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Impacts of radiation therapy on quality of life and pain relief in patients with bone metastases

World Journal of Orthopedics 2024年第9期15卷 841-849页

作者： Armin Hoveidaei Mehdi Karimi Vida Khalafi patrick Fazeli Amir Human Hoveidaei Students’Scientific Research Center Exceptional Talents Development CenterTehran University of Medical SciencesTehran ***Iran Bogomolets National Medical University Kyiv 01601Ukraine Student Research Committee Jahrom University of Medical SciencesJahrom ***Iran Brown University ProvidenceRI 02912United States International Center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of BaltimoreBaltimoreMD 21215United States

Bone metastases(BM)are a common complication in advanced cancer patients,significantly contributing to morbidity and mortality due to their ability to cause pain,fractures,and spinal cord *** therapy(RT)is vital in managing these complications by targeting metastatic lesions to ease pain,improve mobility,and reduce the risk of skeletal-related events such as *** supports the effectiveness of RT in pain relief,showing its ability to provide significant palliation and lessen the need for opioid painkillers,thereby enhancing the overall quality of life(QoL)for patients with ***,optimizing RT outcomes involves considerations such as the choice of radiation technique,dose fractionation schedules,and the integration of supportive care measures to mitigate treatment-related side effects like fatigue and skin *** factors highlight the importance of personalized treatment planning tailored to individual patient needs and tumor *** mini-review aims to provide comprehensive insights into the multifaceted impacts of RT on pain management and QoL enhancement in BM patients,with implications for refining clinical practices and advancing patient care through the synthesis of findings from various studies.

关键词： Radiation therapy Radiotherapy Quality of life Pain relief Bone metastases Bone cancer

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Effect of Butternut Squash (Cucurbita moschata) Seed Powder on the Chemical and Rheological Properties of Stirred Cultured Camel Milk and Yoghurt

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Food and Nutrition Sciences 2024年第7期15卷 576-593页

作者： Collins K. Kangogo patrick S. Muliro Joseph O. Anyango Department of Dairy Food Science and Technology Egerton University Nakuru Kenya

Research shows that producing fermented camel milk is hard because of the milk’s inability to form a firm coagulum, attributed to low levels of κ-casein and ꞵ-lactoglobulin and the large casein micelle size, leading to a weak network of casein formation. In an effort to address this issue, researchers turned to corn starch as a thickening agent, discovering that a concentration of 2.0% effectively improved the viscosity and significantly reduced syneresis in stirred camel milk yoghurt and cultured camel milk. This study explores alternatives to corn starch, focusing on butternut squash seeds as a promising substitute due to their hydrocolloid composition. By incorporating butternut squash (Cucurbita moschata) seed powder (BSSP) as a thickening agent, this study aimed at enhancing the chemical and rheological properties of stirred camel milk yoghurt and cultured camel milk. Fermented camel milk was prepared using 4 litres of camel milk, 2% starter cultures (thermophilic culture for yoghurt and mesophilic aromatic culture for stirred cultured camel milk) and BSSP 0.0% (negative control), 0.4%, 0.8%, 1.2%, 1.6%, 2.0% mixed with 0.4% gelatin. 2.0% corn starch mixed with 0.4% gelatin was used as a standard for comparison. Results showed that increasing the BSSP level significantly (p < 0.05) decreased the moisture content while increasing the total solid content of stirred fermented camel milk products. There was an increase in ash content with an increase in BSSP levels. There was a significant (p < 0.05) reduction in the pH, with an increase in BSSP levels in stirred fermented camel milk samples. Increasing the concentration of BSSP from 0.4% to 2.0% resulted in a significant (p < 0.05) increase in viscosity and a reduction in syneresis of stirred camel milk yoghurt and stirred cultured camel milk samples. This study demonstrated that BSSP effectively enhances the viscosity, reduces syneresis and increases acidity in stirred fermented camel milk products during storage

关键词： Corn Starch Butternut Squash Seed Powder Gelatin Stirred Camel Milk Yoghurt Stirred Cultured Camel Milk

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奥运计时是欧米茄的长期担当

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商业周刊（中文版） 2024年第13期 14-15页

作者： patrick 不详

“团队已经在为米兰和洛杉矶的奥运会工作。我完全相信,欧米茄(OMEGA)作为奥运会正式计时的工作始终是为奥运会研发计时技术与服务,在近100年后的今天依然如此,因为我们知道只有通过创新,才能迈向下一步。”——安世文最初我们认为径赛... 详细信息

“团队已经在为米兰和洛杉矶的奥运会工作。我完全相信,欧米茄(OMEGA)作为奥运会正式计时的工作始终是为奥运会研发计时技术与服务,在近100年后的今天依然如此,因为我们知道只有通过创新,才能迈向下一步。”——安世文最初我们认为径赛、游泳和自行车最仰仗计时,但实际上跳水、击剑、体操等项目也都在奥运会上使用欧米茄(OMEGA)的技术进行测算和计时,它无处不在。你如何向客户和公众传达这一点?

