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Spectrum of Meningitis in Adult at the Douala General Hospital

World Journal of Neuroscience 2014年第2期4卷 144-151页

作者： Yacouba N. Mapoure henry N. Luma Dieudonné Gnonlonfoun paul M. Ossou-Guiet Xaverie Biloa Jacques N. Doumbe Hugo Bertrand N. Mbatchou Benjamin Clet N. Tchaleu Julius Y. Fonsah Albert S. Mouelle Alfred K. Njamnshi Department of Clinical Sciences Douala General Hospital Douala Cameroon Department of Clinical Sciences The University of Douala Douala Cameroon Department of Clinical Sciences Université des Montagnes Douala Cameroon Department of Neurology Brazzaville University Teaching Hospital Brazzaville Congo Department of Neurology National University Hospital Centre Cotonou Bénin Department of Neurology The University of Yaoundé I Yaoundé Cameroon Department of Neurology Yaoundé Central Hospital Yaoundé Cameroon

Objectives: Describe the clinical, aetiological and prognostic features of infectious meningitis in adults at the Douala General Hospital (DGH). Patients and Methods: We carried out a 5-year retrospective cross-sectional study at the DGH, on data from the registers of the bacteriology and biochemistry laboratories. Cases of meningitis were identified from the results of the cerebrospinal fluid (CSF) analysis, and the patient clinical file was obtained. Cases files of patients aged 15 years and above were included. For each patient, sociodemographic, clinical features and hospital mortality data were extracted. Results: During study period, 1877 CSF analyses were recorded and 135 were enrolled for data analysis. Up to 74 patients (55%) were male and the mean age was 40.04 ± 12.5 years. The time lapse between the onset of symptoms and consultation was 12.24 ± 11.16 days. The main clinical signs were meningeal syndrome (96.3%), neck stiffness (71.1%), reduced alertness (64.4%) and confusional states (55.6%). The main aetiology was bacterial (45.19%) withStreptococcus pneumoniae?(45.90%) and?Neisseria meningitis?(29.51%) leading. The other aetiologies were viral (21.48%), fungal with?Cryptococcus neoformans?(20%) and meningeal tuberculosis (13.33%). Fifty eight patients (42.9%) had a positive HIV serology. The mean duration of hospitalization was 9.05 ± 8.1 days, and the total in-hospital mortality was 25.18%. 117 patients (86.8%) had received antibiotherapy before diagnosis. Conclusion: The clinical features of meningitis in the DGH are as in classical description. However, the mortality is high and the major aetiologies appear to be associated with HIV infection at least in part. Prospective multi-centric studies are needed to provide more evidence for the development of staged management guidelines in our resource-limited settings.

关键词： Meningitis Signs Aetiologies Mortality Adults Douala Cameroon

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The effect of volume change and stack pressure on solid-state battery cathodes

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SusMat 2023年第5期3卷 721-728页

作者： Boyang Liu Shengda DPu Christopher Doerrer Dominic Spencer Jolly Robert A.House Dominic L.R.Melvin paul Adamson Patrick S.Grant Xiangwen Gao Peter G.Bruce Department of Materials University of OxfordOxfordUK The Faraday Institution DidcotUK The henry Royce Institute University of OxfordOxfordUK Future Battery Research Center Global Institute of Future TechnologyShanghai Jiao Tong UniversityShanghaiChina Department of Chemistry University of OxfordOxfordUK

Solid-state lithium batteries may provide increased energy density and improved safety compared with Li-ion ***,in a solid-state composite cathode,mechanical degradation due to repeated cathode volume changes during cycling may occur,whichmay be partially mitigated by applying a significant,but often impractical,uniaxial stack ***,we compare the behavior of composite electrodes based on Li4Ti5O12(LTO)(negligible volume change)and Nb2O5(+4%expansion)cycled at different stack *** initial LTO capacity and retention are not affected by pressure but for Nb2O5,they are significantly lower when a stack pressure of<2MPa is applied,due to inter-particle cracking and solid-solid contact loss because of cyclic volume *** confirms the importance of cathode mechanical stability and the stack pressures for long-term cyclability for solid-state *** suggests that low volumechange cathode materials or a proper buffer layer are required for solid-state batteries,especially at low stack pressures.

