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Multispectral sensing of biological liquids with hollow-core microstructured optical fibres

Light(Science & Applications) 2020年第1期9卷 346-357页

作者： Timur Ermatov Roman E.Noskov Andrey AMachnev Ivan gnusov Vsevolod Atkin Ekaterina N.Lazareva Sergei V.german Sergey S.Kosolobov Timofei S.Zatsepin Olga V.Sergeeva Julia S.Skibina Pavel ginzburg Valery V.Tuchin pavlos g.lagoudakis Dmitry A.gorin Skolkovo Institute of Science and Technology 3 Nobelya str.Moscow 121205Russia Department of Electrical Engineering Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Light-Matter Interaction Centre Tel Aviv UniversityRamat AvivTel Aviv 69978Israel Saratov State University 83 Astrakhanskaya str.Saratov 410012Russia Tomsk State University 36 Lenin’s av.Tomsk 634050Russia M.V.Lomonosov Moscow State University Leninskie Gory1-3Moscow 119992Russia SPE LLC Nanostructured glass Technology 10150 Let OktjabrjaSaratov 410033Russia Center for Photonics and 2D Materials Moscow Institute of Physics and TechnologyDolgoprudny 141700Russia Institute of Precision Mechanics and Control of the Russian Academy of Sciences 24 Rabochaya str.Saratov 410028Russia

The state of the art in optical biosensing is focused on reaching high sensitivity at a single wavelength by using any type of optical *** common strategy,however,disregards the promising possibility of simultaneous measurements of a bioanalyte’s refractive index over a broadband spectral ***,we address this issue by introducing the approach of in-fibre multispectral optical sensing(IMOS).The operating principle relies on detecting changes in the transmission of a hollow-core microstructured optical fibre when a bioanalyte is streamed through it via liquid *** offers a unique opportunity to measure the refractive index at 42 wavelengths,with a sensitivity up to ~3000 nm per refractive index unit(RIU)and a figure of merit reaching 99 RIU^(−1) in the visible and near-infra-red spectral *** apply this technique to determine the concentration and refractive index dispersion for bovine serum albumin and show that the accuracy meets clinical needs.

关键词： refractive spectral microstructure

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A hybrid organic-inorganic polariton LED

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Light(Science & Applications) 2019年第1期8卷 475-485页

作者： Rahul Jayaprakash Kyriacos georgiou Harriet Coulthard Alexis Askitopoulos Sai K.Rajendran David M.Coles Andrew J.Musser Jenny Clark Ifor D.W.Samuel graham A.Turnbull pavlos g.lagoudakis David g.Lidzey Department of Physics and Astronomy The University of SheffieldHicks BuildingHounsfield RoadSheffield S37RHUK Department of Physics and Astronomy University of SouthamptonSouthampton SO171BJUK Skolkovo Institute of Science and Technology MoskvaRussia Organic Semiconductor Centre SUPASchool of Physics and AstronomyUniversity of St AndrewsSt.AndrewsFife KY169SSUK Baker Laboratory Cornell University259 East AvenueIthacaNY 14850USA

Polaritons are quasi-particles composed of a superposition of excitons and photons that can be created within a strongly coupled optical ***,we describe a structure in which a strongly coupled microcavity containing an organic semiconductor is coupled to a second microcavity containing a series of weakly coupled inorganic quantum *** show that optical hybridisation occurs between the optical modes of the two cavities,creating a delocalised polaritonic *** electrically injecting electron–hole pairs into the inorganic quantum-well system,we are able to transfer energy between the cavities and populate organic-exciton *** approach represents a new strategy to create highly efficient devices for emerging‘polaritonic’technologies.

关键词： state. inorganic polar

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Tunable optical spin Hall effect in a liquid crystal microcavity

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Light(Science & Applications) 2018年第1期7卷 331-336页

作者： Katarzyna Lekenta Mateusz Król Rafał Mirek KarolinaŁempicka Daniel Stephan Rafał Mazur Przemysław Morawiak Przemysław Kula Wiktor Piecek pavlos g.lagoudakis Barbara Piętka Jacek Szczytko Institute of Experimental Physics Faculty of PhysicsUniversity of WarsawWarsawPoland Institute of Applied Physics Military University of TechnologyWarsawPoland Institute of Chemistry Military University of TechnologyWarsawPoland Department of Physics and Astronomy University of SouthamptonSouthampton SO171BJUK Skolkovo Institute of Science and Technology Novaya St. 100Skolkovo 143025Russian Federation

