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细胞流变学研究Ⅰ 肺癌患者红细胞粘弹性特性分析

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中国血液流变学杂志 1993年第1期3卷 1-6页

作者：龙勉陈浩马俐 kuo-li paul sung 重庆大学生物工程研究中心四川重庆630044 重庆市肿瘤研究所重庆630000 Department of Orthopedics and Institute For Biomedical Engineering University of California.

本文采用平面流动腔技术设计了狭缝流动测试系统，用于评价单个细胞的粘弹性特性，从而提供了一种能直接、定量地测定单个细胞变形能力等参数的方法。通过对１５例肺癌患者手术前、后及放疗前红细胞变形性等参数的测量，并同正常对照组... 详细信息

本文采用平面流动腔技术设计了狭缝流动测试系统，用于评价单个细胞的粘弹性特性，从而提供了一种能直接、定量地测定单个细胞变形能力等参数的方法。通过对１５例肺癌患者手术前、后及放疗前红细胞变形性等参数的测量，并同正常对照组比较，验证了该技术和方法。最后，对平面流动腔内的Ｈｅｌｅ—Ｓｈａｗ流动进行了讨论。

关键词：平面流动腔红细胞变形性肺癌

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Murine lung eosinophil activation and chemokine production in allergic airway inflammation

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Cellular & Molecular Immunology 2010年第5期7卷 361-374页

作者： C Edward Rose Jr Joanne A Lannigan paul Kim James J Lee Shu Man Fu Sun-sang J sung Division of Pulmonary and Critical Care Department of MedicineUniversity of Virginia School of MedicineCharlottesvilleVAUSA Department of Microbiology University of Virginia School of MedicineCharlottesvilleVAUSA Center for Immunity Inflammationand Regenerative Medicine and Division of NephrologyDepartment of MedicineUniversity of Virginia School of MedicineCharlottesvilleVAUSA Division of Pulmonary Medicine Department of Biochemistry and Molecular BiologyMayo Clinic ArizonaScottsdaleAZUSA

Eosinophils play important roles in asthma and lung *** models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these ***,little is known about tissue eosinophils in *** addition,little data on eosinophil chemokine production during allergic airway inflammation are *** this study,the properties and functions of homeostatic and activated eosinophils were *** from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell ***,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine *** intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal *** eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c *** were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed *** production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation.

关键词： allergy chemokines eosinophils lung mouse

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细胞流变学研究的现状和未来的发展

中国血液流变学杂志 1993年第3期3卷 40-42页

作者：龙勉吴云鹏 kuo-li paul sung 重庆大学生物工程研究中心四川重庆630044 Department of Orthopeadics and Institute For Biomedical Engineering University of Califortnia

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Distraction ligamentotaxis for complex proximal interphalangeal joint fracture dislocations:a clinical study and themodified pins rubber band traction system revisited

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Burns & Trauma 2018年第3期6卷 234-241页

作者： Cheng Hean Lo Simone H.Nothdurft Hye-sung Park Eldho paul James Leong Department of Plastic and Reconstructive Surgery Monash Health(Dandenong Hospital)135 David StDandenongVictoria 3175Australia Monash Health(Dandenong Hospital) 135 David StDandenongVictoria 3175Australia Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash University553 St Kilda RoadMelbourneVictoria 3004Australia Department of Surgery Monash UniversityWellington RoadClaytonVictoria 3800Australia

Background:The purpose of this study is to present our experience with the modified pins and rubber band traction system, discuss problems encountered, and make recommendations to optimize outcomes. Methods:Data was collected prospectively from November 2013 to March 2017 at a tertiary referral hospital in Melbourne, Australia. Patients with closed complex proximal interphalangeal joint fracture dislocations that were considered unsuitable for other surgical options were included in the study. Patients underwent dynamic skeletal distraction using the modified (Deshmukh) pins rubber band traction system. Outcomes were measured using the Nominal Rating Scale for pain;Disabilities of the Arm, Shoulder, and Hand (DASH) score;active and passive range of motion;patient rating scale;and complications. Results:Twenty patients underwent the procedure, and 19 were included in analyses. At the final follow-up assessment, an average of 62° and 77° was achieved for proximal interphalangeal joint active and passive range of motion, respectively. Pain levels were low (median score of 0 at rest and 1 ranging, out of 10). Four patients suffered minor pin site infections. Conclusion:Distraction ligamentotaxis is a useful part of the armamentarium, especially in the absence of more suitable procedures. It is important to select appropriate patients, educate, and ensure adherence to postoperative therapy. Employing the Deshmukh frame modification streamlines the theatre processes, and removal of wires at approximately 4 weeks minimizes risk of pin site infection.

