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Remote electrocardiograph monitoring using a novel adhesive strip sensor: A pilot study

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World journal of Cardiology 2016年第10期8卷 559-565页

作者： Charles j Bruce Dorothy j Ladewig Virend K Somers Kevin E Bennet scott Burrichter Christopher G scott Lyle j Olson paul A Friedman Division of Cardiovascular Diseases Mayo Clinic Mayo Clinic Ventures Mayo Clinic Division of Engineering Mayo Clinic Division of Preventice Biomedical Statistics and Informatics Mayo Clinic

The increase in health care costs is not sustainable and has heightened the need for innovative low cost effective strategies for delivering patient care. Remote monitoring holds great promise for preventing or shortening duration of hospitalization even while improving quality of care. We therefore conducted a proof of concept study to examine the quality of electrocardiograph (ECG) recordings obtained remotely and to test its potential utility in detecting harmful rhythms such as atrial fibrillation. We tested a novel adhesive strip ECG monitor and assessed the ECG quality in ambulatory individuals. 2630 ECG strips were analyzed and classified as: Sinus, atrial fibrillation (AF), indeterminate, or other. Four readers independently rated ECG quality: 0: Noise; 1: QRS complexes seen, but P-wave indeterminate; 2: QRS complexes seen, P-waves seen but poor quality; and 3: Clean QRS complexes and P-waves. The combined average rating was: Noise 12%; R-R, no P-wave 10%; R-R, no PR interval 18%; and R-R with PR interval 60% (if Sinus). If minimum diagnostic quality was a score of 1, 88% of strips were diagnostic. There was moderate to high agreement regarding quality (weighted Kappa statistic values; 0.58 to 0.76) and high level of agreement regarding ECG diagnosis (ICC = 0.93). A highly variable RR interval (HRV ≥ 7) predicted AF (AUC = 0.87). The monitor acquires and transmits diagnostic high quality ECG data and permits characterization of AF.

关键词： Remote Electrocardiograph Monitoring Atrial fibrillation Novel Sensor

Improving rice photosynthesis and yield through trehalose 6-phosphate signaling

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Molecular Plant 2022年第4期15卷 586-588页

作者： Matthew j.paul javier A.Miret Cara A.Griffiths Plant Science Rothamsted ResearchAL52JQ HarpendenHertfordshireUK

THE T6P-SnRK1 SIGNALING PATHWAY IN PLANTS,The biosynthetic route for the synthesis of trehalose in plants is through a low-flux pathway that leads to the accumulation of micromolar amounts of trehalose 6-phosphate(T6P)and trehalose when sucrose is available.T6P accumulates in proportion to sucrose(Lunn et al.,2006)as an indispensable regulator of carbohydrate utilization(Schluepmann et al.,2003).At least some of the indispensability of T6P and its profound and widespread effects on plant growth and development can be explained through T6P inhibition of the SNF1-related protein kinase SnRK1(Zhang et al.,2009),a central regulator of plant responses to carbon and energy status.

关键词： molar synthesis explained

Spatial variability in carbon dioxide exchange processes within wet sedge meadows in the Canadian High Arctic

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Advances in Polar Science 2021年第1期32卷 1-19页

作者： Claire M.WRIGHT Amy C.BLASER paul M.TREITZ Neal A.scott Department of Geography and Planning Queen’s UniversityKingstonOntarioCanadaK7L 3N6

Wet sedge meadows are the most productive plant communities in the High ***,the controls on carbon dioxide(CO_(2))exchange processes within wet sedge communities-and the scale at which they operate-are poorly ***,the factors controlling CO_(2)exchange of wet sedge meadows experiencing different moisture regimes are *** data are used to create predictive models of CO_(2)exchange on multiple temporal *** chamber systems recorded CO_(2)fluxes at 30-minute intervals at wet sedge sites in the Canadian High Arctic from june to August in 2014 and *** chambers were also deployed over a larger spatial extent in *** results show that wet sedge communities were strong CO_(2)sinks during the growing season(−7.67 to−44.36 g C·m^(−2)).CO_(2)exchange rates in wetter and drier areas within wet sedge meadows differed significantly(Wilcoxon,p<0.001),suggesting that soil moisture regimes within vegetation types influence net CO_(2)*** Forest models explained a significant amount of the variability in CO_(2)flux rates over time(R2=0.46 to 0.90).The models showed that the drivers of CO_(2)exchange in these communities vary *** moisture regimes indirectly influenced CO_(2)fluxes given that they exhibit different vegetation and temperature-response *** suggest that the response of a single vegetation type to environmental changes may vary depending on microenvironment variability within that community.

