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Minimizing sperm oxidative stress using nanotechnology for breeding programs in rams

Journal of Animal Science and Biotechnology 2023年第6期14卷 2395-2410页

作者： Alejandro Jurado‑Campos pedro Javier Soria‑Meneses Maria Arenas‑Moreira Carlos Alonso‑Moreno Virginia Rodriguez‑Robledo Ana Josefa Soler Jose Julian Garde Maria del Rocio Fernandez‑santos SaBio IREC(CSIC-UCLM-JCCM) Campus UniversitarioS/N02071 AlbaceteSpain. Departamento de Quimica Inorganica Organica Y Bioquimica‑Centro de Innovacion en Quimica Avanzada(ORFEO‑CINQA)Facultad de FarmaciaUniversidad de Castilla-La Mancha02008 AlbaceteSpain. Centro Regional de Investigacion Biomedicas Unidad nanoDrugUniversidad de Castilla-La Mancha02008 AlbaceteSpain. Facultad de Farmacia Universidad de Castilla La Mancha02071 AlbaceteSpain.

Background Artificial insemination(AI)is a routine breeding technology in animal ***,the temperature-sensitive nature and short fertile lifespan of ram sperm samples hamper its use in *** this sense,nanotechnology is an interesting tool to improve sperm protection due to the development of nanomaterials for AI,which could be used as delivery *** this work,we explored the feasibility of vitamin E nanoemulsion(NE)for improving sperm quality during *** With the aim of evaluating this proposal,ejaculates of 7 mature rams of Manchega breed were collected by artificial vagina and extended to 60×10^(6)spz/mL in *** containing control and NE(12 mmol/L)with and without exogenous oxidative stress(100μmol/L Fe2+/ascorbate)were stored at 22 and 15℃and motility(CASA),viability(YO-PRO/PI),acrosomal integrity(PNA-FITC/PI),mitochondrial membrane potential(Mitotracker Deep Red 633),lipoperoxidation(C11 BODIPY 581/591),intracellular reactive oxygen species(ROS)production and DNA status(SCSAR)monitored during 96 *** results show that NE could be used to maintain ram spermatozoa during transport at 15 and 22℃for up to 96 h,with no appreciable loss of kinematic and physiological characteristics of freshly collected *** The storage of ram spermatozoa in liquid form for 2-5 d with vitamin E nanoemulsions may lead more flexibility to breeders in AI *** view of the potential and high versatility of these nanodevices,further studies are being carried out to assess the proposed sperm preservation medium on fertility after artificial insemination.

关键词： Breeding technology Nanoemulsions Nanotechnology Sperm oxidative stress Vitamin E

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P2X7 receptor blockade decreases inflammation,apoptosis,and enteric neuron loss during Clostridioides difficile toxin A-induced ileitis in mice

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World Journal of Gastroenterology 2022年第30期28卷 4075-4088页

作者： Ana A Q A santos Deiziane V S Costa Danielle A Foschetti Antoniella S G Duarte Conceicao S Martins pedro M G Soares Patricia Castelucci Gerly A C Brito Department of Morphology School of MedicineFederal University of CearaFortaleza 60430-170CearaBrazil Department of Physiology and Pharmacology School of MedicineFederal University of CearáFortaleza 60430-170CearaBrazil Department of Pathology and Legal Medicine School of MedicineFederal University of CearaFortaleza 60430-170CearaBrazil Department of Morphology(UFC) Federal University of CearaFortaleza 60430-170CearaBrazil Department of Anatomy Institute of Biomedical SciencesUniversity of São PauloSao Paulo 05508-270Brazil Department of Morphology Federal University of CearaFortaleza 60140-170CearaBrazil

Clostridioides difficile(***)is the most common pathogen causing health care-associated *** TcdA and TcdB have been shown to activate enteric neurons;however,what population of these cells is more profoundly influenced and the mechanism underlying these effects remain *** To characterize a specific population of TcdA-affected myenteric neurons and investigate the role of the P2X7 receptor in TcdA-induced ileal inflammation,cell death,and the changes in the enteric nervous system in *** Swiss mice were used to model TcdA-induced ileitis in ileal loops exposed to TcdA(50μg/Loop)for 4 *** investigate the role of the P2X7 receptor,Brilliant Blue G(50 mg/kg,i.p.),which is a nonspecific P2X7 receptor antagonist,or A438079(0.7μg/mouse,i.p.),which is a competitive P2X7 receptor antagonist,were injected one hour prior to TcdA *** samples were collected to analyze the expression of the P2X7 receptor(by quantitative real-time polymerase chain reaction and immunohistochemistry),the population of myenteric enteric neurons(immunofluorescence),histological damage,intestinal inflammation,cell death(terminal deoxynucleotidyltransferasemediated dUTP-biotin nick end labeling),neuronal loss,and S100B synthesis(immunohistochemistry).RESULTS TcdA upregulated(P<0.05)the expression of the P2X7 receptor gene in the ileal tissues,increasing the level of this receptor in myenteric neurons compared to that in control *** with the control mice indicated that TcdA promoted(P<0.05)the loss of myenteric calretinin+(Calr)and choline acetyltransferase+neurons and increased the number of nitrergic+and Calr+neurons expressing the P2X7 *** of the P2X7 receptor decreased TcdAinduced intestinal damage,cytokine release[interleukin(IL)-1β,IL-6,IL-8,and tumor necrosis factor-α],cell death,enteric neuron loss,and S100B synthesis in the mouse *** Our findings demonstrated that TcdA induced the upregulation of the P

