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Association of initial assessment variables and mortality in severe pediatric traumatic brain injury

World Journal of Pediatric Surgery 2024年第2期7卷 125-133页

作者： Katherine C Bergus Kelli N patterson Lindsey Asti Josh Bricker Tariku J Beyene Lauren N Schulz Dana M Schwartz Rajan K Thakkar Eric A Sribnick Pediatric Surgery Nationwide Children's HospitalColumbusOhioUSA CenterforSurgical Outcomes Research Nationwide Children's HospitalColumbusOhioUSA Neurologic Surgery The Ohio State UniversityColumbusOhioUSA Neurologic Surgery Nationwide Children's HospitalColumbusOhioUSA

Background Predictive scales have been used to prognosticate long-term outcomes of traumatic brain injury(TBI),but gaps remain in predicting mortality using initial trauma resuscitation *** sought to evaluate the association of clinical variables collected during the initial resuscitation of intubated pediatric severe patients with TBI with in-hospital *** Intubated pediatric trauma patients<18 years with severe TBI(Glasgow coma scale(GCS)score≤8)from January 2011 to December 2020 were *** between initial trauma resuscitation variables(temperature,pulse,mean arterial blood pressure,GCS score,hemoglobin,international normalized ratio(INR),platelet count,oxygen saturation,end tidal carbon dioxide,blood glucose and pupillary response)and mortality were evaluated with multivariable logistic *** Among 314 patients,median age was 5.5 years(interquartile range(IQR):2.2-12.8),GCS score was 3(IQR:3-6),Head Abbreviated Injury Score(hAIS)was 4(IQR:3-5),and most had a severe(25-49)Injury Severity Score(ISS)(48.7%,153/314).Overall mortality was 26.8%.GCS score,hAIS,ISS,INR,platelet count,and blood glucose were associated with in-hospital mortality(all p<0.05).As age and GCS score increased,the odds of mortality *** 1-point increase in GCS score was associated with a 35%decrease in odds of *** hAIS,INR,and blood glucose increased,the odds of mortality *** each 1.0 unit increase in INR,the odds of mortality increased by 1427%.Conclusions Pediatric patients with severe TBI are at substantial risk for in-hospital *** are needed to examine whether earlier interventions targeting specific parameters of INR and blood glucose impact mortality.

关键词： mortality pediatric traumatic

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行星科学研究中热发射光谱的实验测量与定标方法

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空间科学学报 2024年第2期44卷 270-286页

作者：杨亚洲 MILLIKEN Ralph E BRAMBLE Michael S patterson William R 邹永廖刘洋中国科学院国家空间科学中心空间天气学国家重点实验室北京100190 布朗大学地球环境与行星科学学院普罗维登斯02912

准确的物质组成信息是解译行星体形成与演化历史的关键,可见–近红外遥感光谱探测一直是获取行星表面成分的主要技术手段.在热红外谱段光谱特征更为丰富,因此随着探测技术的发展,其在行星探测中得到越来越多的应用.尤其是在目前已经实... 详细信息

准确的物质组成信息是解译行星体形成与演化历史的关键,可见–近红外遥感光谱探测一直是获取行星表面成分的主要技术手段.在热红外谱段光谱特征更为丰富,因此随着探测技术的发展,其在行星探测中得到越来越多的应用.尤其是在目前已经实施与立项的国内外小行星探测任务中,都将热发射光谱仪作为核心载荷之一.为了更好地对将来获取的热发射光谱数据进行解译,建立科学合理的数据处理与定标方案是必不可少的.本文对用于行星科学研究的热发射光谱测量装置的设计、测量及数据处理方法进行了系统分析.针对低温、真空条件下热发射测量过程中样品辐射信号与仪器辐射信号难以分离的问题,提出并论证了基于傅里叶变换红外光谱仪原始测量信号–干涉图的数据处理方法.该方法可以更为有效地分离出样品实际辐射信号,从而获得更为准确的发射率光谱数据.研究结果可为国内相关热发射测量装置的设计与搭建以及未来天问二号等探测数据的处理与科学解译提供参考.

