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World Journal of Cardiovascular Diseases 2018年第12期8卷 545-556页

作者： ülle pechter Ingrid Kalev Mai Ots-Rosenberg Department of Internal Medicine University of Tartu Tartu Estonia Institute of General and Molecular Pathology University of Tartu Tartu Estonia

Background: Chronic kidney disease (CKD) is an irreversible decline in the glomerular filtration due to nephrosclerosis and glomerular loss. Rat remnant kidney model enables to assess the benefits of different treatment possibilities. Aim: The aim of our study was to investigate renal morphology and functioning after 12 weeks of treatment with Equisetum arvense and Viscum album. Methods: Male Wistar rats with 5/6 nephrectomy received herbal drug preparation Equisetum/Viscum in a dosage of 0.007 g/kg/die (herbal group) or losartan (180 mg/l, ARB group) or remained untreated. Systolic blood pressure (SBP) and proteinuria were measured. Renal cortex tissue samples examined for focal-segmental glomerulosclerosis (FSGS) and interstitial fibrosis (IF). mRNA was isolated to estimate CCL2/MCP-1 gene transcription. Results: SBP was significantly lower both in herbal group and ARB group compared with untreated animals (p between ARB group and untreated NPX (p = 0.001). Quantitative RT-PCR analysis revealed statistically significant differences of mRNA transcription for MCP-1 between herbal group and untreated group (p Conclusions: We report about beneficial impact of horsetail Equisetum arvense and mistletoe Viscum album treatment on kidney functioning and morphology.

关键词： Equisetum arvense Experimental Chronic Kidney Disease MCP-1 Relative Transcription Viscum album

CCL2/MCP-1 and NFκBGene Transcription in Remnant Kidneys after Physical Activity and Renoprotection

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World Journal of Cardiovascular Diseases 2014年第5期4卷 244-250页

作者： Kalev Ingrid pechter ülle Kõ lvald Külli Aunapuu Marina Uhlinova Jana Ots-Rosenberg Mai Department of Anatomy Tartu University Tartu Estonia Department of General and Molecular Pathology Tartu University Tartu Estonia Department of Internal Medicine Tartu University Tartu Estonia

Chronic kidney disease (CKD) is a progressive disease and affects approximately 10% of the population. The major late pathologic feature of CKD is interstitial fibrosis in the kidney characterized by extracellular matrix deposition but in early stage, several profibrotic and proinflammatory cytokines as well as growth factors are expressed. The renin-angiotensin and ET systems both play an important role in the pathogenesis of CKD and the blockade of these systems has been shown to suppress proinflammatory cytokines and to arrest the progression of CKD. We have demonstrated earlier also the renoprotective effect of physical activity on the experimental CKD progression (pechter et al., 2003). Aim of the study was to investigate the effects of non-drug treatment, physical activity, to the extent of gene expression in experimental CKD and to compare with endothelin receptor blocker (ERB, sitaxentan) and standard nephroprotective drug, angiotensin receptor blocker (ARB, losartan) treatments. Expression of mRNA was assessed by real-time reverse transcription-polymerase chain reaction. CCL2/MCP-1 and nuclear factor-κB (NFκB) gene expression was measured in whole kidneys. Results revealed that CCL2/MCP-1 gene expression (data presented in poster presentation ASN Renal Week 2010, pechter et al.) was increased in the 5/6 NPX rat kidneys, and the increase was lessened significantly after physical activity and losartan therapy. ERB treatment appeared less effective. Combined ARB and ERB treatment as well as drugs alone or physical therapy prevented the increase in systemic blood pressure, albuminuria and CCL2/MCP-1 as well as NFκB gene expression. We conclude that non-drug and drug treatments both were effective regarding the rate of the progression of experimental CKD measured by physiological and molecular biomarkers of chronic inflammation in kidney tissue.

关键词： Remnant Kidney Gene Transcription Hypertension Physical Activity Renoprotection

ON THE NUMERICAL SOLUTION OF QUASILINEAR WAVE EQUATION WITH STRONG DISSIPATIVE TERM

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Applied Mathematics and Mechanics(English Edition) 2004年第7期25卷 806-811页

作者： Aytekin Gülle Department of Mathematics

The numerical solution for a type of quasilinear wave equation is *** three-level difference scheme for quasi-linear waver equation with strong dissipative term is constructed and the convergence is *** error of the d... 详细信息

关键词： periodical problem quasilinear wave equation difference scheme numerical solution

Usage Scenarios for Byte-Addressable Persistent Memory inHigh-Performance and Data Intensive Computing

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Journal of Computer Science & Technology 2021年第1期36卷 110-122页

作者： Michèle Weiland Bernhard Homölle EPCC The University of EdinburghEdinburgh EH89BTU.K. System Vertrieb Alexander GmbH Paderborn 33106Germany

Byte-addressable persistent memory(B-APM)presents a new opportunity to bridge the performance gap between main memory and *** this paper,we present the usage scenarios for this new technology,based on the capabilities of Intel’s *** outline some of the basic performance characteristics of DCPMM,and explain how it can be configured and used to address the needs of memory and I/O intensive applications in the HPC(high-performance computing)and data intensive *** decision trees are presented to advise on the configuration options for BAPM;their use is illustrated with two *** show that the flexibility of the technology has the potential to be truly disruptive,not only because of the performance improvements it can deliver,but also because it allows systems to cater for wider range of applications on homogeneous hardware.

