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In vitro investigations on the effects of graphene and graphene oxide on polycaprolactone bone tissue engineering scaffolds

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Bio-Design and Manufacturing 2024年第5期7卷 651-669页

作者： Yanhao Hou Weiguang Wang paulo bartolo School of Engineering Faculty of Science and EngineeringThe University of ManchesterManchesterUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingaporeSingapore

Polycaprolactone(PCL)scaffolds that are produced through additive manufacturing are one of the most researched bone tissue engineering structures in the *** to the intrinsic limitations of PCL,carbon nanomaterials are often investigated to reinforce the PCL *** several studies that have been conducted on carbon nanomaterials,such as graphene(G)and graphene oxide(GO),certain challenges remain in terms of the precise design of the biological and nonbiological properties of the *** paper addresses this limitation by investigating both the nonbiological(element composition,surface,degradation,and thermal and mechanical properties)and biological characteristics of carbon nanomaterial-reinforced PCL scaffolds for bone tissue engineering *** showed that the incorporation of G and GO increased surface properties(reduced modulus and wettability),material crystallinity,crystallization temperature,and degradation ***,the variations in compressive modulus,strength,surface hardness,and cell metabolic activity strongly depended on the type of ***,a series of phenomenological models were developed based on experimental results to describe the variations of scaffold’s weight,fiber diameter,porosity,and mechanical properties as functions of degradation time and carbon nanomaterial *** results presented in this paper enable the design of three-dimensional(3D)bone scaffolds with tuned properties by adjusting the type and concentration of different functional fillers.

关键词： Additive manufacturing Bone tissue engineering Carbon nanomaterial Graphene Graphene oxide Scaffold

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Application of additively manufactured 3D scaffolds for bone cancer treatment:a review

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Bio-Design and Manufacturing 2022年第3期5卷 556-579页

作者： Yanhao Hou Weiguang Wang paulo bartolo Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringFaculty of Science and EngineeringThe University of ManchesterManchester M139PLUK Singapore Center for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingaporeSingapore

Bone cancer is a critical health problem on a global scale,and the associated huge clinical and economic burdens are still *** many clinical approaches are currently used for bone cancer treatment,these methods usually affect the normal body functions and thus present significant ***,advanced materials and additive manufacturing have opened up promising avenues for the development of new strategies targeting both bone cancer treatment and post-treatment bone *** paper presents a comprehensive review of bone cancer and its current treatment methods,particularly focusing on a number of advanced strategies such as scaffolds based on advanced functional materials,drug-loaded scaffolds,and scaffolds for photothermal/magnetothermal ***,the main research challenges and future perspectives are elaborated.

关键词： Additive manufacturing Biomanufacturing Bone cancer Implants Tissue engineering

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Customized scaffolds for large bone defects using 3D‑printed modular blocks from 2D‑medical images

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Bio-Design and Manufacturing 2024年第1期7卷 74-87页

作者： Anil AAcar Evangelos Daskalakis paulo bartolo Andrew Weightman Glen Cooper Gordon Blunn Bahattin Koc Faculty of Engineering and Natural Sciences Sabanci UniversityIstanbul 34956Türkiye D Bioprinting Laboratory Sabanci University Nanotechnology Research and Application CenterIstanbul 34956Türkiye School of Mechanical Aerospace and Civil EngineeringManchester Institute of BiotechnologyUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore School of Pharmacy and Biomedical Sciences University of PortsmouthPortsmouth PO12UPUK

Additive manufacturing(AM)has revolutionized the design and manufacturing of patient-specific,three-dimensional(3D),complex porous structures known as scaffolds for tissue engineering *** use of advanced image acquisition techniques,image processing,and computer-aided design methods has enabled the precise design and additive manufacturing of anatomically correct and patient-specific implants and ***,these sophisticated techniques can be timeconsuming,labor-intensive,and ***,the necessary imaging and manufacturing equipment may not be readily available when urgent treatment is needed for trauma *** this study,a novel design and AM methods are proposed for the development of modular and customizable scaffold blocks that can be adapted to fit the bone defect area of a *** modular scaffold blocks can be combined to quickly form any patient-specific scaffold directly from two-dimensional(2D)medical images when the surgeon lacks access to a 3D printer or cannot wait for lengthy 3D imaging,modeling,and 3D printing during *** proposed method begins with developing a bone surface-modeling algorithm that reconstructs a model of the patient’s bone from 2D medical image measurements without the need for expensive 3D medical imaging or *** algorithm can generate both patient-specific and average bone ***,a biomimetic continuous path planning method is developed for the additive manufacturing of scaffolds,allowing porous scaffold blocks with the desired biomechanical properties to be manufactured directly from 2D data or *** algorithms are implemented,and the designed scaffold blocks are 3D printed using an extrusion-based AM *** and instructions are also provided to assist surgeons in assembling scaffold blocks for the self-repair of patient-specific large bone defects.