The spin Hall effect,a key enabler in the field of spintronics,underlies the capability to control spin currents over macroscopic *** effect was initially predicted by D'Yakonov and Perel1 and has been recently brought to the foreground by its realization in paramagnetic metals by Hirsch2 and in semiconductors3 by Sih et *** the rapid dephasing of electrons poses severe limitations to the manipulation of macroscopic spin currents,the concept of replacing fermionic charges with neutral bosons such as photons in stratified media has brought some tangible advances in terms of comparatively lossless propagation and ease of detection4–*** advances have led to several manifestations of the spin Hall effect with light,ranging from semiconductor microcavities8,9 to *** date the observations have been limited to built-in effective magnetic fields that underpin the formation of spatial spin *** we demonstrate external control of spin currents by modulating the splitting between transverse electric and magnetic fields in liquid crystals integrated in microcavities.

关键词： effect macroscopic liquid

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Organic photovoltaics for simultaneous energy harvesting and high-speed MIMO optical wireless communications

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Light(Science & Applications) 2021年第3期10卷 379-389页

作者： Iman Tavakkolnia Lethy K.Jagadamma Rui Bian pavlos P.Manousiadis Stefan Videv graham A.Turnbull Ifor D.W.Samuel Harald Haas LiFi Research and Development Centre Department of Elearonic&Electrical EngineeringThe University of StrathclydeTechnology&Innovation Centre99 George StreetGlasgow G11RDUK Organic Semiconductor Centre SUPASchool of Physics and AstronomyUniversity of St AndrewsSt Andrews KY169SSUK pureLiFi Rosebery House9 Haymarket TerraceEdinburgh EH125EZUK

We show that organic photovoltaics(OPVs)are suitable for high-speed optical wireless data receivers that can also harvest *** addition,these OPVs are of particular interest for indoor applications,as their bandgap is larger than that of silicon,leading to better matching to the spectrum of artificial *** selecting a suitable combination of a narrow bandgap donor polymer and a nonfullerene acceptor,stable OPVs are fabricated with a power conversion efficiency of 8.8%under 1 Sun and 14%under indoor lighting *** an optical wireless communication experiment,a data rate of 363 Mb/s and a simultaneous harvested power of 10.9 mW are achieved in a 4-by-4 multipleinput multiple-output(MIMO)setup that consists of four laser diodes,each transmitting 56 mW optical power and four OPV cells on a single panel as receivers at a distance of 40 *** result is the highest reported data rate using OPVs as data receivers and energy *** finding may be relevant to future mobile communication applications because it enables enhanced wireless data communication performance while prolonging the battery life in a mobile device.

关键词： MIMO simultaneous lighting

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Recurrent Transient Osteoporosis during Pregnancy and Treatment with Oral Bisphosphonates: A Case Report

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Open Journal of Obstetrics and gynecology 2017年第10期7卷 1044-1051页

作者： pavlos Sachsanidis Mario Valerio Tartagni Urs graf Clinic of gynecology and Obstetrics Spital Linth Uznach Switzerland

Transient osteoporosis of the hip (TOH), also known as “Bone marrow edema Syndrome”, is a rare disorder mainly affecting pregnant women in their third trimester, as well as middle-aged, overweight men. A 30-year-old Caucasian female g2P2, with history of transient osteoporosis of both ankles and C-Section during the last pregnancy in 2011, presented progressively severe bilateral hip pain with onset already in the 12th gestational week. Imaging of the pelvis and bilateral hips with MRI obtained 6 days after the C-Section demonstrated bilateral bone-marrow edema of the hips. The patient was treated with a monthly single dose of 150 mg ibandronate acid per os, for 3 months and physiotherapy. Repeated MRI performed 5 months postpartum revealed a complete remission of the disease. In contrast to the first onset of transient osteoporosis during the first pregnancy, which was only treated conservatively without bisphosphonates, the remission of the disease and patient’s recovery with oral ibandronate therapy showed to be 4 months shorter. This case is unique in literature for both describing the onset of this rare disease twice in the same patient as well as its oral therapeutic approach.