关键词： byte-addressable data intensive memory intensive persistent

Priorities for Social and Humanities Projects Based on Text Analysis

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Journal of Data and Information Science 2020年第4期5卷 116-125页

作者： Ülle Must Archimedes Foundation Väike-Turu Street 8Tartu 51004Estonia

Purpose:Changes in the world show that the role,importance,and coherence of SSH(social sciences and the humanities)will increase significantly in the coming *** paper aims to monitor and analyze the evolution(or overlapping)of the SSH thematic pattern through three funding instruments since ***/methodology/approach:The goal of the paper is to check to what extent the EU Framework Program(FP)affects/does not affect research on national level,and to highlight hot topics from a given period with the help of text *** project titles and abstracts derived from the EU FP,Slovenian,and Estonian RIS were *** final analysis and comparisons between different datasets were made based on the 200 most frequent *** removing punctuation marks,numeric values,articles,prepositions,conjunctions,and auxiliary verbs,4,854 unique words in ETIS,4,421 unique words in the Slovenian Research Information System(SICRIS),and 3,950 unique words in FP were ***:Across all funding instruments,about a quarter of the top words constitute half of the word *** text analysis results show that in the majority of cases words do not overlap between FP and nationally funded *** some cases,it may be due to using different *** is more overlapping between words in the case of Slovenia(SL)and Estonia(EE)and less in the case of Estonia and EU Framework Programmes(FP).At the same time,overlapping words indicate a wider reach(culture,education,social,history,human,innovation,etc.).In nationally funded projects(bottom-up),it was relatively difficult to observe the change in thematic trends over *** specific results emerged from the comparison of the different programs throughout FP(top-down).Research limitations:Only projects with English titles and abstracts were *** implications:The specifics of SSH have to take into account—the one-to-one meaning of terms/words is not as important as,for example,in the e

关键词： Text analysis SSH Estonian Research Information System(ETIS) Slovenian Research Information System(SICRIS) Community Research and Development Information Service(CORDIS)

Post-keratoplasty astigmatism management by relaxing incisions:a systematic review

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Eye and Vision 2017年第1期4卷 174-180页

作者： Gaëlle Ho Wang Yin Louis Hoffart Ophthalmology Department Aix-Marseille University-APHMHôpital de la Timone264 rue Saint Pierre13385 Marseille Cedex 5France Institut Fresnel UMR 7249 Aix Marseille UniversitéCNRSCentrale MarseilleDomaine universitaire de Saint-Jérôme Avenue Escadrille Normandie Niemen13397 Marseille cedex 20France CERIMED Aix-Marseille University27 Boulevard Jean-Moulin13385 Marseille cedex 05France Ramsay Générale de Santé Clinique Monticelli-VelodromeMarseilleFrance

Postoperative visual acuity can be limited by post-keratoplasty astigmatism,even with a clear corneal *** management can be performed by selective suture removal,adjustment of sutures,optical correction,photorefractive procedures,wedge resection,intra-ocular lens implantation,intracorneal ring segments,relaxing incisions with or without compression sutures and repeated *** incisions can be made in the graft,graft-host interface or host *** the unpredictability of the method because the flat and steep meridians are usually not orthogonal after penetrating keratoplasty,with asymmetric power distribution,all the studies showed an overall reduction of refractive,keratometric or topographic astigmatism,ranging from 30%to 72%with manual or femtosecond-assisted *** patients with astigmatism higher than 6 diopters had residual cylinder less than or equal to 3 diopters,which can be treated by laser excimer ablation or secondary intraocular lens implantation.

关键词： Penetrating keratoplasty Astigmatic keratotomy Relaxing incisions Femtosecond laser

Health Democracy and Storytelling:A Synthesis of Knowledge

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Psycho-Oncologie 2024年第1期18卷 33-41页

作者： Rossi Silvia Sandrine de Montgolfier Joëlle Kivits Aix Marseille Univ INSERMIRDSESSTIMChaire démocratie en santéet engagement des personnes concernées par le cancerMarseille13009France University of Lorraine UR4360 APEMACVandoeuvre-lès-Nancy54500France UniversitéParis-Est Créteil Val de Marne UniversitéParis 12Créteil94000France UniversitéParis Cité ECEVEUMR 1123InsermParis75010France

