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Bioelemental patterns in the cerebrospinal fluid as potential biomarkers for neurodegenerative disorders

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Neural Regeneration Research 2018年第8期13卷 1356-1357页

作者： Fabian Maass paul lingor Department of Neurology University Medical Center GoettingenGermany cluster of excellence nanoscale microscopy and molecular Physiology of the Brain(CNMPB) GoettingenGermany

Neurodegenerative disorders like Parkinson＇s disease （PD） or atypi- cal Parkinsonian syndromes including the different synucleinopa- thies and tauopathies are an important burden for patients, rela- tives, care pro... 详细信息

关键词： PD Bioelemental patterns in the cerebrospinal fluid as potential biomarkers for neurodegenerative disorders

ULK1 as a novel therapeutic target in neurodegeneration

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Neural Regeneration Research 2021年第6期16卷 1212-1213页

作者： Björn Friedhelm Vahsen paul lingor Nuffield Department of Clinical Neurosciences University of OxfordJohn Radcliffe HospitalOxfordUK Department of Neurology University Medical Center GöttingenGöttingenGermany Center for Biostructural Imaging of Neurodegeneration(BIN) DFG Cluster of Excellence Nanoscale Microscopy and Molecular Physiology of the Brain(CNMPB)University Medical Center GöttingenGöttingen Department of Neurology Rechts der Isar Hospital of the Technical University MunichMunichGermany

Axonal degeneration is an early and key pathophysiological feature of many traumatic and neurodegenerative disorders of the central nervous system(CNS),such as spinal cord injury(SCI),Parkinson’s disease(PD),and amyotrophic lateral sclerosis(ALS).As the regenerative capacity of injured axons is severely restricted in the CNS,axonal degeneration frequently results in the irreversible loss of neuronal connections causing progressive neurological deficits and clinical disability.A better understanding of the mechanisms of axon degeneration is therefore hoped to unravel new therapeutic avenues to combat neurodegeneration(lingor et al.,2012).

关键词： degeneration therapeutic neurodegeneration

Calcium channel inhibition-mediated axonal stabilization improves axonal regeneration after optic nerve crush

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Neural Regeneration Research 2016年第8期11卷 1245-1246页

作者： Vinicius T.Ribas paul lingor Brain Institute Federal University of Rio Grande do Norte NatalBrazil Department of Neurology University Medicine Gottingen GottingenGermany Center for Nanoscale Microscopy and Molecular Physiology of the Brain(CNMPB) Gottingen Germany

Axonal projections are specialized neuronal compartments and the longest parts of *** degeneration is a common pathological feature in many neurodegenerative disorders,such as Parkinson’s disease,amyotrophic lateral sclerosis,glaucoma,as well as in traumatic lesions of the central nervous system（CNS）,such as spinal cord injury.

关键词： axonal stabilization degeneration regeneration amyotrophic traumatic specialized neuronal glaucoma optic

Autophagy in degenerating axons following spinal cord injury: evidence for autophagosome biogenesis in retraction bulbs

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Neural Regeneration Research 2015年第2期10卷 198-200页

作者： Vinicius T.Ribas paul lingor Department of Neurology University Medicine Gottingen37075 Gottingen Germany (Ribas VT Lingor P) Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB) Gottingen Germany (Lingor P)

Macroautophagy （here autophagy） is a catabolic mechanism responsible for the degradation of bulk cytoplasm, long-lived proteins and organeUes. During autophagy, the cargos are engulfed by double-membrane structures named phagophores, which expand to form the autophagosomes. Subsequently, these autophagosomes fuse with lysosomes, in which the cytoplasmic cargos are degraded. Autophagy is a constitutive pro- cess, which plays an important role in cellular homeostasis. In primary neurons autophagosome formation occurs continuously and preferentially at the distal end of axons. On the other hand, autophagy is increased by different stresses, and its dysregulation or excessive induction may lead to detrimental effects. Many neurological disorders have been associated with alterations in the autophagic pathway and an increase in autophagy during axonal degeneration was described.

关键词： Autophagy in degenerating axons following spinal cord injury evidence for autophagosome biogenesis in retraction bulbs SCI

Cerebral venous sinus thrombosis after ChAdOx1 nCov- 19 vaccination with a misleading first cerebral MRI scan

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Stroke & Vascular Neurology 2021年第4期6卷 668-670页

作者： Benno Ikenberg Antonia Franziska Demleitner Thomas Thiele Benedikt Wiestler Katharina Götze Georg Mößmer paul lingor Department of Neurology Klinikum rechts der Isar der Technischen Universität MünchenMunchenGermany Institut für Immunologie und Transfusionsmedizin Universitätsmedizin GreifswaldGreifswaldGermany Department of Diagnostic und Interventional Neuroradiology Klinikum rechts der Isar der Technischen Universität MünchenMunchenGermany Department of Medicine III Klinikum rechts der Isar der Technischen Universität MünchenMunchenGermany Institute for Clinical Chemistry and Pathobiochemistry Klinikum rechts der Isar der Technischen Universität MünchenMunchenGermany

SUMMARY Vaccine-induced immune thrombotic thrombocytopenia(VITT)and cerebral venous sinus thrombosis(CVST)have been recently described as rare complications following vaccination against SARS-CoV-2 with vector *** report a case of a young woman who presented with VITT and cerebral CVST 7 days following vaccination with ChAdOx1 nCov-19(AstraZeneca).While the initial MRI was considered void of pathological findings,MRI 3 days later revealed extensive CVST of the transversal and sigmoidal sinus with intracerebral *** tests including a platelet-factor-4-induced platelet activation assay confirmed the diagnosis of *** with intravenous immunoglobulins and argatroban resulted in a normalisation of platelet counts and remission of CVST.

关键词： vaccination cerebral venous