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Arboviruses and Sexually Transmitted Infections in the Bioceanic Route: Health Indicators in a Municipality

Advances in Infectious Diseases 2021年第4期11卷 344-356页

作者： Paloma Almeida Kowalski João Pedro Arantes da Cunha Erika Kaneta Ferri Natália Scigliano Rachel Carvalho Lemos Emily Ruiz Cavalcante Vitor Keisi Medeiros Kataoka Fabiana Moreira Coutinho Elton Hiroyuki Ytamura Moriya Leonardo Marzola Hirata Gabriela Félix Dias Lima Letícia Roque Ribeiro Lucas Matheus Pinto Sávio Carvalho Cobianchi paulo otávio souza leonel State University of Mato Grosso do Sul (UEMS—UniversidadeEstadual de Mato Grosso do Sul) Campo Grande MS Brazil Federal University of Mato Grosso do Sul (UFMS—Universidade Federal de Mato Grosso do Sul) Campo Grande MS Brazil University for the Development of the State and Region of the Pantanal (UNIDERP—Universidade para o Desenvolvimento do Estado e da Regiã o do Pantanal) Campo Grande MS Brazil

Background: the physical integration of South America through a Bioceanic Corridor has been idealized for a long time by the countries that make up Mercosur. This integration will have impacts on the population residing in the cities where the route will be built. Among them, Porto Murtinho, southern Mato Grosso on the border with Paraguay, stands out, where a bridge will be built over the Paraguay River that will link these two countries. Methods: a retrospective, quantitative and cross-sectional study of a descriptive type of documentary approach that sought to analyze the prevalence of arboviruses, Sexually Transmitted Infections (STIs) and Diseases Related to Inadequate Environmental Sanitation (DRIES) notified and stored in the National System of Notifiable Diseases (SINAN). The sample consisted of new cases of these pathologies in the municipality of Porto Murtinho registered between January 2017 and December 2020. Results: there was an increase of 10% in the total number of diseases within this period. The number of dengue cases increased 36 times;the incidence of Syphilis, HIV and HPV decreased;and, finally, maintenance of cases of Gonorrhea, Leptospirosis, Yellow Fever, Zika, Chikungunya, Hepatitis A and B. Conclusions: actions are needed to prevent the increase of these pathologies together with the construction of the Bioceanic Route, thus avoiding damage population health and increased consumption of government resources.

关键词： Bioceanic Route Epidemiology Public Health Sexually Transmitted Diseases Arboviruses

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Benchmarks for Pirá2.0,a Reading Comprehension Dataset about the Ocean,the Brazilian Coast,and Climate Change

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Data Intelligence 2024年第1期6卷 29-63页

作者： paulo Pirozelli Marcos M.José Igor Silveira Flávio Nakasato Sarajane M.Peres Anarosa A.F.Brandão Anna H.R.Costa Fabio G.Cozman Universidade de São paulo Ringgold Standard Institution-Instituto de Estudos Avançados Av.370 São Paulo 05508-900Brazil Universidade de São paulo Ringgold Standard Institution-Instituto de Matemática e Estatística Av.370 São Paulo 05508-900Brazil Universidade de São paulo Rua Cayowaá876 apto 141SÃO PAULO 05018-001Brazil Universidade de São paulo Ringgold Standard Institution Escola Politécnica Av.370São Paulo 05508-900Brazil.

Piráis a reading comprehension dataset focused on the ocean,the Brazilian coast,and climate change,built from a collection of scientific abstracts and reports on these *** dataset represents a versatile language resource,particularly useful for testing the ability of current machine learning models to acquire expert scientific *** its potential,a detailed set of baselines has not yet been developed for Pirá.By creating these baselines,researchers can more easily utilize Piráas a resource for testing machine learning models across a wide range of question answering *** this paper,we define six benchmarks over the Pirádataset,covering closed generative question answering,machine reading comprehension,information retrieval,open question answering,answer triggering,and multiple choice question *** part of this effort,we have also produced a curated version of the original dataset,where we fixed a number of grammar issues,repetitions,and other ***,the dataset has been extended in several new directions,so as to face the aforementioned benchmarks:translation of supporting texts from English into Portuguese,classification labels for answerability,automatic paraphrases of questions and answers,and multiple choice *** results described in this paper provide several points of reference for researchers interested in exploring the challenges provided by the Pirádataset.