关键词： High Arctic carbon dioxide exchange wet sedge soil moisture

On the origin of X-shaped radio galaxies

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Research in Astronomy and Astrophysics 2012年第2期12卷 127-146页

作者： Gopal-Krishna Peter L.Biermann Lszló .Gergely paul j.Wiita National Centre for Radio Astrophysics TIFRPune University Campus Max Planck Institute for Radioastronomy Department of Physics & Astronomy University of Bonn Department of Physics & Astronomy University of Alabama Department of Physics University of Alabama at Huntsville KIT-Karlsruhe Institute for Technology Institute for Experimental Nuclear Physics Department of Theoretical Physics University of Szeged Department of Experimental Physics University of Szeged Department of Physics The College of New Jersey

After a brief, critical review of the leading explanations proposed for the small but important subset of radio galaxies showing an X-shaped morphology （XRGs） we propose a generalized model, based on the jet-shell interaction and spin- flip hypotheses. The most popular scenarios for this intriguing phenomenon invoke either hydrodynamical backflows and over-pressured cocoons or rapid jet reorienta- tions, presumably from the spin-flips of central engines following the mergers of pairs of galaxies, each of which contains a supermassive black hole. We confront these models with a number of key observations, and thus argue that none of the models is capable of explaining the entire range of the salient observational properties of XRGs, although some of the arguments raised in the literature against the spin-flip scenario are probably not tenable. We then propose a new scenario which also involves galac- tic mergers but would allow the spin of the central engine to maintain its direction. Motivated by detailed multi-band observations of the nearest radio galaxy, Centaurus A, this new model emphasizes the role of the interactions between the jets and the shells of stars and gas that form and rotate around the merged galaxy and can cause temporary deflections of the jets, occasionally giving rise to an X-shaped radio struc- ture. Although each model is likely to be relevant to a subset of XRGs, the bulk of the evidence indicates that most of them are best explained by the jet-shell interaction or spin-flip hypotheses.

关键词： galaxies: active - galaxies: jets - gravitational waves - ISM - radiocontinuum: galaxies

Characteristics of a gold-doped electrode for application in high-performance lithium-sulfur battery

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journal of Energy Chemistry 2022年第1期31卷 116-128,I0004页

作者： Vittorio Marangon Daniele Di Lecce Dan j.L.Brett paul R.Shearing jusef Hassoun University of Ferrara Department of Chemical and Pharmaceutical SciencesVia Fossato di Mortara 17Ferrara44121Italy Electrochemical Innovation Lab Department of Chemical EngineeringUCLLondon WC1E 7JEUnited Kingdom The Faraday Institution Quad OneBecquerel AveHarwell CampusDidcot OX11 ORAUnited Kingdom National Interuniversity Consortium of Materials Science and Technology(INSTM) University of Ferrara Research UnitUniversity of FerraraVia Fossato di Mortara17Ferrara 44121Italy

Bulk sulfur incorporating 3 wt% gold nano-powder is investigated as possible candidate to maximize the fraction of active material in the Li-S battery *** material is prepared via simple mixing of gold with molten sulfur at 120℃,quenching at room temperature,and *** comprehensive study reports relevant electrochemical data,advanced X-ray computed tomography(CT)imaging of the positive and negative electrodes,and a thorough structural and morphological characterization of the S:Au 97:3 w/w *** cathode exhibits high rate capability within the range from C/10 to 1C,a maximum capacity above 1300 mAh gs^(-1),and capacity retention between 85%and 91%after 100 cycles at 1C and C/3 *** novel formulation enables a sulfur fraction in the composite cathode film as high as 78 wt%,an active material loading of 5.7 mg cm^(-2),and an electrolyte/sulfur(E/S)ratio of 5μL mg^(-1),which lead to a maximum areal capacity of 5.4 mAh cm^(-2).X-ray CT at the micro-and nanoscale reveals the microstructural features of the positive electrode that favor fast conversion kinetics in the *** analysis of sulfur distribution in the porous cathode displays that electrodeposition during the initial cycle may trigger an activation process in the cell leading to improved ***,the tomography study reveals the characteristics of the lithium anode and the cell separator upon a galvanostatic test prolonged over 300 cycles at a 2C rate.