关键词： Intra-articular fracture dislocations Proximal interphalangeal Pins rubber band distraction ligamentotaxis

Catabolic and Anabolic Enzymes Profiles in Trauma Tissues

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微循环学杂志 2009年第4期 72-73页

作者： KL paul sung College of Bioengineering Chongqing University Depart ment of Bioengineering and Orthopaedics University of California at San Diego

Tissues involved in trauma injury will result in lost of innervation and vascularity and reach an "acellular" state before tissue healing and regeneration *** post-trauma state,the oxygen and nutrition exchange will p... 详细信息

关键词： Catabolic and Anabolic Enzymes Profiles in Trauma Tissues ACL

Design of multi-functional dual hole patterned carbon nanotube composites with superhydrophobicity and durability

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Nano Research 2013年第6期6卷 389-398页

作者： sung-Hoon Park Eun-Hyoung Cho Jinseung Sohn paul Theilmann Kunmo Chu sunghee Lee Yoonchul Sohn Dongouk Kim Byunghoon Kim Samsung Advanced Institute of Technology Yong-in 446-712 R. O. Korea Department of Electrical Engineering University of California San Diego La Jolla California 92093 USA

Most current research on nanocomposites has focused on their bulk attributes, i.e., electrical, microwave, thermal, and mechanical properties. In practical applications, surface properties such as robustness against environmental contamination are critical design considerations if intrinsic properties are to be maintained. The aim of this research is to combine the bulk properties of nanocomposites with the superhydrophobic surface properties provided by imprinting techniques to create a single multi-functional system with enhanced bulk properties. We report the development of a highly conductive superhydrophobic nanotube composite, which is directly superimposed with a durable dual hole pattern through imprinting techniques. The dual hole pattern avoids the use of high slenderness ratio structures resulting in a surface which is robust against physical damage. Its stable superhydrophobic properties were characterized both theoretically and experimentally. By incorporating high aspect ratio carbon nanotubes （CNTs）, the dual patterned composites can also be effectively used for anti-icing and deicing applications where their superhydrophobic surface suppresses ice formation and their quick electric heating response at low voltage eliminates remaining frost. In addition, superior electromagnetic interference （EMI） shielding effectiveness （SE） was attained, with one of the highest values ever reported in the literature.

关键词： dual hole nanoimprint lithography superhydrophobic arbon nanotube durability multifunction

Effect of Oxidized LDL （ox-LDL） on Viscoelasticities of Erythrocyte and Its Molecular Mechanism of Membrane Protein

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Effect of Oxidized LDL （ox-LDL） on Viscoelasticities of Er...

Signal pathways underlying the MMP-2 production in ACL fibroblast under mechanical injury

2007中国生物医学工程联合学术年会

作者： Lanping Amy sung paul sung Department of Bioengineering and Center for Molecular Genetics University of CaliforniaSan DiegoLa JollaCA 92093USA College of Bioengineering Chongqing UniversityChongqing 400044PR China Department of Bioengineering and Center for Molecular GeneticsUniversity of CaliforniaSan DiegoLa JollaCA 92093USA

＜正＞In this research work, the effects of ox-LDL oxidative damage on erythrocyte membrane viscoelasticity and its molecular mechanism have been investigated with micropipette aspiration system, thiol radical determination and SDS-PAGE analysis of membrane protein. The experimental results indicated that erythrocyte membrane oxidative damage has a great influence upon the membrane mechanical properties. The oxidative damage led to decrease of free thiol radical contents in membrane protein and induce the cross-linking between different membrane proteins through formation of dithiol bond. The analysis of SDS-PAGE of erythrocyte membrane protein presented that a new high molecular weight （HMW） band was appeared before the spectrin1,2 and some new protein bands were appeared between spectrin1,2 and band3. The concentration of ox-LDL has induced the percentages of Band3, spectrin, B4.1, B4.2 and lower molecular bands （B5,6, B8） are decreased. The ox-LDL injuring times have the relative smaller effects on RBC membrane protein components. The decrease of free thoil radical should be the results of intermolecular and intramolecular association in erythrocyte membrane proteins. The experimental results suggested that thoil radical oxidative damage may be an important molecular mechanism of ox-LDL inducing changes of erythrocyte membrane viscoelasticity even whole cell deformation.

关键词： atherosclerosis erythrocyte oxidative damage viscoelasticity membrane protein

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Signal pathways underlying the MMP-2 production in ACL fibro...

Expression of matrix metalloprotease and tissue inhibitor of metalloprotease genes in human anterior cruciate ligament fibroblast

2008年全国生物流变学与生物力学学术会议

作者： KL paul sung "111"project Laboratory of Biomechanics and Tissue Repair Bioengineering CollegeChongqing UniversityChongqing 400044China Departments of Bioengineering and Orthopaedics University of CaliforniaSan Diego9500 Gilman DriveLa JollaCA 92093-0412USA

Introduction:Anterior cruciate ligament(ACL) is susceptible to injury and has a poor healing *** current standard treatment for PCL injuries in active adults with functional instability is ligament reconstruction but it does not restore the normal PCL *** is revealed that ligament fibroblasts,especially following ligament injuries release a high amount of matrix metalloproteinases(MMPs) that

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Expression of matrix metalloprotease and tissue inhibitor of...