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CXCR5^(+)PD-1^(++)CD4^(+)T cells colonize infant intestines early in life and promote B cell maturation

Cellular & Molecular Immunology 2023年第2期20卷 201-213页

作者： Ana jordan-Paiz Glòria Martrus Fenja L.Steinert Max Kaufmann Adrian F.Sagebiel Renée R.C.E.Schreurs Anne Rechtien Martin E.Baumdick Johannes M.Jung Kimberly J.Möller Lucy Wegner Cordula Grüttner Laura Richert Roland Thünauer Jennifer Schroeder-Schwarz Johannes Bvan Goudoever Teunis B.H.Geijtenbeek Marcus Altfeld Steven T.Pals Daniel Perez paul L.Klarenbeek Christian Tomuschat Guido Sauter Ingo Königs Udo Schumacher Manuel A.Friese Nathaniel Melling Konrad Reinshagen Madeleine J.Bunders Department of Virus Immunology Leibniz Institute of VirologyHamburg20251Germany University Medical Center Hamburg-Eppendorf Hamburg20246Germany Institute of Neuroimmunology and Multiple Sclerosis Center for Molecular Neurobiology HamburgUniversity Medical Center Hamburg-EppendorfHamburg20251Germany Department of General Visceral and Thoracic SurgeryUniversity Medical Center Hamburg-EppendorfHamburg20246Germany Department of Experimental Immunology Amsterdam Infection&Immunity InstituteAmsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterUniversity of Amsterdam and Vrije Universiteit AmsterdamAmsterdam1105 AZThe Netherlands I.Department of Medicine University Medical Center Hamburg-EppendorfHamburg20246Germany Partner Site Hamburg-Lübeck-Borstel-Riems German Center for Infection Research(DZIF)Hamburg20246Germany University of Bordeaux Institut National de la Santéet de la Recherche MédicaleBordeaux Population Health Research Center UMR1219 and INRIA SISTM TeamBordeaux33000France Institute of Anatomy and Experimental Morphology University Medical Center Hamburg-EppendorfHamburg20246Germany Department of Pathology Amsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Rheumatology and Clinical Immunology and Department of Experimental Immunology Amsterdam Infection&Immunity InstituteAmsterdam University Medical CenterUniversity of AmsterdamAmsterdam1007 MBThe Netherlands Amsterdam Rheumatology&Immunology Center Amsterdam University Medical CenterUniversity of AmsterdamAmsterdam1105 AZThe Netherlands Department of Pediatric Surgery University Medical Center Hamburg-EppendorfHamburg20246Germany Institute of Pathology University Medical Center Hamburg-EppendorfHamburg20246Germany Department of Pediatric Surgery Altona Children’s HospitalHamburg22763Germany III.Department of Medicine University M

Gastrointestinal infections are a major cause for serious clinical complications in *** induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++CD4+T cells(TFH cells).We investigated the ontogeny of CXCR5+PD-1++CD4+T cells in human *** CXCR5+PD-1++CD4+T cells were absent in fetal intestines,CXCR5+PD-1++CD4+T cells increased after birth and were abundant in infant intestines,resulting in significant higher numbers compared to *** findings were supported by scRNAseq analyses,showing increased frequencies of CD4+T cells with a TFH gene signature in infant intestines compared to ***-cultures of autologous infant intestinal CXCR5+PD-1+/−CD4+T cells with B cells further demonstrated that infant intestinal TFH cells were able to effectively promote class switching and antibody production by B *** together,we demonstrate that functional TFH cells are numerous in infant intestines,making them a promising target for oral pediatric vaccine strategies.

