检索结果-南通市图书馆

Management of extracranial carotid artery stenosis during endovascular treatment for acute ischaemic stroke:results from the MR CLEAN Registry

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2023年第3期8卷 229-237,I0074-I0085页

作者： Sabine L Collette Michael P Rodgers Marianne A A van Walderveen Kars C j Compagne paul j Nederkoorn jeannette Hofmeijer jasper M Martens Gert j de Borst Gert jan R Luijckx Charles B L M Majoie Aad van der Lugt Reinoud P H Bokkers Maarten Uyttenboogaart University Medical Centre Groningen University of GroningenGroningenThe Netherlands Leiden University Medical Centre LeidenThe Netherlands Erasmus MC University Medical CentreRotterdamThe Netherlands Amsterdam University Medical Centres University of AmsterdamAmsterdamThe Netherlands Rijnstate Hospital ArnhemThe Netherlands University Medical Centre Utrecht University of UtrechtUtrechtThe Netherlands

Background The optimal management of ipsilateral extracranial internal carotid artery(ICA)stenosis during endovascular treatment(EVT)is *** compared the outcomes of two different strategies:EVT with vs without carotid artery stenting(CAS).Methods In this observational study,we included patients who had an acute ischaemic stroke undergoing EVT and a concomitant ipsilateral extracranial ICA stenosis of≥50%or occlusion of presumed atherosclerotic origin,from the Dutch Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands(MR CLEAN)Registry(2014-2017).The primary endpoint was a good functional outcome at 90 days,defined as a modified Rankin Scale score≤*** endpoints were successful intracranial reperfusion,new clot in a different vascular territory,symptomatic intracranial haemorrhage,recurrent ischaemic stroke and any serious adverse *** Of the 433 included patients,169(39%)underwent EVT with *** 123/168(73%)patients,CAS was performed before intracranial *** 42/224(19%)patients who underwent EVT without CAS,a deferred carotid endarterectomy or CAS was *** with and without CAS were associated with similar proportions of good functional outcome(47%vs 42%,respectively;adjusted OR(aOR),0.90;95%CI,0.50 to 1.62).There were no major differences between the groups in any of the secondary endpoints,except for the increased odds of a new clot in a different vascular territory in the EVT with CAS group(aOR,2.96;95%CI,1.07 to 8.21).Conclusions Functional outcomes were comparable after EVT with and without *** during EVT might be a feasible option to treat the extracranial ICA stenosis but randomised studies are warranted to prove non-inferiority or superiority.

关键词： stenosis carotid treatment

Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Forest Ecosystems 2024年第1期11卷 24-31页

作者： Goran Ståhl Terje Gobakken Svetlana Saarela Henrik j.Persson Magnus Ekstrom Sean P.Healey Zhiqiang Yang johan Holmgren Eva Lindberg Kenneth Nystrom Emanuele Papucci Patrik Ulvdal Hans OleØrka Erik Næsset Zhengyang Hou Håkan Olsson Ronald E.McRoberts Department of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of Environmental Sciences and Natural Resource Management Norwegian University of Life SciencesÅsNorway USDA Forest Service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for Silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias Model-based inference Design-based inference

Globalization and Chinese Education in the Early 20th Century

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers of Education in China 2013年第3期8卷 398-419页

作者： paul j.BAILEY Department of History University of DurhamDurham DH13EXUK

With China’s growing significance in the global economy ever more evident,studies in recent years have highlighted multiple aspects of China’s“Globalization”(or global connections)that predate the contemporary *** article focuses on educational reform in the late Qing and early Republic as a way of illuminating a significant aspect of China’s Globalization during this *** particular,the article highlights the role of an emerging Chinese educational“lobby”that was involved in administration,teaching,and textbook compilation;furthermore,this lobby pioneered the introduction of new ideas,concepts,and innovative practice from abroad in the specialized journals on education-the first of their kind in China-which they edited and contributed *** significantly,contributors to these journals engaged with and discussed educational issues and problems that were simultaneously being debated in the *** the process Chinese educators and officials were able to draw upon,either to valorize or critique,a wide spectrum of contemporary foreign educational debate and practice in their prognosis of domestic education and its *** picture that emerges of Chinese education during this period is one in which Chinese educators perceived themselves very much as active participants in a global educational community.

