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Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PAnTHEIA-SEOm trial

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero magda Palka-Kotlowska Axel mariño-m.ndez Alberto Carm.na-Bayonas Javier Gallego A J muñoz martín paula Jim.nez-Fonseca Luis Cabezon-Gutierrez Departm.nt of medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Departm.nt of Internal medicine Hospital Universitario de TorrejonMadrid 28850Spain Departm.nt of medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Departm.nt of medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Departm.nt of medical Oncology Hospital General Universitario de ElcheElche 03202Spain Departm.nt of medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUnD The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains *** To study the prognostic significance of SIRI and weight loss in metastatic pancreatic *** The PAnTHEIA-Spanish Society of medical Oncology(SEOm)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOm Real World-Evidence work *** pilot study sought to analyze the association between weight loss and inflammatory status as defined by *** cohort stems from a proof-of-concept pilot study conducted at one of the coordinating *** with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were *** index was calculated using the product of neutrophil and m.nocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation *** study evaluated associations between overall survival(OS),SIRI and weight *** A total of 50 patients were included.66%of these patients were male and the median age was 66 *** sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple *** the first line palliative chemotherapy treatm.nts:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were adm.nistered gemcitabine.42%had a weight loss>5%in the three m.nths(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRImo;Pm.ng 21 patients with>5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI *** difference was statistically significant(P<0.000).For pat

关键词： Pancreatic cancer nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index Weight loss

Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern

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Journal of molecular Cell Biology 2024年第3期16卷 9-23页

作者： Ilaria Frasson Linda Diam.nte m.nuela Zangrossi Elena Carbognin Anna Dalla Pietà Alessandro Penna Antonio Rosato Ranieri Verin Filippo Torrigiani Cristiano Salata marìa paula Dizanzo Lorenzo Vaccaro Davide Cacchiarelli Sara n.Richter marco m.ntagner Graziano martello Departm.nt of molecular medicine University of PaduaPadua 35121Italy Departm.nt of Biology Armenise/Harvard Pluripotent Stem Cell Biology LaboratoryUniversity of PaduaPadua 35131Italy Departm.nt of Surgery Oncology and GastroenterologyUniversity of PaduaPadua 35128Italy Veneto Institute of Oncology IOV-IRCCS Padua 35128Italy Departm.nt of Comparative Biomedicine and Food Science University of PaduaPadua 35020Italy Telethon Institute of Genetics and medicine(TIGEm) Armenise/Harvard Laboratory of Integrative GenomicsPozzuoli 80078Italy Departm.nt of Translational medicine University of Naples Federico IINaples 80138Italy School for Advanced Studies Genomics and Experimental Medicine ProgramUniversity of Naples Federico IINaples 80138Italy microbiology and Virology Unit Padua University HospitalPadua 35128Italy

The high mutation rate of SARS-CoV-2 leads to the emergence of multiple variants,some of which are resistant to vaccines and drugs targeting viral *** host dependency factors,*** proteins required for viral replication,would help prevent the developm.nt of ***,it remains unclear whether different SARS-CoV-2 variants induce conserved cellular responses and exploit the same core host *** this end,we compared three variants of concern and found that the host transcriptional response was conserved,differing only in kinetics and *** regularly interspaced short palindromic repeats screening identified host genes required for each variant during *** of the genes were shared by multiple *** validated our hits with small molecules and repurposed the US Food and Drug Adm.nistration-approved *** the drugs were highly active against all the tested variants,including new variants that emerged during the study(Delta and Omicron).mechanistically,we identified reactive oxygen species production as a key step in early viral *** such as n-acetyl cysteine(nAC)were effective against all the variants in both hum.n lung cells and a hum.nized mouse *** study supports the use of available antioxidant drugs,such as nAC,as a general and effective anti-COVID-19 approach.