关键词： TFH cells B cells Antibodies Intestine Pediatrics

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Gut sterilization in experimental colitis leukocyte mediated colon injury, and effects on angiogenesis/lymphangiogenesis

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Open Journal of Gastroenterology 2013年第1期3卷 12-24页

作者： Mihir Patel Justin Olinde Allison Tatum Chaitanya V. Ganta Walter E. Cromer Ankur R. Sheth Merilyn H. Jennings J. Michael Mathis Traci Testerman paul A. jordan Kenneth Manas Christopher P. Monceaux J. Steven Alexander Department of Cellular Biology and Anatomy LSU Health Shreveport Shreveport USA Department of Gastroenterology and Hepatology LSU Health Shreveport Shreveport USA Department of Microbiology and Immunology LSU Health Shreveport Shreveport USA Department of Molecular and Cellular Physiology LSU Health Shreveport Shreveport USA

Inappropriate responses to normal commensal bacteria trigger immune activation in both inflammatory bowel disease and experimental colitis. How gut flora contribute to the pathogenesis of inflammatory bowel disease is unclear, but may involve entrapment of leukocytes and remodeling of the vascular system. Here we evaluated how the progression and tissue remodeling in experimental colitis differ in a germ- free model of mouse colitis. Four treatment groups were used: control, antibiotic-treated (ABX), dextran sulfate colitis (DSS) and DSS pre- and co-treated with antibiotics (DSS + ABX). In days 0 - 3 of the study, germ-free mice received antibiotics (vancomycin, neomycin, and metronidazole). During the next 11 days, antibiotics were continued and DSS (3%) added to “colitis” groups. Disease activity, weight, stool form and blood were monitored daily. Mice were sacrificed and tissue samples harvested. Histopathological scores in controls (0.00) and in ABX (1.0+/–0.81) were significantly (p –0). Extents of injury, inflammation and crypt damage were all improved in DSS + ABX. The Disease Activity Index score (day 11) was significantly worse in the DSS group compared to the DSS + ABX group. Stool blood and form scores were also significantly improved among these groups. Importantly, myeloper- oxidase was significantly reduced in DSS + ABX, indicating that neutrophil infiltration was blocked. Colitis was associated with an increase in blood and lymphatic vessels;both of these events were also significantly reduced by gut sterilization. Our experiment shows that clinical and histopathological severity of colitis was significantly worse in the DSS colitis group compared to the DSS + ABX group, supporting the hypothesis that development of IBD is likely to be less severe with appropriate antibiotic treatment. In particular, gut sterilization effectively reduces leuko- cyte-dependent (PMN) injury to improve outcomes and may be an important target for therapy.

关键词： Crohn’s Disease Antibiotics Myeloperoxidase Lymphatics Angiogenesis

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<i>Helicobacter</i>infection decreases basal colon inflammation, but increases disease activity in experimental IBD

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Open Journal of Gastroenterology 2013年第3期3卷 177-189页

作者： Christopher P. Monceaux Traci L. Testerman Moheb Boktor paul jordan Patrick Adegboyega David J. McGee Merilyn H. Jennings Courtney P. Parker Shelly Gupta Ping Yi Vijay C. Ganta Haidy Galous Kenneth Manas J. Steven Alexander Department of Gastroenterology and Hepatology LSU Health Shreveport Shreveport USA Department of Microbiology and Immunology LSU Health Shreveport Shreveport USA Department of Molecular and Cellular Physiology LSU Health Shreveport Shreveport USA Department of Pathology LSU Health Shreveport Shreveport USA

Background: Helicobacter species are best known for their roles in the pathology of gastritis;however, several Helicobacter species also colonize the intestine, and less is known about effects of Helicobacter on the development of intestinal inflammation. To evaluate contributions of Helicobacter in inflammatory bowel disease, we investigated whether and how pre-existing intestinal colonization would affect disease severity and biomarkers of inflammation in experimental IBD. Materials and Methods: Mice were infected with H. muridarum 2 weeks prior to induction of colitis mediated by 3% dextran sulfate (DSS). Disease activity index, stool blood and consistency, colon length, myeloperoxidase, histopathology, blood and lymphatic vessels, and numbers of dilated mucosal crypts were measured in control, DSS-only, H. muridarum-infected, and H. muridarum-infected + DSS mice. Results: Prior to DSS challenge, H. muridarum-infected mice showed little distal gut injury by several indices of colon inflammation with decreased blood vessel density in the submucosa, and lower lymphatic density in the mucosa and submucosa. However, after DSS colitis, H. muridarum-infected mice exhibited significantly greater disease. Weight change, stool bleeding, diarrhea, and angiogenesis were all increased in H. muridarum-infected mice in DSS colitis compared to DSS controls. Conclusions: Our data show that Helicobacter colonization of the intestine, unlike that of the stomach, lowers basal gut inflammatory scores, but increases disease activity and inflammation in an acute colitis model. Intestinal Helicobacter infection may therefore represent a significant sub-clinical factor which predisposes the gut to inflammatory injury.