关键词：行星探测热发射光谱实验室测量定标

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冰火两重天纽约Othership洗浴中心

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室内设计与装修 2024年第9期 8-11页

作者： [美国]Futurestudio 秋落(编译) Ian patterson(摄影) Futurestudio

Othership是一种社交桑拿和冰浴体验,客人在此仿佛进入另一个世界。Othership提供有指导的课程、自由流动和社交活动,将呼吸法、肢体运动和现场音乐融为一体,创造了一个能让人快乐地拥抱情绪和脆弱心理的环境,让人们善待自己,拥有健康... 详细信息

Othership是一种社交桑拿和冰浴体验,客人在此仿佛进入另一个世界。Othership提供有指导的课程、自由流动和社交活动,将呼吸法、肢体运动和现场音乐融为一体,创造了一个能让人快乐地拥抱情绪和脆弱心理的环境,让人们善待自己,拥有健康的心态,并建立社区。

关键词：洗浴中心社交活动肢体运动健康的心态自由流动呼吸法善待自己

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Experimental investigation on surface deformation of soft half plane indented by rigid wedge

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Applied Mathematics and Mechanics(English Edition) 2016年第10期37卷 1349-1360页

作者： Xiaohua TAN Yilan KANG E.A.patterson Tianjin Key Laboratory of High Speed Cutting and Precision Machining Tianjin University of Technology and Education School of Engineering University of Liverpool Tianjin Key Laboratory of Modern Engineering Mechanics School of Mechanical Engineering Tianjin University

In this work, the mechanical behavior of a block of soft material subject to large deformation from a series of wedge-shaped indenters is evaluated. Data fields acquired from digital image correlation （DIC） are compared with the existing theoretical models. The slope angles of the wedges vary from 5° to 73.5°, and the minimum measure- ment uncertainties of the DIC system are established in advance to define the accuracy. It is concluded that the assumptions underpinning the analytical theory make it difficult to characterize large deformation of soft materials during contact. The strain fields are also obtained from the measured displacement field and verify the previously postulated existence of two deformation sectors, namely, a so-called shrinkage sector symmetric to the loading axis and an expansion sector, which become smaller with the increasing load and decreasing wedge angle.

关键词： contact mechanics wedge indentation large deformation sector division,digital image correlation (DIC)

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The American democracy 5th ed.

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2001年

作者： Thomas E. patterson.

来源：畅想之星图书光盘版（南... 评论

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PicoRio:An Open-Source,RISC-V Small-Board Computer to Elevate the RISC-V Software Ecosystem

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Tsinghua Science and Technology 2021年第3期26卷 384-386页

作者： Zhangxi Tan Lin Zhang David patterson Yi Li RISC-V International Open Source Laboratory Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China

PicoRioTM is an open-source project stewarded by the RISC-V International Open Source(RIOS)laboratory—***—a nonprofit research lab at Tsinghua-Berkeley Shenzhen Institute(TBSI).The RIOS Lab uses collaborative engineering from both academia and industry to elevate the RISC-V software and hardware *** Pico Rio,we create an open,affordable,Linux-capable RISC-V hardware platform to aid software developers in porting many modern programs that require Javascript or *** Rio will build upon high-quality IPs and software components from expert industry engineers and academic *** Rio is not proprietary to any specific vendor and platform,and will have complete documentation that can help people to build quality products in a short amount of *** plan is to ship Pico Rio 1.0 in 1H2021.

