Diagnosis of anti-neutrophil cytoplasmic antibodies(ANCA)-associated vasculitis is usually not difficult in patient with systemic disease, including lung and kidneys involvement, and laboratory signs of inflammation. ...
详细信息
Diagnosis of anti-neutrophil cytoplasmic antibodies(ANCA)-associated vasculitis is usually not difficult in patient with systemic disease, including lung and kidneys involvement, and laboratory signs of inflammation. The presence of ANCA and the results of histological investigation confirm diagnosis of ANCAassociated vasculitis. Cyclophosphamide/azathioprine in combination with high dose steroids are used to induce and maintain remission of systemic vasculitis. The clinical trials also showed efficacy of rituximab that induces depletion of b-cells. Our understanding and management of ANCA-associated vasculitis improved significantly over the last decades but there is still a lot of debate over its classification, diagnostic criteria, assessment of activity and optimum treatment.
Authors analysed foliar nutrition data from the ICP Forests(International Co-operative Programme on the Assessment and Monitoring of Air Pollution on Forests)monitoring network in two neighbouring Central European cou...
详细信息
Authors analysed foliar nutrition data from the ICP Forests(International Co-operative Programme on the Assessment and Monitoring of Air Pollution on Forests)monitoring network in two neighbouring Central European countries:the CZ(Czech Republic)and SK(Slovakia).Authors evaluated altogether seven coniferous(six Norway spruce and one Scots pine)and six broadleaves(five European beech and one Sessile oak)in intensively monitored *** longest time series cover more than 20 years(1995-2017 in CZ;1995-2013 in SK).The data show a significant decrease of the concentration of major nutrients,mainly P and *** roughly half of plots,the concentration of P is near or below the deficiency limit(1.2 g·kg-1),the concentration of K has dropped by 10%to 50%,especially in stands of broadleaves during the evaluated *** time P and K have shown significantly decreasing trends on one third of the evaluated coniferous plots and a similar situation has occurred on broadleaf *** countries differ in Mg trends-there is a decrease of Mg concentration in needles in SK compared with Czech coniferous *** the other hand,in beech leaves there is a decrease of Mg in both countries,and in CZ the trend over time for Mg is *** observed changes in nutrition level with stable or slightly increasing N concentration and with a drop in phosphorus and base cations have led to nutrient imbalance,especially between N and P.
Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse reaction caused mostly by drugs. Three of 22 AGEP cases (13.6%), recruited by us as part of two prospective multinational studies, o...
详细信息
Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse reaction caused mostly by drugs. Three of 22 AGEP cases (13.6%), recruited by us as part of two prospective multinational studies, occurred 24 to 48 hours after a spider bite. We suggest that a spider bite is a possible trigger for AGEP.
暂无评论