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Phenotypic Detection and Susceptibility Pattern for the Detection of Extended Spectrum β-Lactamase-Producing <i>Klebsiella pneumonia </i>Isolates in Nairobi, Kenya

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Open Journal of Medical Microbiology 2013年第2期3卷 91-94页

作者： patrick mutharia ndiba Department of Microbiology Faculty of Medicine Kenya Methodist University Meru Kenya

Klebsiella pneumoniae is an opportunistic pathogen that is an important cause of nosocomial infections. Detection of ESBL producers’ poses a special challenge for clinical microbiology laboratories, although ESBL producing pathogens are able to hydrolyze extended-spectrum penicillins, cephalosporins, and aztreonam, the minimum inhibitory concentrations (MIC) of some and perhaps even all of these agents may be within the susceptible range. The third generation cephalosporins have the reputation for being useful against a broad range of bacterial infections. However, resistance to these agents is something that must still be considered and creates obstacles for their clinical use. A total of 80 multi drug resistant clinical isolates of Klebsiella pneumoniae were obtained from a study on anaerobes associated with Pelvic Inflammatory disease (P.I.D), KEMRI S.S.C No.495. The isolates were identified by standard microbiological procedures. Antimicrobial susceptibility testing was carried out by Kirby-Bauer method. Upon identification, the antibiogram profiles of the isolates were determined and those resistant to third-generation cephalosporins were tested for production of ESBL. ESBL production among the multi drug resistant isolates was detected using the phenotypic confirmatory disc diffusion test (PCDDT) and double disk synergy test (DDST). While using standard double disk synergy test (DDST) as screening method for identifying potential ESBL producers, ceftriaxone was the most efficient antimicrobial in screening isolates as potential ESBL producers followed by cefotaxime.

关键词： Extended Spectrum β Lactamases (ESBL) Double Disk Synergy Test Phenotypic Confirmatory Disc Diffusion Test (PCDDT)

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Diagnostic Capacity for Tuberculosis in Various Laboratories within Meru County, Kenya

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Journal of Tuberculosis Research 2019年第4期7卷 238-245页

作者： David Mwenya Nakitare patrick mutharia ndiba Frank Onyambu Sarah Wandili School of Health Sciences Meru University of Science and Technology Meru Kenya Department of Biological Sciences Meru University of Science and Technology Meru Kenya

Background: The Division of Leprosy, Tuberculosis and Lung Disease reported a notification rate of 217/100,000 in Meru County. This study aimed at determining diagnostic capacity for tuberculosis in various medical laboratories within Meru County. Objective: To determine the diagnostic capacity for tuberculosis in various laboratories within Meru County. Materials and Methods: This was a cross-sectional survey which utilized quantitative techniques to establish the potential and capacity of TB diagnostic laboratories in selected medical institutions. Observational checklist was used to determine essential requirements for sample processing. Data entry was done through use of Statistical Package for Social Sciences (SPSS). Data analysis was done using Chi-square. Results: Results indicated that there was significant difference in laboratory diagnostic capacity at [χ2 (1 df, N = 26) = 18.49, p = 0.000 2 (1 df, N = 26) = 18.49, p = 0.000 Conclusion: Public operated laboratories had enhanced Tuberculosis (TB) diagnostic capacity as compared to the private laboratories.

关键词： Diagnostic Capacity Tuberculosis

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