Aims:Health democracy requires tools and methodologies to involve non-scientific actors in the development and implementation of health *** could be one of the tools to make health democracy *** aim is to describe how storytelling is used in relation to health democracy,the aims of its use,the methodology adopted and the results ***:We conducted a narrative review of the *** search equation was composed by the keyword“narration”and its variations“récit de vie”,“histoire de vie”and“medécine narrative”and by the keyword“démocratie en santé”/“démocratie sanitaire”.Results:We obtained 135 results and included six articles,published between 2015 and *** interest of storytelling in a health democracy approach concerns six main themes:a)the plurality of experiences;b)empowerment;c)the recognition of different types of knowledge;d)the involvement of all care actors in care;storytelling as a lever for change;e)in the care pathway;f)in health ***:The limited number of articles included in this literature review raises questions about the diffusion of the concept of health democracy associated with that of *** can contribute to the dissemination and effectiveness of health democracy:it is a complementary tool to quantitative tools for understanding the experiences of users of the health care system,and its use is particularly relevant to chronic diseases such as cancer.

关键词： Health democracy storytelling narratives narrative medicine

Comparison of Ashes Produced in a Biomass Moving Grate Boiler by Wood Chips and Sewage Sludge

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Fluid Dynamics & Materials Processing 2022年第5期18卷 1419-1425页

作者： Baraket Nada Brandelet Benoit TrouvéGwenaëlle Rogaume Yann Universitéde Lorraine-LERMAB-ERBE Epinal88000France LGRE Institut de Recherche Jean-Baptiste Donnet Universitéde Haute-AlsaceMulhouse6809France ADEME Angers49004France

One option to fight global warming is to convert our use of fossil energy into renewables such as biomass ***,the forest preservation and the quality of the ambient air are also two major ***,the use of biomass waste without any supplementary emissions could represent a part of the *** this study,two fuels were considered for a 200 kW moving grate boiler.A multicyclone and a bag filter were fitted on the *** first fuel consisted of classical wood chips whereas the second was a mixture of wood chips with sewage *** second fuel presented a high ashes mass ratio compared to wood *** aim was to verify the possibility to burn this kind of fuel without any modification of the *** first relevant result is that the conventional pollutants,i.e.,CO and NOx,remained under the emissions limits even with the sewage sludge *** Total Suspended Particles emissions at the exhaust were always under 5.4 mg·Nm-3 dry based corrected at 6%of O_(2),which is low with respect to the standard *** majority of the ashes remained on the combustion ***,with both fuels,about 5%of ashes mass remained in the heat ***,the heat exchanger was more clogged with the second fuel,which produced five time more *** may lead to a yield ***,sewage sludge can be used in a wood boiler without any issue if an automatic exchanger sweep is fitted on the installation.

关键词： Combustion energy biomass ashes TSP

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Othello

Othello

Pure Hydrocarbons:An Efficient Molecular Design Strategy for the Next Generation of Host Materials for Phosphorescent Organic Light-Emitting Diodes

作者： William Shakespeare edited by Edward pechter (Concordia University and University of Victoria)

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Accounts of Materials Research 2022年第3期3卷 379-390页

作者： Cyril Poriel Joëlle Rault-Berthelot 不详 UniversitéRennes CNRSISCR-6226F-35000 RennesFrance

CONSPECTUS:Fantastic progresses have been made since the discovery of phosphorescent organic light-emitting diodes(PhOLEDs)in 1998(Nature 1998,395,151).In the emissive layer of a PhOLED,a heavy-metal complex(emitter)is dispersed as a guest in an organic semiconductor(host)in order to harvest both singlet and triplet *** host/guest technique is essential to reach highperformance ***,designing high-efficiency host materials for red,green,and blue phosphors has been the main driving force of the ***,the most efficient PhOLEDs report very high external quantum efficiency(EQE)above 27%for the three *** molecular design of these high-efficiency host materials is based on small functional units,which have a crucial role in the device *** functional units are constructed on the assembly of electron-rich and/or electron-poor molecular fragments(such as carbazole,phenylamine,phosphine oxide,oxadiazole,pyridine,sulfone,etc.),which allows to finely tune the molecular orbitals energy levels(HOMO and LUMO)and the mobility of the charge carriers(hole and electrons).However,these molecular fragments incorporate heteroatoms,which in turn increase the molecular design complexity and production cost of the target materials and also create potential instability in the ***,the fragile C−N,C−P,and C−S bonds of such heteroatom-based hosts are involved,in part,in the OLED *** the instability of OLEDs is one of the most important problem to address at the current stage of development,developing new generations of host materials,without heteroatoms,has appeared as an important challenge in the *** recent years,this new generation of host materials,called Pure HydroCarbons(PHC),only incorporating carbon and hydrogen atoms,has drawn the attention of the scientific *** host materials only contain benzene rings,one of the most robust and inert building unit,which are assemble with suitable linkages to a

关键词： Strategy Host Molecular