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Endoscopic dilation of complete oesophageal obstructionswith a combined antegrade-retrograde rendezvoustechnique

World Journal of Gastroenterology 2016年第7期22卷 2366-2372页

作者： Reto Bertolini Christa Meyenberger paul martin putora Franziska Albrecht martina Anja Broglie Sandro J Stoeckli Michael Christian Sulz Division of Gastroenterology and Hepatology Kantonsspital St.Gallen9007 St.GallenSwitzerland Department of Radiation Oncology Kantonsspital St.Gallen9007 St.GallenSwitzerland Department of Otorhinolaryngology Head and Neck SurgeryKantonsspital St.Gallen9007 St.GallenSwitzerland

AIM: To investigate the combined antegraderetrograde endoscopic rendezvous technique for complete oesophageal obstruction and the swallowing ***: This single-centre case series includes consecutive patients who were unable to swallow due to complete oesophageal obstruction and underwent combined antegrade-retrograde endoscopic dilation(CARD) within the last 10 years. The patients' demographic characteristics, clinical parameters, endoscopic therapy, adverse events, and outcomes were obtained retrospectively. Technical success was defined as effective restoration of oesophageal patency. Swallowing success was defined as either percutaneous endoscopic gastrostomy(PEG)-tube independency and/or relevant improvement of oral food intake, as assessed by the functional oral intake scale(FOIS)(≥ level 3).RESULTS: The cohort consisted of six patients [five males; mean age 71 years(range, 54-74)]. All but one patient had undergone radiotherapy for head and neck or oesophageal cancer. Technical success was achieved in five out of six patients. After discharge, repeated dilations were performed in all five patients. During follow-up(median 27 mo, range, 2-115), three patients remained PEG-tube dependent. Three of four patients achieved relevant improvement of swallowing(two patients: FOIS 6, one patient: FOIS 7). One patient developed mediastinal emphysema following CARD, without a need for ***: The CARD technique is safe and a viable alternative to high-risk blind antegrade dilation in patients with complete proximal oesophageal obstruction. Although only half of the patients remained PEG-tube independent, the majority improved their ability to swallow.

关键词： Oesophageal obstruction Rendezvoustechnique Combined antegrade-retrograde endoscopicdilation Endoscopic dilation Head and neck cancer Radiotherapy

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Emerging insights into the function of very long chain fatty acids at cerebellar synapses

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Neural Regeneration Research 2025年第6期20卷 1709-1710页

作者： martin-paul Agbaga Mohiuddin Ahmad Department of Cell Biology and Ophthalmology University of Oklahoma Health Sciences Centerand Dean McGee Eye InstituteOklahoma CityOKUSA

Very long chain-saturated and-polyunsaturated fatty acids(VLC-SFA and VLC-PUFA, respectively) are a functionally important class of fatty acids containing 28 carbons or more in their acyl chain. They are synthesized by the elongation of very long fatty acids-4(ELOVL4) enzyme, expressed mainly in the brain, retina, skin, testes, and meibomian gland, where these fatty acids are found(Agbaga et al., 2008). Further, these organs exhibit tissuespecific VLC-PUFA and VLC-SFA biosynthesis and incorporation into complex lipids for specific functions. In the brain, skin, and Meibomian glands, the ELOVL4 mainly makes VLC-SFA, which are incorporated into complex sphingolipids. In the retina, the ELOVL4 makes VLC-PUFA that are incorporated into phosphatidylcholine, that are critical for visual function, while in testes and sperm, the VLC-PUFA are incorporated into sphingolipids that are critical for fertility(Yeboah et al., 2021).