关键词： Helicobacter Colon Lymphatics Crohn’s Disease Ulcerative Colitis

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Utilization of Extracorporeal Membrane Oxygenation for Pulmonary Toxicity Caused by Inhaled Synthetic Cannabinoid. A Harbinger of Future Complications Associated with Inhaled Cannabinoid Products

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International Journal of Clinical Medicine 2020年第2期11卷 53-61页

作者： Robert March paul Guentert Elizabeth Kloska-Kearney David Kwak Cody Yerger Michael McBride J. R. Majewski Ross McCauley jordan Hatch Jacob Speybroeck Allen Betts Mat Marsee Sufyan Zackariya Faisal Shariff Shivani Patel Ali Sualeh Anthony Thomas Edward Evans Donald Westerhausen Mark Walsh Saint Joseph Regional Medical Center Mishawaka IN USA Indiana University School of Medicine—South Bend South Bend IN USA Department of Pulmonary and Critical Care Medicine Methodist Hospital Indianapolis IN USA

There has been a dramatic increase in medical complications related to synthetic cannabinoid (SC) use either by water pipe or vaping. The legalization of marijuana in an increasing number of states has also resulted in an increase in a number of complications related not just to marijuana, but in particular, to SC. As a result, there have been recent increased reports of acute pulmonary injury related to inhaled SC products. We describe that rarely endotracheal intubation with mechanical ventilation has been required to treat the acute respiratory distress syndrome (ARDS) and the diffuse alveolar hemorrhage (DAH) associated with the acute toxicity of SC inhalation. We describe the second reported case of successful utilization of mechanical ventilation and extracorporeal membrane oxygenation (ECMO) in order to treat acute pulmonary toxicity caused by SC inhalation by a water pipe. While the exact pathophysiology of these interesting and recent pulmonary complications is unknown, the recent increase in exposure to SC via water pipe systems and vaping suggests that there will be many more cases of patients that will require ECMO as a form of life-saving therapy.

关键词： Synthetic Cannabinoid Extracorporeal Membrane Oxygenation Mechanical Ventilation Water Pipe Vaping Pulmonary Toxicity

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解码民俗服装:行列舞者的着装规则(下)

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长江大学学报（社会科学版） 2020年第6期43卷 21-27页

作者：劳雷尔·霍顿保罗·乔丹·史密斯程萌桑俊[译] 塞内卡南卡罗来纳州29678 西雅图华盛顿州98052 华中师范大学国家文化产业研究中心湖北武汉430079 长江大学人文与新媒体学院湖北荆州434023

民俗服装是指少数种族的、宗派的和职业化的小范围服装传统,于众多学者而言,这是一个过时的术语。民俗学者又往往对某些似乎仅反映日常穿着的服装视若无睹。在服装行为上有两种立场:一是男女舞者都穿T恤,二是男舞者逐渐开始穿短裙。这... 详细信息

民俗服装是指少数种族的、宗派的和职业化的小范围服装传统,于众多学者而言,这是一个过时的术语。民俗学者又往往对某些似乎仅反映日常穿着的服装视若无睹。在服装行为上有两种立场:一是男女舞者都穿T恤,二是男舞者逐渐开始穿短裙。这两种立场有助于打开参与者所使用的复杂的交流资源,并暗示在此相对未开发的领域进行民俗研究,可能会收获颇丰。