关键词： cathode interface mechanical degradation stack pressure solid-state battery

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Novel predictors of permanent pacemaker implantation following transcatheter aortic valve replacement

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World Journal of Cardiology 2023年第11期15卷 582-598页

作者： Somto Nwaedozie Haibin Zhang Javad Najjar Mojarrab Param Sharma paul Yeung Peter Umukoro Deepa Soodi Rachel Gabor Kelley Anderson Romel Garcia-Montilla Department of Cardiovascular Disease Marshfield ClinicMarshfieldWI 54449United States Hospitalist Medicine Marshfield ClinicMarshfieldWI 54449United States Department of Nephrology Henry Ford Health SystemDetroitMI 48202United States Department of Hospital Medicine Marshfield ClinicMarshfieldWI 54449United States Department of Nephrology Hendricks Regional HealthDanvilleIN 46122United States Clinical Research Center Marshfield ClinicMarshfieldWI 54449United States Department of Trauma Surgery and Surgical Critical Care Marshfield ClinicMarshfieldWI 54449United States

BACKGROUND Conduction and rhythm abnormalities requiring permanent pacemakers(PPM)are short-term complications following transcatheter aortic valve replacement(TAVR),and their clinical outcomes remain *** novel predictors of post-TAVR PPM,like QRS duration,QTc prolongation,and supraventricular arrhythmias,have been poorly *** To evaluate the effects of baseline nonspecific interventricular conduction delay and supraventricular arrhythmia on post-TAVR PPM requirement and determine the impact of PPM implantation on clinical *** RESULTS Out of the 357 patients that met inclusion criteria,the mean age was 80 years,188(52.7%)were male,and 57(16%)had a PPM *** demographics,valve type,and cardiovascular risk factors were similar except for type II diabetes mellitus(DM),which was more prevalent in the PPM cohort(59.6%vs 40.7%;P=0.009).The PPM cohort had a significantly higher rate of pre-procedure right bundle branch block,prolonged QRS>120 ms,prolonged QTc>470 ms,and supraventricular *** was a consistently significant increase in the odds ratio(OR)of PPM implantation for every 20 ms increase in the QRS duration above 100 ms:QRS 101-120[OR:2.44;confidence intervals(CI):1.14-5.25;P=0.022],QRS 121-140(OR:3.25;CI:1.32-7.98;P=0.010),QRS 141-160(OR:6.98;CI:3.10-15.61;P120(aOR:2.18;CI:1.02-4.66;P=0.045)and marginally significant for supraventricular arrhythmias(aOR:1.82;CI:0.97-3.42;P=0.062).The PPM cohort had a higher adjusted OR of heart failure(HF)hospitalization(aOR:2.2;CI:1.1-4.3;P=0.022)and nonfatal myocardial infarction(MI)(aOR:3.9;CI:1.1-14;P=0.031)without any difference in mortality(aOR:1.1;CI:0.5-2.7;P=0.796)at one *** Pre-TAVR type II DM and QRS duration>120,regardless of the presence of bundle branch blocks,are predictors of post-TAVR *** 1-year post-

关键词： Transcatheter aortic valve replacement Balloon-expandable valve Self-expandable valve Myocardial infarction Left bundle-branch block Nonspecific inter-ventricular defect Coronary artery bypass graft Coronary artery disease

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Hugoton气田井间勘探:直接研究地层、地震岩石物理特征和页岩各向异性

Hugoton气田井间勘探:直接研究地层、地震岩石物理特征和页岩各向...

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美国勘探地球物理学家学会第66届年会

作者： Marty Williams Wan Leighton henry Tan Anthony Vassiliou John Beck Tamas Nemeth Charles Savage paul Gutowski paul Garossino Don Howlett Ron Jackson Dale Cox John Stock Cecil Hoffpauir 曹辉 Amoco Production Company Amoco Production Company Amoco Production Company Amoco Production Company Amoco Production Company Amoco Production Company Amoco Production Company Amoco Production Company Amoco Production Company Texaco Texaco Conoco Conoco Conoco

堪萨斯州西南部Hugoton气田的Morrow层段是1995年春季高分辨率井间地震勘探的目的层。此次勘探的井间距大于2000ft,测量了近3000ft的地层剖面。所用仪器是Texaco公司120in3的空气枪以及Conoco公司的由15个检波器组成的检波器串。由于农...