关键词： hardware Open Berkeley

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The gut microbiome: an orchestrator of xenobiotic metabolism

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Acta Pharmaceutica Sinica B 2020年第1期10卷 19-32页

作者： Stephanie L.Collins Andrew D.patterson Department of Biochemistry Microbiologyand Molecular Biologythe Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Veterinary and Biomedical Science the Pennsylvania State UniversityUniversity ParkPA 16802USA

Microbes inhabiting the intestinal tract of humans represent a site for xenobiotic *** gut microbiome,the collection of microorganisms in the gastrointestinal tract,can alter the metabolic outcome of pharmaceuticals,environmental toxicants,and heavy metals,thereby changing their *** chemical modification of xenobiotics by the gut microbiome,either through the intestinal tract or re-entering the gut via enterohepatic circulation,can lead to increased metabolism or bioactivation,depending on the enzymatic activity within the microbial *** enzymes encoded within the microbiome include those that reverse the modifications imparted by host detoxification ***,the microbiome can limit xenobiotic absorption in the small intestine by increasing the expression of cell-cell adhesion proteins,supporting the protective mucosal layer,and/or directly sequestering ***,host gene expression is regulated by the microbiome,including CYP450s,multi-drug resistance proteins,and the transcription factors that regulate *** the microbiome affects the host and pharmacokinetics of the xenobiotic,xenobiotics can also influence the viability and metabolism of the *** understanding of the complex interconnectedness between host,microbiome,and metabolism will advance with new modeling systems,technology development and refinement,and mechanistic studies focused on the contribution of human and microbial metabolism.

关键词： Gut microbiome Xenobiotic metabolism Absorption Gastrointestinal tract Pharmacokinetics Enterohepatic circulation Bioactivation

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Intersection of autophagy with pathways of antigen presentation

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Protein & Cell 2012年第12期3卷 911-920页

作者： Natalie L.patterson Justine D.Mintern Department of Biochemistry and Molecular Biology The University of MelbourneParkvilleVictoria 3010Australia

Traditionally,macroautophagy(autophagy)is viewed as a pathway of cell *** ensures the elimination of damaged or unwanted cytosolic components and provides a source of cellular nutrients during periods of ***,autophagy can also directly intersect with,and impact,other major pathways of cellular ***,we will review the contribution of autophagy to pathways of antigen *** autophagy machinery acts to modulate both MHCⅠ and MHCⅡ antigen *** such autophagy is an important participant in pathways that elicit host cell immunity and the elimination of infectious pathogens.

关键词： autophagy antigen presentation antigen presenting cells dendritic cells MHCⅠ MHCⅡ

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Prospects for improving research communication and the incentive system in science

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中国科技期刊研究 2015年第1期26卷 3-7页

作者： Mark patterson Randy Schekman eLife 24 Hills RoadCambridgeUK CB2 1JP Dept. of Mol. and Cell Biology Li Ka Shing CenterUC BerkeleyBerkeleyCA 94720-3370

Much concern has been expressed in recent years about the processes associated with publishing research in high-profile journals,particularly within the life sciences and biomedicine[1-4].Researchers are frequently subjected to substantial delays in communicating their work,overzealous reviewers make demands for extensive revision,and essential information and data are often relegated

关键词：科学期刊发行工作中国行业管理

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Commerce and Empire in the Borderlands： How do Merchants and Trade Fit into Qing Frontier History？

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Frontiers of History in China 2014年第3期9卷 361-383页

作者： C. patterson Giersch Department of History Wellesley College Wellesley MA 02481 USA

As our understanding of the Qing empire and its various borderlands has evolved, so too have we come to appreciate China＇s early modem commercial sophistication. In recent North American studies of the Qing, the links between commerce and conquest have come under investigation, and we are increasingly urged to pay attention to merchants and merchant capital. But how should we understand the relationship between merchants and the Qing empire in the borderlands？ This article surveys selected work on the borderlands and commercialization, primarily in the Northwest and Southwest. The goal is to initiate a more comprehensive discussion of how to understand the intersection of commerce and empire while also making some suggestions for ways that borderlands history might shape future work on China.

关键词： Borderlands frontiers Qing empire merchants commerce

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