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Tp53 gene mediates distinct dopaminergic neuronal damage in different dopaminergic neurotoxicant models

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Neural Regeneration Research 2017年第9期12卷 1413-1417页

作者： Tao Lu paul kim Yu Luo Department of Neurological Surgery Case Western Reserve University Medical Faculty Kunming University of Science and Technology

Tp53, a stress response gene, is involved in diverse cell death pathways and its activation is implicated in the pathogenesis of Parkinson＇s disease. However, whether the neuronal Tp53 protein plays a direct role in regulating dopaminergic （DA） neuronal cell death or neuronal terminal damage in different neurotoxicant models is unknown. In our recent studies, in contrast to the global inhibition of Tp53 function by phar- macological inhibitors and in traditional Tp53 knock-out mice, we examined the effects of DA-specific Tp53 gene deletion after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and methamphetamine exposure. Our data suggests that the Tp53 gene might be involved in both neuronal apoptosis and neuronal termi- nal damage caused by different neurotoxicants. Additional results from other studies also suggest that as a master regulator of many pathways that regulate apoptosis and synaptic terminal damage, it is possible that Tp53 may function as a signaling hub to integrate different signaling pathways to mediate distinctive target pathways. Tp53 protein as a signaling hub might be able to evaluate the microenvironment of neurons, assess the forms and severities of injury incurred, and determine whether apoptotic cell death or neuro- nal terminal degeneration occurs. Identification of the precise mechanisms activated in distinct neuronal damage caused by different forms and severities of injuries might allow for development of specific Tp53 inhibitors or ways to modulate distinct downstream target pathways involved.

关键词： Parkinson's disease Tp53 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity apoptosis methamphetamine

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Boosting charge collection efficiency via large-area free-standing Ag/ZnO core-shell nanowire array electrodes

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Progress in Natural Science:Materials International 2019年第2期29卷 124-128页

作者： Yuyi Feng paul kim Clayton A.Nemitz Kwang-Dae kim Yoonseok Park Karl Leo James Dorman Jonas Weickert Yongtian Wang Lukas Schmidt-Mende School of Optics and Photonics Beijing Institute of Technology Department of Physics University of Konstanz Chemical and Biomolecular Engineering University of California94720 Berkeley USA Department of Physics and Astronomy University of North Carolina Dresden Integrated Center for Applied Physics and Photonic Materials (IAPP) Dresden University of Technology Chemical Engineering Department Louisiana State University

Hybrid nanostructures, comprising of a metal core and a semiconductor shell layer, show great potential for a new generation of low-cost solar cells due to their unique electronic and optical properties. However, experimental results have fallen far short of the ultra-high efficiency(i.e. beyond Shockley-Queisser limit) predicted by theoretical simulations. This limits the commercial application of these materials. Here, a non-transparent organic solar cell with an array of Ag/ZnO nanowires has been experimentally fabricated to increase the internal quantum efficiency(IQE) by a factor of 2.5 compared to a planar counterpart. This result indicates a significant enhancement of charge collection efficiency due to the ultrafast Ag nanowire channels. This hybrid nanostructure can also serve as a perfect back reflector for semi-transparent solar cells, which can result in enhanced light absorption by a factor of 1.8 compared to the reference samples. The enhanced charge collection and light absorption can make these Ag/ZnO nanostructures available for the application of modern optoelectronic devices.

关键词： Vertically aligned nanowires Silver Core-shell Charge collection efficiency Light harvesting Semi-transparent organic solar cells

Murine lung eosinophil activation and chemokine production in allergic airway inflammation

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Cellular & Molecular Immunology 2010年第5期7卷 361-374页

作者： C Edward Rose Jr Joanne A Lannigan paul kim James J Lee Shu Man Fu Sun-sang J Sung Division of Pulmonary and Critical Care Department of MedicineUniversity of Virginia School of MedicineCharlottesvilleVAUSA Department of Microbiology University of Virginia School of MedicineCharlottesvilleVAUSA Center for Immunity Inflammationand Regenerative Medicine and Division of NephrologyDepartment of MedicineUniversity of Virginia School of MedicineCharlottesvilleVAUSA Division of Pulmonary Medicine Department of Biochemistry and Molecular BiologyMayo Clinic ArizonaScottsdaleAZUSA