关键词： Transient Osteoporosis Pregnancy Oral Treatment Bisphosphonates

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The Recurrence Rate in Meningiomas: Analysis of Tumor Location, Histological grading, and Extent of Resection

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Open Journal of Modern Neurosurgery 2012年第1期2卷 6-10页

作者： Konstantinos Violaris Vasileios Katsarides pavlos Sakellariou 不详

Background: Purpose of this study was to evaluate various parameters of meningioma after surgical treatment and analyze predictive factors for recurrence. Methods: During 1992-2007, 353 patients were operated for intracranial meningioma in our department. They were followed since, and related data were combined with parameters such as tumor histology (WHO system), tumor location and the extent of tumor resection (Simpson’s scale). The results were analyzed with respect to tumor reappearance. This study was approved by the ethics committee of g. Papanikolaou Hospital. Results: The mean follow up period was 6.45 years. The overall percentage of recurrence was 21.52%. grade 1 meningiomas (benign) recurred at a rate of 19.1%, grade 2 tumors (atypical) showed 41.7% rate of recurrence and grade 3 meningiomas (malignant) recurred at a rate of 75%. Tumor histopathology was not significant to recurrence (p > 0.001). The location of meningiomas was not found to be significant to recurrence (p > 0.001). Complete tumor resection was accomplished in 269 patients (76.2%). Incomplete resection (Simpson grades 2-5) took place in 84 cases (23.8%). The recurrence rate after complete resection was 13.8%, while the rate for cases with incomplete resection was 46.7%. The extent of removal was significantly associated with recurrence (p gioma surgery. The rate of recurrence was related primarily to the extent of surgical removal. Neither tumor site, nor tumor histology were predictive factors for recurrence (ma-lignant meningiomas excluded).

关键词： Intracranial Meningioma Histology Resection Extent Recurrence

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COVID-19-Associated Pulmonary Aspergillosis (CAPA)

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Journal of Intensive Medicine 2021年第2期1卷 71-80页

作者： george Dimopoulos Maria-Panagiota Almyroudi pavlos Myrianthefs Jordi Rello Department of Critical Care University Hospital ATTIKONNational and Kapodistrian University of AthensAthens 12462Greece Department of Emergency Medicine University Hospital ATTIKONNational and Kapodistrian University of AthensAthens 12462Greece Department of Critical Care Agioi Anargyroi HospitalNational and Kapodistrian University of AthensAthens 14564Greece Universitat Internacional de Catalunya Barcelona 08035Spain

Invasive Pulmonary Aspergillosis(IPA)has been recognized as a possible secondary infection complicating Coronavirus disease 2019(COVID-19)and increasing *** aim of this review was to report and summarize the available data in the literature concerning the incidence,pathophysiology,diagnosis,and treatment of COVID-19-Associated Pulmonary Aspergillosis(CAPA).Currently,the incidence of CAPA is unclear due to different definitions and diagnostic criteria used among the *** was estimated that approximately 8.6%(206/2383)of mechanically ventilated patients were diagnosed with either proven,probable,or putative *** host factors of invasive aspergillosis are rarely recognized in patients with CAPA,who are mainly immuno-competent presenting with comorbidities,while the role of steroids warrants further *** epithelial injury and diffuse pulmonary micro thrombi in combination with immune dysregulation,hyper inflammatory response,and immunosuppressive treatment may be *** between two forms of CAPA(e.g.,tracheobronchial and parenchymal)is required,whereas radiological signs of aspergillosis are not typically evident in patients with severe COVID-19 *** previous studies,the European Organization for Research and Treatment of Cancer/Mycoses Study group(EORTC/MSg)criteria,a clinical algorithm to diagnose Invasive Pul-monary Aspergillosis in intensive care unit patients(AspICU algorithm),and influenza-associated pulmonary aspergillosis(IAPA)criteria were used for the diagnosis of proven/probable and putative CAPA,as well as the differentiation from colonization,which can be *** fumigatus is the most commonly isolated pathogen in respiratory *** lavage(BAL)and serum galactomannan(gM),𝛽-d-glucan(with limited specificity),polymerase chain reaction(PCR),and Aspergillus-specific lateral-flow device test can be included in the diagnostic work-up;however,these approaches ar

关键词： COVID-19 Aspergillosis Diagnosis Treatment Intensive care unit Severe acute respiratory syndrome Coronavirus 2(SARS-CoV-2) Voriconazole

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