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direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the China Jinping underground laboratory(CJPL)

Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji Chen Hao Zhang Li‑Yong Zhang Jian‑Jun He Richard James deBoer Michael Wiescher Alexander Heger david Kahl Jun Su daniel Odell Xin‑Yue Li Jian‑Guo Wang Long Zhang Fu‑Qiang Cao Zhi‑Cheng Zhang Xin‑Zhi Jiang Luo‑Huan Wang Zi‑Ming Li Lu‑Yang Song Liang‑Ting Sun Qi Wu Jia‑Qing Li Bao‑Qun Cui Li‑Hua Chen Rui‑Gang Ma er‑Tao Li Gang Lian Yao‑de Sheng Zhi‑Hong Li Bing Guo Wei‑Ping Liu Key Laboratory of Beam Technology of the Ministry of education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China China Institute of Atomic energy Beijing 102413China College of Physics and Optoelectronic engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China College of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOe) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the China Jinping underground *** measurement was performed down to the low-energy limit of e_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRe *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate China Jinping underground laboratory(CJPL) JUNA

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Pharmacological insights into autophagy modulation in autoimmune diseases

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3364-3378页

作者： Ming-Yue Wu er-Jin Wang du Feng Min Li Richard d.Ye Jia-Hong Lu State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao 9999078China Key Laboratory of Protein Modification and degradation State Key Laboratory of Respiratory DiseaseCollege of Basic Medical ScienceGuangzhou Medical UniversityGuangzhou 510000China School of Pharmaceutical Sciences National and Local United Engineering Lab of Druggability and New Drugs EvaluationGuangdong Provincial Key Laboratory of New Drug Design and EvaluationSun Yat-sen UniversityGuangzhou 510000China Kobilka Institute of Innovative drug discovery School of Life and Health Sciencesthe Chinese University of Hong KongShenzhen 518000China

As a cellular bulk degradation and survival mechanism,autophagy is implicated in diverse biological ***-wide association studies have revealed the link between autophagy gene polymorphisms and susceptibility of autoimmune diseases including systemic lupus erythematosus(SLe)and inflammatory bowel disease(IBd),indicating that autophagy dysregulation may be involved in the development of autoimmune diseases.A series of autophagy modulators have displayed protective effects on autoimmune disease models,highlighting the emerging role of autophagy modulators in treating autoimmune *** review explores the roles of autophagy in the autoimmune diseases,with emphasis on four major autoimmune diseases[SLe,rheumatoid arthritis(RA),IBd,and experimental autoimmune encephalomyelitis(eAe)].More importantly,the therapeutic potentials of small molecular autophagy modulators(including autophagy inducers and inhibitors)on autoimmune diseases are comprehensively analyzed.

关键词： Autophagy Autoimmune disease Systemic lupus erythematosus Inflammatory bowel disease Rheumatoid arthritis experimental autoimmune encephalomyelitis Autophagy inducer Autophagy inhibitor

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Increased P wave duration in patients with depression or anxiety disorder

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Neural Regeneration Research 2010年第7期5卷 545-549页

作者： emel Koer Aytekin Alelik Abdulkadir Koer elif nder Ahmet Ataoglu department of Psychiatry Medical Faculty Düzce University department of Internal Medicine Medical Faculty Düzce University department of Neurology Medical Faculty Düzce University

BACKGROUNd： Activation of the sympathetic nervous system plays an important role in regulating cardiovascular actions. P wave parameters can provide general information on central cardiovascular autonomic regulatory responses, which are altered in patients with anxiety disorders and depression. In particular, there are no reports addressing changes in P wave duration and dispersion. OBJeCTIVe： To compare the differences in P wave duration and P wave dispersion between patients with anxiety disorders and depression, because patients with anxiety disorders and depression develop abnormal electrocardiograms. deSIGN, TIMe ANd SeTTING： A non-randomized concurrent controlled study was performed. Patients with depression and general anxiety disorders were admitted at the psychiatry outpatient clinics of the Medical Faculty of duezce University of Turkey between May 2005 and October 2006. PARTICIPANTS： A total of 71 consecutive patients with depression and anxiety disorders, as well as 50 physically and mentally healthy age- and gender-matched controls were selected. MeTHOdS： electrocardiogram records were obtained at the time of admission to the outpatient clinics. MAIN OUTCOMe MeASUReS： P wave duration and P wave dispersion were measured. ReSULTS： Both the maximum （Prnax） and minimum （Pmin） P wave duration were greater in patients with psychiatric disorders than in healthy controls. Pmax was significantly greater in patients with depression or anxiety disorders （Bonferroni test, P 〈 0.017）. The P wave dispersion was similar between patients and controls （P 〉 0.017）. P waves were similar between panic patients and other anxiety patients. Beck depression results were positively correlated with Prawn and Prnax （r= 0.374, 0.302, P = 0.013, 0.049, respectively）, and not associated with P wave dispersion （P 〉 0.05）. CONCLUSION： Psychiatric disorders are associated with increases in Prnax, but not with P wave dispersion. The P wave changes were associated with the degree of depr

