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Correlating the global increase in type 1 diabetes incidence across age groups with national economic prosperity: A systematic review

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World Journal of Diabetes 2019年第12期10卷 560-580页

作者： Natalia Gomez-Lopera Nicolas Pineda-Trujillo paula andrea diaz-valencia Grupo Mapeo Genetico Departamento de PediatríaFacultad de MedicinaUniversidad de AntioquiaMedellín 050010470Colombia Epidemiology Group.School of Public Health.Universidad de Antioquia Medellín 050010470Colombia

BACKGROUND The global epidemiology of type 1 diabetes(T1D)is not yet well known,as no precise data are available from many countries.T1D is,however,characterized by an important variation in incidences among countries and a dramatic increase of these incidences during the last decades,predominantly in younger *** the United States and Europe,the increase has been associated with the gross domestic product(GDP)per *** our previous systematic review,geographical variation of incidence was correlated with socio-economic *** To investigate variation in the incidence of T1D in age categories and search to what extent these variations correlated with the GDP per *** A systematic review was performed to retrieve information about the global incidence of T1D among those younger than 14 years of *** study was carried out according to the PRISMA *** the analysis,the incidence was organized in the periods:1975-1999 and *** searched the incidence of T1D in the age-groups 0-4,5-9 and *** compared the incidences in countries for which information was available for the two *** obtained the GDP from the World *** analysed the relationship between the incidence of T1D with the GDP in countries reporting data at the national *** We retrieved information for 84 out of 194 countries around the *** found a wide geographic variation in the incidence of T1D and a worldwide increase during the two *** largest contribution to this increase was observed in the youngest group of children with T1D,with a relative increase of almost double when comparing the two periods(P value=2.5×e-5).Twenty-six countries had information on the incidence of T1D at the national level for the two *** was a positive correlation between GDP and the incidence of T1D in both periods(Spearman correlation=0.52 from 1975-1999 and Spearman correlation=0.53 from 2000-2017).CONCLUSION The incidence increase was

关键词： Type 1 diabetes Incidence Children Age categories Gross domestic product per capita

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Proximity to corridors benefits bird communities in vegetated interrow vineyards in Mendoza, Argentina

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Avian Research 2024年第2期15卷 147-155页

作者： andrea paula Goijman Agustín Zarco EEA La Consulta Instituto Nacional de Tecnología Agropecuaria(INTA)San CarlosMendozaArgentina Instituto Argentino de Investigacion en las Zonas Aridas(IADIZA)CONICET 5500MendozaArgentina

Management under ecological schemes and increasing habitat heterogeneity,are essential for enhancing biodiversity in *** provide several contributions to agriculture,for example pest control,recreation and enhancing human mental health,and have intrinsic *** are also ideal model organisms because they are easy to survey,and species respond differently to agricultural land use at different *** borders of crops are key for many species of birds,and distance to the border have been found to be an important factor in vineyard-dominated *** evaluate if there are differences in the bird assemblage,between the interior compared to borders within vineyards,using a hierarchical community occupancy *** hypoth-esized that occupancy of birds is greater in environments with greater heterogeneity,which in this study was considered to be contributed by the proximity to vegetated *** expected that vineyard borders close to corridors will have higher bird occupancy than the center of the *** research was conducted in three vineyards with biodiversity-friendly management practices,in Gualtallary,Mendoza,*** surveys were conducted over three breeding seasons from 2018 to *** and richness of the bird community was more closely associated with the borders adjacent to the corridors than with the interior of the vineyards,as we initially predicted,although the assemblage of birds did not differ *** than 75%of the registered species consume exclusively or partially ***-friendly management and ecological schemes,together with vegetated corridors provide multiple benefits for biodiversity *** ap-proaches not only minimize the use of agrochemicals but also prioritize soil cover with spontaneous vegetation,which supports a diverse community of insectivorous bird species,potentially contributing to pest control.