关键词： functions function insight

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Evolving landscape and novel treatments in, metastatic castrate-resistant prostate cancer

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Asian Journal of Andrology 2013年第3期15卷 342-349页

作者： paul J Toren martin E Gleave Department of Urologic Sciences Faculty of Medicine University of British Columbia Vancouver BC V5Z 1M9 Canada

Treatment options for castrate-resistant prostate cancer （CRPC） have advanced in recent years and significantly improved the Outlook for patients with this aggressive and lethal disease. Further understanding of the biology＇of CRPC has led to several new targeted therapies and continues to emphasize the importance of androgen receptor （AR） directed therapy. The treatment landscape is rapidly changing and further biologically rationale, biomarker-based ongoing clinical trials are needed. We review the recent results of major clinical trials in CRPC. New and investigational agents now in clinical evaluation are reviewed including inhibitors of angiogenesis, microtubules, chaperones, AR and intracellular kinases, as well as immunotherapy, radiopharmaceuticals and bone-targeted agents. The recent improvement in prognosis for CRPC brings continued optimism for further improvements. Thoughtful planning of clinical trials and further understanding of the mechanisms of resistance to therapies will allow for continued progress in patient care.

关键词： prostate cancer treatment resistance androgen receptor antagonists molecular targets

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The GWmodel R package:further topics for exploring spatial heterogeneity using geographically weighted models

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Geo-Spatial Information Science 2014年第2期17卷 85-101页

作者： Binbin LU paul HARRIS martin CHARLTON Chris BRUNSDON School of Remote Sensing and Information Engineering Wuhan University129 Luoyu RoadWuhan 430079China Rothamsted Research North WykeOkehamptonDevonUK National Centre for Geocomputation National University of Ireland MaynoothMaynoothCo.KildareIreland

In this study,we present a collection of local models,termed geographically weighted(GW)models,which can be found within the GWmodel R package.A GW model suits situations when spatial data are poorly described by the global form,and for some regions the localized fit provides a better *** approach uses a moving window weighting technique,where a collection of local models are estimated at target ***,model parameters or outputs are mapped so that the nature of spatial heterogeneity can be explored and *** particular,we present case studies using:(i)GW summary statistics and a GW principal components analysis;(ii)advanced GW regression fits and diagnostics;(iii)associated Monte Carlo significance tests for non-stationarity;(iv)a GW discriminant analysis;and(v)enhanced kernel bandwidth selection *** Election data-sets from the Republic of Ireland and US are used for *** study is designed to complement a companion GWmodel study,which focuses on basic and robust GW models.

关键词： principal components analysis semi-parametric GW regression discriminant analysis Monte Carlo tests election data

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Improving Shape from Shading with Interactive Tabu Search

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Journal of Computer Science & Technology 2016年第3期31卷 450-462页

作者： Jing Wu paul L. Rosin Xianfang Sun Ralph R. martin School of Computer Science and Informatics Cardiff University Cardiff CF24 3AA U.K.

Optimisation based shape from shading （SFS） is sensitive to initialization： errors in initialization are a signifi- cant cause of poor overall shape reconstruction. In this paper, we present a method to help overcome this problem by means of user interaction. There are two key elements in our method. Firstly, we extend SFS to consider a set of initializations, rather than to use a single one. Secondly, we efficiently explore this initialization space using a heuristic search method, tabu search, guided by user evaluation of the reconstruction quality. Reconstruction results on both synthetic and real images demonstrate the effectiveness of our method in providing more desirable shape reconstructions.

关键词： shape from shading user interaction tabu search

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High-performance solutions of geographically weighted regression in R

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Geo-Spatial Information Science 2022年第4期25卷 536-549页

作者： Binbin Lu Yigong Hu Daisuke Murakami Chris Brunsdon Alexis Comber martin Charlton paul Harris School of Remote Sensing and Information Engineering Wuhan UniversityWuhanChina Department of Data Science Institute of Mathematical StatisticsTokyoJapan National Centre for Geocomputation Maynooth UniversityMaynoothIreland School of Geography University of LeedsLeedsUK Sustainable Agriculture Sciences North Wyke Rothamsted ResearchOkehamptonUK

