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Can high resolution manometry parameters for achalasia be obtained by conventional manometry?

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World Journal of Gastrointestinal Pathophysiology 2015年第3期6卷 58-61页

作者： Fernando AM Herbella Marco G patti Hospital Sao Paulo Surgical GastroenterologyDivision of Esophagus and StomachFederal University of Sao Paulo Department of Surgery Pritzker School of MedicineUniversity of Chicago

High resolution manometry(HRM) is a new technology that made important contributions to the field of gastrointestinal physiology. HRM showed clear advan-tages over conventional manometry and it allowed the creation of different manometric parameters. On the other side, conventional manometry is still wild available. It must be better studied if the new technology made possible the creation and study of these parameters or if they were always there but the colorful intuitive panoramic view of the peristalsis from the pharynx to the stomach HRM allowed the human eyes to distinguish subtle parameters unknown or uncomprehend so far and if HRM parameters can be reliably obtained by conventional manometry and data from conventional manometry still can be accepted in achalasia studies. Conventional manometry relied solely on the residual pressure to evaluate lower esophageal sphincter(LES) relaxation while HRM can obtain the Integrated Relaxation Pressure. Esophageal body HRM parameters defines achalasia subtypes, the Chicago classification, based on esophageal pressurization after swallows. The characterization of each subtype is very intuitive by HRM but also easy by conventional manometry since only wave amplitudes need to be measured. In conclusion, conventional manometry is still valuable to classify achalasia according to the Chicago classification. HRM permits a better study of the LES.

关键词： Achalasia Esophagus High resolution manometry Conventional manometry Lower esoph- ageal sphincter Esophageal body Chicago classification

Multidisciplinary approach for patients with esophageal cancer

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World Journal of Gastroenterology 2012年第46期18卷 6737-6746页

作者： Victoria M Villaflor Marco E Allaix Bruce Minsky Fernando A Herbella Marco G patti Department of Medicine Section Hematology/Oncology University of Chicago Medicine Department of Surgery University of Chicago Medicine Radiation Oncology University of Chicago Medicine

Patients with esophageal cancer have a poor prognosis because they often have no symptoms until their disease is advanced. There are no screening recommendations for patients unless they have Barrett's esophagitis or a significant family history of this disease. Often, esophageal cancer is not diagnosed until patients present with dysphagia, odynophagia, anemia or weight loss. When symptoms occur, the stage is often stage Ⅲ or greater. Treatment of patients with very early stage disease is fairly straight forward using only local treatment with surgical resection or endoscopic mucosal resection. The treatment of patients who have locally advanced esophageal cancer is more complex and controversial. Despite multiple trials, treatment recommendations are still unclear due to conflicting data. Sadly, much of our data is difficult to interpret due to many of the trials done have included very heterogeneous groups of patients both histologically as well as anatomically. Additionally, studies have been underpowered or stopped early due to poor accrual. In the United States, concurrent chemoradiotherapy prior to surgical resection has been accepted by many as standard of care in the locally advanced patient. Patients who have metastatic disease are treated palliatively. The aim of this article is to describe the multidisciplinary approach used by an established team at a single high volume center for esophageal cancer, and to review the literature which guides our treatment recommendations.

关键词： Esophageal Cancer Multimodality therapy Multidisciplinary therapy Chemoradiotherapy Esophageal resection Esophagectomy

A Comparison of Linear Array and Hybrid Capture 2 for Detection of Carcinogenic HPV and Cervical Precancer and Cancer

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A Comparison of Linear Array and Hybrid Capture 2 for Detect...

Ceruloplasmin-ferroportin system of iron traffic in vertebrates

24th International Papillomavirus Conference and Clinical Workshop

作者： patti Gravitt Mark Diane Philip Johns Hopkin University NCI/NIH（USA） NCI/NIH（USA） NCI/NIH（USA）

＜正＞We evaluated Linear Array（LA）,a commercialized PGMY09/11 L1 consensus primer PCR test that detects 37 human papillomavirus（HPV）genotypes by reverse line blot hybridization,for the detection of individual HPV genotypes and carcino- genic HPV and its clinical performance for detecting 2-year cumulative cervical precancer and cancer using archived speci- mens from the ASCUS and LSIL Triage Study（ALTS）LA testing was conducted on enrollment specimens from women referred

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World Journal of Biological Chemistry 2014年第2期5卷 204-215页

作者： Giovanni Musci Fabio Polticelli Maria Carmela Bonaccorsi di patti Department of Biosciences and Territory University of Molise Pesche 86090 Italy Department of Sciences University Roma Tre00146 Rome Italy National Institute of Nuclear Physics Roma Tre Section 00146 Rome Italy Department of Biochemical Sciences Sapienza University of Rome 00185 Rome Italy

Safe trafficking of iron across the cell membrane is a delicate process that requires specific protein carriers. While many proteins involved in iron uptake by cells are known, only one cellular iron export protein has been identified in mammals: ferroportin(SLC40A1). Ceruloplasmin is a multicopper enzyme endowed with ferroxidase activity that is found as a soluble isoform in plasma or as a membrane-associated isoform in specific cell types. According to the currently accepted view, ferrous iron transported out of the cell by ferroportin would be safely oxidized by ceruloplasmin to facilitate loading on transferrin. Therefore, the ceruloplasminferroportin system represents the main pathway for cellular iron egress and it is responsible for physiological regulation of cellular iron levels. The most recent findings regarding the structural and functional features of ceruloplasmin and ferroportin and their relationship will be described in this review.

