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Intersecting pathways in inflammation and cancer: Hepatocellular carcinoma as a paradigm

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World Journal of clinical Oncology 2012年第2期3卷 15-23页

作者： Philip Y Wai paul c kuo Department of Surgery Loyola University Chicago Stritch School of Medicine Maywood IL 60153 United States

Viral infection and chemical carcinogens trigger somatic changes resulting in activation of oncogenes during tumor initiation in the development of cancer. However, a critical interaction resides in the synergism between these somatic changes and an inflamed tumor microenvironment where myeloid and hematopoietic cells are subverted to enhance tumor progression. The causative molecular mechanisms leading to the development of hepatocellular cancer remain incompletely understood but appear to result from multiple factors related to direct hepatocyte injury and the ensuing inflammatory changes mediated by the host response to tissue injury, DNA damage, repair of cellular damage, and chronic, repetitive injury. In this review, the molecular and cellular changes that regulate inflammation and tissue repair will be compared to the activated local tumor microenvironment. cell-cell signaling within this microenvironment that enhances tumor progression and inhibits anti-tumor immunity will be

关键词： Hepatocellular cancer Inflammation Tumor microenvironment

Healing cocktail Therapy for Non-healing Tissue-AcL

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生物医学工程学杂志 2005年第S1期22卷 13-14页

作者： paul kuo-Li SUNG Department of Orthopaedic Surgery School of Medicine

Most clinicians agree that patients with reconstructed AcL or PcL do not possess normal knee functions. With understanding the molecular events involved in the ligament injury, there would be a chance to find a cockta... 详细信息

关键词： Healing cocktail Therapy for Non-healing Tissue-AcL NFkB MMPs

cR Geometry in 3-D(Dedicated to Professor Haim Brezis with admiration)

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chinese Annals of Mathematics,Series B 2017年第2期38卷 695-710页

作者： paul c.YANG department of mathematics princeton universityFine HallW ashington RoadPrinceton NJ 08544 USA.

cR geometry studies the boundary of pseudo-convex manifolds. By concentrating on a choice of a contact form, the local geometry bears strong resemblence to conformal geometry. This paper deals with the role conformally invariant operators such as the Paneitz operator plays in the cR geometry in dimension three. While the sign of this operator is important in the embedding problem, the kernel of this operator is also closely connected with the stability of cR structures. The positivity of the cR-mass under the natural sign conditions of the Paneitz operator and the cR Yamabe operator is discussed. The cR positive mass theorem has a consequence for the existence of minimizer of the cR Yamabe problem. The pseudo-Einstein condition studied by Lee has a natural analogue in this dimension, and it is closely connected with the pluriharmonic *** author discusses the introduction of new conformally covariant operator P-prime and its associated Q-prime curvature and gives another natural way to find a canonical contact form among the class of pseudo-Einstein contact forms. Finally, an isoperimetric constant determined by the Q-prime curvature integral is discussed.

关键词： Paneitz operator, Embedding problem, Yamabe equation, Mass,P-prime, Q-prime curvature

Impact of cOVID-19 on Liver Transplant Activity in the USA: Variation by Etiology and cirrhosis complications

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Journal of clinical and Translational Hepatology 2023年第1期11卷 130-135页

作者： Yong-Fang kuo paul Kwo Robert J Wong Ashwani K.Singal Department of Biostatistics University of Texas Medical BranchGalvestonTXUSA Division of Gastroenterology and Hepatology Veterans Affairs Palo Alto Healthcare SystemStanford University School of MedicinePalo AltoCAUSA University of South Dakota Sanford School of MedicineVermillionSDUSA Avera Transplant Institute Sioux FallsSDUSA