关键词： Clostridioides difficile Clostridioides difficile toxin A P2X7 receptor Enteric nervous system Enteric neuron Enteric glia

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Seamless and non-repetitive 4D texture variation synthesis and real-time rendering for measured optical material behavior

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Computational Visual Media 2019年第2期5卷 161-170页

作者： Martin Ritz Simon Breitfelder pedro santos Arjan Kuijper Dieter W. Fellner Fraunhofer IGD Darmstadt64283Germany TU Darmstadt Darmstadt64289Germany TU Graz Graz8010Austria

We show how to overcome the single weakness of an existing fully automatic system for acquisition of spatially varying optical material behavior of real object surfaces. While the expression of spatially varying material behavior with spherical dependence on incoming light as a 4D texture(an ABTF material model) allows flexible mapping onto arbitrary 3D geometry, with photo-realistic rendering and interaction in real time,this very method of texture-like representation exposes it to common problems of texturing, striking in two disadvantages. Firstly, non-seamless textures create visible artifacts at boundaries. Secondly, even a perfectly seamless texture causes repetition artifacts due to their organised placement in large numbers over a 3D surface. We have solved both problems through our novel texture synthesis method that generates a set of seamless texture variations randomly distributed over the surface at shading time. When compared to regular 2D textures, the inter-dimensional coherence of the 4D ABTF material model poses entirely new challenges to texture synthesis, which includes maintaining the consistency of material behavior throughout the 4D space spanned by the spatial image domain and the angular illumination hemisphere. In addition, we tackle the increased memory consumption caused by the numerous variations through a fitting scheme specifically designed to reconstruct the most prominent effects captured in the material model.

关键词： optical material behavior reflectance modeling 4D texture synthesis texturing

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Initial medication adherence in newly diagnosed glaucoma patients:three adherence measures

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International Journal of Ophthalmology(English edition) 2023年第4期16卷 630-637页

作者： Joana Menino pedro Camacho AndréCoelho Escola Superior de Tecnologia da Saúde Instituto Politécnico de LisboaLisbon 1990-096Portugal H&TRC-Health&Technology Research Center ESTeSLEscola Superior de Tecnologia da SaúdeInstituto Politécnico de LisboaLisbon 1990-096Portugal iNOVA4Health NOVA Medical SchoolFaculdade de Ciências MédicasNMSFCMUniversidade NOVA de LisboaLisbon 1150-82Portugal Instituto de Oftalmologia Dr.Gama pinto Lisbon 1150-255Portugal

AIM:To determine initial medication adherence in newly diagnosed glaucoma patients treated with anti-glaucoma ***:This retrospective and observational study included all patients diagnosed with glaucoma in the Primary Health Care units in Portugal during the years 2012 and 2013,which in consequence received a first prescription for anti-glaucoma *** was collected from electronic prescribing records of the primary care units and from pharmacy claims *** of glaucoma treatment and early discontinuation were measured,and the combination of(non)-initiation and early discontinuation accounted for initial medication(non)-***:A total of 3548 new glaucoma patients(40.1%male;59.9%female)were *** 1133(31.9%)patients were initially classified as non-users,since there was no pharmacy claim found for their first prescription for glaucoma ***,277(11.5%)patients early discontinued their treatment,acquiring only their first ***,the initial medication non-adherence rate was 39.7%since 1410 patients either didn’t initiate treatment or discontinued it ***:This study,reveals a major opportunity to improve glaucoma treatment and its control,since a large proportion of patients fail to engage with their prescribed therapy,which implies that implementation of individual or group strategies that enable patients with glaucoma to correctly perform their treatment is still needed.