关键词： Iron homeostasis Ferroportin Ceruloplasmin Hemochromatosis Copper

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双联电容器振荡器电路

火工情报 2003年第3期 92-97页

作者： patti

一种用于雷管延时起爆的电子延时电路(10)包括有许多新的装置，如一个新的振荡器(24)、一个程序计时器电路(32)、一个运行控制电路(46)，它们在一起合作使用。振荡器(34)产生一个时钟信号，该信号是由一个电容器(34a)相对于一个参考电... 详细信息

一种用于雷管延时起爆的电子延时电路(10)包括有许多新的装置，如一个新的振荡器(24)、一个程序计时器电路(32)、一个运行控制电路(46)，它们在一起合作使用。振荡器(34)产生一个时钟信号，该信号是由一个电容器(34a)相对于一个参考电压超过REF的放电速度确定的。当一个电压超过REF时，第二个电容器(34b)充电。当第一电容器(34a)的电压低于REF时，一个内部信号产生，电容器进行转换，第一电容器(34a)充电。同时第二电容器(34b)放电。针对这个内部信号，一个锁存器(latch)(34f)产生一个时钟脉冲。程序计时电路(32)包括一个脉动(ripple)计数器(38)和一个程序存储器(programbank)(40)，当初始化时，程序存储器(40)在计数器中输入一次计数。计数器(38)的每一阶段都有单独的设置和清除输入信号，程序存储器(40)针对计数器的每个阶段都有一个设置电路和一个清除电路。每个清除电路产生一个固定持续时间信号，每个设置电路能产生一个两种不同持续时间的信号，其中一个超过了清除信号。在编程过程中，可以选择短或长的持续时间的设置信号，在输入的计数器中，较长的设置信号或者清除信号确定计数器阶段状态。运行控制电路(46)控制着一个门(34h)，这个门允许振荡器脉冲对计数器加1，当关闭门(34h)时应有一个暂时的断电，这样能防止计时器(32)重新初始化。

关键词：电容器振荡器电路时钟信号

Fireworks MX 2004网页图形编辑标准教材中文版中文

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2004年

作者：（美）patti Schulze 赵宏峰杨常青译

本书介绍了Fireworks中位图图像和矢量图像制作的基础知识，并详细讲解了一些高级技术，且介绍了Fireworks与Dreamweaver的集成特性。

ISBN: (纸本)7121001586

本书介绍了Fireworks中位图图像和矢量图像制作的基础知识，并详细讲解了一些高级技术，且介绍了Fireworks与Dreamweaver的集成特性。

关键词：制作网页软件工具

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苏格兰皇家列车奢华之旅

空中英语教室（高级版．彭蒙惠英语） 2009年第9期 24-27,44-45页

作者： patti Nickell

根据历史传说，英国维多利亚女王当年搭火车行遍苏格兰时，爱上了苏格兰之美，因此决定非在此地盖座城堡不可，也正因如此，巴尔莫勒尔城堡便跻身英国皇室居所之一。可惜的是，我并不是来苏格兰买城堡的，而是即将追随维多利亚女王的足... 详细信息

根据历史传说，英国维多利亚女王当年搭火车行遍苏格兰时，爱上了苏格兰之美，因此决定非在此地盖座城堡不可，也正因如此，巴尔莫勒尔城堡便跻身英国皇室居所之一。可惜的是，我并不是来苏格兰买城堡的，而是即将追随维多利亚女王的足迹，搭火车游览苏格兰。由于我搭的是优雅的苏格兰皇家列车，因此这趟旅程享受到的高标准服务和奢华享受，铁定不下于维多利亚女王。

关键词：苏格兰列车维多利亚历史传说标准服务城堡火车英国

圣路易斯电力大厦改建坤龙设计公司新办公大楼

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中国建筑装饰装修 2011年第9期 162-167页

作者： patti Gabriel Architectural Imageworks LLC

尽管整个建筑的外观和原始框架基本上都非常健全,但如果要打造成以建筑设计和工程实践为重点的办公室,仍然需要有新意的方案来利用巨大的空间。

关键词：建筑设计办公大楼电力大厦改建空间分隔工程实践办公室设计师

Data Analytics of an Information System Based on a Markov Decision Process and a Partially Observable Markov Decision Process

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Journal of Computer Science Research 2023年第1期5卷 21-30页

作者： Lidong Wang Reed L.Mosher Terril C.Falls patti Duett Institute for Systems Engineering Research Mississippi State UniversityVicksburgMS 39180USA

Data analytics of an information system is conducted based on a Markov decision process(MDP)and a partially observable Markov decision process(POMDP)in this *** analytics over a finite planning horizon and an infinite planning horizon for a discounted MDP is performed,*** iteration(VI),policy iteration(PI),and Q-learning are utilized in the data analytics for a discounted MDP over an infinite planning horizon to evaluate the validity of the MDP *** optimal policy to minimize the total expected cost of states of the information system is obtained based on the *** the analytics for a discounted POMDP over an infinite planning horizon of the information system,the effects of various parameters on the total expected cost of the information system are studied.

关键词： Predictive modelling Information system MDP POMDP Cybersecurity Q-learning