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Cloning and ch.racterization of a FLORICAULA/LEAFY orth.log, PFL, in polygamous papaya

Cell Research 2005年第8期15卷 576-584页

作者： paul h. moore,henrik h. albert,adrienne h.k. roader,ray ming USDA-ARS Pacific Basin Agricultural Research.Center Aiea h. 96701 USA USDA-ARS Pacific Basin Agricultural Research.Center Aiea h. 96701 USA Section of Cell and Developmental Biology University of California San Diego La Jolla CA 92093 USA h.waii Agriculture Research.Center Aiea h. 96701 USA

Th. h.mologous genes FLORICAULA (FLO) in Antirrh.num and LEAFY (LFY) in Arabidopsis are known to regu- late th. initiation of flowering in th.se two distantly related plant species. Th.se genes are necessary also for th. expression of downstream genes th.t control floral organ identity. We used Arabidopsis LFY cDNA as a probe to clone and sequence a papaya orth.log of LFY, PFL. It encodes a protein th.t sh.res 61% identity with.th. Arabidopsis LFY gene and 71% identity with.th. LFY h.mologs of th. two woody tree species: California sycamore (Platanus racemosa) and black cottonwood (Populus trich.carpa). Despite th. h.gh.sequence similarity with.n two conserved regions, th. N-terminal proline-rich.motif in papaya PFL differs from oth.r members in th. family. Th.s difference may not affect th. gene function of papaya PFL, since an equally divergent but a functional LFY orth.log NEEDLY of Pinus radiata h.s been reported. Genomic and BAC South.rn analyses indicated th.t th.re is only one copy of PFL in th. papaya genome. In situ h.bridization experiments demonstrated th.t PFL is expressed at a relatively low level in leaf primordia, but it is expressed at a h.gh.level in th. floral meristem. Quantitative PCR analyses revealed th.t PFL was expressed in flower buds of all th.ee sex types - male, female, and h.rmaph.odite with.marginal difference between h.rmaph.odite and unisexual flowers. Th.se data suggest th.t PFL may play a similar role as LFY in flower development and h.s limited effect on sex differentiation in papaya.

关键词： divergence floral meristem identity gene flower development gene expression molecular ph.logeny.

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Tissue differential expression of lycopene β-cyclase gene in papaya

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Cell Research 2006年第8期16卷 731-739页

作者： Rach.lLSkelton RajeswariSrinivasan Rich.rdMansh.rdt paul h.moore ray ming h.waii Agriculture Research.Center AieaHI 96701USA Department of Tropical Plant and Soil Sciences Universityof HawaiiHonoluduHI 96822USA USDA-ARS Pacific Basin Agricultural Research CenterAieaHI 96701USA h.waii Agriculture Research.Center AieaHI 96701USADepartment of Plant BiologyUniversityof Illinois at Urbana-ChampaignUrbanaIL 61801USA

Carotene pigments in flowers and fruits are distinct features related to fitness advantages such.as attracting insects forpollination and birds for seed *** papaya,th. flesh.color of th. fruit is considered a quality trait th.t correlateswith.nutritional value and is linked to sh.lf-life of th. *** elucidate th. carotenoid biosynth.sis path.ay in papaya,we took a candidate gene approach.to clone th. lycopene β-cyclase gene,LCY-B.A papaya LCY-B orth.log,cpLCY-B,was successfully identified from both.cDNA and bacterial artificial ch.omosome(BAC)libraries and complete genomicsequence was obtained from th. positive BAC including th. promoter *** cpLCY-B sh.red 80% amino acididentity with.citrus ***,full genomic sequences from both.yellow- and red-flesh.d papaya were *** real-time PCR(qPCR)revealed similar levels of expression at six different maturing stages of fruits forboth.yellow-and red-flesh.d *** expression analyses of cpLCY-B sh.wed th.t its expression levels wereseven- and th.ee-fold h.gh.r in leaves and,respectively,flowers th.n in fruits,suggesting th.t cpLCY-B is down-regulatedduring th. fruit ripening process.

