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Application of CRISPR/Cas-mediated base editing for directed protein evolution in plants

Science China(Life Sciences) 2020年第4期63卷 613-616页

作者： Niklas Capdeville patrick schindele Holger Puchta Botanical Institute Molecular Biology and BiochemistryKarlsruhe Institute of TechnologyKarlsruhe 76131Germany

Breeding for improved cultivars of existing crops depends mainly on the available amount of genetic variability in yield or quality related *** thousands of years,humans have relied on naturally occurring mutations to recombine and select improved *** chemical or physical mutagens,the amount and range of mutations could be increased,accelerating the development of new ***,naturally occurring or randomly induced mutations lead to unpredictable breeding outcomes and therefore necessitate tedious rounds of backcrossing to eventually produce useful phenotypes(Pacher and Puchta,2017).

关键词： breeding crops cultivar

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From gene editing to genome engineering: restructuring plant chromosomes via CRISPR/Cas

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aBIOTECH 2020年第1期1卷 21-31页

作者： Carla Schmidt patrick schindele Holger Puchta Botanical Institute Karlsruhe Institute of TechnologyPOB 698076133 KarlsruheGermany

In the last years,tremendous progress has been achieved in the field of gene editing in *** the induction of single site-specific double-strand breaks(DSBs),the knockout of genes by non-homologous end joining has become routine in many plant ***,the efficiency of inducing pre-planned mutations by homologous recombination has also been improved ***,very little effort has been undertaken until now to achieve more complex changes in plant genomes by the simultaneous induction of several *** reports have been published on the efficient induction of ***,the induction of intrachromosomal inversions and interchromosomal recombination by the use of CRISPR/Cas has only recently been *** this review,we want to sum up these results and put them into context with regards to what is known about natural chromosome rearrangements in ***,we review the recent progress in CRISPR/Cas-based mammalian chromosomal rearrangements,which might be inspiring for plant *** the long run,the controlled restructuring of plant genomes should enable us to link or break linkage of traits at will,thus defining a new area of plant breeding.

关键词： Chromosomal rearrangements CRISPR/Cas Genome engineering Inversion Translocation

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