关键词： Additive manufacturing Modular scaffolds Large bone defect Customized scaffold design Patient-specific scaffolds

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Ballistic design and testing of a composite armour reinforced by CNTs suitable for armoured vehicles

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Defence Technology（防务技术） 2024年第2期32卷 173-195页

作者： Evangelos Ch.Tsirogiannis Evangelos Daskalakis Mohamed H.Hassan Abdalla M.Omar paulo bartolo EODH SA Research and Development DepartmentLakkoma Chalkidikis63080Greece School of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchesterM139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological University639798Singapore

This paper is investigating the use of composite armour reinforced by nanomaterials, for the protection of light armoured(LAV) and medium armoured military vehicles(MAV), and the interaction between the composite materials and high-performance ballistic projectiles. Four armour materials, consisted of front hybrid fibre reinforced polymer cover layer, ceramic strike-face, fibre reinforced polymer intermediate layer and the metal matrix composite reinforced backplate, were manufactured and assembled by adhesive technology. The proposed laminated protection system is suitable for armoured ground vehicles;however, it could be used as armour on ground, air and naval platforms. The design of the protection system, including material selection and thickness, was elaborated depending on the performance requirements of Level 4 + STANAG 4569 military standard(projectile 14.5 mm × 114 mm API B32) and especially on a design philosophy which is analysed with the specifications. The backplate of this new composite is a hybrid material of Metal Matrix Composite(MMC) reinforced with carbon nanotubes(CNTs), manufactured with the use of powder metallurgy technique. The composite backplate material was morphologically, mechanically and chemically analysed. Results show that all plates are presenting high mechanical properties and ballistic characteristics, compared to commonly used armour plates. Real military ballistic tests according to AEP-STANAG 4569 were carried out for the total composite armour systems. After the ballistic tests, AA2024-CNT3 showed the best protection results, compared with the other plates(AA2024-CNT1 and AA2024-CNT2), with the projectile being unable to fully penetrate the composite plate.

关键词： Passive armour protection Protective armour Ballistic performance Hybrid composites Vehicle protection

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Electrospun polyvinyl alcohol fibres incorporating an antimicrobial gel for enzymatically controlled reactive oxygen species release

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Bio-Design and Manufacturing 2024年第6期7卷 899-925页

作者： Joel Yupanqui Mieles Cian Vyas Evangelos Daskalakis Mohamed Hassan James Birkett Abdalla M.Omar Gavin Humphreys Carl Diver paulo bartolo Department of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUK Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore 639798Singapore Department of Chemistry University of ManchesterManchester M139PLUK Division of Pharmacy and Optometry University of ManchesterManchester M139PLUK Department of Engineering Manchester Metropolitan UniversityManchester M139PLUK

Wounds pose a risk to the skin,our body's primary defence against *** rise of antibiotic resistance has prompted the development of novel ***-101^(■)is an antimicrobial gel that delivers therapeutic levels of hydrogen peroxide(H_(2)O_(2)),a reactive oxygen species,directly to the wound *** this study,electrospinning was used to incorporate RO-101^(■)into a polyvinyl alcohol(PVA)sub-micron fibrous mesh that can act as a delivery agent,achieve a sustained release profile,and provide a barrier against *** incorporation of this gel into sub-micron fibres was confirmed via nuclear magnetic resonance ***,scanning electron microscopy exhibited smooth and uniform meshes with diameters in the 200-500 nm ***/RO-101 electrospun meshes generated H_(2)O_(2) in concentrations exceeding 1 m M/(g·m L)(1 m M=1 mmol/L)after 24 h,and the role of sterilisation on H_(2)O_(2) release was ***/RO-101meshes exhibited antimicrobial activity against both Gram-positive Staphylococcus aureus(***)and Gram-negative Pseudomonas aeruginosa(***)bacteria,achieving viable count reductions of up to 1 log unit CFU/mm^(2)(CFU:colony-forming units).Moreover,these meshes were capable of disrupting biofilm formation,even against multidrug-resistant organisms such as methicillin-resistant ***(MRSA).Furthermore,increasing the RO-101^(■)concentration resulted in higher H_(2)O_(2) production and an enhanced antimicrobial effect,while fibroblast cell viability and proliferation tests showed a concentration-dependent response with high cytocompatibility at low RO-101^(■)*** study therefore demonstrates the potential of highly absorbent PVA/RO-101 meshes as potential antimicrobial wound dressings.

关键词： Antimicrobial Electrospinning Hydrogen peroxide Polyvinyl alcohol Reactive oxygen species Tissue engineering Wound dressing

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Robotic in situ bioprinting for cartilage tissue engineering

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International Journal of Extreme Manufacturing 2023年第3期5卷 118-142页

作者： Yaxin Wang Rúben F Pereira Chris Peach Boyang Huang Cian Vyas paulo bartolo Department of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUnited Kingdom Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto4050-313PortoPortugal Instituto de Investigacao e Inovaao em Saúde Universidade do Porto4200-135PortoPortugal Instituto de Engenharia Biomédica Universidade do Porto4200-135PortoPortugal Manchester University NHS Foundation Trust ManchesterUnited Kingdom Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore639798Singapore

Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in significant pain,mobility issues,and *** surgical treatments have a limited capacity for efficacious cartilage repair,and long-term patient outcomes are not ***-dimensional bioprinting has been used to fabricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue ***,conventional in vitro bioprinting has limitations due to the challenges associated with the fabrication and implantation of bioprinted constructs and their integration with the native cartilage *** situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional *** this review,we focus on the new frontier of robotic-assisted in situ bioprinting surgical systems for cartilage *** outline existing clinical approaches and the utilization of robotic-assisted surgical *** and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are defined and ***,we discuss the challenges and potential future perspectives of in situ bioprinting for cartilage applications.

关键词： in situ bioprinting cartilage tissue engineering robotic in situ bioprinting minimally invasive surgery bioinks

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