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A Pivotal Role of DELLAs in Regulating Multiple Hormone Signals

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Molecular Plant 2016年第1期9卷 10-20页

作者： Jean-Michel Daviere patrick Achard Institut de Biologie Moleculaire des Plantes (IBMP) UPR2357 associe avec l'Universite de Strasbourg 12 rue General Zimmer 67084 Strasbourg Cedex France

Plant phenotypic plasticity is controlled by diverse hormone pathways, which integrate and convey infor- mation from multiple developmental and environmental signals. Moreover, in plants many processes such as growth, development, and defense are regulated in similar ways by multiple hormones. Among them, gibberellins （GAs） are phytohormones with pleiotropic actions, regulating various growth processes throughout the plant life cycle. Previous work has revealed extensive interplay between GAs and other hor- mones, but the molecular mechanism became apparent only recently. Molecular and physiological studies have demonstrated that DELLA proteins, considered as master negative regulators of GA signaling, inte- grate multiple hormone signaling pathways through physical interactions with transcription factors or reg- ulatory proteins from different families. In this review, we summarize the latest progress in GA signaling and its direct crosstalk with the main phytohormone signaling, emphasizing the multifaceted role of DELLA proteins with key components of major hormone signaling pathways.

关键词： gibberellins DELLAs hormone crosstalk plant development phenotypic plasticity

The immune tolerant phase of chronic HBV infection： new perspectives on an old concept

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Cellular & Molecular Immunology 2015年第3期12卷 258-263页

作者： Antonio Bertoletti patrick T Kennedy Emerging Infectious Diseases (EID) Program Duke-NUS Graduate Medical School Singapore Viral Hepatitis Laboratory Singapore Institute for ClinicalSciences Agency of Science Technology and Research (A＊STAR) Singapore and Blizard Institute Barts and The London School of Medicine & DentistryLondon UK

Chronic hepatitis B virus （HBV） infection progresses through distinct disease phases that are strongly associated with patient age. The so-called immune tolerant （IT） phase represents the classical early phase of infection; it is associated with high levels of HBV replication and lack of clinical signs of liver Inflammation. Whether this phase of HBV infection is also associated with immunological features of ＂tolerance＇ has recently been challenged. Here, we review the data that dispute this concept of immune tolerance and then propose an alternative interpretation of the immunopathological events that take place during this early phase of CHB infection.

关键词： Hepatitis B antiviral immunity T cells

A survey of the Szeg? equation Dedicated to Professor Jean-Yves Chemin on the Occasion of His 60th Birthday

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Science China Mathematics 2019年第6期62卷 1087-1100页

作者： patrick Gérard Sandrine Grellier Laboratoire de Mathématiques d'Orsay Université Paris-Sud CNRSUniversité Paris-Saclay Institut Denis Poisson-Université d'Orléans/Université de Tours CNRS UMR

We survey the main properties of the cubic Szeg? equation from the PDE viewpoint, emphasising global existence of smooth solutions, analytic regularity, growth of high Sobolev norms and the effects of weak damping.

关键词： cubic Szego equation integrable system Hankel operator spectral analysis analytic regularity wave turbulence

Artificially Generated Facial Images for Gender Classification Using Deep Learning

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Computer Systems Science & Engineering 2023年第2期44卷 1341-1355页

作者： Valliappan Raman Khaled ELKarazle patrick Then Coimbatore Institute of Technology Coimbatore641014India Swinburne University of Technology Kuching95530Malaysia

Given the current expansion of the computer visionﬁeld,several appli-cations that rely on extracting biometric information like facial gender for access control,security or marketing purposes are becoming more common.A typical gender classiﬁer requires many training samples to learn as many distinguishable features as ***,collecting facial images from individuals is usually a sensitive task,and it might violate either an individual's privacy or a speciﬁc data privacy *** order to bridge the gap between privacy and the need for many facial images for deep learning training,an artiﬁcially generated dataset of facial images is *** acquire a pre-trained Style-Generative Adversar-ial Networks(StyleGAN)generator and use it to create a dataset of facial *** label the images according to the observed gender using a set of criteria that differentiate the facial features of males and females *** use this manually-labelled dataset to train three facial gender classiﬁers,a custom-designed network,and two pre-trained networks based on the Visual Geometry Group designs(VGG16)and(VGG19).We cross-validate these three classiﬁers on two separate datasets containing labelled images of actual *** testing,we use the UTKFace and the Kaggle gender *** experimental results suggest that using a set of artiﬁcial images for training produces a comparable performance with accuracies similar to existing state-of-the-art methods,which uses actual images of *** average classiﬁcation accuracy of each classiﬁer is between 94%and 95%,which is similar to existing proposed methods.

关键词： Facial recognition data collection facial images generative adversarial networks facial gender estimation

Optimal Ternary Cubic Two-Weight Codes

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Chinese Journal of Electronics 2018年第4期27卷 734-738页

作者： SHI Minjia HUANG Daitao SOL patrick Key Laboratory of Intelligent Computing & Signal Processing Ministry of EducationAnhui University School of Mathematical Sciences Anhui University CNRS/LAGA University of Paris 8

We study trace codes with defining set L,a subgroup of the multiplicative group of an extension of degree m of a certain ring of order 27. These codes are abelian, and their ternary images are quasi-cyclic of coindex three(a.k.a. cubic codes). Their Lee weight distributions are computed by using Gauss sums. These codes have three nonzero weights when m is singly-even. When m is odd, under some hypothesises on the size of L, we obtain two new infinite families of two-weight codes which are optimal. Applications of the image codes to secret sharing schemes are also given.

