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Multipotent mesenchymal stromal cells:A promisingstrategy to manage alcoholic liver disease

World Journal of Gastroenterology 2016年第1期22卷 24-36页

作者： Fernando Ezquer Flavia Bruna Sebastián Calligaris paulette conget Marcelo Ezquer Centro de Medicina Regenerativa Facultad de MedicinaClínica Alemana-Universidad del DesarrolloSantiago 7710162Chile

Chronic alcohol consumption is a major cause of liver *** term alcoholic liver disease(ALD)refers to a spectrum of mild to severe disorders including steatosis,steatohepatitis,cirrhosis,and hepatocellular *** limited therapeutic options,stem cell therapy offers significant potential for these *** this article,we review the pathophysiologic features of ALD and the therapeutic mechanisms of multipotent mesenchymal stromal cells,also referred to as mesenchymal stem cells(MSCs),based on their potential to differentiate into hepatocytes,their immunomodulatory properties,their potential to promote residual hepatocyte regeneration,and their capacity to inhibit hepatic stellate *** perfect match between ALD pathogenesis and MSC therapeutic mechanisms,together with encouraging,available preclinical data,allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage ALD onset and progression.

关键词： Alcoholic liver disease Cellular therapy Alcoholic steatohepatitis Hepatic function recovery Mesenchymal stem cells

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Could cancer and infection be adverse effects of mesenchymal stromal cell therapy?

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World Journal of Stem Cells 2015年第2期7卷 408-417页

作者： Martha L Arango-Rodriguez Fernando Ezquer Marcelo Ezquer paulette conget Center for Regenerative Medicine School of Medicine Clínica Alemana Universidad del Desarrollo

Multipotent mesenchymal stromal cells [also referred to as mesenchymal stem cells(MSCs)] are a heterogeneous subset of stromal cells. They can be isolated from bone marrow and many other types of tissue. MSCs are currently being tested for therapeutic purposes(i.e., improving hematopoietic stem cell engraftment, managing inflammatory diseases and regenerating damaged organs). Their tropism for tumors and inflamed sites and their context-dependent potential for producing trophic and immunomodulatory factors raises the question as to whether MSCs promote cancer and/or infection. Thisarticle reviews the effect of MSCs on tumor establishment, growth and metastasis and also susceptibility to infection and its progression. Data published to date shows a paradoxical effect regarding MSCs, which seems to depend on isolation and expansion, cells source and dose and the route and timing of administration. Cancer and infection may thus be adverse or therapeutic effects arising form MSC administration.

关键词： Cancer Infection Mesenchymal stem cells Therapy Biosafety

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