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A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon

World Journal of Gastroenterology 2007年第7期13卷 1079-1084页

作者： Aldo Roda patrizia simoni Maria Magliulo Paolo Nanni Mario Baraldini Giulia Roda Enrico Roda Department of Pharmaceutical Sciences University of Bologna Via Belmeloro 6 Bologna 40126 Italy Department of Internal Medicine and Gastroenterology University of Bologna via Massarenti 9 Bologna 40126 Italy

AIM： To develop a new formulation with hydroxy propyl methyl cellulose and Shellac coating for extended and selective delivery of butyrate in the ileo-caecal region and colon. METHODS： One-gram sodium butyrate coated tablets containing ^13C-butyrate were orally administered to 12 healbhy subjects and 12 Crohn＇s disease patients and the rate of ^13C-butyrate absorption was evaluated by t3CO2 breath test analysis for eight hours. Tauroursodeoxycholic acid （500 rag） was co-administered as a biomarker of oro-ileal transit time to determine also the site of release and absorption of butyrate by the time of its serum maximum concentration. RESULTS： The coated formulation delayed the ^13C-butyrate release by 2-3 h with respect to the uncoated tablets. Sodium butyrate was delivered in the intestine of all subjects and a more variable transit time was found in Crohn＇s disease patients than in healthy subjects. The variability of the peak ^13CO2 in the kinetic release of butyrate was explained by the inter-subject variability in transit time. However, the coating chosen ensured an efficient release of the active compound even in patients with a short transit time. CONCLUSION： Simultaneous evaluation of breath ^13CO2 and tauroursodeoxycholic acid concentrationtime curves has shown that the new oral formulation consistently releases sodium butyrate in the ileo-cecal region and colon both in healthy subjects and Crohn＇s disease patients with variable intestinal transit time. This formulation may be of therapeutic value in inflammatory bowel disease patients due to the appropriate release of the active compound.

关键词： Sodium butyrate Inflammatory boweldiseases Ulcerative colitis Crohn's disease Controlledrelease formulation Pharmacokinetics Stable isotope Breath test

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Exocrine pancreatic function during the early recovery phase of acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 316-319页

作者： Raffaele Pezzilli patrizia simoni Riccardo Casadei Antonio M.Morselli-Labate Department of Digestive Diseases and Internal Medicine Department of Surgery University of BolognaSant'Orsola-Malpighi Hospital

BACKGROUND:Exocrine pancreatic dysfunction has been reported in humans in the convalescent period after acute pancreatitis,but the data are scarce and *** study aimed to prospectively assess the exocrine pancreatic function in patients with acute pancreatitis at the time of their refeeding. METHODS:Fecal elastase-1 was determined on the day of refeeding in all consecutive acute pancreatitis patients with their first episode of the *** were 75 patients including 60(80.0%)patients with mild acute pancreatitis and 15(20.0%)patients with severe acute pancreatitis. Etiologically 61 patients(81.3%)had biliary disease,1(1.3%) had alcoholic disease and 3(4.0%)had hypertriglyceridemia. No causes of acute pancreatitis were found in the remaining 10 patients(13.3%).The mean(±SD)refeeding time after the attack of acute panereatitis was 11.2±10.2 days. RESULTS:Pathological values of FE-1 were found in 9 of the 75 patients(12.0%):7(9.3%)patients with mild pancreatitis and 2(2.7%)patients with severe pancreatitis(P=1.000). The frequency of the pathological values of fecal elastase-1 was significantly different from that of various etiologies of the disease(P=0.030).It was significantly lower in patients with biliary pancreatitis(9.8%;P=0.035)than in one patient with alcoholic pancreatitis(P=0.126),one patient with hypertriglyceridemia-induced pancreatitis(33.3%; P=0.708),and one patient with idiopathic pancreatitis (10.0%;P=0.227).Pathological fecal elastase-1 was not significantly related to sex,age or day of ***:Exocrine pancreatic function should be routinely assessed in patients with acute pancreatitis at the time of refeeding in order to supplement their diet with pancreatic extracts.

关键词： exocrine pancreatic insufficiency pancreatic elastase pancreatic pseudocyst pancreatitis,acute necrotizing pancreatitis,alcoholic

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Beneficial effect of sulphate-bicarbonate-calcium water on gallstone risk and weight control

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World Journal of Gastroenterology 2012年第9期18卷 930-937页

作者： Stefano Ginanni Corradini Flaminia Ferri Michela Mordenti Luigi Iuliano Maria Siciliano Maria Antonella Burza Bruno Sordi Barbara Caciotti Maria Pacini Edoardo Poli Adriano De Santis Aldo Roda Carolina Colliva patrizia simoni Adolfo Francesco Attili Gastroenterology Division Department of Clinical MedicineSapienza University of RomeViale dell' Universita' 37 Department of Medical Sciences and Biotechnology Vascular Medicine and Atherothrombosis LaboratorySapienza University of Rome Direzione Sanitaria Terme di Chianciano Department of Pharmaceutical Science Alma Mater-University of Bologna Department of Clinical Medicine Alma MaterUniversity of Bologna

AIM： To investigate the effect of drinking sulphate-bi- carbonate-calcium thermal water （TW） on risk factors for atherosclerosis and cholesterol gallstone disease.

关键词： Thermal water Gallstones Oxidative stress Body weight Bile acid

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Non-invasive panel tests for gastrointestinal motility monitoring within the MARS-500 Project

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World Journal of Gastroenterology 2013年第14期19卷 2208-2216页

作者： Aldo Roda Mara Mirasoli Massimo Guardigli patrizia simoni Davide Festi Boris Afonin Galina Vasilyeva Department of Chemistry "G.Ciamician" University of Bologna-Alma Mater Studiorum Department of Medical and Surgical Sciences University of Bologna-Alma Mater Studiorum State Scientific Center of Russian Federation-Institute of Biomedical Problems of the Russian Academy of Sciences(IBMP)

AIM:To develop an integrated approach for monitoring gastrointestinal motility and inflammation state suitable for application in long-term ***:Breath tests based on the oral administration of 13 C-labeled or hydrogen-producing substrates followed by the detection of their metabolites(13 CO 2 or H 2) in breath were used to measure gastrointestinal motility parameters during the 520-d spaceflight ground simulation within the MARS-500 *** particular,the gastric emptying rates of solid and liquid contents were evaluated by 13 C-octanoic acid and 13 Cacetate breath tests,respectively,whereas the orocecal transit time was assessed by an inulin H 2-breath test,which was performed simultaneously with the 13 C-octanoic acid breath test.A ready-to-eat,standardized pre-packaged muffin containing 100 mg of 13 C-octanoic acid was used in the 13 C-octanoic acid breath test to avoid the extemporaneous preparation of solid *** addition,a cassette-type lateral flow immunoassay was employed to detect fecal calprotectin,a biomarker of intestinal *** no items could be introduced into the simulator during the experiment,all materials and instrumentation required for test performance during the entire mission simulation had to be provided at the beginning of the ***:The experiments planned during the simulation of a manned flight to Mars could be successfully performed by the crewmembers without any external *** evident alterations(i.e.,increasing or decreasing trends) in the gastric emptying rates were detected using the 13 C-breath tests during the mission simulation,as the gastric emptying half-times were in the range of those reported for healthy *** contrast to the 13 C-breath tests,the results of the inulin H 2-breath test were difficult to interpret because of the high variability of the H 2 concentration in the breath samples,even within the same *** variability suggested that the H 2-breath

关键词： Breath test Gastrointestinal inflammation Gastrointestinal motility Spaceflight Stress

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