关键词： glaucoma glaucoma treatment initiation early discontinuation initial medication adherence

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Effect of climate and altitude on plant community composition and richness in Brazilian inselbergs

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Journal of Mountain Science 2020年第8期17卷 1931-1941页

作者： Herval Vieira pinto-JUNIOR pedro Manuel VILLA Luis Fernando Tavares de MENEZES Miriam Cristina Alvarez PEREIRA Universidade Federal de Vigosa Department of Plant BiologyLaboratory of Ecology and Evolution of Plants36570-900Vicosa-MGBrazil Universidade Federal de Vigosa Department of Forest EngineeringLaboratory of Forest Restoration36570-900Vicosa-MGBrazil Universidade Federal do Espirito Santo Department of Agrarian and Biological SciencesLaboratory of Ecology of Restinga and Mata Atlantica29932-900Sao Mateus-ESBrazil Universidade Federal do Espirito Santo Department of Biology29500-000Alegre-ESBrazil

Plant communities are shaped by multiple factors along environmental gradients;however,studies are limited on how environmental filtering drives community composition and species richness on tropical *** evaluate the influence of altitude and climatic variables related to temperature and precipitation on plant community composition and species richness on Brazilian *** assume as a premise that both climate and altitude would induce changes on plant community composition and species richness at the local *** used plant inventory data from 370 sampling units across four inselberg sites in the Atlantic Forest of Espírito Santo State,south-eastern *** tested the univariate and multivariate effects of altitude and climate variables on community composition and species richness with multiple *** in species richness between inselbergs were evaluated using sample-based data to estimate rarefaction and extrapolation *** addition,differences in species composition and taxonomic beta diversity were examined via novel frequency-based metrics.A contrasting climate pattern was observed between the inselberg sites,with south sites being wet compared to the dry conditions found in northern *** richness by rarefaction showed a similar pattern within regional sites;however,there were marked differences between *** richness and beta diversity showed significant differences among sites,with higher values in southern sites than in northern *** a multi-model comparison between inselberg sites,altitude significantly influenced community composition and species richness and explained more variance than climate *** finding suggested that climate could act to some extent on these tropical inselbergs;however,altitude was a better predictor of plant community composition and species richness at the local level.

关键词： Atlantic Forest Biome Beta diversity Abiotic filtering Climate models Environmental filtering Latitudinal gradient

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Static-based early-damage detection using symbolic data analysis and unsupervised learning methods

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Frontiers of Structural and Civil Engineering 2015年第1期9卷 1-16页

作者： Joao pedro santos Christian CREMONA Andre D. ORCESI Paulo SILVEIRA Luis CALADO Department of Structures Av. Brasil 101 Lisbon 1700-066 Portugal Technical Center for Bridge Engineering CEREMA B.P. 214 Provins Cedex 77487 France Materials and Structures Department IFSTTAR University Paris-Est 14-20 Boulevard Newton Champs sur Marne Marne la Vallee Cedex2 F-77447 France Department of Civil Engineering Technical University Lisbon Avenida Rovisco Pais Lisbon 1096 Portugal

A large amount of researches and studies have been recently performed by applying statistical and machine learning techniques for vibration-based damage detection. However, the global character inherent to the limited number of modal properties issued from operational modal analysis may be not appropriate for early-damage, which has generally a local character. The present paper aims at detecting this type of damage by using static SHM data and by assuming that early-damage produces dead load redistribution. To achieve this objective a data driven strategy is proposed, consisting of the combination of advanced statistical and machine learning methods such as principal component analysis, symbolic data analysis and cluster analysis. From this analysis it was observed that, under the noise levels measured on site, the proposed strategy is able to automatically detect stiffness reduction in stay cables reaching at least 1%.

关键词： structural health monitoring early-damage detection principal component analysis symbolic data symbolic dissimilarity measures cluster analysis numerical model damage simulations

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Evaluation of Cinnamon by Solid-State NMR Employing Relaxometry

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Materials Sciences and Applications 2023年第3期14卷 142-147页

作者： pedro Paulo Merat Roberto Cucinelli Neto Vitor santos Ramos Maria Inês Bruno Tavares Instituto de Macromoléculas Professora Eloisa Mano (IMA) da Universidade Federal do Rio de Janeiro UFRJ Centro de Tecnologia Ilha do Fund&atildeo Rio de Janeiro Brasil IFRJ Avenida República do Paraguai Duque de Caxias Brasil

To evaluate the molecular dynamics and the molecular regions presented in the cinnamon types it was chosen to evaluate them without any treatment, and for that it was used low-field nuclear magnetic resonance (NMR) through the pulse sequence such as MSE-FID, an NMR sequence in the time domain, and from the longitudinal relaxation time (with a time constant T1), employing the inversion-recovery pulse sequence. The low-field NMR results indicate that the techniques chosen were a very good alternative to evaluate these types of samples food and their structural organization according to their constituents. The molecular mobility is different.