关键词： P wave depression anxiety panic disorder scales sympathetic modulation electrocardiogram P wave duration P wave dispersion

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Nonseparating Independent Sets and Maximum Genus of Graphs

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Acta Mathematicae Applicatae Sinica 2022年第3期38卷 719-728页

作者： Chao YANG Han ReN er-ling WeI Center of Intelligent Computing and Applied Statistics School of MathematicsPhysics and StatisticsShanghai University of Engineering ScienceShanghai 201620China School of Mathematical Sciences East China Normal UniversityShanghai 200241China Shanghai Key Laboratory of PMMP Shanghai 200241China School of Mathematics Renmin University of ChinaBeijing 100872China

A subset I of vertices of an undirected connected graph G is a nonseparating independent set(NSIS)if no two vertices of I are adjacent and G􀀀I is *** Z(G)denote the cardinality of a maximum NSIS of G.A nonseparating independent set containing Z(G)vertices is called the maximum nonseparating independent *** this paper,we firstly give an upper bound for Z(G)of regular graphs and determine Z(G)for some types of circular ***,we show a relationship between Z(G)and the maximum genus M(G)of a general ***,an important formula is provided to compute Z(G),i.e.,Z(G)=Σx∈I dI(x)+2(M(G-I)-γM(G))+(ξ(G-I)-ξ(G));where I is the maximum nonseparating independent set and ξ(G)is the Betti deficiency(Xuong,1979)of G.

关键词： nonseparating independent sets maximum genus graph embedding decycling set

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基于肝脏类器官系统探讨布乐韦肽抑制丁型肝炎病毒复制的体外研究

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中华传染病杂志 2024年第3期42卷 160-166页

作者：沈乐而陈金梅郭庆鑫田璐瑛陈小华上海交通大学医学院附属第六人民医院感染病科上海200030

目的构建丁型肝炎病毒(HdV)感染的肝脏类器官系统,并探讨钠离子-牛磺胆酸共转运蛋白(NTCP)受体抑制剂布乐韦肽对HdV复制的抑制作用。方法将由诱导多能干细胞(iPSC)分化的肝细胞样细胞(HLC)接种于倒置胶体晶体聚乙二醇支架(ICC),构建肝... 详细信息

目的构建丁型肝炎病毒(HdV)感染的肝脏类器官系统,并探讨钠离子-牛磺胆酸共转运蛋白(NTCP)受体抑制剂布乐韦肽对HdV复制的抑制作用。方法将由诱导多能干细胞(iPSC)分化的肝细胞样细胞(HLC)接种于倒置胶体晶体聚乙二醇支架(ICC),构建肝脏类器官系统。质粒转染人肝癌细胞(HuH7)后,收获细胞上清中的HdV颗粒,同时提取HepG2.2.15细胞上清液中的乙型肝炎病毒(HBV)颗粒,将HBV和HdV颗粒共同感染肝脏类器官,构建HdV感染的肝脏类器官,同时以未感染HdV的肝脏类器官作为阴性对照组。采用免疫荧光法在激光共聚焦显微镜下观察肝脏类器官单元的结构及丁型肝炎抗原(HdAg)和乙型肝炎表面抗原(HBsAg)的表达。蛋白质印迹法检测肝脏类器官中NTCP和HdAg的蛋白质水平。布乐韦肽Pre组为感染HdV前在肝脏类器官中加入布乐韦肽进行预处理,布乐韦肽Post组为感染24h后加入布乐韦肽,IFN-α组为感染24h后加入α干扰素,并设未经药物处理的空白对照组,比较4组的HdV复制情况。采用实时荧光定量聚合酶链反应(RT-qPCR)检测iPSC分化过程中Nanog同源框(NANOG)、性别决定区Y框(SOX)2、SOX17、叉头框蛋白A2(FOXA2)、肝细胞核因子4α(HNF-4α)、白蛋白、甲胎蛋白、NTCP的mRNA相对表达量,以及药物干预后4组HdV mRNA表达量。统计学分析采用两独立样本t检验。结果iPSC分化为HLC的21d内,NANOG的mRNA表达量逐渐下降,SOX17、FOXA2的表达量先升后降,HNF-4α、白蛋白、甲胎蛋白、NTCP的表达量逐渐升高。iPSC中NTCP的蛋白质水平为0.118±0.003,低于HLC的1.315±0.073,差异有统计学意义(t=11.92,PdV感染后肝脏类器官中HdAg的蛋白质水平高于未感染HdV的阴性对照组(1.284±0.128比0.157±0.040),差异有统计学意义(t=23.27,PdAg与HBsAg高表达。用药干预后第3天,分别与空白对照组(1.000±0.077)比较,IFN-α组(0.453±0.028)和布乐韦肽Pre组(0.136±0.012)的HdVmRNA相对表达量均下降,差异均有统计学意义(t=19.95、33.15,均PdVmRNA相对表达量差异无统计学意义(t=0.94,P>0.05)。结论iPSC衍生的HLC与ICC构建的肝脏类器官能模拟人体肝脏功能,并成功感染HdV颗粒。经布乐韦肽早期阻断能有效降低HdV感染肝脏类器官系统中病毒的复制水平。