关键词： Natural language processing Question answering Benchmarks Language resource DomainOriented dataset Scientific knowledge text dataset

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Sarcopenia and Anemia Are Predictors of Poor Prognostic in Cervical Cancer Patients

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Open Journal of Obstetrics and Gynecology 2024年第5期14卷 693-704页

作者： Leandro Santos de Araujo Resende Francine Vilela de Amorim Miguel Soares Conceição Rodrigo Menezes Jales Patrick Nunes Pereira Luis otávio Sarian Glauco Baiocchi Sophie Derchain Agnaldo Lopes da Silva Filho Department of Gynecology and Obstetrics Botucatu Medical School S&#227o Paulo State University UNESP S&#227o Paulo Brazil Department of Health Sciences University of Sao Francisco S&#227o Paulo Brazil Department of Obstetrics and Gynecology School of Medical Science State University of Campinas (UNICAMP) Campinas Brazil Department of Gynecologic Oncology AC Camargo Cancer Center Sao Paulo Brazil Department of Gynecology and Obstetrics School of Medicine of the Federal University of Minas Gerais Belo Horizonte Brazil

Objective: Evaluate pretreatment sarcopenia and anemia as prognostic factors in women undergoing treatment for cervical cancer (CC) with concurrent chemoradiotherapy (CCRT). Methods: 151 women with CC were analysed in this cohort study. Pretreatment computed tomography (CT) images were analysed to assess skeletal muscle index (SMI). Hazard ratios (HR) and multivariate Cox proportional HR were used to analyse association between low SMI, age, body mass index (BMI), haemoglobin levels, histological type, and International Federation of Gynaecology and Obstetrics (FIGO) stage with PFS and OS. Results: A total of 151 patients were included, 53 (35.1%) presented pretreatment sarcopenia;51 (34%) stage I/II and 100 (66%) stage III/IV. Among those patients in advanced stage (III/IV) 37 (70%) (p = 0.28) were sarcopenic at the beginning of treatment. Sarcopenia was associated with worse progression-free survival (PFS) and overall survival (OS) in our cohort [HR 0.97 (p = 0.01)] [HR 0.73 (p = 0.001)], as well as anemia [HR 0.73 (p = 0.001)] [HR 0.78 (p = 0.001)]. Linear regression models indicated that despite showing no association with age, neutrophil or platelet counts, sarcopenia was associated with pretreatment anemia levels (p = 0.01). After a multivariate analysis, only haemoglobin (anemia) and complete CCRT remained associated with PFS and OS. Sarcopenia and anemia were associated with worse PFS and OS in FIGO stage I/II. Conclusion: Pretreatment sarcopenia was significantly associated with low haemoglobin levels. Anemia and incomplete CCRT were independently associated with poor prognosis in women with CC. Pretreatment sarcopenia, as low SMI, was a predictor of poor prognostic in early stages of CC.

关键词： Cervical Cancer Sarcopenia Anemia Chemoradiotherapy

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Development of Pre-Broken Sugar Cane Submitted to Treatments with Fertilizer and Vegetable Regulators

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Agricultural Sciences 2018年第10期9卷 1240-1249页

作者： Tiago Gazola Mário Luiz Cipola Filho paulo otávio Risso Universidade Estadual Paulista “Júlio de Mesquita filho”—UNESP—FCA Botucatu Brazil Universidade de Marília Marília Brazil Universidade do Sagrado Coraç o Bauru Brazil

The objective of this work was to evaluate the development of pre-budded sugarcane seedlings from buds submitted to treatments with fertilizer and plant regulators. The experiment was conducted in a completely randomized design with six replicates. The treatments of the yolks were carried out in the concentration of 1% of volume with the following products: Witness—without treatment of the gems;Kinetin 0.009% + Gibberellic acid 0.005% + 4-Indole-3-butyric acid 0.005% (Stimulate®);Seaweed Extract (Ascophyllum nodosum) and Potassium Hydroxide—3.5% K2O (ExpertGrow®) and ethephon 72% (Ethrel®) + pH Reducer (Kill®). The percentage of shoot buds, number of tillers, number of leaves, leaf area, stem diameter, shoot dry mass, root and total were evaluated. The control, as well as Stimulate®and Ethrel®provided higher sprouting percentages. Ethrel®was the product that promoted the highest number of tillers and leaves. The leaf area did not change due to the use of the products or not. The dry mass of both shoot, root and total leaves showed no significant weight changes among the evaluated treatments. It is concluded that the use of ExpertGrow®is not recommended for treatment of pre-sprouted sugarcane seedlings because it provided fewer shoots at 28 days after planting of the yolk and that Ethrel®is recommended because it provided a larger number of the buds evaluated.