Background and Aims:The cOVID-19 pandemic has impacted the care of patients with liver *** examined impact of cOVID-19 on liver transplant(LT)activity in the ***:LT listings in the United Network for Organ Sharing(UNOS)database(April 2018–May 2021)were analyzed to examine the impact of cOVID-19 pandemic on the LT activity based on etiology:hepatitis c virus(HcV),alcohol-associated liver disease(ALD),alcoholic hepatitis(AH),and nonalcoholic steatohepatitis(NASH)complications:hepatocellular carcinoma(Hcc)and acute-on-chronic liver failure(AcLF)grade 2 or 3 and Model for End-Stage Liver Disease(MELD)*** regression models assessed time trend changes on a log ***:Of 23,871 recipients(8,995 in the cOVID era,April 2018–February 2020),mean age 52 years,62% men,61% caucasian,32%ALD,15%Hcc,30%AcLF grades 2–3,and mean MELD score 20.5,monthly LT changes were a decrease of 3.4%for overall LTs and 22%for Hcc after September 2020,and increase of 4.5%for ALD since 11/2020 and 17%since 03/2021 for AcLF grade 2–*** MELD scores increased by 0.7 and 0.36 after June 2020 for HcV and Hcc ***:The cOVID-19 pandemic has impacted LT activity,with a decrease of LTs especially for Hcc,and an increase of LTs for ALD and severe *** are needed to reorganize cirrhosis patients to overcome the aftereffects of cOVID-19 pandemic.

关键词： cOVID-19 UNOS OLT Region Public policies

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini Jpaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Beta-blockers and physical frailty in patients with endstage liver disease

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World Journal of Gastroenterology 2018年第33期24卷 3770-3775页

作者： Selena Z kuo Blanca Lizaola Hilary Hayssen Jennifer c Lai Division of Gastroenterology/Hepatology Department of Medicine University of CaliforniaSan Francisco

AIM To investigate beta-blocker(BB) use in patients with cirrhosis and determine their effects on physical frailty and overall *** Adult outpatients with cirrhosis listed for liver transplantation underwent testing of physical frailty using the performance-based Liver Frailty Index, comprised of chair stands, grip strength, and balance testing, as well as self-reported assessments of exhaustion and physical activity. BB use was assessed from medical chart review. Univariable and multivariable logistic regression were performed to determine BB use and their association with measures of physical frailty. competing risk analyses were performed to determine the effect of BB use on wait-list mortality, as defined by death or delisting for being too sick for *** Of 344 patients, 35% were female, median age was 60, median model for end stage liver disease was 15, and 53% were prescribed a BB. compared to those not on BB, patients on BB were similar except for percentage female(25% vs 46%; P ct to tests of physical frailty, BB use was not associated with increased odds of frailty(by the Liver Frailty Index), exhaustion, or low physical activity. BB use was, however, significantly associated with a decreased adjusted risk of mortality(SHR 0.55; P = 0.005).cONcLUSION In patients with cirrhosis awaiting liver transplantation, BB use is not associated with physical frailty. We confirmed the known survival benefits with BB use, and concerns about adverse effects should not deter their utilization when indicated.

关键词： Beta-blockers cirrhosis End-stage liver disease Frailty

ADDITIVE PERTURBATIONS OF LOcAL c-SEMIGROUPS

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Acta Mathematica Scientia 2015年第6期35卷 1566-1576页

作者： chung-cheng kuo Department of Mathematics Fu Jen University

In this paper, we apply the contraction mapping theorem to establish some bounded and unbounded additive perturbation theorems concerning local c-semigroups. Some growth conditions of perturbations of local c-semigrou... 详细信息

关键词： local c-semigroup generator abstract cauchy problem perturbation

A class of Normal Weighted composition Operators on the Fock Space of c^n

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Acta Mathematica Sinica,English Series 2015年第11期31卷 1789-1797页

作者： Lian kuo ZHAO School of Mathematics and computer Science Shanxi Normal University

This paper characterizes a class of normal weighted composition operators and their spectrum on the Fock space of cn.

关键词： Fock space weighted composition operator normal spectrum

Analysis and design of a smart card based authentication protocol

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Journal of Zhejiang University-Science c(computers and Electronics) 2013年第12期14卷 909-917页

作者： kuo-Hui YEH kuo-Yu TSAI Jia-Li HOU Department of Information Management National Dong Hwa University Department of Management Information Systems Hwa Hsia Institute of Technology

Numerous smart card based authentication protocols have been proposed to provide strong system security and robust individual privacy for communication between parties these days. Nevertheless, most of them do not provide formal analysis proof, and the security robustness is doubtful. chang and cheng(2011) proposed an efficient remote authentication protocol with smart cards and claimed that their proposed protocol could support secure communication in a multi-server environment. Unfortunately, there are opportunities for security enhancement in current schemes. In this paper, we identify the major weakness, i.e., session key disclosure, of a recently published protocol. We consequently propose a novel authentication scheme for a multi-server environment and give formal analysis proofs for security guarantees.

关键词： Authentication Privacy Security Smart card