关键词：丁型肝炎布乐韦肽诱导多能干细胞肝脏类器官丁型肝炎病毒感染

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Analysis of Microstructure and Mechanical Properties of Ultrafine Grained Low Carbon Steel

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Journal of Wuhan University of Technology(Materials Science) 2016年第5期31卷 1099-1104页

作者：刘和平 SUN Feng'er SUN Hu'er LIU Bin WANG Yi JIN Xuejun School of Materials Science and engineering North University of ChinaTaiyuan 030051China School of Materials Science and engineering Taiyuan University of TechnologyTaiyuan 030024China School of Materials Science and engineering Shanghai Jiao Tong UniversityShanghai 200240China

A novel design scheme of hot stamping, quenching and partitioning process was conducted in a quenchable boron steel to obtain the nanometric duplex microstructure comprising ultrafine retained austenite and martensite. It is shown that the materials possess excellent mechanical properties and the ductility can be further improved without compromising the strength. The newly treated steel shows excellent mechanical properties and the total elongation of the steel increases from 6.6% to 14.8% compared with that of hot stamped and quenched steel. Therefore, this kind of steel has become another group of advanced high-strength steels. The microstructure which is mainly responsible for such excellent mechanical properties was investigated.

关键词： hot stamping quenching and partitioning(Q&P) retained austenite martensite grain refinement

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澎溪河流域面源污染预报预警平台

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中国农村水利水电 2024年第5期 98-104页

作者：杨雨寒蒋安娜彭虹陈刚徐剑乔武汉大学水利水电学院湖北武汉430072 武汉大学资源与环境科学学院湖北武汉430079 中铁第四勘察设计院集团有限公司湖北武汉430072

基于流域“空-地-水”一体化模型体系与多层次协同架构,提出了澎溪河流域面源污染预报预警平台技术体系,建立了澎溪河流域面源污染预报预警平台,平台通过自动收集并处理气象数据等,在控制中心驱动下调用气象模型、陆地模型、水动力模型... 详细信息

基于流域“空-地-水”一体化模型体系与多层次协同架构,提出了澎溪河流域面源污染预报预警平台技术体系,建立了澎溪河流域面源污染预报预警平台,平台通过自动收集并处理气象数据等,在控制中心驱动下调用气象模型、陆地模型、水动力模型和水质模型,实现未来3~15 d陆面产流以及TN、TP、NH3-N等污染物通量的逐时预报,可自动对突发污染风险进行预报预警,为流域智慧化管理和面源污染综合治理提供技术支撑。

关键词：澎溪河流域面源污染通量风险预报预警平台

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乌司他丁对非体外循环冠状动脉旁路移植术患者术后肺部并发症的影响

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中华麻醉学杂志 2024年第3期44卷 260-266页

作者：张召耳建旭翟文倩任珉郭志刚韩建阁天津市胸科医院麻醉科天津300222 天津市心血管急危重症重点实验室天津300222 天津市心血管病研究所天津300222 天津市胸科医院心血管外科天津300222

目的评价乌司他丁对非体外循环冠状动脉旁路移植术(OPCABG)患者术后肺部并发症(PPCs)的影响。方法回顾性收集2021年9月至2023年8月择期行OPCABG患者的病历资料。根据患者术中是否使用乌司他丁分为乌司他丁组与对照组。通过倾向性评分匹... 详细信息