关键词： SARS-CoV-2 variants of concern host dependency factors antivirals n-acetyl cysteine

Perceived value of microfinance and SmE perform.nce: The role of exploratory innovation

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International Journal of Innovation Studies 2024年第2期8卷 172-185页

作者： Christian Sarfo Jing A.Zhang Conor O'Kane paula O'Kane Departm.nt of m.nagem.nt University of LincolnBrayford PoolLincoln LN67TSUnited Kingdom Departm.nt of m.nagem.nt Otago Business SchoolUniversity of OtagoPO Box 56Dunedin9054New Zealand

This study exam.nes how perceived value of microfinance and exploratory innovation affect small and medium-sized enterprises(SmE)perform.nce in the context of a developing *** on the strategic innovation and microfinance literature,we hypothesize that(1)perceived value of microfinance affects exploratory innovation and SmE perform.nce,and(2)exploratory innovation serves as an effective mechanism through which microfinance enhances SmE *** employ partial least squares structural equation modeling(PLS-SEm)to test our *** a sample of 581 Ghanaian SmEs with microfinance,the results of the PLS SEm support our *** further conducted a qualitative analysis of comm.nts provided by the SmEs(n=144)to gain a deeper understanding of exploratory innovation in developing *** findings show that SmEs purposefully attempt to strengthen their exploratory inno-vation in *** discuss the theoretical and practical implications of these findings as well as future research avenues.

关键词： Perceived value of microfinance Exploratory innovation SmE perform.nce

Hepatocellular Ballooning is Due to Highly Pronounced Glycogenosis Potentially Associated with Steatosis and metabolic Reprogramm.ng

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 52-61页

作者： Silvia Ribback Kristin Peters mohd Yasser Jessica Prey paula Wilhelmi Qin Su Frank Dombrowski Peter Bannasch Institut für Pathologie Universitaetsmedizin GreifswaldGreifswaldGermany Cell marque Millipore-SigmaRocklinCAUSA Germ.n Cancer Research Center(DKFZ) HeidelbergGermany

Background and Aims:Hepatocellular ballooning is a comm.n finding in chronic liver disease,mainly characterized by rarefied cytoplasm that often contains mallory-Denk bodies(mDB).Ballooning has mostly been attributed to degeneration but its striking resemblance to glycogenotic/steatotic changes characterizing preneoplastic hepatocellular lesions in animal models and chronic hum.n liver diseases prompts the question whether ballooned hepatocytes(BH)are damaged cells on the path to death or rather viable cells,possibly involved in neoplastic ***:Using specim.ns from 96 cirrhotic hum.n livers,BH characteristics were assessed for their glycogen/lipid stores,enzyme activities,and proto-oncogenic signaling cascades by enzyme-and imm.nohistochemical approaches with serial paraffin and cryostat ***:BH were present in 43.8%of cirrhotic *** pronounced excess glycogen storage of(glycogenosis)and/or lipids(steatosis)were characteristic,ground glass features and mDB were often *** glucose-6-phosphatase,increased glucose-6-phosphate dehydrogenase activity and altered imm.noreactivity of enzymes involved in glycolysis,lipid metabolism,and cholesterol biosynthesis were ***,components of the insulin signaling cascade were upregulated along with insulin dependent glucose transporter glucose transporter 4 and the v-akt murine thymoma viral oncogene homolog/mammalian target of rapamycin signaling pathway associated with de novo ***:BH are hallmarked by particularly pronounced glycogenosis with facultative steatosis,m.ny of their features being rem.niscent of metabolic aberrations docum.nted in preneoplastic hepatocellular lesions in experim.ntal animals and chronic hum.n liver ***,BH are not damaged entities facing death but rather viable cells featuring metabolic reprogramm.ng,indicative of a preneoplastic nature.

关键词： Chronic liver disease Carbohydrate metabolism Insulin signaling Preneoplasia metabolic reprogramm.ng

m.noam.ne Oxidase-B Inhibitor Rasagiline Effects on motor and non-motor Symptoms in Individuals with Parkinson’s Disease: A Systematic Review and meta-Analysis

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Advances in Parkinson's Disease 2024年第3期13卷 27-56页

作者： paula Abola mitchell Wolden Departm.nt of Clinical Research University of Jamestown Jamestown United States of America