关键词：民俗服装行列舞者着装规则

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解码民俗服装:行列舞者的着装规则(上)

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长江大学学报（社会科学版） 2020年第5期43卷 49-56页

作者：劳雷尔·霍顿保罗·乔丹·史密斯程萌(译) 桑俊(译) 塞内卡南卡罗来纳州29678 西雅图华盛顿州98052 华中师范大学国家文化产业研究中心湖北武汉430079 长江大学人文与新媒体学院湖北荆州434023

民俗服装是指少数种族的、宗派的和职业化的小范围服装传统,于众多学者而言,这是一个过时的术语。民俗学者又往往对某些似乎仅反映日常穿着的服装选择视若无睹。在服装行为上有两种立场:一是男女舞者都穿T恤,二是男舞者逐渐开始穿短裙... 详细信息

民俗服装是指少数种族的、宗派的和职业化的小范围服装传统,于众多学者而言,这是一个过时的术语。民俗学者又往往对某些似乎仅反映日常穿着的服装选择视若无睹。在服装行为上有两种立场:一是男女舞者都穿T恤,二是男舞者逐渐开始穿短裙。这两种立场有助于打开参与者所使用的复杂的交流资源,并暗示在此相对未开发的领域进行民俗研究,可能会收获颇丰。

关键词：民俗服装行列舞者着装规则

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Rapid production of new oligodendrocytes is required in the earliest stages of motor skill learning

Rapid production of new oligodendrocytes is required in the ...

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中国神经科学学会第十二届全国学术会议

作者： Lin XIAO David Ohayon Ian A.McKenzie Alexander Sinclair-Wilson jordan Wright Alexander Fudge Ben Emery Hui-Liang LI William D Richardson Wolfson Institute for Biomedical Research University College London Institute of Neuroscience Second Military Medical University Centre de Biologie du Développement University Paul Sabatier Jungers Center for Neurosciences Research Oregon Health and Science University

Objective To investigate the possible role of oligodendrocyte in learning. Methods By searching published expression databases, we identified a novel marker of newly-forming oligodendrocytes – the ecto-enzyme Enpp6 – and used this to track oligodendrocyte differentiation in adult mice as they learned a motor skill(running on a complex wheel with unevenly spaced rungs). Results Production of Enpp6-expressing immature oligodendrocytes was accelerated within just 2.5 hours exposure to the complex wheel in subcortical white matter and within 4 hours in motor cortex. Conditional deletion of Myelin regulatory factor(Myrf) in oligodendrocyte precursors blocked formation of new Enpp6+ oligodendrocytes and impaired learning within the same -3 hour time frame. This very early requirement for oligodendrocytes suggests a direct and active role in learning, closely linked to synaptic strengthening. Running performance of normal mice continued to improve over the following week accompanied by secondary waves of oligodendrocyte precursor proliferation and differentiation. Conclusion We conclude that new oligodendrocytes contribute to both early and late stages of motor skill learning.

关键词： motor learning motor performance skill learning glia oligodendrocyte precursor cell NG2 cell myelin white matter mouse

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“纳”样的生活

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现代装饰（家居） 2015年第9期 54-61页

作者： Andrea Rekalidis Alan Wisniewski Anthony Keeler ferm LIVING Flamant j-me Jan Hoekstra jordan Murphy Michael Bang Maria Berntsen Mika Tolvanen paul Rowan Sarah Bttger StokkeAustad Sung Wook ParkUmbra Theresa Arns 伏平范嘉苑 Nir Meiri Design Studio

日常生活中，家居收纳是不得不面临的一大难题，要想做到好的收纳，同时还能起到装饰美化居室的效果还真得花点心思。“断含离”是由日本杂物管理咨询师山下英子提出的生活理念，所谓“断舍离”就是断绝不需要的东西，舍弃多余的废物，... 详细信息