关键词： Lithium-sulfur battery Sulfur loading Electrolyte/sulfur ratio Gold nanoparticles X-ray tomography

Arthropod prey of imported fire ants （Hymenoptera： Formicidae） in Mississippi sweetpotato fields

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Insect Science 2013年第4期20卷 467-471页

作者： Tahir Rashid jian Chen james T. Vogt paul j. McLeod Aicorn State University Extension~Research Demonstration Farm & Tech Transfer Center Mound Bayou Mississippi USDA ARS Bio- logical Control of Pests Research Unit Stoneville Mississippi USDA FS Inventory & Analysis Knoxville Tennessee Department of Entomology University of Arkansas Fayetteville Arkansas United States

The red imported fire ants, Solenopsis invicta （Buren）, are generally considered pests. They have also been viewed as beneficial predators feeding on other insect pests of various agroecosystems. This study documents the foraging habits of fire ants in a sweetpotato field in Mississippi. Fire ant foraging trails connecting outside colonies to a sweetpotato field were exposed and foraging ants moving out of the field toward the direction of the colony were collected along with the solid food particles they were carrying. The food material was classified as arthropod or plant in origin. The arthropod particles were identified to orders. Fire ant foragers carried more arthropods than plant material. Coleoptera and Homoptera were the most abundant groups preyed upon. These insect orders contain various economically important pests of sweetpotato. Other major hexapod groups included the orders Hemiptera, Diptera and Collembola. The quantity of foraged material varied over the season. No damage to sweetpotato roots could be attributed to fire ant feeding. Imported fire ant foraging may reduce the number of insect pests in sweetpotato fields.

关键词： foraging imported fire ant predation Solenops& invicta sweetpotato

Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010

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World journal of Gastroenterology 2011年第7期17卷 867-897页

作者： Chakshu Sharma Karim M Eltawil paul D Renfrew Mark j Walsh Michele Molinari Department of Surgery Queen Eliz-abeth Ⅱ Health Sciences Center Dalhousie University

Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic.

关键词： Diagnosis Epidemiology Palliation Pancreatic cancer Therapy

An improved culturing method for opiine fruit fly parasitoids and its application to parasitoid monitoring in the field

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Insect Science 2018年第1期25卷 99-108页

作者： Ayad Masry Michael j. Furlong Anthony R. Clarke john paul Cunningham School of Earth Environmental and Biological Sciences School Queensland University of Technology (QUT) Brisbane Queensland Australia School of Biological Sciences the University of Queensland St Lucia Queensland Australia plant Biosecurity Cooperative Research Centre Bruce ACT Australia Department of Economic Development Jobs Transport and Resources AgriBio Centre La Trobe University Bundoora Victoria Australia

Good culturing methods play an important role in the study of insect behavior and its application to pest management. Here, we describe and validate a new method for rearing the parasitoid wasp, Diachasmirnorpha kraussii, which attacks some of the world＇s worst fruit fly pests and is an internationally used biological control agent. Our method differs from standard culturing approaches by presenting adult wasps with host- infested artificial media within a ＂culturing bag,＂ which mimics a natural （fruit） oviposition substrate. In laboratory trials using wild collected D. kraussii, the culturing bag method was compared to the use of host-infested nectarines, and a commonly used laboratory method of presenting host-infested artificial media within Petri dishes. The culturing bag method proved to be a significant improvement on both methods, combining the advantages of high host survival in artificial media with parasitism levels that were the equivalent to those recorded using host-infested fruits. In our field study, culturing bags infested with the Queensland fruit fly, Bactrocera tryoni, and hung in a mixed peach and nectarine orchard proved to be effective ＂artificial fruits＂ attracting wild D. kraussii for oviposition. Significantly more adult wasps were reared from the culturing bags compared to field collected fruits. This was shown to be due to higher fruit fly larval density in the bags, as similar percentage parasitism rates were found between the culturing bags and ripe fruits. We discuss how this cheap, time-efficient method could be applied to collecting and monitoring wild D. kraussii populations in orchards, and assist in maintaining genetic variability in parasitoid laboratory cultures.

关键词： Bactrocera biological control fruit fly mass rearing natural enemies Tephritidae wasp

Irritable bowel syndrome: A microbiome-gut-brain axis disorder?

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World journal of Gastroenterology 2014年第39期20卷 14105-14125页

作者： paul j Kennedy john F Cryan Timothy G Dinan Gerard Clarke 1.15 Biosciences Institute Department of Psychiatry Alimentary Pharmabiotic Centre University College Cork Cork Ireland Department of Anatomy and Neuroscience Alimentary Pharmabiotic CentreUniversity College CorkCork Ireland

Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions.

关键词： Irritable bowel syndrome Microbiome Anxiety Tryptophan Abdominal pain Gastrointestinal motility Cognition