Objective: In the m.nuscript titled m.noam.ne Oxidase-B Inhibitor Rasagiline Effects on motor and non-motor Symptoms in Individuals with Parkinsons Disease: A Systematic Review and meta-Analysis, the objective was to conduct a systematic review with meta-analysis to investigate the effects that Rasagiline has on motor and non-motor symptoms in individuals with PD. Introduction: Rasagiline is a second-generation m.noam.ne oxidase-B (mAO-B) inhibitor used both as m.notherapy and adjunctive therapy for Parkinsons Disease (PD). methods: A systematic literature search and meta-analysis were performed with randomized control trials that investigated the effects of Rasagiline on motor and non-motor symptoms in individuals with PD. The systematic search was conducted in Pubmed, Cochrane, and EBSCO databases. methodological quality was assessed using the Cochrane Grading Recomm.ndations Assessm.nt, Developm.nt and Evaluation approach. Results: Fourteen studies were included in our review. There were trivial to small and statistically significant improvem.nts in motor symptoms for individuals with PD treated with Rasagiline compared to placebo. non-motor symptoms showed no significant improvem.nt with Rasagiline compared to placebo in five of six meta-analyses. Results were based on very low to moderate certainty of evidence. Conclusion: 1 mg/day Rasagiline significantly improved Parkinsonian motor symptoms in individuals with PD compared with placebo. For all outcomes, the 1 mg/day Rasagiline group was favored over the placebo group.

关键词： Parkinson’s Disease m.noam.ne Oxidase-B Inhibitor Rasagiline non-motor Symptoms motor Symptoms UPDRS PDQ-39 OFF Time

Biomass gasification,catalytic technologies and energy integration for production of circular methanol:new horizons for industry decarbonisation

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Journal of Environm.ntal Sciences 2024年第6期140卷 306-318页

作者： Luis F.Bobadilla Lola Azancot miriam González-Castañ Estela Ruíz-López Laura Pastor-Pérez Francisco J.Durán-Olivencia Runping Ye Katie Chong paula HBlanco-Sánchez Zenthao Wu Tomás R.Reina JoséA.Odriozola Departam.nto de Química Inorgánica e Instituto de Ciencia de materiales de Sevilla Centro Mixto CSIC-Universidad de SevillaAvda.Américo Vespucio 49Sevilla 41092Spain Departam.nto de Ingeniería Universidad Loyola AndalucíaAvda.de Las Universidades s/nSevilla 41704Spain Key Laboratory of Jiangxi Province for Environm.nt and Energy Catalysis School of Chemistry and Chemical EngineeringNanchang UniversityNanchang330031China Energy and Bioproducts Research Institute(EBRI) Aston UniversityBirminghamB47ETUnited Kingdom Departm.nt of Chemical and Process Engineering University of SurreyGuildfordGU27XHUnited Kingdom

The Intergovernm.ntal Panel on Climate Change(IPCC)recognises the pivotal role of renewable energies in the future energy system and the achievem.nt of the zero-emission *** implem.ntation of renewables should provide major opportunities and enable a more secure and decentralised energy supply *** fuels provide long-term solutions for the transport sector,particularly for applications where fuels with high energy density are *** addition,it helps reducing the carbon footprint of these sectors in the *** on biomass characteristics feedstock is essential for scaling-up gasification from the laboratory to *** review deals with the transformation biogenic residues into a valuable bioenergy carrier like biomethanol as the liquid sunshine based on the combination of modified mature technologies such as gasification with other innovative solutions such as membranes and microchannel *** abatem.nt is a critical process in product gas upgrading since tars compromise downstream processes and equipm.nt,for this,membrane technology for upgrading syngas quality is discussed in this *** reactor technology with the design of state-of-the-art multifunctional catalysts provides a path to develop decentralised biomethanol synthesis from biogenic ***,the developm.nt of a process chain for the production of(i)methanol as an intermediate energy carrier,(ii)electricity and(iii)heat for decentralised applications based on biomass feedstock flexible gasification,gas upgrading and methanol synthesis is analysed.

关键词： Biogenic residues Gasification Biomethanol Circular Economy microreactors

Histological Assessm.nt of Bone Regeneration in the maxilla with Homologous Bone Graft:A Feasible Option for maxillary Bone Reconstruction

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Journal of Renewable materials 2024年第1期12卷 131-148页

作者： Sergio Henrique Gonçalves motta Ana paula Ramos Soares Juliana Campos Hasse Fernandes Gustavo Vicentis Oliveira Fernandes Graduate Center of Faculdade Redentor CLIVORio de JaneiroBrazil Periodontics and Oral medicine Departm.nt University of Michigan School of DentistryAnn ArborMI48109USA Centre for Interdisciplinary Research in Health(CIIS) Universidade Católica PortuguesaViseu3504-505Portugal