关键词： Three-weight codes Two-weight codes Gauss sums Trace codes

Skew Cyclic Codes over a Non-chain Ring

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Chinese Journal of Electronics 2017年第3期26卷 544-547页

作者： SHI Minjia YAO Ting SOL patrick Key Laboratory of Intelligent Computing & Signal Processing Ministry of Education Anhui University National Mobile Communications Research Laboratory Southeast University School of Mathematical Sciences of Anhui University CNRS/LAGA University of Paris 82 rue de la Libert93 526 Saint-Denis France

We study skew cyclic codes over a nonchain ring,which generalizes our previous results in IEICE *** Fundamentals of Electronic Communications and Computer Sciences,*** describe generator polynomials of skew cyclic codes over this ring and investigate the structural properties of skew cyclic codes over the ring by a decomposition *** generator polynomial of the dual code of a skew cyclic code are ***,the idempotent generators of skew cyclic codes are *** examples are also presented to illustrate the discussed results.

关键词： Linear codes Gray map Dual codes Skew cyclic codes Generator polynomial

Evidence-based endoscopic management of Barrett’s esophagus

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Gastroenterology Report 2015年第1期3卷 54-62页

作者： patrick Yachimski Chin Hur Division of Gastroenterology Hepatology&Nutrition Vanderbilt University Medical CenterNashvilleTNUSA Division of Gastroenterology&Institute for Technology Assessment Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Barrett’s esophagus(BE)develops as a consequence of chronic esophageal acid exposure,and is the major risk factor for esophageal adenocarcinoma(EAC).The practices of endoscopic screening for—and surveillance of—BE,while widespread,have failed to reduce the incidence of *** majority of EACs are diagnosed in patients without a known history of BE,and current diagnostic tools are lacking in their ability to stratify patients with BE into those at low risk and those at high risk for progression to ***,advances in endoscopic imaging and mucosal therapeutics have provided unprecedented opportunities for intervention for BE,and have vastly altered the approach to management of BE-associated mucosal neoplasia.

关键词： Barrett’s esophagus esophageal adenocarcinoma endoscopic surveillance endoscopic eradication therapy

Diversity of Saccharomyces boulardii CNCM I-745 mechanisms of action against intestinal infections

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World Journal of Gastroenterology 2019年第18期25卷 2188-2203页

作者： Dorota Czerucka patrick Rampall Department of Human Health Division of Ecosystems and Immunity Center Scientific of Monaco Center Scientific of Monaco

The yeast Saccharomyces boulardii CNCM I-745 is one of the probiotics recommended for the prevention of antibiotic-associated diarrhea. Studies conducted in vivo and in vitro demonstrated that in the case of infectious diseases there are two potential sites of action of Saccharomyces boulardii CNCM I-745:(1)An action on enteropathogenic microorganisms(adhesion of bacteria and their elimination or an effect on their virulence factors: Toxins, lipopolysaccharide,etc.); and(2) a direct action on the intestinal mucosa(trophic effects, effects on epithelial reconstitution, anti-secretory effects, anti-inflammatory,immunomodulators). Oral administration of Saccharomyces boulardii CNCM I-745 to healthy subjects does not alter their microbiota. However, in the case of diseases associated with the use of antibiotics or chronic diarrhea, Saccharomyces boulardii CNCM I-745 can restore the intestinal microbiota faster. The interaction of Saccharomyces boulardii CNCM I-745 with the innate immune system have been recently demonstrated thus opening up a new therapeutic potential of this yeast in the case of diseases associated with intestinal infections but also other pathologies associated with dysbiosis such as inflammatory diseases.

关键词： Saccharomyces boulardii CNCM I-745 Probiotics Yeast Intestinal infection Mechanism

Adopting novel ecosystems as suitable rehabilitation alternatives for former mine sites

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Ecological Processes 2013年第1期2卷 221-231页

作者： David Doley patrick Audet Centre for Mined Land Rehabilitation Sustainable Minerals InstituteThe University of QueenslandBrisbane(St.Lucia)QLD 4072Australia

The nature and extent of environmental disturbance associated with mining commonly entails completely new and challenging combinations of climate,lithology and ***,the outcomes of ecological processes associated with the recovery or restoration of ecosystems cannot be predicted reliably from previously known associations between their physical and biological *** radically disturbed sites,we propose that it is not practicable to aim for the restoration of historical ***,hybrid(reversibly different)or novel(irreversibly different)ecosystems comprising new combinations of physical and biological components,including both native and non-native species,could provide levels of stability and functionality acceptable to all stakeholders and within feasible management *** propose that limiting physical conditions of the landscape can be identified and managed,and that alternative species combinations for introduction to these new landscapes may be considered with cautious optimism.

关键词： Natural ecological analogues Novel ecosystems Mining Landscape suitability