关键词： Globalization nation-building educational reform Chinese educational lobby educational press

Malignant transformation by oncogenic K-ras requires IDH2-mediated reductive carboxylation to promote glutamine utilization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cancer Communications 2023年第2期43卷 285-289页

作者： Rui Liu Panpan Liu Huichang Bi jianhua Ling Huiqin Zhang Mingquan Zhang Yumin Hu paul j Chiao Peng Huang jinyun Liu Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhouGuangdong 510060P.R.China School of Materials Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong 510275P.R.China School of Pharmaceutical Sciences Southern Medical UniversityGuangzhouGuangdong 510515P.R.China Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030USA Metabolic Research Platform Center for Precision MedicineZhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China

Dear Editor,Oncogenic K-ras mutation plays a major role in malignant transformation and induces significant alterations in cancer cell metabolism[1–4].However,the major molecular players mediating metabolic alterations during K-ras-driven cancer development remain *** observations that tumorigenesis often requires multiple hits suggest that K-ras mutation likely needs the coordination of other molecular events that enable adaptive cellular metabolism for a full malignant *** on our previous study on the impact of K-ras onmitochondrial metabolism[1,5]and our recent findings that mitochondrial isocitrate dehydrogenase 2(IDH2)could promote the“reverse”flow of the tricarboxylic acid(TCA)cycle fromα-KG to isocitrate and enhance the survival and proliferation of acute myeloid leukemia cells[6],we investigated the potential role of IDH2 in metabolic adaptation during K-ras-driven tumorigenesis.

关键词： metabolism alterations cancer

Multiplexed laser particles for spatially resolved single-cell analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2019年第1期8卷 526-530页

作者： Sheldon j.j.Kwok Nicola Martino paul H.Dannenberg Seok-Hyun Yun Harvard Medical School and Wellman Center for Photomedicine Massachusetts General Hospital50 Blossom StreetBostonMA 02114USA Harvard-MIT Health Sciences and Technology Massachusetts Institute of Technology77 Massachusetts AvenueCambridgeMA 02139USA LASE Innovation Inc. 650 E.Kendall Street2nd FLCambridgeMA 02142USA

Biomolecular analysis at the single-cell level is increasingly important in the study of cellular heterogeneity and its consequences,particularly in organismic development and complex diseases such as ***-cell molecular analyses have led to the identification of new cell types1 and the discovery of novel targets for diagnosis and *** these analyses are performed predominantly on dissociated single cells,emerging techniques seek understanding of cellular state,cellular function and cell–cell interactions within the native tissue environment by combining optical microscopy and single-cell molecular *** techniques include in situ multiplexed imaging of fluorescently labeled proteins and nucleotides,as well as low-throughput ex vivo methods in which specific cells are isolated for downstream molecular ***,these methods are limited in either the number and type of molecular species they can identify or the number of cells that can be ***-throughput methods are needed for comprehensive profiling of many cells(>1000)to detect rare cell types,discriminate relevant biomarkers from intrinsic population noise,and reduce the time and cost of *** established,highthroughput single-cell analyses are not directly applicable because they require tissue dissociation,leading to a loss of spatial *** current methods exist that can seamlessly connect spatial mapping to single-cell *** this Perspective,we review current methods for spatially resolved single-cell analysis and discuss the prospect of novel multiplexed imaging probes,called laser particles,which allow individual cells to be tagged in tissue and analyzed subsequently using high-throughput,comprehensive single-cell techniques.

关键词： diagnosis spatially resolved

Cell Wall Microstructure Analysis Implicates Hemicellulose Polysaccharides in Cell Adhesion in Tomato Fruit Pericarp Parenchyma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2009年第5期2卷 910-921页

作者： jose j. Ordaz-Ortiz Susan E. Marcus j. paul Knox Centre for Plant Sciences Faculty of Biological Sciences University of Leeds Leeds LS2 9JT United Kingdom

Methods developed to isolate intact cells from both unripe and ripe tomato fruit pericarp parenchyma have allowed the cell biological analysis of polysaccharide epitopes at the surface of separated cells. The LM7 pectic homogalacturonan epitope is a marker of the junctions of adhesion planes and intercellular spaces in parenchyma systems. The LM7 epitope persistently marked the former edge of adhesion planes at the surface of cells separated from unripe and ripened tomato fruit and also from fruits with the Cnr mutation. The LM 11 xylan epitope was associated, in sections, with cell walls lining intercellular space but the epitope was not detected at the surface of isolated cells, being lost during cell isolation. The LM15 xyloglucan epitope was present at the surface of cells isolated from unripe fruit in a pattern reflecting the former edge of cell adhesion planes/intercellular space but with gaps and apparent breaks. An equivalent pattern of LM15 epitope occurrence was revealed at the surface of cells isolated by pectate lyase action but was not present in cells isolated from ripe fruit or from Cnr fruit. In contrast to wild-type cells, the LM5 galactan and LM21 mannan epitopes occurred predominantly in positions reflecting intercellular space in Cnr, suggesting a concerted alteration in cell wall microstructure in response to this mutation. Galactanase and mannanase, along with pectic homogalacturonan-degrading enzymes, were capable of releasing cells from unripe fruit parenchyma. These observations indicate that hemicellulose polymers are present in architectural contexts reflecting cell adhesion and that several cell wall polysaccharide classes are likely to contribute to cell adhesion/cell separation in tomato fruit pericarp parenchyma.

