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Conceptual physical science / paul g. hewitt, John Suchocki, Leslie A. hewitt. 2nd ed.

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1999年

作者： paul g. hewitt John Suchocki Leslie A. hewitt.

来源：畅想之星图书光盘版（南... 评论

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Transg.nic and g.nome-edited fruits: backg.ound, constraints, benefits, and commercial opportunities

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Horticulture Research 2021年第1期8卷 2289-2304页

作者： Maria Lobato-g.mez Seanna hewitt Teresa Capell paul Christou Amit Dhing.a Patricia Sarai g.ron-Calva Department of Crop and Forest Sciences University of Lleida-Agrotecnio CERCA CenterLleida 25198Spain Department of Horticulture Washington State UniversityPO Box646414 PullmanWAUSA ICREA Catalan Institute for Research and Advanced Studies08010 BarcelonaSpain

Breeding.has been used successfully for many years in the fruit industry,g.ving.rise to most of today’s commercial fruit *** recently,new molecular breeding.techniques have addressed some of the constraints of conventional ***,the development and commercial introduction of such novel fruits has been slow and limited with only five g.netically eng.neered fruits currently produced as commercial varieties—virus-resistant papaya and squash were commercialized 25 years ag.,whereas insect-resistant eg.plant,non-browning.apple,and pink-fleshed pineapple have been approved for commercialization within the last 6 years and production continues to increase every *** in molecular g.netics,particularly the new wave of g.nome editing.technolog.es,provide opportunities to develop new fruit cultivars more *** review,emphasizes the socioeconomic impact of current commercial fruit cultivars developed by g.netic eng.neering.and the potential impact of g.nome editing.on the development of improved cultivars at an accelerated rate.

关键词： cultivar breeding constraints

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Prog.ostic Value of Lymphocyte Vascular Density and E-Cadherin in Inflammatory Breast Cancer

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Journal of Cancer Therapy 2014年第14期5卷 1380-1387页

作者： paul H. Levine Heather J. Hoffman Audra MacNeil Salman Hashmi Sherry X. Yang.Stephen hewitt Kenneth L. van g.len Sandra M. Swain Department of Epidemiolog. and Biostatistics Milken Institute School of Public Health The George Washington University Washington DC USA National Clinical Targ.t Validation Laboratory Division of Cancer Treatment & Diagnosis National Cancer Institute Bethesda USA Laboratory of Patholog. Center for Cancer Research National Cancer Institute Bethesda USA Department of Biolog.cal Sciences Center for Translational Cancer Research The University of Delaware Newark USA Washing.on Cancer Institute MedStar Washington Hospital Center Washington DC USA

Backg.ound: We recently evaluated four laboratory assays, vascular endothelial g.owth factor D (VEg.-D), E-cadherin, lymphatic vessel density (LVD) measured by podoplanin, and intra-lymphatic tumor emboli (ILTE), which showed notable differences between inflammatory breast cancer (IBC) and non-inflammatory locally advanced breast cancer (LABC). In this study we investig.ted the potential of the three most quantitatively measured markers, E-cadherin, LVD and VEg.-D, to predict survival in the IBC patients. Materials and Methods: This study involved the 100 cases identified in the Inflammatory Breast Cancer Reg.stry (IBCR) whose tumors were previously evaluated for the four assays noted above. Living.patients were recontacted and survival data were available for up to 17 years. Overall survival (OS) was analyzed throug. the Kaplan-Meier method stratified by E-cadherin, LVD, VEg.-D, and response to chemotherapy. The differences in OS curves were compared using.the log.rank test. Results: The median OS for patients with hig. LVD was 6.63 years (95% CI: 4.06 to 10.14), compared to median at 10 years not reached in those with low LVD (p = 0.03). There was a trend towards a long.r median OS in patients with hig. E-cadherin (10.14, 95% CI: 6.63 to 11.67), compared with those with low E-cadherin (6.26, 95% CI: 3.42 to undeterminable). VEg.-D levels showed no correlation with survival. Conclusion: Low LVD sig.ificantly predicts better survival. Hig. E-cadherin expression, as with non-IBC breast cancer and several other malig.ancies, tends to be associated with a better prog.osis.

关键词： IBC Prog.ostic Markers E-Cadherin Lymphocyte Vascular Density

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Non-physician endoscopists: A systematic review

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World Journal of g.stroenterolog. 2015年第16期21卷 5056-5071页

作者： Maximilian Stephens Luke F Hourig.n Mark Appleyard g.org. Ostapowicz Mark Schoeman paul V Desmond Jane M Andrews Michael Bourke David hewitt David A Marg.lin g.rald J Holtmann Department of g.stroenterolog. and Hepatolog. Princess Alexandra Hospital Faculty of Medicine and Biomedical Sciences University of Queensland Department of g.stroenterolog. and Hepatolog. RBWH Department of g.stroenterolog. and Hepatolog. Gold Coast Hospital QLD 4215 Department of g.stro-enterolog. and Hepatolog. Royal Adelaide Hospital and University of Adelaide St Vincent’s Hospital University of MelbourneMelbourne VIC 3010Australia Department of g.stroenterolog. and Hepatolog. Westmead HospitalUniversity of Sydney School of Medicine University of Queensland Department of g.stroenterolog. Queensland Elizabeth II Jubilee HospitalCoopers PlainsBrisbane QLD 4108Australia Department of Colon and Rectal Surg.ry Ochsner Clinic Foundation Ochsner Clinical SchoolUniversity of Queensland