关键词： Avian Bayesian analysis Field scale agroecosystem Management Multi-species occupancy model Nature’s contributions to people

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Auxin EvoDevo: Conservation and Diversification of Genes Regulating Auxin Biosynthesis, Transport, and Signaling

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Molecular Plant 2019年第3期12卷 298-320页

作者： Michaela Sylvia Matthes Norman Bradley Best Janlo M.Robil Simon Malcomber andrea Gallavotti paula McSteen Division of Biological Sciences Interdisciplinary Plant Group and Missouri Maize CenterUniversity of Missouri-Columbia301 Christopher Bond Life Sciences CenterColumbiaMO 65211USA Department of Biological Sciences California State UniversityLongBeachCA 90840USA Waksman Institute of Microbiology Rutgers UniversityPiscatawayNJ 08854-8020USA Department of Plant Biology Rutgers UniversityNew BrunswickNJ 08901USA Present address:National Science Foundation 2415 Eisenhower AvenueAlexandriaVA 22314USA

The phytohormone auxin has been shown to be of pivotal importance in growth and development of land *** underlying molecular players involved in auxin biosynthesis, transport, and signaling are quite well understood in ***, functional characterizations of auxin-related genes in economically important crops, specifically maize and rice, are still *** this article, we comprehensively review recent functional studies on auxirelated genes in both maize and rice, compared with what is known in Arabidopsis, and highlight conservation and diversification of their functions. Our analysis is illustrated by phylogenetic analysis and publicly available gene expression data for each gene family, which will aid in the identification of auxin-related genes for future *** challenges and future directions for auxin research in maize and rice are *** in gene editing techniques provide powerful tools for overcoming the issue of redundancy in these gene families and will undoubtedly advance auxin research in crops.

关键词： auxin maize Arabidopsis rice

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Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease

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Neural Regeneration Research 2023年第7期18卷 1450-1456页

作者： Tamara andrea Alarcón Sarah Martins Presti-Silva Ana paula Toniato Simões Fabiola Mara Ribeiro Rita Gomes Wanderley Pires Department of Physiological Sciences Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Laboratory of Molecular and Behavioral Neurobiology Health Science CenterUniversidade Federal do Espirito SantoVitoriaBrazil Department of Biochemistry and Immunology Institute o Biological SciencesUniversidade Federal de Minas GeraisAvenida Antônio CarlosBelo HorizonteBrazil

Parkinson’s disease is the most common movement disorder,affecting about 1%of the population over the age of 60 ***’s disease is characterized clinically by resting tremor,bradykinesia,rigidity and postural instability,as a result of the progressive loss of nigrostriatal dopaminergic *** addition to this neuronal cell loss,Parkinson’s disease is characterized by the accumulation of intracellular protein aggregates,Lewy bodies and Lewy neurites,composed primarily of the proteinα-*** it was first described almost 200 years ago,there are no disease-modifying drugs to treat patients with Parkinson’s *** addition to conventional therapies,non-pharmacological treatment strategies are under investigation in patients and animal models of neurodegenerative *** such strategies,environmental enrichment,comprising physical exercise,cognitive stimulus,and social interactions,has been assessed in preclinical models of Parkinson’s *** enrichment can cause structural and functional changes in the brain and promote neurogenesis and dendritic growth by modifying gene expression,enhancing the expression of neurotrophic factors and modulating *** this review article,we focus on the current knowledge about the molecular mechanisms underlying environmental enrichment neuroprotection in Parkinson’s disease,highlighting its influence on the dopaminergic,cholinergic,glutamatergic and GABAergic systems,as well as the involvement of neurotrophic *** describe experimental pre-clinical data showing how environmental enrichment can act as a modulator in a neurochemical and behavioral context in different animal models of Parkinson’s disease,highlighting the potential of environmental enrichment as an additional strategy in the management and prevention of this complex disease.

