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Clear cell sarcoma of the pancreas,an unusual cancer with unusual metastatic site or unusual primary site?

World Journal of Clinical Cases 2024年第25期12卷 5653-5656页

作者： Jhenyffer Carvalho Moreno pedro luiz serrano uson junior Universidade 9 de Julho Sao Paulo 01509120Brazil Center for Personalized Medicine Hospital Israelita Albert EinsteinSão Paulo 05652900Brazil Department of Oncology Hospital do CoraçãoSao Paulo 04004030Brazil

Clear cell sarcoma(CCS)is a type of malignant tumor that can arise from tendons and *** malignant proliferation of cells with melanocytic lineage normally occurs in young patients,and it is normally identified in ***,different sites including gastrointestinal organs are also *** difficulties in the molecular and histopathology evaluation,the diagnosis is often confused with malignant *** cases are treated with surgical resection,but overall,the prognosis is *** this editorial,we will discuss a very interesting case of CCS identified in the *** will discuss the literature and controversies in the management of this type of ***,we will address molecular strategies to be incorporated in those cases to better understand the primary location of the ***,future perspectives of the field and new strategies of treatment will be described.

关键词： Clear cell sarcoma Soft tissue sarcoma Metastatic cancer Pancreatic cancer Pancreatectomy

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Immunotherapy in biliary tract cancers:Current evidence and future perspectives

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World Journal of Gastrointestinal Oncology 2022年第8期14卷 1446-1455页

作者： pedro luiz serrano uson junior Raphael LC Araujo Center for Personalized Medicine Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil Department of Surgery Universidade Federal de São PauloSão Paulo 04039-002Brazil Department of Oncology Hospital Israelita Albert EinsteinSão Paulo 05652-900Brazil

Bile duct tumors are comprised of tumors that originate from both intrahepatic and extrahepatic bile ducts and gallbladder *** are aggressive tumors and chemotherapy is still the main treatment for advanced-stage disease and most of these cases have a poor overall *** are aimed at treatments with better outcomes and less toxicity which makes immunotherapy an area of significant *** Food and Drug Administration approvals of immune checkpoint inhibitors(ICI)for agnostic tumors based on biomarkers such as microsatellite instability-high and tumor mutation burden-high are important steps in the treatment of patients with advanced bile duct *** limited responses with isolated checkpoint inhibitors in later lines of systemic treatment in advanced disease,drug combination strategies have been demonstrating encouraging results to enhance ICI efficacy.

关键词： Biliary tract cancer Cholangiocarcinoma Anti-programmed cell death protein-1 Anti-programmed death ligand-1 Microsatellite instability high Tumor mutational burden high

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Perspectives on immunotherapy utilization for hepatobiliary cancers in the United States

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Hepatobiliary Surgery and Nutrition 2020年第4期9卷 501-504页

作者： pedro luiz serrano Usón junior Daniel Ahn Mohamad Bassam Sonbol Tanios Bekaii-Saab Mitesh J.Borad Hospital Israelita Albert Einstein São PauloBrazil Mayo Clinic Cancer Center Mayo ClinicPhoenixAZUSA

Strategies involving immunotherapy and targeted therapies are emerging in the last years as valuable options for patients with hepatobiliary cancer(HBC)including hepatocellular carcinoma(HCC),gallbladder cancer(GBC),i... 详细信息

关键词： immunotherapy hepato biliary

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