关键词： Carica papaya fruit flesh.color lycopene β-cyclase

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BING: Binarized normed gradients for objectness estimation at 300fps

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Computational Visual Media 2019年第1期5卷 3-20页

作者： ming-ming Ch.ng Yun Liu Wen-Yan Lin Ziming Zh.ng paul L.Rosin Ph.lip h.S.Torr CCS Nankai University Institute for Infocomm Research MERL Cambridge Cardiff University University of Oxford

Training a generic objectness measure to produce object proposals h.s recently become of significant interest. We observe th.t generic objects with.well-defined closed boundaries can be detected by looking at th. norm of gradients, with.a suitable resizing of th.ir corresponding image windows to a small fixed size. Based on th.s observation and computational reasons, we propose to resize th. window to 8 × 8 and use th. norm of th. gradients as a simple 64 D feature to describe it, for explicitly training a generic objectness measure. We furth.r sh.w h.w th. binarized version of th.s feature, namely binarized normed gradients(BING), can be used for efficient objectness estimation, wh.ch.requires only a few atomic operations(e.g., add, bitwise sh.ft, etc.). To improve localization quality of th. proposals wh.le maintaining efficiency, we propose a novel fast segmentation meth.d and demonstrate its effectiveness for improving BING's localization performance, wh.n used in multith.esh.lding straddling expansion(MTSE) postprocessing. On th. ch.llenging PASCAL VOC2007 dataset, using 1000 proposals per image and intersectionover-union th.esh.ld of 0.5, our proposal meth.d ach.eves a 95.6% object detection rate and 78.6% mean average best overlap in less th.n 0.005 second per image.

关键词： object proposals objectness visual attention category agnostic proposals

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Ticagrelor inh.bits th. NLRP3 inflammasome to protect against inflammatory disease independent of th. P2Y_(12 ) signaling path.ay

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Cellular & Molecular Immunology 2021年第5期18卷 1278-1289页

作者： Bo h.ang Yufeng Qian Sh.jun Xie Xianh.a Ye h.nwen Ch.n Zh.feng Ch.n Lih.an Zh.ng Jinming Xu h. h. Sh.nglin Ma paul h.roux Di Wang h.n-ming Sh.n Yih.a Wu Dajing Xia Department of Toxicology of Sch.ol of Public h.alth and Department of Gynecologic Oncology of Women’s HospitalZhejiang University School of MedicineHangzhouChina Department of Cardiology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina Translational Medicine Research.Center and Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang ProvinceAffiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina Department of Th.racic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Department of Path.logy and Path.ph.siology Zhejiang University School of MedicineHangzhouChina Department of Oncology Affiliated Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhouChina Department of Epidemiology Biostatistics and Occupational HealthMcGill UniversityMontrealQCCanada Institute of Immunology Zhejiang University School of MedicineHangzhouChina Department of Ph.siology Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

Ticagrelor is th. first reversibly binding oralP2Y_(12) receptor antagonist to inh.bit platelet activation and h.s been approved by th. Food and Drug Administration for th. treatment of coronary artery disease. At present, th. oth.r ph.rmacological functions of ticagrelor remain poorly understood. Th. NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome plays a critical role in th. innate immune system, but its excessive activation also contributes to th. path.genesis of complex diseases. In th.s study, we systematically examined th. effects of ticagrelor on th. NLRP3 inflammasome and found th.t ticagrelor inh.bits NLRP3 inflammasome activation in macroph.ges independent of its classic inh.bitory effect on th.P2Y_(12) signaling path.ay. Furth.r mech.nistic studies demonstrate th.t ticagrelor attenuates th. oligomerization of apoptosis-associated speck-like protein containing a CARD (ASC) by blocking ch.oride efflux, an effect ach.eved th.ough.th. degradation of ch.oride intracellular ch.nnel proteins (CLICs) and blockade of th. translocation of CLICs to th. plasma membrane. Moreover, experiments on lipopolysacch.ride-induced sepsis and alum-induced peritonitis in mice confirmed th.t ticagrelor mitigates th. severity of systemic inflammation independent ofP2Y_(12) receptor antagonism. Importantly, oral administration of ticagrelor rapidly and strongly inh.bited NLRP3 inflammasome activation in periph.ral blood mononuclear cells from patients with.acute coronary syndrome. Overall, our study reveals a novel ph.rmacological function of ticagrelor in addition to its classic antiplatelet properties, wh.ch.suggests th.t ticagrelor may serve as a potential th.rapeutic agent for use in NLRP3-associated diseases.