Bone biomaterials have been increasingly used to reconstruct maxillary atrophic ***,the aim of this study was to evaluate bone reconstruction in the maxilla using a homologous cortico-cancellous FFB(lyophilized)graft and verify its *** individuals were included from 2014 to *** first surgery was performed to install homologous bone blocks in the *** period of the second intervention varied between 5 m.nths and 15 days to 11 m.nths(≈7.93 m.nths).The biopsies were taken from the central region of the matured graft during the surgery for implant *** patients presented clinical and radiographic conditions for the installation of dental *** was a 100%of survival *** histological assessm.nt showed that the homologous block bone graft was an osteoconductive biomaterial,with connective tissue present,and newly formed bone juxtaposed on its *** were bone trabeculae with osteocytes and active osteoblasts with connective tissue in the m.neralization process;the remodeling process can be found through the reverse lines.A limited focus of necrosis with fibrosis was detected,with small resorption and areas of inflammatory infiltrate,but without clinical *** homologous block bone graft can be considered a feasible option to substitute the autogenous bone graft(gold standard),with predictable clinical and favorable histological *** patients had a shorter surgical period,low morbidity,and an unlimited amount of biomaterial available at an accessible cost.

关键词： Regeneration bone graft histology homologous allogenous autogenous

Assessm.nt of four different dietary am.no acid profiles recomm.nded for ISA Brown layer hens: A validation study

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Animal nutrition 2024年第2期17卷 438-446页

作者： mehdi Toghyani Shemil macelline Juliano C.de paula Dorigam Peter V.Chrystal Peter H.Selle Sonia Y.Liu School of Life and Environm.ntal Sciences Faculty of Science The University of Sydney Poultry Research Foundation The University of Sydney Evonik Operations GmbH

The current feeding study was designed to validate the two dietary essential am.no acid profiles(EAAP)established based on linear broken-line(LBL) and quadratic broken-line(QBL) models, in a previous study, against Evonik(Am.nOHen) and breeder recomm.ndations for ISA Brown layers for peak production(PP, 20 to 44 weeks of age), and post peak production(post PP, 44 to 75 weeks of age). The EAAP based on LBL models on average had 19.5% and 26.0% lower digestible AA(Lys, met + Cys, Thr, Trp, Ile and Val), than the EAAP based on QBL models for PP and post PP, respectively. The EAAP based on Am.nOHen and breeder recomm.ndation had lower digestible AA than QBL, and higher EAAP than LBL models for both production phases. At 20 weeks of age, 224 ISA Brown layer hens were weighed and randomly allocated to individual battery cages. Each of the four diets was replicated 8 times with 7 birds per replicate. Egg production was recorded daily, and egg weights were measured at the end of each week. Feed consumption was measured at the end of each period. The egg production rate was not significantly affected by the diets and remained at around 98.0%(PP) and 95.0%(post PP)(P > 0.05). Birds fed diets based on LBL recomm.ndation consistently laid smaller eggs, resulting in a lower egg mass(59.8 vs. 62.0 g egg/hen per day during PP, and 60.3 vs. 63.0 g egg/hen per day during post PP; P no significant effect on feed intake and body weight(P > 0.05). The highest feed conversion ratio(FCR) during PP(P = 0.067) and post PP(P n LBL recomm.ndation. In conclusion, all four EAAP tested in this study support an above average egg production rate. However, the EAAP based on LBL models may potentially decrease the input feed cost per kilogram of eggs but are not set to optimise FCR and maximise egg mass.

关键词： Ideal am.no acid profile Regression model Egg production Egg mass

The Subscription Economy and Its Contribution to the Global Economy

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m.nagem.nt Studies 2024年第3期12卷 137-145页

作者： paula Cobzaru Alexandru Tugui “Alexandru Ioan Cuza”University of Iasi Romania

The subscription economy has become a dom.nant influence in the current business environm.nt,fundam.ntally transform.ng the m.nner in which organizations interact with customers and create *** article exam.nes the substantial influence of the subscription economy on the worldwide economy,evaluating its effects on different industries and *** research exam.nes relevant literature and case studies to identify the main factors,difficulties,and possibilities related to the subscription ***,its objective is to exam.ne the consequences for firms,customers,and economic expansion,elucidating the possibility of continuous value generation and innovation.

关键词： subscription model subscription economy business model shift new digital economy global economy