关键词： Ascophyllum nodosum Pre-Budded Seedlings Plant Regulators Saccharum spp.

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Antioxidant and antitumor potential of wild and IMT-Acultivated Osmundea pinnatifida

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Journal of Oceanology and Limnology 2019年第3期37卷 825-835页

作者： SILVA J.paulo ALVES Celso PINTEUS Susete SILVA Joana VALADO Ana PEDROSA Rui PEREIRA leonel UCIBIO-REQUIMTE Department of ChemistryFaculty of Sciences and TechnologyUniversidade NOVA de LisboaCaparica 2829-516Portugal MARE-Marine and Environmental Sciences Centre School of Tourism and Maritime TechnologyPolytechnic Institute of LeiriaPeniche 2520-641Portugal Instituto Politécnico de Coimbra ESTESC-Coimbra Health SchoolBiomedical Sciences LaboratoryR.5 de OutubroS.Martinho do BispoAp.7006Coimbra 3046-854Portugal Centre of Pharmacology and Chemical Biopathology Faculty of MedicineUniversity of PortoPorto 4200-319Portugal MARE-Marine and Environmental Sciences Centre Department of Life SciencesFaculty of Sciences and TechnologyUniversity of CoimbraCoimbra 3000-456Portugal

Osmundea pinnatifida is a red edible seaweed known as pepper *** was cultivated in the farm of ALGAplus(ílhavo,Portugal).This farm is integrated with a seabream and seabass commercial aquaculture and uses the nutrient-enriched water resultant from the fish production as its cultivation medium in the integrated multi-trophic aquaculture(IMTA)*** and IMTA-cultivated samples of *** da were screened for antioxidant and antitumor *** antioxidant capacity of solvent extracts from wild and IMTA cultivated samples was assessed in two methods(2,2-diphenyl-1-picrylhydrazyl(DPPH)and oxygen radical absorbance capacity(ORAC)),and their total phenolic contents(TPC)were *** activity was evaluated in three different tumor cell lines(HepG-2,MCF-7,and SH-SY5Y)through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** the solvents used for extraction,dichloromethane was the most eff ective to extract phenolic compounds and presented higher ORAC.A significant correlation was found between TPC and ORAC,which was also sustained by the principal components analysis(PCA).Dichloromethane extracts induced a cytostatic eff ect on MCF-7 cells and showed weak cytotoxicity to SH-SY5Y cells and weak impact on cell ***,there were no statistically signifi cant differences in the biological activities shown by the wild and IMTA-cultivated ***,*** can be obtained in an economical and environmentally sustainable way through IMTA,maintaining bioactive properties in a high potential for further nutraceutical purposes.

关键词： edible seaweed bioactive compounds polyphenols cytotoxic activity antiproliferative activity

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Duodenal stenting for malignant gastric outlet obstruction:Prospective study

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World Journal of Gastroenterology 2012年第9期18卷 938-943页

作者： Eduardo Guimaräes Hourneaux Moura Flávio Coelho Ferreira Spencer Cheng Diogo Turiani Hourneaux Moura paulo Sakai Bruno Zilberstain Gastrointestinal Endoscopy Unit University of Sao Paulo Department of Gastroenterology University of Sao Paulo

AIM： To evaluate the results of duodenal stenting for palliation of gastroduodenal malignant obstruction by using a gastric outlet obstruction score （GOOS）.