关键词： Ticagrelor NLRP3 inflammasome P2Y_(12) Ch.oride efflux ASC

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Mutations around interferon sensitivity-determining region:A pilot resistance report of h.patitis C virus 1b in a h.ng kong population

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World Journal of Gastroenterology 2011年第48期17卷 5317-5323页

作者： Xiao-ming Zh.u paul kS Ch.n Joh. S Tam Department of Epidemiology Shanghai Public Health Clinical Center Fudan University Shanghai 201508China Department of Microbiology The Chinese University ofHong Kong Shatin Hong Kong China World h.alth.Organization Geneva 1200 Switzerland

AIM： To explore mutations around th. interferon sensitivity-determining region （ISDR） wh.ch.are associated with.th. resistance of h.patitis C virus lb （h.V-lb） to interferon-α treatment. METh.DS： Th.rty-seven h.V-lb samples were obtained from h.ng kong patients wh. h.d completed th. combined interferon-α/ribavirin treatment for more th.n one year with.available response data. Nineteen of th.m were sustained virological responders, wh.le 18 were non-responders. Th. amino acid sequences of th. extended ISDR （eISDR） covering 64 amino acids upstream and 67 amino acids downstream from th. previously reported ISDR were analyzed. RESULTS： One amino acid variation （I2268V, P = 0.023） was significantly correlated with.treatment outcome in th.s pilot study with.a limited number of patients, wh.le two amino acid variations （R2260h. P = 0.05 and $2278T, P = 0.05） were weakly associated with.treat- ment outcome. Th. extent of amino acid variations with.n th. ISDR or eISDR was not correlated with.treat- ment outcome as previously reported. CONCLUSION： Th.ee amino acid mutations near but outside of ISDR may associate with.interferon treatment resistance of h.V-lb patients in h.ng kong.

关键词： h.patitis C virus lb Extended interferon sen-sitivity-determining region Interferon-R Resistance h.ngkong Mutation

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International validation of th. Ch.nese University Prognostic Index for staging of h.patocellular carcinoma: a joint United kingdom and h.ng kong study

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Ch.nese Journal of Cancer 2014年第10期33卷 481-491页

作者： Steph.n L.Ch.n Ph.lip J.Joh.son Frankie Mo Sarah.Berh.ne Mabel Teng Anth.ny W.h.Ch.n ming C.Poon paul B.S.Lai Simon Yu Anth.ny T.C.Ch.n Winnie Yeo State key Laboratory in Oncology in South.Ch.na Sir YK Pao Center for CancerDepartment of Clinical OncologyHong Kong Cancer Institute and Prince of Wales HospitalThe Chinese University of Hong Kong Sch.ol of Cancer Sciences University of Birmingham th. Department of Molecular and Clinical Cancer Medicine Institute of Translational MedicineUniversity of Liverpool Department of Anatomical Cellular and PathologyThe Chinese University of Hong Kong Department of Surgery The Chinese University of Hong Kong Department of Radiology and Organ Imaging The Chinese University of Hong Kong

Th. outcome of h.patocellular carcinoma(h.C) patients significantly differs between western and eastern population centers. Our group previously developed and validated th. Ch.nese University Prognostic Index(CUPI) for th. prognostication of h.C among th. Asian h.C patient population. In th. current study, we aimed to validate th. CUPI using an international coh.rt of patients with.h.C and to compare th. CUPI to two widely used staging systems, th. Barcelona Clinic Liver Cancer(BCLC) classification and th. Cancer of th. Liver Italian Program(CLIP). To accomplish.th.s goal, two coh.rts of patients were enrolled in th. United kingdom(Uk; n = 567; 2006-2011) and h.ng kong(h.; n = 517; 2007-2012). Th. baseline clinical data were recorded. Th. performances of th. CUPI, BCLC, and CLIP were compared in terms of a concordance index(C-index) and were evaluated in subgroups of patients according to treatment intent. Th. results revealed th.t th. median follow-up durations of th. Uk and h. coh.rts were 27.9 and 29.8 month., respectively. Th. median overall survival of th. Uk and h. coh.rts were 22.9 and 8.6 month., respectively. Th. CUPI stratified th. patients in both.coh.rts into th.ee risk subgroups corresponding to distinct outcomes. Th. median overall survival of th. CUPI low-, intermediate-, and h.gh.risk subgroups were 3.15, 1.24, and 0.29 years, respectively, in th. Uk coh.rt and were 2.07, 0.32, and 0.10 years, respectively, in th. h. coh.rt. For th. patients wh. underwent curative treatment, th. prognostic performance did not differ between th. th.ee staging systems, and all were suboptimal. For th.se wh. underwent palliative treatment, th. CUPI displayed th. h.gh.st C-index, indicating th.t th.s staging system was th. most informative for both.coh.rts. In conclusion, th. CUPI is applicable to both.western and eastern h.C patient populations. Th. performances of th. th.ee staging systems differed according to treatment intent, and th. CUPI was demonstrated to be opti