关键词： acetylcholine brain-derived neurotrophic factor dopamine environment enrichment gamma-aminobutyric acid glial cell line-derived neurotrophic factor glutamate molecular mechanisms Parkinson’s disease

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论大数据背景下金融合规管理中的隐私问题及其伦理对策

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财经理论与实践 2021年第1期42卷 2-9页

作者：吕耀怀 paula andrea Aravena 杭州师范大学公共管理学院浙江杭州311121 智利大学经济与商业学院智利圣地亚哥7561160

大数据技术在金融领域的广泛应用,一方面,改善了金融服务;另一方面,由于大数据技术自身的属性而可能导致更多、更大的隐私风险。在这种背景下,金融领域的合规管理面临双重的隐私风险:一是金融实体之业务活动所可能产生的隐私风险,二是... 详细信息

大数据技术在金融领域的广泛应用,一方面,改善了金融服务;另一方面,由于大数据技术自身的属性而可能导致更多、更大的隐私风险。在这种背景下,金融领域的合规管理面临双重的隐私风险:一是金融实体之业务活动所可能产生的隐私风险,二是合规管理自身所可能产生的隐私风险。因此,为了应对金融领域中合规管理所可能遭遇的隐私问题,也就需要有两个方面的伦理对策:一是针对金融实体全部业务活动中隐私风险的伦理对策,二是针对有权接触、利用金融客户数据、信息的合规管理人员的伦理对策。除了基本的伦理对策之外,为了使得柔性的伦理对策不至于成为花瓶般的摆设,有必要为其设置相应的制度保障。

关键词：大数据金融合规隐私伦理

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Minimally invasive nephrectomy for inflammatory renal disease

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Asian Journal of Urology 2020年第4期7卷 345-350页

作者： paula andrea Pena Lynda Torres-Castellanos German Patino Stefania Prada Luis Gabriel Villarraga Nicolas Fernandez Pontificia Universidad Javeriana School of MedicineBogota D.C.Colombia Department of Urology Hospital Universitario San IgnacioPontificia Universidad JaverianaSchool of MedicineBogota D.C.Colombia Division of Urology Hospital Universitario San IgnacioPontificia Universidad JaverianaBogota D.C.Colombia Division of Urology Hospital Universitario San IgnacioPontificia Universidad JaverianaSchool of MedicineBogota D.C.Colombia Department of Urology Fundacion Santa Fe de BogotaColombia Division of Urology Hospital for SickKidsUniversity of TorontoTorontoCanada

Objective:Once chronic inflammatory renal disease(IRD)develops,it creates a severe peri-fibrotic process,which makes it a relative contraindication for minimally invasive surgery(MIS).Our objective is to show that laparoscopic nephrectomy(LN)is a surgical option in IRD with fewer complications and better ***:Retrospective review of patients who underwent a modified-surgical laparoscopic transperitoneal nephrectomy was *** search included all operated patients between May 2013 and May 2018 that had a pathology result with any renal inflammatory condition(xanthogranulomatous pyelonephritis,chronic nephritis,and renal tuberculosis).We describe intra-operative variables such as operative time,blood loss,conversion rate,postoperative complications and length of hospital ***:There were 51 patients who underwent laparoscopic nephrectomy with a confirmatory pathology report for *** identified four(8%)major complications;three of them required transfusion and one conversion to open *** mean operative time was 233108 *** estimated blood loss was 206242 mL excluding the conversion cases and 281423 mL including *** mean length of hospital stay was 3.02.0 ***:Laparoscopic nephrectomy for IRD can safely be *** is a reproducible technique with low risks and complication *** experience supports that releasing the kidney first and leaving the hilum for the end is a safe approach when vascular structures are embedded into a single block of inflammatory and scar tissue.