Eosinophils play important roles in asthma and lung *** models are widely used for assessing the functional significance and mechanistic basis for eosinophil involvements in these ***,little is known about tissue eosinophils in *** addition,little data on eosinophil chemokine production during allergic airway inflammation are *** this study,the properties and functions of homeostatic and activated eosinophils were *** from normal tissues expressed costimulation and adhesion molecules B7-1,B7-2 and ICAM-1 for Ag presentation but little major histocompatibility complex(MHC)class II,and were found to be poor stimulators of T-cell ***,these eosinophils expressed high levels of chemokine mRNA including C10,macrophage inflammatory protein(MIP)-1a,MIP-1c,MIP-2,eotaxin and monocyte chemoattractant protein-5(MCP-5),and produced chemokine *** intracellular chemokines decreased rapidly with concomitant surface marker downregulation upon in vitro culturing consistent with piecemeal *** eosinophils from mice with induced allergic airway inflammation exhibited increased chemokines mRNA expression and chemokines protein production and upregulated MHC class II and CD11c *** were also found to be the predominant producers of the CCR1 ligands CCL6/C10 and CCL9/MIP-1c in inflamed *** production of C10 and MIP-1c correlated with the marked influx of CD11bhigh lung dendritic cells during allergic airway inflammation and the high expression of CCR1 on these dendritic cells(DCs).The study provided baseline information on tissue eosinophils,documented the upregulation of activation markers and chemokine production in activated eosinophils,and indicated that eosinophils were a key chemokine-producing cell type in allergic lung inflammation.

关键词： allergy chemokines eosinophils lung mouse

Tensorial tomographic Fourier ptychography with applications to muscle tissue imaging

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Advanced Photonics 2024年第2期6卷 50-60页

作者： Shiqi Xu Xi Yang paul Ritter Xiang Dai Kyung Chul Lee Lucas Kreiss Kevin C.Zhou Kanghyun kim Amey Chaware Jadee Neff Carolyn Glass Seung Ah Lee Oliver Friedrich Roarke Horstmeyer Duke University DurhamNorth CarolinaUnited States Friedrich-Alexander University ErlangenGermany UC San Diego La JollaCaliforniaUnited States Yonsei University SeoulRepublic of Korea UC Berkeley BerkeleyCaliforniaUnited States Duke University Medical Center DurhamNorth CarolinaUnited States

We report tensorial tomographic Fourier ptychography(T^(2)oFu),a nonscanning label-free tomographic microscopy method for simultaneous imaging of quantitative phase and anisotropic specimen information in *** upon Fourier ptychography,a quantitative phase imaging technique,T^(2)oFu additionally highlights the vectorial nature of *** imaging setup consists of a standard microscope equipped with an LED matrix,a polarization generator,and a polarization-sensitive *** tensors of anisotropic samples are computationally recovered from polarized intensity measurements across three *** demonstrate T^(2)oFu’s efficiency through volumetric reconstructions of refractive index,birefringence,and orientation for various validation samples,as well as tissue samples from muscle fibers and diseased heart *** reconstructions of healthy muscle fibers reveal their 3D fine-filament structures with consistent ***,we demonstrate reconstructions of a heart tissue sample that carries important polarization information for detecting cardiac amyloidosis.

关键词： computational imaging three-dimensional imaging phase retrieval microscopy polarization-sensitive imaging labelfree imaging

Smoking cessation prior to elective total joint arthroplasty results in sustained abstinence postoperatively

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World Journal of Orthopedics 2024年第7期15卷 627-634页

作者： Billy Insup kim Jeffrey O'Donnell Colleen M Wixted Thorsten Markus Seyler William A Jiranek Michael paul Bolognesi Sean Patrick Ryan Department of Orthopedic Surgery Hospital for Special SurgeryNew YorkNY 10021United States Department of Orthopedic Surgery New York UniversityNew YorkNY 10003United States Department of Orthopedic Surgery Duke University HospitalDurhamNC 27560United States

BACKGROUND Tobacco use is a well-documented modifiable risk factor for perioperative *** To determine the tobacco abstinence rates of patients who made cessation efforts prior to a total joint arthroplasty(TJA)*** A retrospective evaluation was performed on 88 self-reported tobacco users who underwent TJA between 2014-2022 and had tobacco cessation dates within 3 mo of *** patients were contacted via phone survey to understand their tobacco use pattern,and patient reported outcomes.A total of 37 TJA patients *** Our cohort was on average 61-years-old,60%(n=22)women,with an average body mass index of 30 kg/m^(2).The average follow-up time was 2.9±1.9 years.A total of 73.0%(n=27)of patients endorsed complete abstinence from tobacco use prior to *** cessation methods were used perioperatively including prescription therapy(13.5%),over the counter nicotine replacement(18.9%),cessation programs(5.4%).At final follow up,43.2%(n=16)of prior tobacco smokers reported complete *** who were able to maintain cessation postoperatively had improved Patient-Reported Outcomes Measurement Information System(PROMIS)-10 mental health scores(49 vs 58;P=0.01),and hip dysfunction and osteoarthritis outcome score for joint replacement(***)scores(63 vs 82;P=0.02).No patients in this cohort had a prosthetic joint infection or required revision *** We report a tobacco cessation rate of 43.2%in patients undergoing elective TJA nearly 3 years *** undergoing TJA who were able to remain abstinent had improved PROMIS-10 mental health scores and *** *** perioperative period provides clinicians a unique opportunity to assist active tobacco smokers with cessation efforts and improve postoperative outcomes.