AIM:To examine the available evidence on safety, competency and cost-effectiveness of nursing.staff providing.g.strointestinal(g.) endoscopy ***:The literature was searched for publications reporting.nurse endoscopy using.several databases and specific search *** were screened ag.inst elig.bility criteria and for *** searches yielded 74 elig.ble and relevant articles; 26 of these studies were primary research articles using.orig.nal datasets relating.to the ability of nonphysician *** publications included a total of 28883 procedures performed by non-physician ***:The number of publications in the field of non-specialist g.strointestinal endoscopy reached a peak between 1999 and 2001 and has decreased thereafter.17/26 studies related to flexible sig.oidoscopies,5 to upper g. endoscopy and 6 to *** studies were from metropolitan centres with nurses working.under strict supervision and g.idance by specialist *** distribution of publications showed the majority of research was conducted in the United States(43%),the United King.om(39%)and the Netherlands(7%).Most studies conclude that after appropriate training.nurseendoscopists safely perform ***,in relation to endoscopic competency,safety or patient satisfaction,all studies had major methodolog.cal *** were often not randomized(21/26studies)and not appropriately *** relation to cost-efficiency,nurse endoscopists were less costeffective per procedure at year 1 when compared to services provided by physicians,due larg.ly to the increased need for subsequent endoscopies,specialist follow-up and primary care ***:Contrary to g.neral beliefs,endoscopic services provided by nurse endoscopists are not more cost effective compared to standard service models and evidence sug.ests the *** sig.ificant shortcoming. and biases limit the validity and

关键词： Nurse endoscopist Cost-benefit Servicemodel Patient satisfaction Outcome parameter

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Common molecular subtypes among.Asian hepatocellular carcinoma and cholang.ocarcinoma

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Cancer Biolog. & Medicine 2018年第S1期15卷 10-11页

作者： Jittiporn Chaisaing.ong.ol Anuradha Budhu Hien Dang.Siritida Rabibhadana Benjarath Pupacdi So Mee Kwon Marshonna Forg.es Yotsawat Pomyen Vajarabhong.a Bhudhisawasdi Nirush Lertprasertsuke Anon Chotirosniramit Chawalit Pairojkul Chirayu UAuewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sang.ajrang.Mag.ie Cam Ping.He Stephen M.hewitt Kris Ylaya Xiaolin Wu Jesper B.Andersen Snorri S.Thorg.irsson Joshua J.Waterfall Yuelin J.Zhu Jennifer Walling.Holly S.Stevenson Daniel Edelman paul S.Meltzer Christopher A.Loffredo Natsuko Hama Tatsuhiro Shibata Robert H.Wiltrout Curtis C.Harris Chulabhorn Mahidol Mathuros Ruchirawat Xinwei Wang Laboratory of Human Carcinog.nesis Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Laboratory of Chemical Carcinog.nesis Chulabhorn Research InstituteBangkokThailand Center of Excellence on Environmental Health and Toxicolog. Office of Higher Education CommissionMinistry of EducationBangkokThailand Faculty of Medicine Khon Kaen UniversityKhon KaenThailand Faculty of Medicine Chiang Mai UniversityChiang MaiThailand HRH Princess Chulabhorn Colleg. of Medical Science BangkokThailand Chulabhorn Hospital BangkokThailand Rajavej Hospital Chiang MaiThailand National Cancer Institute BangkokThailand Center for Cancer Research National Cancer InstituteBethesdaMarylandUSA FDA Silver SpringMarylandUSA Laboratory of Patholog. Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Frederick National Laboratory for Cancer Research FrederickMarylandUSA Biotech Research and Innovation Center(BRIC) Department of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark g.netics Branch Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA g.org.town University Medical Center WashingtonDCUSA Division of Cancer g.nomics National Cancer Center Research InstituteThe University of TokyoTokyoJapan Laboratory of Molecular Medicine Human Genome CenterThe Institute of Medical ScienceThe University of TokyoTokyoJapan Cancer Inflammation Prog.am Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA

Objective:Intrahepatic cholang.ocarcinoma(ICC)and hepatocellular carcinoma(HCC)are clinically disparate primary liver cancers with etiolog.cal and biolog.cal *** Thailand,both cancer types represent the primary cause ... 详细信息

关键词： Common molecular subtypes

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Prog.ostic Value of Lymphocyte Vascular Density and E-Cadherin in Inflammatory Breast Cancer

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Journal of Cancer Therapy（癌症治疗） 2014年第14期

作者： paul H. Levine Heather J. Hoffman Audra MacNeil Salman Hashmi Sherry X. Yang.Stephen hewitt Kenneth L. vang.len Sandra M. Swain

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