关键词： Enteral stenting Gastric outlet obstructionscoring system Gastroduodenal malignancy Self-expan-dable metal stent

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Numerical Study on the Effect of Submerged Depth on the Horizontal Plate Wave Energy Converter

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China Ocean Engineering 2014年第5期28卷 687-700页

作者： Flávio Medeiros SEIBT Eduardo Costa COUTO Elizaldo Domingues dos SANTOS Liércio André ISOLDI Luiz Alberto Oliveira ROCHA paulo Roberto de Freitas TEIXEIRA Graduate Program of Ocean Engineering Universidade Federal do Rio Grande96203-900 Rio Grande RS Brazil Mechanical Engineering Department Universidade Federal do Rio Grande do Sul90050-170 Porto Alegre RS Brazil

The growing search for clean and renewable energy sources has given rise to the studies of exploring sea wave energy. This paper is concerned with the numerical evaluation of the main operational principle of a submerged plate employed for the conversion of wave energy into electrical one. The numerical model used to solve the conservation equations of mass, momentum and transport of volume fraction is based on the finite volume method （FVM）. In order to tackle with the flow of mixture of air-water and its interaction with the device, the multiphase model volume of fluid （VOF） is employed. The purpose of this study is the evaluation of a numerical model for improvement of the knowledge about the submerged plate wave energy converter, as well as the investigation of the effect of the distance from the plate to the bottom of the sea （HP） on the performance of the converter. The simulations for several distances of the plate from the seabed show that the optimal efficiency is 64%, which is obtained for HP=0.53 m （88% of the depth）. This efficiency is 17% larger than that found in the worst case （HP=0.46 m, 77% of the depth）.

关键词： numerical simulation submerged plate wave energy conversion efficiency

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Yield of surgery in solid pseudopapillary neoplasms of the pancreas: A case series and literature review

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World Journal of Gastrointestinal Oncology 2021年第6期13卷 589-599页

作者： Flávio Silano Ricardo Bandeira de Melo Amaral Rodolfo Carvalho Santana Vanessa Costa Neves JoséCelso Ardengh paulo Cezar Galvão do Amaral Digestive Surgery Hospital São Rafael/Rede D’OrSalvador 40285000BahiaBrazil Department of Surgery of the Upper Digestive System São Rafael Hospital/Rede D’Or Hospital GroupSalvador 41253-190BahiaBrazil Surgery and Anatomy Hospital das Clinicas da Faculdade de Medicina de Ribeirão Preto-Universidade de São PauloSão Paulo 04611-000São PauloBrazil Endoscopy Service Hospital 9 de JulhoSão Paulo 04611-000São PauloBrazil Imaging and Diagnosis Escola Paulista de Medicina-São Paulo Federal UniversitySão Paulo 04611-000SPBrazil

BACKGROUND Solid pseudopapillary neoplasms(SPN)of the pancreas represents approximately 2%of non-endocrine tumors of the *** is described in the literature as a rare and predominant tumor in young *** To report a case series with SPN and analyzing clinical,surgical,anatomopathological characteristics,as well as the prognosis and review of *** Retrospective analysis of patients undergoing surgery,with histological diagnosis of SPN between 1998 and 2018,using standardized and prospectively completed forms,performed at the Surgery Service of the Upper Digestive System at Hospital São Rafael/Rede D’Or in *** of literature through a database search in MEDLINE/PubMed of retrospective *** Fourteen female patients with the average age of 31.6 years(range min-max)were *** patients(85.7%)were asymptomatic,being an incidental diagnosis or due to screening for other *** patient had abdominal pain due to gastric compression and another patient had *** 14 patients were staged with computerized tomography or magnetic resonance *** had evidence of *** 8 patients(57.1%),the tumor was in the tail and *** average size was 6.7 cm(range min-18).The type of surgery was according to the anatomical location of the *** was no lymph node *** two cases,vascular resection with the use of a prosthesis was required for *** surgical margins were *** all cases,postoperative immunohistochemistry confirmed that it was a solid pseudo-papillary neoplasia of the *** has been no disease recurrence in any case so *** The tumors had a benign,indolent and histopathological behavior compatible with the *** surgery is recommended in all cases.

关键词： Frantz tumor Malignancy Solid pseudo-papillary tumor Surgical treatment Survival Pancreas

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Seaweeds’nutraceutical and biomedical potential in cancer therapy:a concise review

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Journal of Cancer Metastasis and Treatment 2021年第1期7卷 189-212页

作者： João Cotas Diana Pacheco Ana M.M.Gonçalves paulo Silva Loïc G.Carvalho leonel Pereira University of Coimbra MARE-Marine and Environmental Sciences CentreDepartment of Life SciencesCalçada Martim de FreitasCoimbra 3000-456Portugal Department of Biology and CESAM University of AveiroAveiro 3810-193Portugal UCIBIO-REQUIMTE Departamento de QuímicaFaculdade de Ciências e TecnologiaUniversidade Nova de LisboaCaparica 2829-516Portugal The James Hutton Institute Dundee DD25DAScotlandUK Heriot-Watt University Edinburgh EH144ASScotlandUK.