堪萨斯州西南部Hugoton气田的Morrow层段是1995年春季高分辨率井间地震勘探的目的层。此次勘探的井间距大于2000ft,测量了近3000ft的地层剖面。所用仪器是Texaco公司120in3的空气枪以及Conoco公司的由15个检波器组成的检波器串。由于农业生产、浅层气（2000至3000ft）开采和深层油气（5500ft）开发等强环境噪声的影响,原始资料的质量一般较差。但由于空间采样快,动态范围大,使得处理中噪声压制做得很好,即使对沿相距4000ft的两井对角线传播的射线也是如此。用于旅行时反演的总的拾取质量很好。地质与地球物理试验都很成功。试验证明震源很适合于目的层深度和井间距。检波器记录数据的频率一直到尼奎斯特滤波器的起始频率（900Hz）。岩石的传输频率也达到与此相同的、人工强制截止频率。各向异性反演与偏移获得了高质量的反射地震数据。试验还证实了原来预测的目的层段页岩～砂岩界面之间复杂的物理关系。地震数据反映出了地层中河道砂的形态,该河道砂在一口井中出现,在另一口井中未见到（在地面3D地震数据中见不到该河道砂）。数据的质量足以用于反演地层（或页岩）的各向异性。然而,由于油气开发等原因,在Morrow碎屑岩地层出现严重各向异性页岩（vp的各向异性特征ε＞30％;vs的各向异性特征γ＞50％）的地段,试验没有完成。此外,在波场分离和下行波场成象方面,还有大量工作要做,以便对数据更好地进行地质解释。

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Quality of Life in Men Treated for Early Prostate Cancer: A Prospective Patient Preference Cohort Study

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Journal of Cancer Therapy 2011年第4期2卷 448-457页

作者： Carmel Nirupa Anandadas Susan Elizabeth Davidson Noel William Clarke Stephen Charles William Brown John paul Logue Lynne Gilmore Richard Swindell Gerald Nicholas Collins Patrick henry O’Reilly Guy David Wemyss-Holden Maurice Waiming Lau Pradip Madhukar Javle Vijay Alini Chandi Ramani Richard James Brough James Pinson Wylie Richard Andrew Cowan 不详

Objectives: In 1997, a study was launched to investigate the treatment of early prostate cancer. Using a patient preference design, health-related quality-of-life (HRQOL) and disease specific HRQOL was assessed prospectively to compare men undergoing radical prostatectomy (RP), hypo-fractionated conformal radiotherapy (CRT) or brachytherapy (BT). Methods: Patients with localised prostate cancer were counselled by a urological surgeon, clinical oncologist and specialist uro-oncology nurse. Patients received treatment according to individual preference. 430 men chose and received RP (n = 217), CRT (n = 161) and BT (n = 52). 354 (82%) completed pre-treatment RAND 36-Item Short-Form Health survey version-2 (SF36v2) and University of California, Los Angeles Prostate cancer index (UCLA-PCI) questionnaires. HRQOL score changes from baseline to 24 months were compared using Kruskall-Wallis test. Results: Pre-treatment, the CRT cohort scored lower for physical function (p = 0.0029) and general health perception (p = 0.0021). The BT cohort reported better baseline scores for urinary function (p = 0.0291), urinary bother (p = 0.0030), sexual function (p = 0.0009) and bowel bother (p = 0.0063). At 24 months, bowel function was similar for CRT and BT but both modalities were worse than RP (p = 0.0010). Urinary continence deteriorated most following RP (p < 0.0001) but BT had worse urinary bother (p = 0.0153). Sexual function deteriorated most following RP and BT (p < 0.0005). Percentages of patients achieving erections adequate for sexual activity (from baseline to 24 months) were 66% to 29% for RP, 62% to 49% for CRT and 88% to 65% for BT. Conclusion: This data demonstrates significant differences in disease specific quality-of-life between RP, CRT and BT and should be available for men with early prostate cancer making treatment decisions.