关键词： Cinnamon Low-Field NMR NMR Relaxation Functional Food

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High Order of Accuracy for Poisson Equation Obtained by Grouping of Repeated Richardson Extrapolation with Fourth Order Schemes

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Computer Modeling in Engineering & Sciences 2021年第8期128卷 699-715页

作者： Luciano Pereira da Silva Bruno Benato Rutyna Aline Roberta santos Righi Marcio Augusto Villela pinto Graduate Program in Numerical Methods in Engineering Federal University of ParanaCuritiba81531-980Brazil Graduate Program in Space Sciences and Technologies Aeronautics Institute of TechnologySao Jose dos Campos12228-900Brazil Department of Mechanical Engineering Federal University of ParanaCuritiba81531-980Brazil

In this article,we improve the order of precision of the two-dimensional Poisson equation by combining extrapolation techniques with high order *** high order solutions obtained traditionally generate non-sparse matrices and the calculation time is very *** can obtain sparse matrices by applying compact *** this article,we compare compact and exponential finite difference schemes of fourth *** numerical solutions are calculated in quadruple precision(Real*16 or extended precision)in FORTRAN language,and iteratively obtained until reaching the round-off error magnitude around 1.0E−*** procedure is performed to ensure that there is no iteration *** Repeated Richardson Extrapolation(RRE)method combines numerical solutions in different grids,determining higher orders of *** main contribution of this work is based on a process that initializes with fourth order solutions combining with RRE in order to find solutions of sixth,eighth,and tenth order of *** multigrid Full Approximation Scheme(FAS)is also applied to accelerate the convergence and obtain the numerical solutions on the fine grids.

关键词： Tenth order accuracy RRE compact scheme exponential scheme multigrid finite difference

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Microstructural characterization and mechanical behavior analysis of 7075-T6 aluminum subjected to simulated lightning strikes

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Chinese Journal of Aeronautics 2021年第12期34卷 39-50页

作者： Luis Henrique santos Weslei Patrick Teodosio SOUSA Sara Silva Ferreira DE DAFE pedro Americo Magalhaes JUNIOR Department of Mechanical Engineering Pontificia Universidade Catolica de Minas GeraisBelo Horizonte 30535-901Brazil

Aircrafts damages caused by lightning strikes have been known since the early days of ***,the physical effects on the aircraft structure are still being *** work seeks to evaluate the lightning strike effects in the aluminum alloy *** were submitted to lightning strike simulation in laboratory and the damages evaluated through characterization *** and profilometry tests have shown material loss to 0.272 mm depth in the damaged *** addition,it was detected the material accumulation occurrence in the damage vicinity of the *** the damage,it was found a region where metallurgical changes were *** tensile and microhardness tests results have shown reduction in the percentage elongation and hardness increasing in the material affected by *** results are corroborated by the X-Ray Diffraction(XRD)and Rietveld Method(red line)that indicated an increasing in dislocation density and micro-deformation in the material *** microscopy results have shown the presence of microcracks on the normal and cross-section surface of the samples *** Energy Dispersive X-Ray Spectroscopy(EDXS)and Electron Backscattered Diffraction Test(EBSD)found coarse intermetallic phases and precipitates compounds with dimensions greater than 1 lm in *** were responsible for nucleation of the microcracks that propagate along the material grain boundaries.

关键词： Aircraft structure Characterization techniques Lightning strikes Precipitates Microcracks

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Tracheobronchial Polyflex stents for the management of benign refractory hypopharyngeal strictures

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World Journal of Gastroenterology 2012年第6期18卷 551-556页

作者： Rui Almeida Silva Nuno Mesquita pedro Pimentel Nunes Elisabete Cardoso Ricardo Marcos pinto Luís Moreira Dias Department of Gastroenterology Instituto Português de Oncologia do Porto Francisco GentilR.Doutor António Bernardino de Almeida 4200-072PortoPortugal Department of Gastroenterology Centro Hospitalar do PortoLargo Prof.Abel Salazar 4099-001PortoPortugal

AIM:To describe a modified technique for placement of a tracheobronchial self-expanding plastic stent(SEPS) in patients with benign refractory hypopharyngeal strictures in order to improve dysphagia and allow stricture ***:A case series of four consecutive patients with complex hypopharyngeal strictures after combinedtherapy for laryngeal cancer,previously submitted to multiple sessions of dilation without lasting improvement,is *** patients underwent placement of a small diameter and unflared tracheobronchial *** outcome measurements were improvement of dysphagia and avoiding of repeated ***:The modified introducer system allowed an easy and technically successful deployment of the tracheobronchial Polyflex stent through the *** four patients developed complications related to stent *** patients had stent migration(one proximal and one distal),two patients developed phanryngocutaneous fistulas and all patients with stents in situ for more than 8 wk had hyperplastic tissue growth at the upper end of the *** recurrence was observed at 4 wk follow-up after stent removal in all patients CONCLUSION:Although technically feasible,placement of a tracheobronchial SEPS is associated with a high risk of *** diameter stents must be kept in place for longer than 3 mo to allow adequate time for stricture remodeling.

关键词：塑料支架耐火材料狭窄气管管理改性技术保持时间导引系统

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