目的评价乌司他丁对非体外循环冠状动脉旁路移植术(OPCABG)患者术后肺部并发症(PPCs)的影响。方法回顾性收集2021年9月至2023年8月择期行OPCABG患者的病历资料。根据患者术中是否使用乌司他丁分为乌司他丁组与对照组。通过倾向性评分匹配及扩展的Cox比例风险回归模型调整混杂因素。主要结局指标为术后30 d内PPCs发生情况,次要结局指标为ICU停留时间、住院时间及其他不良事件发生情况。结果最终纳入1532例患者,585例(38.2%)患者发生PPCs。与对照组比较,乌司他丁组PPCs发生率降低(匹配前:42.7%vs.35.2%,P=0.004;匹配后:42.2%vs.35.6%,P=0.033),急性肾损伤发生率降低,ICU停留时间、住院时间和其他不良事件发生率差异无统计学意义(P>0.05)。在混杂因素调整前及调整后的Cox比例风险回归模型中,使用乌司他丁后PPCs发生风险降低(调整前HR=0.81,95%CI 0.67~0.99,P=0.004;调整后HR=0.79,95%CI 0.65~0.96,P=0.022)。年龄大于65岁、PPCs高风险患者使用乌司他丁后PPCs发生风险降低(HR=0.667,95%CI 0.542~0.821,P<0.001;HR=0.641,95%CI 0.516~0.812,P<0.001)。结论OPCABG患者术中使用乌司他丁有助于降低PPCs的发生风险。

关键词：手术后并发症胰蛋白酶抑制剂冠状动脉旁路移植术,非体外循环

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Zero phase error control based on neural compensation for flight simulator servo system

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Journal of Systems engineering and electronics 2006年第4期17卷 793-797页

作者： Liu Jinkun He peng er Lianjie School of Automation Science & electrical engineering Beijing Univ. of Aeronautics and AstronauticsBeijing 100083 P.R.China Computing Lad Oxford Univ.Parks Road OxfordOX13QD U.K.

Using the future desired input value, zero phase error controller enables the overall system＇s frequency response exhibit zero phase shift for all frequencies and a small gain error at low frequency range, and based on this, a new algorithm is presented to design the feedforward controller. However, zero phase error controller is only suitable for certain linear system. To reduce the tracking error and improve robustness, the design of the proposed feedforward controller uses a neural compensation based on diagonal recurrent neural network. Simulation and real-time control results for flight simulator servo system show the effectiveness of the proposed approach.

关键词： zero phase error servo system neural network robust control flight simulator.

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自制外敷痛风方对急性痛风发作的疗效评价

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中国医药科学 2024年第19期14卷 94-97,147页

作者：吴昊姚怡梦李儿杭州市西溪医院内分泌科浙江杭州310009

目的评价自制外敷痛风方辅助治疗痛风急性发作的效果。方法选取2022年6—12月因急性痛风性关节炎(AGA)发作在杭州市西溪医院住院患者80例,按照随机数表法分为对照组(n=40)和观察组(n=40)。对照组患者使用常规西药治疗方案(秋水仙碱、碳... 详细信息

目的评价自制外敷痛风方辅助治疗痛风急性发作的效果。方法选取2022年6—12月因急性痛风性关节炎(AGA)发作在杭州市西溪医院住院患者80例,按照随机数表法分为对照组(n=40)和观察组(n=40)。对照组患者使用常规西药治疗方案(秋水仙碱、碳酸氢钠和塞来昔布),治疗组在对照组基础上加自制外敷痛风方进行治疗。比较两组的各项关节症状体征积分、整体疗效评价、患者满意度、达到有效标准所需时间以及血沉(eSR)、C反应蛋白(CRP)、血尿酸(UA)水平等。结果治疗7 d后,观察组各项关节症状体征评分和eSR、CRP水平均低于对照组,差异有统计学意义(P<0.05)。观察组的总有效率高于对照组,差异有统计学意义(P<0.05),并且观察组达到有效标准所需时间短于对照组,差异有统计学意义(P<0.05)。观察组的治疗满意度明显高于对照组,差异有统计学意义(P<0.05)。结论自制外敷痛风方辅助治疗痛风急性发作具有明显快速减轻临床症状,减轻炎症反应,副作用小等特点,值得临床推广。

关键词：外用痛风方急性痛风性关节炎急性发作疗效评定

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