关键词： Early Prostate Cancer Quality of Life Patient Preference Prostatectomy Hypo-Fractionated Radiotherapy Brachytherapy

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HELLO,GOODBYE Reliving Beatlemania

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城市漫步（上海版、英文） 2015年第8期 52-52页

作者： henry TWITCHELL 不详

You’ve probably heard of this paul McCartney fellow–he’s the man who has recently been featured in collaborations with Kanye West and *** what about his role forming the Fab Four?If you missed Beatlemania the first time around(you young soul,you),now is the time to delve back into the thick of *** if you’ve been a lifelong Beatles fan,then there’s no time like the present to relive the glory ***’s because the Lafayette Arts Center’s latest exhibit The Beatles,Tomorrow has come to town.

关键词： Beat has And

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Distribution of Eye Diseases in Kasungu District, Malawi, Central Africa—A Retrospective Cross-Sectional Study

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Advances in Infectious Diseases 2018年第2期8卷 64-69页

作者： Richard Kang Jae Jun Kim paul Chung Gyuri Hwang Jung Sung Kim Seunghan Baek Eun Jung Im George Talama The School of Public Health UC Berkeley Berkeley CA USA College of Agriculture and Life Sciences Cornell University Ithaca NY USA The Biology Department Allegheny College Meadville PA USA Korea International School Gyeonggi-do South Korea henry M. Gunn High School Palo Alto California USA Department of Computer Science Johns Hopkins University Baltimore MD USA Classics College of Letters Arts and Sciences USC LA USA Kasungu District Hospital Kasungu Malawi

Analysis of eye diseases of patients at Kasungu District Hospital in Malawi was made. Malawi is one of the poorest countries in the world and the health system faces a lot challenges in terms of resources. The study was, therefore, done to understand the burden and distribution of eye diseases in this resource-limited setting. A retrospective study was conducted by extracting data from data registers in the outpatient eye department for the period of May 2015 to June 2016. The data of the reported eye diseases analyzed with variables such as patient gender, eye disease type, patient age and times of the year. There was no association between eye diseases and gender nor with times of the year. However, it was noted that the commonest type of eye disease was conjunctivitis. And, there was strong association of some disease type with age, for example, conjunctivitis was common in young age group while cataract was common in the elderly. It was shown in this study that many of the eye diseases endemic in Africa do generally occur in this selected district as well. However, the analysis presents the possibility of reducing the incidences of many diseases by preventive measures and access to health facilities on time.

关键词： Eye Diseases Kasungu District Malawi

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Socio-Demographic Determinant of Yellow Fever Patient: A Retrospective Study (2020), Federal Medical Center, Asaba

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Journal of Biosciences and Medicines 2022年第12期10卷 225-238页

作者： Ngozi Esther Ezunu Joy Ifeyinwa Egeonu Ajiri henry Osihro Uyi-Oghosa Onyemushani Said Abdulkareem Omole Clementina Oyakhire Onyema Edith Wayemeru Chidera Olivia Okey-Ezufo Chikadibia Eze-Otulaka Faith Inegbejie Clever Ajiri Oghale Diana Chinenye Ofomata Grace Nnenna Onubogu Orhomuromo paul Okpomo Eguolo Unique Okorhi Onobhase Theresa Agbele Anastacia Okwudili Ojimba Adesuwa Queen Aigbokhaode Francis Chinedu Ugoeze Victor Azubike Osiatuma Emmanuel Okechukwu Ezunu Obianuju Nkemjika Jisieike Erhinyaye Omoyibo Efe Department of Nursing Federal Medical Centre Asaba Nigeria CCDRC Federal Medical Centre Asaba Nigeria Department of Internal Medicine Federal Medical Centre Asaba Nigeria Department of Radiology Federal Medical Centre Asaba Nigeria Department of Health Information Management Federal Medical Centre Asaba Nigeria Department of Pediatrics Federal Medical Centre Asaba Nigeria

Background: Yellow fever is transmitted primarily to humans and non-human primates through the bite of an infected female mosquito Aedes Spp. It is prevented mainly by vaccination. Method: This retrospective observational study at the Center for Communicable Disease Control and Research (CCDCR) Federal Medical Center Asaba (F.M.C) was conducted on all patients diagnosed and managed with yellow fever in the year 2020. We studied a total number of 57 patients’ case files seen within the period. A chi-square test was done to test the null and alternative hypotheses. Result: About 48 (84.2%) males and female 9 (15.8%) females were mostly affected and gender was significant with a chi-squared value of 26.6 and p-value of 0.00. Conclusion: To eradicate this virus, vaccination and health promotions should be encouraged by the health care workers supported by the government. This is to ensure that a greater proportion of the affected community can be immunized.

