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作者： Mohamed Abdulkadir Hassan-Kadle Mugtaba Sulaiman Osman pavel petrovich Ogurtsov Department of Hospital Medicine Peoples’Friendship University of Russia(RUDN University)Moscow 117198Russia Abrar Research and Training Center Abrar UniversityDepartment of Internal MedicineDivision of Gastroenterology and HepatologyDufle Specialist HospitalMogadishu 25Somalia Department of Psychiatry School of MedicineRoyal College of Surgeons in Ireland RCSIBeaumont HospitalDublin 9Ireland

AIM To provide a clear understanding of viral hepatitis epidemiology and their clinical burdens in *** A systematic review and meta-analysis was conducted as Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive literature search of published studies on viral hepatitis was performed from 1977-2016 in Pub Med, Google Scholar, Science Direct, World Health Organization African Index Medicus and the Africa Journals Online databases, as well as on the Ministry of Health website. We also captured unpublished articles that were not available on online *** Twenty-nine studies from Somalia and Somali immigrants(United Kingdom,United States,Italy,Libya)with a combined sample size for each type of viral hepatitis[hepatitis A virus(HAV):1564,hepatitis B virus(HBV):8756,hepatitis C virus(HCV):6257,hepatitis D virus(HDV):375 and hepatitis E virus(HEV):278]were *** overall pooled prevalence rate of HAV was 90.2%(95%CI:77.8%to 96%).The HAV prevalence among different age groups was as follows:40 years old,86.96%(95%CI:75.68%to 93.47%).The overall pooled prevalence of HBV was 18.9%(95%CI:14%to 29%).The overall pooled prevalence among subgroups of HBV was20.5%(95%CI:5.1%to 55.4%)in pregnant women;5.7%(95%CI:2.7%to 11.5%)in children;39.2%(95%CI:33.4%to 45.4%)in patients with chronic liver disease,including hepatocellular carcinoma(HCC);7.7%(95%CI:4.2%to 13.6%),12.4%(95%CI:6.3%to 23.0%)and 11.8%(95%CI:5.3%to 24.5%)in age groups40years old,*** HBV prevalence among risk groups was 20%(95%CI:7.19%to 44.64%)in female prostitutes,21.28%(95%CI:7.15%to48.69%)in hospitalized adults,5.56%(95%CI:0.99%to 25.62%)in hospitalized children,60%(95%CI:31.66%to 82.92%)in patients with acute hepatitis,33.55%(9

关键词： Viral hepatitis Hepatitis A virus Hepatitis B virus Hepatitis C virus Hepatitis D virus Hepatitis E virus Systematic review Meta-analysis,Somalia

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Aminothiols exchange in coronavirus disease 2019

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Frigid Zone Medicine 2023年第1期3卷 37-41页

作者： Fefelova Elena Viktorovna Karavaeva Tatyana Mikhailovna Parshina Anastasia Anatolyevna Ma Van De Vasilina Denisovna Tereshkov pavel petrovich Department of Pathological Physiology Chita State Medical AcademyChita 672090Russia Department of Chemistry and Biochemistry Chita State Medical AcademyChita 672090Russia Department of Faculty Therapy Chita State Medical AcademyChita 672090Russia Laboratory of Experimental and Clinical Biochemistry and Immunology Chita State Medical AcademyChita 672090Russia

Objective:Clinical manifestation of the inflammatory process in its relation to biochemical markers(total cysteine[Cys],cysteine-glycine[CysGly],glutathione[GSH],glutamate-cysteine[Glu-Cys],homocysteine[Hcy],the ratio of reduced to oxidized glutathione[GSH/GSSG],the ratio of reduced to oxidized cysteine[CySH/CySS],malondialdehyde-oxidized low-density lipoproteins[MDA-oxLDL])has been studied in patients with coronavirus disease 2019(COVID-19).Material and methods:48 patients with mild to severe COVID-19 and 20 healthy volunteers were included in our *** participants were divided into 4 experimental groups according to inflammation intensity estimated based on the serum levels of interleukin 6(IL-6).Results:All 4 groups showed the prevalence of male patients and elevated serum levels of IL-6(by 54.6%).There was no comorbidity in patients with mild COVID-19(nasopharyngitis symptoms)and in healthy control subjects.50%of patients with lung damage had accompanying *** of aminoethyl metabolism were detected in COVID-19 patients:as reflected by the decreased levels of Cys,CysGly,and Glu-Cys and the increased levels of GSH as compared to the control ***:Elevation of IL-6 over 7.5 pg/mL was associated with decreased GSH/GSSG and CySH/CySS ratios indicating enhanced oxidative stress and was followed by protein oxidation,specifically MDA-oxLDL.

关键词： coronavirus disease 2019 aminothiols oxidative stress interleukin-6 oxidized lipoproteins

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