关键词： Cell walls fruit development tomato cell adhesion cell separation polysaccharide.

Cell Wall Biology： Perspectives from Cell Wall Imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2011年第2期4卷 212-219页

作者： Kieran j.D. Lee Susan E. Marcus j. paul Knox Centre for Plant Sciences Faculty of Biological Sciences University of Leeds Leeds LS2 9JT UK

Polysaccharide-rich plant cell walls are important biomaterials that underpin plant growth, are major repositories for photosynthetically accumulated carbon, and, in addition, impact greatly on the human use of plants. Land plant cell walls contain in the region of a dozen major polysaccharide structures that are mostly encompassed by cellulose, hemicelluloses, and pectic polysaccharides. During the evolution of land plants, polysaccharide diversification appears to have largely involved structural elaboration and diversification within these polysaccharide groups. Cell wall chemistry is well advanced and a current phase of cell wall science is aimed at placing the complex polysaccharide chemistry in cellular contexts and developing a detailed understanding of cell wall biology. Imaging cell wall glycomes is a challenging area but recent developments in the establishment of cell wall molecular probe panels and their use in high throughput procedures are leading to rapid advances in the molecular understanding of the spatial heterogeneity of individual cell walls and also cell wall differences at taxonomic levels. The challenge now is to integrate this knowledge of cell wall heterogeneity with an understanding of the molecular and physiological mechanisms that underpin cell wall properties and functions.

关键词： Cell structure cell walls fluorescence imaging development cell wall imaging polysaccharides

Iron and liver fibrosis: Mechanistic and clinical aspects

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2019年第5期25卷 521-538页

作者： Kosha j Mehta Sebastien je Farnaud paul A Sharp School of Population Health and Environmental Sciences Faculty of Life Sciences and Medicine King’s College London Division of Human Sciences School of Applied Sciences London South Bank University Faculty Research Centre for Sport Exercise and Life Sciences Coventry University Department of Nutritional Sciences School of Life Course Sciences Faculty of Life Sciences and Medicine King's College London

Liver fibrosis is characterised by excessive deposition of extracellular matrix that interrupts normal liver functionality. It is a pathological stage in several untreated chronic liver diseases such as the iron overload syndrome hereditary haemochromatosis, viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis and diabetes. Interestingly, regardless of the aetiology, iron-loading is frequently observed in chronic liver diseases. Excess iron can feed the Fenton reaction to generate unquenchable amounts of free radicals that cause grave cellular and tissue damage and thereby contribute to fibrosis. Moreover, excess iron can induce fibrosis-promoting signals in the parenchymal and non-parenchymal cells, which accelerate disease progression and exacerbate liver pathology. Fibrosis regression is achievable following treatment, but if untreated or unsuccessful, it can progress to the irreversible cirrhotic stage leading to organ failure and hepatocellular carcinoma, where resection or transplantation remain the only curative options. Therefore,understanding the role of iron in liver fibrosis is extremely essential as it can help in formulating iron-related diagnostic, prognostic and treatment strategies. These can be implemented in isolation or in combination with the current approaches to prepone detection, and halt or decelerate fibrosis progression before it reaches the irreparable stage. Thus, this review narrates the role of iron in liver fibrosis. It examines the underlying mechanisms by which excess iron can facilitate fibrotic responses. It describes the role of iron in various clinical pathologies and lastly,highlights the significance and potential of iron-related proteins in the diagnosis and therapeutics of liver fibrosis.

关键词： Iron Liver pathologies Liver fibrosis Hepatic stellate cells Cirrhosis

Sexual/aggressive behavior of wild yak(Bos mutus Prejevalsky1883) during the rut: influence of female choice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Science Bulletin 2014年第22期59卷 2756-2763页

作者： paul j. Buzzard Donghua Xu Huan Li China Exploration & Research Society

Wild yaks(Bos mutus)ranged across the Tibetan Plateau in large herds before being forced to remote areas of the ***,little has been published about their behavioral *** present the first extensive study on wild yak behavior during the *** gathered data on activity budgets,aggressive/sexual behaviors,and the behavior of bulls inside and outside mixed groups during 11 days in 2010 and 9 days in *** ate less and were more social during the rut than during *** ate less than females and socialized more during the *** observed yaks for 234.25 h and recorded 2,078 aggressive/sexual *** bulls inspected and tended cows showing off their profiles during lateral displays,the most common type of indirect *** bulls inside mixed sex groups rested less and socialized more than bulls *** initiated intense intra-sexual competition and led at least 25 bulls on *** then incited fight frenzies of numerous bulls from inside and outside the groups before copulations,and fights could be *** discuss female choice selecting for large size and fighting ability in males,the similarity of yak and bison(genus Bison)behavior,and conservation implications.

关键词：攻击行为野牦牛发情期女性战斗能力青藏高原行为生态学社会化