关键词： Smoking cessation Total joint arthroplasty Outcomes Tobacco use Postoperative abstinence

Utilizing Instilling Negative Pressure Wound Therapy with Vashe Wound Solution for an Infected Sternal Dehiscence: A Case Report

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Surgical Science 2023年第3期14卷 231-239页

作者： Linnea T. Mauro Courtney M. Janowski Mariah J. Janowski Adalberto C. Gonzalez Eugene J. Sidoti Luis G. Fernandez paul J. kim Marc R. Matthews Valleywise Medical Center Department of Surgery Phoenix Arizona Department of Surgery Division of Trauma Surgery/Surgical Critical Care University of Texas Health Science Center Tyler Texas The University of Texas Tyler School of Medicine Endowed Chair in Trauma Surgery Tyler Texas Trauma Wound Care UT Health East Tyler Texas Department of Surgery University of Texas Medical Branch Galveston Texas Medicine and Nursing University of Texas Arlington Texas Department of Medical Education Health Science Center Tyler Texas Department of Physician Assistant Studies School of Health Professions University of North Texas Fort Worth Texas ACS National Committee on Trauma Chicago USA Plastic Surgery Department of Surgery University of Texas Southwestern Dallas Texas University of Arizona & Creighton University Schools of Medicine The Arizona Burn Center Phoenix Arizona

Utilization of negative pressure wound therapy with instillation (NPWTi) for sternal dehiscence wounds secondary to sternal wound infection after surgery has become an accepted therapy. NPWTi accelerates wound healing through macrostrain, microstrain, and cyclic fluid instillation. Wounds benefit from additional superficial infection control with the removal of microorganisms, the release of proinflammatory mediators, stimulation of angiogenesis, as well as mechanical debridement. However, very few cases of utilizing NPWTi in the treatment of sternal wound infections have been reported in the literature. This case study describes the use of NPWTi with hypochlorous acid for the treatment of a sternal wound infection.

关键词： Negative Pressure Wound Therapy with Instillation NPWT NPWTi NPWT with Dwell Hypochlorous Acid Vashe Wound Solution Sternal Dehiscence

Convolutional Neural Network Model for Fire Detection in Real-Time Environment

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Computers, Materials & Continua 2023年第11期77卷 2289-2307页

作者： Abdul Rehman Dongsun kim Anand paul School of Computer Science and Engineering Kyungpook National UniversityDaeguKorea

Disasters such as conflagration,toxic smoke,harmful gas or chemical leakage,and many other catastrophes in the industrial environment caused by hazardous distance from the peril are *** calamities are causing massive fiscal and human life ***,Wireless Sensors Network-based adroit monitoring and early warning of these dangerous incidents will hamper fiscal and social *** authors have proposed an early fire detection system uses machine and/or deep learning *** article presents an Intelligent Industrial Monitoring System(IIMS)and introduces an Industrial Smart Social Agent(ISSA)in the Industrial SIoT(ISIoT)*** proffered ISSA empowers smart surveillance objects to communicate autonomously with other *** Industrial IoT(IIoT)entity gets authorization from the ISSA to interact and work together to improve surveillance in any industrial *** ISSA uses machine and deep learning algorithms for fire-related incident detection in the industrial *** authors have modeled a Convolutional Neural Network(CNN)and compared it with the four existing models named,FireNet,Deep FireNet,Deep FireNet V2,and Efficient Net for identifying the *** train our model,we used fire images and smoke sensor *** image dataset contains fire,smoke,and no fire *** evaluation,the proposed and existing models have been tested on the *** to the comparative analysis,our CNN model outperforms other state-of-the-art models significantly.

关键词： Fire detection industrial surveillance system smart devices smart social agent(SSA) machine learning algorithms CNN

Precise photoelectrochemical tuning of semiconductor microdisk lasers

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Advanced Photonics 2023年第5期5卷 68-76页

作者： Debarghya Sarkar paul HDannenberg Nicola Martino Kwon-Hyeon kim Yue Wu Seok-Hyun Yun Harvard Medical School BostonMassachusettsUnited States Massachusetts General Hospital Wellman Center for PhotomedicineBostonMassachusettsUnited States Massachusetts Institute of Technology Harvard-MIT Health Sciences and TechnologyCambridgeMassachusettsUnited States

Micro-and nanodisk lasers have emerged as promising optical sources and probes for on-chip and free-space ***,the randomness in disk diameter introduced by standard nanofabrication makes it challenging to obtain deterministic *** address this,we developed a photoelectrochemical(PEC)etching-based technique that enables us to precisely tune the lasing wavelength with subnanometer *** examined the PEC mechanism and compound semiconductor etching rate in diluted sulfuric acid *** this technique,we produced microlasers on a chip and isolated particles with distinct lasing *** precisely tuned disk lasers were then used to tag cells in *** results demonstrate that this scalable technique can be used to produce groups of lasers with precise emission wavelengths for various nanophotonic and biomedical applications.