As an established spatial analytical tool,Geographically Weighted Regression(GWR)has been applied across a variety of ***,its usage can be challenging for large datasets,which are increasingly prevalent in today’s digital *** this study,we propose two high-performance R solutions for GWR via Multi-core Parallel(MP)and Compute Unified Device Architecture(CUDA)techniques,respectively GWR-MP and *** compared GWR-MP and GWR-CUDA with three existing solutions available in Geographically Weighted Models(GWmodel),Multi-scale GWR(MGWR)and Fast GWR(FastGWR).Results showed that all five solutions perform differently across varying sample sizes,with no single solution a clear winner in terms of computational ***,solutions given in GWmodel and MGWR provided acceptable computational costs for GWR studies with a relatively small sample *** a large sample size,GWR-MP and FastGWR provided coherent solutions on a Personal Computer(PC)with a common multi-core configuration,GWR-MP provided more efficient computing capacity for each core or thread than *** cases when the sample size was very large,and for these cases only,GWR-CUDA provided the most efficient solution,but should note its I/O cost with small *** summary,GWR-MP and GWR-CUDA provided complementary high-performance R solutions to existing ones,where for certain data-rich GWR studies,they should be preferred.

关键词： Non-stationarity big data parallel computing Compute Unified Device Architecture(CUDA) Geographically Weighted models(GWmodel)

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Bulbosum to Go： A Toolbox to Utilize Hordeum vulgarelbulbosum Introgressions for Breeding and Beyond

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Molecular Plant 2015年第10期8卷 1507-1519页

作者： Neele Wendler martin Mascher Axel Himmelbach paul Johnston Richard Pickering Nils Stein Leibniz Institute of Plant Genetics and Crop Plant Research (IPK) CorrensstraSe 3 06466 Seeland (or) Gatersleben Germany New Zealand Institute for Plant and Food Research Limited Private Bag 4704 Christchurch 8140 New Zealand

Hordeum bulbosum L., a wild relative of barley （Hordeum vulgare L.）, has been considered as a valuable source of genetic diversity for barley improvement. Since the 1990s, a considerable number of barley/H, bulbosum introgression lines （IL）s has been generated, with segments introgressed from H. bulbosum harboring a diverse set of desirable traits. However, the efficient utilization of these ILs has been hampered, largely due to the lack of suitable molecular tools for their genetic characterization and highly reduced interspecific recombination frequencies in the region of the introgression. In the present study, we utilized genotyping-by-sequencing for the detailed molecular characterization of 145 ILs. Genotypic information allows the genetic diversity within the set of ILs to be determined and a strategy was outlined to tackle the obstacle of reduced recombination frequencies. Furthermore, we compiled exome capture re-sequencing information of barley and H. bulbosum and designed an integrated barley/ H. bulbosum sequence resource with polymorphism information on interspecific and intraspecific sequence variations of both species. The integrated sequence will be valuable for marker development in barley/H, bulbosum ILs derived from any barley and H. bulbosum donors. This study provides the tools for the widespread utilization of barley/H, bulbosum ILs in applied barley breeding and academic research.

关键词： Hordeum vulgare Hordeum bulbosum introgression line genotyping-by-sequencing (GBS) exomecapture NGS

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Psychological burden of food allergy

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World Journal of Gastroenterology 2007年第25期13卷 3456-3465页

作者： martin Teufel Tilo Biedermann Nora Rapps Constanze Hausteiner Peter Henningsen paul Enck Stephan Zipfel Department of Internal Medicine VI -Psychosomatic Medicine and Psychotherapy University of Tübingen Tübingen 72076 Germany Department of Dermatology University of Tübingen Tübingen 72076 Germany Department of Psychosomatic Medicine University Hospital Technical University Munich 81675 Germany