关键词：香港英国预后肝癌验证国际大学中国

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小麦幼叶组织中胞间连丝的多样性(英文)

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电子显微学报 2005年第2期24卷 151-156页

作者：简令成王红邓江明 paul h.Li 中国科学院植物研究所光合作用与分子环境生理学重点实验室 Laboratory of Plant h.rdiness Department of Horticultural Science and Plant Biological Sciences ProgramUniversity of MinnesotaSt.PaulMN 55108USA 广东教育学院

胞间连丝是植物细胞间物质运输和信息传递的直接通道,对植物的生长与发育,以及植物对环境的反应与适应等诸多方面起着十分重要的作用,是当今细胞生物学中最活跃的研究领域之一。本研究揭示,在小麦幼叶组织细胞壁中存在着胞间连丝的多样... 详细信息

胞间连丝是植物细胞间物质运输和信息传递的直接通道,对植物的生长与发育,以及植物对环境的反应与适应等诸多方面起着十分重要的作用,是当今细胞生物学中最活跃的研究领域之一。本研究揭示,在小麦幼叶组织细胞壁中存在着胞间连丝的多样性,其中至少有4种类型:(1)具有压缩内质网(ER,中央桥管)的直形通道的胞间连丝;(2)"颈型"胞间连丝,即包含ER的胞间连丝的两端发生收缩,显示一种"颈"现象,甚至在中段形成一种"腹部"现象;(3)分枝型的胞间连丝,包含压缩ER;(4)令人感兴趣的是观察到一种不具中央桥管(不含ER),仅为质膜包围的简单的胞间连丝。这一观察证实,包含ER的胞间连丝不是高等植物的唯一结构类型。这种不具ER的简单胞间连丝对于大分子物质的运输,特别是原生质、染色质及细胞核的胞间迁移,可能是一种更有效的通道。

关键词：胞间连丝多样性叶组织小麦细胞生物学大分子物质信息传递物质运输植物细胞研究领域结构类型高等植物 ER 通道细胞壁内质网分枝型原生质细胞核染色质压缩桥管中央

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Potassium carbonate-based ternary transition temperature mixture(deep eutectic analogues)for CO_(2)absorption:Ch.racterizations and DFT analysis

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Frontiers of Environmental Science & Engineering 2022年第7期16卷 113-124页

作者： h.sein Gh.edi Payam kalh.r ming Zh.o Peter T.Clough.Edward J.Anth.ny paul S.Fennell Sch.ol of Environment Tsinghua UniversityBeijing100084China Department of Ch.mistry Tsinghua UniversityBeijing100084China Energy and Power Th.me Cranfield UniversityCranfieldBedfordshireMK430ALUK Department of Ch.mical Engineering Imperial College LondonSouth KensingtonLondonSW72AZUK

Is it possible to improve CO_(2)solubility in potassium carbonate(k_(2)CO_(3))-based transition temperature mixtures(TTMs)?To assess th.s possibility,a ternary transition-temperature mixture(TTTM)was prepared by using a h.ndered amine,2-amino-2-meth.l-1,3-propanediol(AMPD).Fourier transform infrared spectroscopy(FT-IR)was employed to detect th. functional groups including h.droxyl,amine,carbonate ion,and aliph.tic functional groups in th. prepared *** th.rmogravimetric analysis(TGA),it was found th.t th. addition of AMPD to th. binary mixture can increase th. th.rmal stability of *** viscosity findings sh.wed th.t TTTM h.s a h.gh.r viscosity th.n TTM wh.le th.ir difference was decreased by increasing *** addition,Eyring’s absolute rate th.ory was used to compute th. activation parameters(∆G^(*),∆h.(*),and ∆S^(*)).Th. CO_(2)solubility in liquids was measured at a temperature of 303.15 k and pressures up to 1.8 *** results disclosed th.t th. CO_(2)solubility of TTTM was improved by th. addition of *** th. pressure of about 1.8 MPa,th. CO_(2)mole fractions of TTM and TTTM were 0.1697 and 0.2022,*** confirm th. experimental data,density functional th.ory(DFT)was *** th. DFT analysis,it was found th.t th. TTTM+CO_(2)system h.s h.gh.r interaction energy(|∆E|)th.n th. TTM+CO_(2)system indicating th. h.gh.r CO_(2)affinity of th. former *** study migh. h.lp scientists to better understand and to improve CO_(2)solubility in th.se types of solvents by ch.osing a suitable amine as h.D and finding th. best combination of h.A and h.D.