关键词： Yellow Fever Socio-Demograpic Determinants Asaba

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香料第四十一次年度评论

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香料香精化妆品 1986年第1期 49-68页

作者： paul Z.Bedoukian 汪雅芬

香料工业贸易气氛在一九八四年是活跃的,人们对食用和日用香料香精的需求导致了销售量和销售额的增长。预测前景亦是乐观的。国际食用与日用香料公司(IFF)的总裁henry Walter Jr.曾在“食用香料和萃取物生产者协会”成立七十五周年庆祝... 详细信息

香料工业贸易气氛在一九八四年是活跃的,人们对食用和日用香料香精的需求导致了销售量和销售额的增长。预测前景亦是乐观的。国际食用与日用香料公司(IFF)的总裁henry Walter Jr.曾在“食用香料和萃取物生产者协会”成立七十五周年庆祝大会上致词时提出,在今后的十七年中,食用香料市场将增长三到六倍,相当于每年约增长30％。被吞并掉的企业为数不少,部分是由于变化的形势使开办中型企业越来越困难。不管怎样,眼看经营多年的公司一个接一个地倒闭是令人悲伤的。在近三十年内,公司的数量已缩减至三分之一,尽管香料工业的规

关键词：化合物紫罗兰酮香料工业烯醛

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海底沉积物生物多样性在生态系统过程中的重要性

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人类环境杂志 1997年第8期26卷 570-575页

作者： paul V.R.Snelgrove T.henry Blackburn Pat A.Hutchings Daniel M.Alongi J.Frederick Grassle Herman Hummel Gary King Isao Koike P.J.D.Lambshead Niels B.Ramsing Vivianne Solis-Weiss 胡海瑛 Newfounfland Memorial大学丹麦奥胡斯大学悉尼澳大利亚博物馆澳大利亚海洋科学研究所 Rutgers大学荷兰皇家艺术和科学院缅因大学的Darling海洋中心东京大学海洋研究所伦敦自然历史博物馆丹麦奥胡斯大学生物科学研究所墨西哥Laboratorio de Ecologia Costera at the Instituto de Ciencius del Mar y Limnolngia

大洋底部多数为沉积物所覆盖,因此沉积物就构成了地球空间覆盖中最大的一个单一生态系统。虽然生活在沉积物表面和内部的微型、小型和大型海洋有机体中只有一小部分被描述过,而且很少有人试图对物种总数和生物地理分布进行统计,但对若... 详细信息

大洋底部多数为沉积物所覆盖,因此沉积物就构成了地球空间覆盖中最大的一个单一生态系统。虽然生活在沉积物表面和内部的微型、小型和大型海洋有机体中只有一小部分被描述过,而且很少有人试图对物种总数和生物地理分布进行统计,但对若干物种的比较全面的了解足以说明底栖有机体对生态系统主要过程有显著的影响。底栖有机体参与碳、氮、硫的循环,水体的演变,污染物的传播、积累、二次污染和迁移,以及沉积物的稳定性等过程。虽然对群体之间的联系和功能上的冗余水平知之甚少,但在群体内部还是可能存在大量冗余的。说明生物多样性对于海底系统参与生态系统功能来说是必要的证据很少,但鉴于它们之间联系了解很少,预测性知识也仅限于几个物种,所以目前还无法准确推断物种的减少如何影响这些功能和生态系统的健康。因此,"做最坏的打算"作为一种保险的方法是可行的,而且要尽量避免由于捕渔、污染、栖息地的破坏,非本地(外来)物种的引入和全球变暖所造成的物种和基因多样性的减少。同时,科学家们应充分利用当前蓬勃发展的科学技术和对生物多样性的高昂的兴趣,以提供关于底栖生物和生态系统过程的具体而全面的信息。

关键词：海底沉积物生物多样性生态系统过程

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