One fifth of the population report adverse reactions to food. Reasons for these symptoms are heterogeneous, varying from food allergy, food intolerance, irritable bowel syndrome to somatoform or other mental disorders. Literature reveals a large discrepancy between truly diagnosed food allergy and reports of food allergy symptoms by care seekers. In most studies currently available the characterization of patient groups is incomplete, because they did not distinguish between immunologic reactions and other kinds of food reactions. In analysing these adverse reactions, a thorough physical and psychological diagnostic approach is important. In our qualitative review, we present those diagnostic measures that are evidenced-based as well as clinically useful, and discuss the various psychological dimensions of adverse reactions to food. It is important to acknowledge the complex interplay between body and mind： Adults and children suffering from food allergy show impaired quality of life and a higher level of stress and anxiety. Pavlovian conditioning of adverse reactions plays an important role in maintaining symptoms. The role of personality, mood, or anxiety in food reactions is debatable. Somatoform disorders ought to be identified early to avoid lengthy and fiustrating investigations. A future task will be to improve diagnostic algorithms, to describe psychological aspects in clearly characterised patient subgroups, and to develop strategies for an optimized management of the various types of adverse reactions to food.

关键词： Food allergy Food reactions Diagnostic measures Psychological aspects Quality of life

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Skeleton-based canonical forms for non-rigid 3D shape retrieval

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Computational Visual Media 2016年第3期2卷 231-243页

作者： David Pickup Xianfang Sun paul L.Rosin Ralph R.martin School of Computer Science and Informatics Cardiff University

The retrieval of non-rigid 3D shapes is an important task. A common technique is to simplify this problem to a rigid shape retrieval task by producing a bending-invariant canonical form for each shape in the dataset to be searched. It is common for these techniques to attempt to "unbend" a shape by applying multidimensional scaling(MDS) to the distances between points on the mesh, but this leads to unwanted local shape distortions. We instead perform the unbending on the skeleton of the mesh, and use this to drive the deformation of the mesh itself. This leads to computational speed-up, and reduced distortion of local shape detail. We compare our method against other canonical forms: our experiments show that our method achieves state-of-the-art retrieval accuracy in a recent canonical forms benchmark, and only a small drop in retrieval accuracy over the state-of-the-art in a second recent benchmark, while being significantly faster.

关键词： canonical forms shape retrieval skeletons pose invariance

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Lead halide perovskite nanowires stabilized by block copolymers for Langmuir-Blodgett assembly

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Nano Research 2020年第5期13卷 1453-1458页

作者： Hao Liu martin Siron Mengyu Gao Dylan Lu Yehonadav Bekenstein Dandan Zhang Letian Dou A.paul Alivisatos Peidong Yang Department of Chemistry University of CaliforniaBerkeleyCalifornia 94720USA Department of Materials Science and Engineering University of CaliforniaBerkeleyCalifornia 94720USA Materials Science Division Lawrence Berkeley National LaboratoryBerkeleyCalifornia 94720USA Kavli Energy NanoScience Institute BerkeleyCalifornia 94720USA Center for Advanced Low-dimension Materials Donghua UniversityShanghai 201620China Department of Materials Science and Engineering Technion-Israel institute of technologyHaifa 3200003Israe Davidson School of Chemical Engineering Purdue UniversityWest LafayetteIndiana 47907USA

The rapid development of solar cells based on lead halide perovskites(LHPs)has prompted very active research activities in other closely-related *** nanostructures of such materials display superior optoelectronic ***,onedimensional(1D)LHPs nanowires show anisotropic optical properties when they are highly ***,the ionic nature makes them very sensitive to external environment,limiting their large scale practical ***,we introduce an amphiphilic block copolymer,polystyrene-block-poly(4-vinylpyridine)(PS-P4VP),to chemically modify the surface of colloidal CsPbBr3 *** resulting core-shell nanowires show enhanced photoluminescent emission and good colloidal stability against *** advantage of the stability enhancement,we further applied a modified Langmuir-Blodgett technique to assemble monolayers of highly aligned nanowires,and studied their anisotropic optical properties.

关键词： nanowires anisotropic optical properties aligned monolayer lead halide perovskites stability enhancement

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