日常生活中，家居收纳是不得不面临的一大难题，要想做到好的收纳，同时还能起到装饰美化居室的效果还真得花点心思。“断含离”是由日本杂物管理咨询师山下英子提出的生活理念，所谓“断舍离”就是断绝不需要的东西，舍弃多余的废物，脱离对物品的执着，透过整理物品了解自己，整理心中的混沌，让人生轻松而愉快。

关键词：生活理念管理咨询装饰美物品整理人生

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Le Fresnoy国立当代艺术工作室

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城市环境设计 2016年第1期 78-85页

作者： Bernard Tschumi Francois Gillet Mark Haukos Tom Kowalski Robert Young Jim Sullivan Yannis Aesopos Douglas Gauthier Eric Liftin Robert Moric Sheri Olsen jordan Parnass Tsuto Sakamoto Henning Ehrhardt Jean-Francois Erhel Véronique Descharrèires Vincent Tehvenon paul H.Huchard Louis Choulet

法国Le Fresnoy国立当代艺术工作室的竞赛目标是创造一个能为电影、录像和电子传媒等艺术提供展出、表演和制作场地的跨领域设施。将不同门类的艺术置于同一个项目中是教学层面的一次大胆尝试,目的是在不同领域的交叉地带催生实验与创... 详细信息

法国Le Fresnoy国立当代艺术工作室的竞赛目标是创造一个能为电影、录像和电子传媒等艺术提供展出、表演和制作场地的跨领域设施。将不同门类的艺术置于同一个项目中是教学层面的一次大胆尝试,目的是在不同领域的交叉地带催生实验与创新。该项目位于法国北部的老工业城市图尔昆,基地选在市内一处建于20世纪20年代的废弃建筑,这里曾集

关键词：当代艺术工作室 Le Fresnoy

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Pregnancy and inflammatory bowel diseases: Current perspectives, risks and patient management

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2015年第4期6卷 156-171页

作者： Pegah Hosseini-Carroll Monica Mutyala Abhishek Seth Shaheen Nageeb Demiana Soliman Moheb Boktor Ankur Sheth Jonathon Chapman James Morris paul jordan Kenneth Manas Felix Becker Jonathan Steven Alexander Department of Medicine Section of Gastroenterology and Hepatology Louisiana State University Health Sciences Center Department of Molecular and Cellular Physiology Louisiana State University Health Sciences Center Digestive Health Center of Louisiana Department of General and Visceral Surgery

Inflammatory bowel diseases(IBD) are chronic idiopathic inflammatory conditions characterized by relapsing and remitting episodes of inflammation which can affect several different regions of the gastrointestinal tract, but also shows extra-intestinal manifestations. IBD is most frequently diagnosed during peak female reproductive years, with 25% of women with IBD conceiving after their diagnosis. While IBD therapy has improved dramatically with enhanced surveillance and more abundant and powerful treatment options, IBD disease can have important effects on pregnancy and presents several challenges for maintaining optimal outcomes for mothers with IBD and the developing fetus/neonate. Women with IBD, the medical team treating them(both gastroenterologists and obstetricians/gynecologists) must often make highly complicated choices regarding conception, pregnancy, and post-natal care(particularly breastfeeding) related to their choice of treatment options at different phases of pregnancy as well as post-partum. This current review discusses current concerns and recommendations for pregnancy duringIBD and is intended for gastroenterologists, general practitioners and IBD patients intending to become,(or already) pregnant, and their families. We have addressed patterns of IBD inheritance, effects of IBD on fertility and conception(in both men and women), the effects of IBD disease activity on maintenance of pregnancy and outcomes, risks of diagnostic procedures during pregnancy and potential risks and complications associated with different classes of IBD therapeutics. We also have evaluated the clinical experience using "top-down" care with biologics, which is currently the standard care at our institution. Post-partum care and breastfeeding recommendations are also addressed.

关键词： Inflammatory bowel diseases Pregnancy Biologics Br

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