Seaweeds have been a food source since ancient times(600 BC)and are still widely used in Asia,mainly in traditional Chinese medicine and Japanese folk ***,seaweed compounds and extracts have been gaining interest from the biomedical and pharmaceutical market *** have been referenced as feasible solutions in finding new potential compounds and therapies in prevention,control,and reduction of cancer development due to the multirole of some bioactive components(e.g,phenolic compounds and sulphated polysaccharides).Moreover,seaweeds are rich in important health-promoting molecules[such as poly and highly unsaturated fatty acids(PUFAs and HUFAs),essential amino acids,vitamins,and dietary fibers]and minerals(calcium,iron,iodine,magnesium,phosphorus,potassium,zinc,copper,manganese,selenium,and fluoride).In this review,the potential therapeutic effects of seaweed in the prevention and treatment of cancer are approached,as well as nutraceutical properties of seaweed to promote cell homeostasis.

关键词： Seaweed compounds nutraceutical bioactive molecules cancer prevention cancer treatment

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In vitro induced pluripotency from urine-derived cells in porcine

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World Journal of Stem Cells 2022年第3期14卷 231-244页

作者： Kaiana Recchia Lucas Simões Machado Ramon Cesar Botigelli Naira Caroline Godoy Pieri Gabriela Barbosa Raquel Vasconcelos Guimarães de Castro Mariana Groke Marques Laís Vicari de Figueiredo Pessôa paulo Fantinato Neto Flávio Vieira Meirelles Aline Fernanda de souza Simone Maria Massami Kitamura Martins Fabiana Fernandes Bressan Department of Surgery Faculty of Veterinary Medicine and Animal SciencesUniversity of São PauloPirassununga 13635-000São PauloBrazil Department of Pharmacology and Biotechnology Institute of BioscienceSão Paulo State UniversityBotucatu 18618-689São PauloBrazil Department of Veterinary Medicine Faculty of Animal Sciences and Food EngineeringUniversity of São PauloPirassununga 13635-000São PauloBrazil Embrapa Suínos e Aves Empresa Brasileira de Pesquisa AgropecuáriaConcordia 89715-899Santa CatarinaBrazil Department of Animal Sciences Faculty of Animal Sciences and Food EngineeringUniversity of São PauloPirassununga 13635-000São PauloBrazil

BACKGROUND The generation of induced pluripotent stem cells(iPSC)has been a game-changer in translational and regenerative medicine;however,their large-scale applicability is still hampered by the scarcity of accessible,safe,and reproducible *** porcine model is a large biomedical model that enables translational applications,including gene editing,long term in vivo and offspring analysis;therefore,suitable for both medicine and animal *** To reprogramme in vitro into pluripotency,and herein urine-derived cells(UDCs)were isolated from porcine *** The UDCs were reprogrammed in vitro using human or murine octamer-binding transcription factor 4(OCT4),SRY-box2(SOX2),Kruppel-like factor 4(KLF4),and C-MYC,and cultured with basic fibroblast growth factor(bFGF)*** characterize the putative porcine iPSCs three clonal lineages were submitted to immunocytochemistry for alkaline phosphatase(AP),OCT4,SOX2,NANOG,TRA181 and SSEA 1 *** transcripts related to the pluripotency(OCT4,SOX2 and NANOG)were analyzed via reverse transcription quantitative realtime polymerase chain reaction in different time points during the culture,and all three lineages formed embryoid bodies(EBs)when cultured in suspension without bFGF *** The UDCs were isolated from swine urine samples and when at passage 2 submitted to in vitro *** of putative iPSCs were obtained only from UDCs transduced with the murine factors(mOSKM),but not from human factors(hOSKM).Three clonal lineages were isolated and further cultured for at least 28 passages,all the lineages were positive for AP detection,the OCT4,SOX2,NANOG markers,albeit the immunocytochemical analysis also revealed heterogeneous phenotypic profiles among lineages and passages for NANOG and SSEA1,similar results were observed in the abundance of the endogenous transcripts related to pluripotent *** the clonal lineages when cultured in suspension without

关键词： Induced pluripotent stem cells Noninvasive Pluripotency Reprogramming Urine Porcine

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