关键词： microdisk lasers semiconductor precision lasing photoelectrochemical etching laser particle nanophotonics

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The ALMA-QUARKS Survey.Ⅱ.The ACA 1.3 mm Continuum Source Catalog and the Assembly of Dense Gas in Massive Star-Forming Clumps

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Research in Astronomy and Astrophysics 2024年第6期24卷 119-139页

作者：许峰玮 Ke Wang Tie Liu Lei Zhu Guido Garay Xunchuan Liu paul Goldsmith Qizhou Zhang Patricio Sanhueza Shengli Qin Jinhua He Mika Juvela Anandmayee Tej Hongli Liu Shanghuo Li Kaho Morii Siju Zhang Jianwen Zhou Amelia Stutz Neal JEvans Kee-Tae kim Shengyuan Liu Diego Mardones Guangxing Li Leonardo Bronfman Ken’ichi Tatematsu Chang Won Lee Xing Lu Xiaofeng Mai Sihan Jiao James O.Chibueze Keyun Su Viktor L.Tóth Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China Department of Astronomy School of PhysicsPeking UniversityBeijing 100871China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China Departamento de Astronomía Universidad de ChileLas Condes7591245 SantiagoChile Jet Propulsion Laboratory California Institute of Technology4800 Oak Grove DrivePasadena CA 91109USA Center for Astrophysics|Harvard&Smithsonian 60 Garden StreetCambridgeMA 02138USA National Astronomical Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Astronomical Science Program The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan School of Physics and Astronomy Yunnan UniversityKunming 650091China Yunnan Observatories Chinese Academy of SciencesKunming 650216China Department of Physics University of HelsinkiPO Box 64FI-00014 HelsinkiFinland Indian Institute of Space Science and Technology Thiruvananthapuram 695547KeralaIndia Max Planck Institute for Astronomy Königstuhl 17D-69117 HeidelbergGermany Department of Astronomy Graduate School of ScienceThe University of Tokyo7-3-1 HongoBunkyo-kuTokyo 113-0033Japan Max-Planck-Institut für Radioastronomie Auf dem Hügel 6953121 BonnGermany Departamento de AstronomÂıa Universidad de ConcepcionCasilla 160-CConcepci onChile Department of Astronomy The University of Texas at AustinTexas 78712-1205USA Korea Astronomy and Space Science Institute 776 Daedeokdae-roYuseong-guDaejeon 34055Republic of Korea Institute of Astronomy and Astrophysics Academia SinicaRoosevelt RoadTaipei 10617TaiwanChina South-Western Institute for Astronomy Research Yunnan UniversityKunming 650091China Korea Astronomy and Space Science Institute 776 Daedeok-daeroYuseong-guDaejeon 34055Republic of

Leveraging the high resolution,sensitivity,and wide frequency coverage of the Atacama Large Millimeter/submillimeter Array(ALMA),the QUARKS survey,standing for“Querying Underlying mechanisms of massive star formation with ALMA-Resolved gas Kinematics and Structures”,is observing 139 massive starforming clumps at ALMA Band 6(λ~1.3 mm).This paper introduces the Atacama Compact Array(ACA)7 m data of the QUARKS survey,describing the ACA observations and data *** multiwavelength data,we provide the first edition of QUARKS atlas,offering insights into the multiscale and multiphase interstellar medium in high-mass star *** ACA 1.3 mm catalog includes 207 continuum sources that are called ACA *** gas kinetic temperatures are estimated using three formaldehyde transitions with a non-LTE radiation transfer model,and the mass and density are derived from a dust emission *** ACA sources are massive(16–84 percentile values of 6–160 M_(⊙)),gravity-dominated(M∝R^(1.1))fragments within massive clumps,with supersonic turbulence(M>1)and embedded star-forming *** find a linear correlation between the masses of the fragments and the massive clumps,with a ratio of 6%between the *** considering fragments as representative of dense gas,the ratio indicates a dense gas fraction(DGF)of 6%,although with a wide scatter ranging from 1%to 10%.If we consider the QUARKS massive clumps to be what is observed at various scales,then the size-independent DGF indicates a self-similar fragmentation or collapsing mode in protocluster *** the ACA data over four orders of magnitude of luminosity-to-mass ratio(L/M),we find that the DGF increases significantly with L/M,which indicates clump evolutionary *** observed a limited fragmentation at the subclump scale,which can be explained by a dynamic global collapse process.

关键词： stars:formation ISM:kinematics and dynamics ISM:clouds stars:protostars

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