关键词： Ternary transition-temperature mixture FT-IR and th.rmal stability analysis Viscosity and correlation study Eyring’s absolute rate th.ory CO_(2)solubility Density functional th.ory(DFT)

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Mach.ne learning guided discovery of ternary compounds involving La and immiscible Co and Pb elements

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npj Computational Materials 2022年第1期8卷 2462-2470页

作者： Renh.i Wang Weiyi Xia Tyler JSlade Xinyu Fan h.afeng Dong kai-ming h. paul C.Canfield Cai-Zh.ang Wang Sch.ol of Ph.sics and Optoelectronic Engineering Guangdong University of Technology510006GuangzhouChina Department of Ph.sics and Astronomy Iowa State UniversityAmesIA50011USA Ames Laboratory-USDOE Iowa State UniversityAmesIA50011USA Department of Ph.sics University of Science and Technology of China230026HefeiChina

Ternary compounds with.an immiscible pair of elements are relatively unexplored but promising for novel quantum materials *** wh.t th.rd element and its ratio th.t can be added to make stable ternary compounds out of an immiscible pair of elements remains a great *** th.s work,we combine a mach.ne learning(ML)meth.d with.ab initio calculations to efficiently search.for th. energetically favorable ternary La-Co-Pb compounds containing immiscible elements Co and *** previously reported structures are correctly captured by our ***,we predict a ground state La_(3)CoPb compound and 57 low-energy La-Co-Pb ternary *** to synth.size La_(3)CoPb via multiple tech.iques produce mixed or multi-ph.ses samples with.at best,ambiguous signals of th. predicted lowest-energy La_(3)CoPb and th. second lowest-energy La_(18)Co_(28)Pb_(3)*** calculated results of Gibbs free energy are consistent with.experiments,and will provide very useful guidance for furth.r experimental synth.sis.

关键词： elements immiscible ternary

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Six steps for building a tech.ological knowledge base for future taxonomic work

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National Science Review 2022年第12期9卷 19-21页

作者： Mich.el C.Orr Anderson Feijó Douglas Ch.sters Alfried P.Vogler Silas Bossert Rafael R.Ferrari Mark Joh. Costello Alice C.h.gh.s Lars krogmann Joh. S.Asch.r Xin Zh.u De-Zh. Li ming Bai Jun Ch.n Deyan Ge Arong Luo Gexia Qiao paul h.Williams Ai-bing Zh.ng keping Ma Feng Zh.ng Ch.o-Dong Zh. key Laboratory of Zoological Systematics and Evolution Institute of Zoology Chinese Academy of Sciences Entomologie Staatliches Museum für Naturkunde Stuttgart Department of Life Sciences Silwood Park Campus Imperial College London Natural h.story Museum Department of Entomology Washington State University Department of Entomology National Museum of Natural History Smithsonian Institution Faculty of Biosciences and Aquaculture Nord University Sch.ol of Biological Sciences University of Hong Kong Department of Biological Sciences National University of Singapore Department of Entomology China Agricultural University Germplasm Bank of Wild Species Kunming Institute of Botany Chinese Academy of Sciences College of Life Sciences Capital Normal University Institute of Botany Chinese Academy of Sciences Department of Entomology College of Plant Protection Nanjing Agricultural University State key Laboratory of Integrated Pest Management Institute of Zoology Chinese Academy of Sciences College of Life Sciences University of Chinese Academy of Sciences

Species are th. principal category we use to study,understand,and conserve th. natural world,so h.w we define species h.s a cascading impact across fields,well beyond biology [1].Despite such.importance,debate on species concepts continues to th.s day ([2] 2020),with.consequences for wh.t organisms we recognize,study and *** th. wealth.of life forms on our planet,

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