbor Embedding(t-SNE),for reducing the dimensionality of the highly complex hyperspectral data and compare its performance with Principal Component Analysis(PCA)method,which despite the introduction of many nonlinear dimensionality reduction techniques over the years,had achieved the best results for real-world data across several studies in *** we explore the potential of Kernel t-SNE,an extension to the t-SNE method that allows for the usage of the technique in streaming data or online *** results show that,in a direct comparison,t-SNE achieves better metrics than PCA for most of the data sets in this work and that the regressor(Support Vector Regression,SVR)performs better with the t-SNE reduced features as inputs,accomplishing better predictions with lower error *** the results with current literature,our shallow learning model paired with t-SNE achieves either better or on par results than those reported,even competing with more advanced models that use deep learning techniques,which should propel the introduction of t-SNE in more studies that require dimensionality reduction.

关键词： Hyperspectral images Dimensionality reduction Regression T-SNE Support vector machines Wine grape berries

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Application of Extended Multiplicative Signal Correction to Short-Wavelength near Infrared Spectra of Moisture in Marzipan

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Journal of Data Analysis and Information Processing 2013年第3期1卷 30-34页

作者： pedro dos santos Panero Francisco dos santos Panero Joao dos santos Panero Henrique Eduardo Bezerra da Silva Campus Novo Paraiso Instituto Federal de EducacaoCiencia e Tecnologia de RoraimaBoa VistaBrazil Instituto Federal de Educacao Ciencia e Tecnologia de RoraimaBoa VistaBrazil Departamento de Engenharia Eletrica Universidade Federal de RoraimaBoa VistaBrazil Departamento de Quimica Universidade Federal de RoraimaBoa VistaBrazil

Short-wavelength near infrared spectroscopy (SW-NIR) is a very rapid, versatile and precise technique, which can be used in many different situations and for very types of products and chemical compounds. Extended multiplicative signal correction (EMSC) is a modification of the standard MSC pre-processing method that allows the separation of physical light scattering effects from chemical (vibrational) light absorbance effects in spectra. In this paper, the EMSC is applied and compared with first derivate, second derivate, MSC and SNV in combination of PLSR to obtain robust models in terms of accuracy and predict ability with a reduced calibration data set using SW-NIR spectra of moisture in marzipan. The Extended Multiplicative Signal Correction—EMSC and combination methods provide the best results in terms of prediction ability and calibration SW-NIR spectra of moisture in marzipan. The best classification results were obtained by Extended Multiplicative Signal Correction followed by second derivates.

关键词： EMSC PLSR SW-NIR Extended Multiplicative Signal Correction Chemometrics

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Suicide Attempts in a General Hospital: A Case-Control

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Open Journal of Psychiatry 2023年第S2期13卷 518-531页

作者： Fernanda Menezes de Faria Marília Capuço Oliveira Gerardo Maria de Araújo Filho Celina Dias santos Lazzaro Ellen Thaís França dos santos Gouveia Maria Fernanda Birolli pedro Bueno da Silveira Agrelli Yoichi Takaki Konno Ana Carolina Gonçalves Olmos Department of Neurological Sciences Psyquiatry and Medical Psychology Faculdade de Medicina de S&#227o José do Rio Preto S&#227o Paulo Brazil

Objective: This study aims is to conduct a comparative analysis of the clinical and sociodemographic profiles of individuals referred to Consultation-Liaison Psychiatry (CLP) at a tertiary general hospital, specifically focusing on those seeking assistance due to suicide attempts (TS) versus CLP requests for other reasons (non-TS) between the years 2010 and 2020. Additionally, we aim to assess factors associated with suicide attempts. Method: This retrospective controlled study involves a thorough examination of medical records encompassing 3913 patients who received CLP services at the Hospital de Base (HB) and the Children and Maternity Hospital (HCM) of São José do Rio Preto Medical School Foundation (Funfarme) from June 2010 to June 2020. The patient cohort is categorized into two groups: those with requests for SA (n = 677) and those with requests for other reasons. Results: In the SA group, as opposed to the non SA group, statistically significant differences were observed for gender (predominantly female), employment status (employed), marital status (single), and age (younger). Notably, a higher prevalence of psychiatric antecedents (88.7%, n = 555 vs. 73.6% n = 2018) was found in the SA group, indicating a significant association. The frequency of SA requests remained stable over the years. Among the SA group, mood disorders were the most prevalent (39%, n = 372), followed by disorders related to substance use (21.2%, n = 202), and personality disorders (16%, n = 152). A history of previous suicide attempts emerged as a crucial factor for the recurrence of SA (p-value ≤ 0.001). Exogenous intoxication emerged as the most frequently employed method in attempts (79.6%, n = 539), particularly prevalent among patients diagnosed with mood disorders (41%, n = 314). A significant association was observed between the method of attempt and the nosological psychiatric diagnosis (χ2 = 42.277;p ≤ 0.001). Regarding outcomes, the majority of patients were refer

关键词： Consultation-Liaison Psychiatry Exogenous Intoxication General Hospital Mood Disorders Suicide Attempt

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Bartter's syndrome:clinical findings,genetic causes and therapeutic approach

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World Journal of Pediatrics 2021年第1期17卷 31-39页

作者： Flavia Cristina Carvalho Mrad Sílvia Bouissou Morais Soares Luiz Alberto Wanderley de Menezes Silva pedro Versiani dos Anjos Menezes Ana Cristina Simoes-e-Silva Interdisciplinary Laboratory of Medical Investigation Faculty of MedicineFederal University of Minas Gerais(UFMG)Av.Alfredo Balena190Room#281Belo HorizonteMG 30130-100Brazil Pediatric Nephrology Unit Faculty of MedicineUFMGBelo HorizonteBrazil

Backgound Bartter's syndrome(BS)is a rare group of salt losing tubulopathies due to the impairment of transport mecha-nisms at the thick ascending limb of the Henle's *** sources Literature reviews and original research articles were collected from database,including PubMed and *** According to the time of onset and symptoms,BS can be classified into antenatal and classic *** studies have identified different subtypes of *** types Ⅰ,Ⅱ and Ⅲ are caused by mutations on genes encoding the luminal Na^(+)-K^(+)-2Cl^(-) co-transporter,the luminal K+ channel ROMK,and the basolateral chloride channel ClC-Kb(CLCNKB),***-of-function mutations of Barttin CLCNK type accessory beta subunit cause BS type Ⅳ*** mutations of CLCNKB and CLCNKA cause BS type Ⅳ*** type Ⅴ consists in a novel transient form characterized by antenatal presentation due to mutations in the MAGE family member *** gain-of-function mutations of the extracellular calcium sensing receptor gene can result in an autosomal dominant condition of *** clinical and biochemical alterations in BS include polyuria,dehydration,hypokalemia,hypochloremic metabolic alka-losis,hyperreninemia,high levels of prostaglandins,normal or low blood pressure,hypercalciuria and failure to *** focuses mainly at correcting dehydration and electrolyte disturbances and in measures to reduce polyuria,including the use of nonsteroidal anti-inflammatory medications to control excessive renal prostaglandin E2 *** Early diagnosis and treatment of BS may prevent long-term consequences such as growth failure,nephrocal-cinosis and end-stage renal disease.

关键词： Bartter's syndrome Hypercalciuria Hypokalemia Metabolic alkalosis Nephrocalcinosis

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