关键词： Inflammation Kidney diseases Laparoscopy Minimally invasive surgical procedures Nephrectomy Nephritis Nephroureterectomy

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The barren stalk2 Gene Is Required for Axillary Meristem Development in Maize

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Molecular Plant 2019年第3期12卷 374-389页

作者： Hong Yao andrea Skirpan Brian Wardell Michaela S.Matthes Norman B.Best Tyler McCubbin Amanda Durbak Taylor Smith Simon Malcomber paula McSteen Division of Biological Sciences Interdisciplinary Plant GroupBond Life Sciences CenterUniversity of MissouriColumbiaMO65211USA Department of Biology Penn State UniversityUniversity ParkPA16802USA Department of Biological Sciences California State UniversityLongBeachCA90840USA Division of Biological Sciences Interdisciplinary Plant GroupColumbiaMO65211USA Present address:National Science Foundation 2415 Eisenhower AvenueAlexandriaVA22314USA

The diversity of plant architecture is determined by axillary meristems (AMs). AMs are produced from small groups of stem cells in the axils of leaf primordia and generate vegetative branches and reproductive inflorescences . Previous studies identified genes critical for AM development that function in auxin biosynthesis, transport, and signaling. barren stalkl (ba1), a basic helix-loop-helix transcription factor, acts downstream of auxin to control AM formation. Here, we report the cloning and characterization of barren stalk2 (ba2), a mutant that fails to produce ears and has fewer branches and spikelets in the tassel, indicating that ba2 functions in reproductive AM development. Furthermore, the ba2 mutation suppresses tiller growth in the teosinte branchedl mutant, indicating that ba2 also plays an essential role in vegetative AM development. The ba2 gene encodes a protein that co-localizes and heterodimerizes with BA1 in the nucleus . Characterization of the genetic interaction between ba2 and ba1 demonstrates that ba1 shows a gene dosage effect in ba2 mutants, providing further evidence that BA1 and BA2 act together in the same pathway. Characterization of the molecular and genetic interaction between ba2 and additional genes required for the regulation of ba1 further supports this finding. The ba1 and ba2 genes are orthologs of rice genes, LAX PANICLE1 (LAX1) and LAX2, respectively, hence providing insights into pathways controlling AMs development in grasses.

关键词： maize axillary meristem inflorescenee auxin

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Gastroschisis at the Leon University Hospital, Nicaragua

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Reproductive and Developmental Medicine 2022年第2期6卷 86-91页

作者： Dania Maria Pastora Bucardo paula andrea Pimienta Ramirez Department of Pediatrics Faculty of MedicineNational Autonomous University of Nicaragua UNAN-LeonLeonNicaragua Center for Precision Environmental Health Department of Molecular and Cellular BiologyBaylor College of MedicineHoustonTexasUSA

Objective::The prevalence of midline birth defects, such as gastroschisis, has increased worldwide, over the last few decades. This study aims to explore the prevalence, maternal epidemiological characteristics, and natural history of neonates affected by gastroschisis at the University Hospital of Leon city, ***:Data were collected from the birth defect surveillance system of the Hospital Oscar Danilo Rosales (HEODRA). The analysis included all pregnancies that had gastroschisis complications between January 1 and December 31, 2020. The prevalence of gastroschisis was calculated according to maternal age. The mothers were interviewed, and the clinical records of the newborns were ***::Among the 4,460 deliveries included in this study, four cases of gastroschisis were identified, including three live births and one stillbirth. The gastroschisis rate was 8.9 per 10,000 live births (95% confidence interval [CI]: 0.18-17.8). The prevalence among mothers younger than 20 years and those older than 20 years was 26.4 (95% CI: -3.43 to 56.25) and 3.01 (95% CI: 2.89-8.90)/10,000 births, respectively. Mothers of gastroschisis-affected fetuses were of rural origin ( n = 3), had normal body mass indexes ( n = 3), were exposed to tobacco and wood smoke ( n = 2), and one was exposed to pesticides during the periconceptional period. Primary closure of the gastroschisis was performed on one patient, and complex gastroschisis for intestinal perforation was observed in another patient. The mean hospitalization duration was 33 days, and two patients were discharged alive. Conclusions::Gastroschisis was a significant birth defect among children delivered at HEODRA in 2020. Its prevalence in Nicaragua was higher than that in other countries in the region. All complicated pregnancies were young women with unplanned pregnancies, from rural areas, with exposure to secondhand smoke, and without vitamin supplements before or during the first trimester of pregnancy.

关键词： Environmental exposures Gastroschisis Preterm deliveries

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Massive gastrointestinal bleeding: An unusual case of asymptomatic extrarenal, visceral, fibromuscular dysplasia

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World Journal of Gastroenterology 2007年第43期13卷 5771-5774页

作者： paula andrea Rodriguez Urrego Mark Flanagan Wilson S Tsai Craig Rezac Nicola Barnard Department of Pathology Robert Wood Johnson Medical School-University of Medicine and Dentistry of New Jersey United States Department of Surgery RWJMS-UMDNJ United States Department of Heart Lung and Esophageal Surgery University of Pittsburgh Medical Center United States

Extrarenal fibromuscular dysplasia causing gastro- intestinal bleeding without other manifestations and especially sparing renal vasculature is uncommon. The diagnosis of this entity is usually made by radiographic appearance and the treatment is controversial. To our knowledge only seven cases of visceral fibromuscular dysplasia as a primary manifestation of the disease have been described, symptoms range from abdominal pain to gangrene. This is the first case of visceral fibromuscular dysplasia presenting with otherwise asymptomatic gastrointestinal bleeding, without bowel necrosis or ischemic changes. We provide a review of the literature.

关键词： Fibromuscular dysplasia Extrarenal Visceral Gastrointestinal bleeding Intimal fibroplasia

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A Systematic Bibliographical Review: Barriers and Facilitators for Access to Legal Abortion in Low and Middle Income Countries

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Open Journal of Preventive Medicine 2018年第5期8卷 147-168页

作者： Freddy André s Barrios Arroyave paula andrea Moreno Gutié rrez Sexual and Reproductive Health Universidad el Bosque Bogota Colombia Doctoral Student in Epidemiology and Biostatistics CES University Medellin Colombia Department of Community Health Faculty of Medicine Fundacion Universitaria Autonoma de las Americas Pereira Colombia

Background: There is a complex interplay between women’s preferences, abortion services availability and the context in which these are provided. Even in countries where it is legal, denial of abortion is common, especially in low and middle income countries, forcing women to look for the service elsewhere and bringing serious consequences to the health and wellbeing of many women and their families. This non-systematic review pretends to answer the question: Which are the barriers to and facilitators for the access to legal abortion services in low and middle income countries? Methods: A non-systematic bibliographical review. Inclusion criteria: all quantitative, qualitative and evidence synthesis studies performed in low and middle income countries according to the World Bank classification for 2015 and published in English, Spanish and Portuguese language, between 2005 and 2017. Exclusion criteria: articles evaluating the efficacy of interventions, addressing the knowledge about abortion procedures among health care students and personnel, as well as those that only included sex workers. Results: The database search yield 199 articles in MEDLINE. 24 in Scopus and 38 in Scielo. A total of 22 articles including 15 countries from Africa (n = 6), Asia (n = 5), Central and South America (n = 3) and Europe (n = 1). The legal status of abortion in each of these countries was studied and described. For the analysis of the information, three categories of deepening were established: Laws and policies, Service delivery and Women’s abortion care-seeking behavior. Conclusion: the determinants of access to abortion in low and middle income countries are convoluted as multiple delays and barriers usually overlap. Similarly, stigmatization has a great impact across all the steps of abortion provision. Multiple facilitators were proposed in the three aspects of abortion provision, but they need to be adjusted depending on the context of each country.

关键词： Abortion Legal Reproductive Rights Public Health Abortion Applicants

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