关键词：欧米茄奥运会 OMEGA 洛杉矶计时

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以汽车节强化品牌定位捷豹路虎财报印证策略奏效

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商业周刊（中文版） 2024年第14期 16-17页

作者： patrick 不详

上午的小雨,使古德伍德速度节场地里更加泥泞。这个盛会起源于里士满公爵九世于1936年发起的汽车爬坡赛,经过丰富发展但在1963年停办了。1993年,十一世里士满公爵将其恢复并且发扬光大。每年一次,它是展示汽车技术和速度的盛会,更是领... 详细信息

上午的小雨,使古德伍德速度节场地里更加泥泞。这个盛会起源于里士满公爵九世于1936年发起的汽车爬坡赛,经过丰富发展但在1963年停办了。1993年,十一世里士满公爵将其恢复并且发扬光大。每年一次,它是展示汽车技术和速度的盛会,更是领略汽车历史与文化的嘉年华。与传统的车展和赛事不同,古德伍德速度节专注于汽车文化的展览、竞技、延伸和深层次的挖掘,不同年代的经典跑车、老爷车以及越野车等同台亮相,融汇了汽车文化历史发展和现实,让车迷可以尽情欣赏汽车的过去与未来,并与专业人士共同分享对汽车的热爱,堪称“全球最伟大的汽车运动盛典”,被誉为车展界中的“百科全书”。

关键词：财报文化历史发展嘉年华里士满古德伍德强化品牌历史与文化百科全书

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爱马仕飞马行空

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商业周刊（中文版） 2024年第1期 86-87页

作者： patrick 不详

多年来我越来越坚信爱马仕活动的策划者们,一定是孩子,聪明的孩子,一次次地重新教我,该怎样玩耍。他们的作品让每个观众都想回到童年,再过一遭。这次在上海,是比利时导演Jaco Van Dormael、编舞家Michele Anne De Mey和Astragales舞团... 详细信息

多年来我越来越坚信爱马仕活动的策划者们,一定是孩子,聪明的孩子,一次次地重新教我,该怎样玩耍。他们的作品让每个观众都想回到童年,再过一遭。这次在上海,是比利时导演Jaco Van Dormael、编舞家Michele Anne De Mey和Astragales舞团共同编织的梦幻奇境。

关键词：爱马仕聪明的孩子策划者比利时

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百达翡丽现任总裁泰瑞·斯登:创新是我们的传统保持战略的纯粹性非常重要

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商业周刊（中文版） 2024年第14期 14-15页

作者： patrick 不详

为庆祝百达翡丽北京源邸开幕10周年,品牌倾情呈现“北京时间落邸为家”特别展览,以时间之艺致敬中国。斯登家族第四代传人、百达翡丽现任总裁泰瑞·斯登(Thierry Stern)亲临现场,与宾客共同庆贺这一具有纪念意义的周年庆典。

关键词：现任总裁纯粹性纪念意义宾客第四代

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双鸡酒庄第四代掌门人Brice de La Morandiere:来上海开几瓶酒

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商业周刊（中文版） 2024年第3期 12-13页

作者： patrick 不详

提起勃良第(Burgundy)这个法国古老的葡萄酒产区,人们通常会想起“红酒之王”罗曼尼康帝(Domaine de la Romanée-Conti)。而几乎同样没有争议的“白葡萄酒之王”里费维(Leflaive),声音也许没有那么大,却也稳健发展,经历了四代传承。由... 详细信息

提起勃良第(Burgundy)这个法国古老的葡萄酒产区,人们通常会想起“红酒之王”罗曼尼康帝(Domaine de la Romanée-Conti)。而几乎同样没有争议的“白葡萄酒之王”里费维(Leflaive),声音也许没有那么大,却也稳健发展,经历了四代传承。由于其酒标上的两只雄鸡的图样,中国消费者喜欢称它为“双鸡酒庄”。近日,笔者有幸与里费维庄园(即“双鸡酒庄”)的继承人、第四代掌门人Bricede La Morandiere对谈。

关键词：尼康酒庄稳健发展 die

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Comparative effectiveness of immunotherapy and chemotherapy in patients with metastatic colorectal cancer stratified by microsatellite instability status

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World Journal of Clinical Oncology 2024年第4期15卷 540-547页

作者： Chen-Gu Niu Jing Zhang Aniket-Vijay Rao Utsav Joshi patrick Okolo Department of Internal Medicine Rochester General HospitalRochesterNY 14621United States Department of Psychiatry Rainier SpringsVancouverWA 98663United States Department of Hematology and Medical Oncology Moffitt Cancer CenterTampaFL 33606United States Department of Gastroenterology Rochester General HospitalRochesterNY 14621United States

BACKGROUND Immunotherapy have demonstrated promising outcomes in patients with high microsatellite instability(MSI)(MSI-H)metastatic colorectal ***,the comparative effectiveness of Immunotherapy and chemotherapy for patients with low MSI(MSI-L),and microsatellite stable(MSS)metastatic colorectal cancer remains *** To investigate immunotherapy vs chemotherapy for treatment of MSI-L/MSS metastatic colorectal cancer,and to evaluate the success of immunotherapy against chemotherapy in managing MSI-H metastatic colorectal cancer during a follow-up of 50 *** We conducted a retrospective cohort study using the National Cancer Database(NCDB)to evaluate the overall survival(OS)of patients with metastatic colorectal cancer treated with immunotherapy or *** study population was stratified by MSI status(MSI-H,MSI-L,and MSS).Multivariable Cox proportional hazard models were used to assess the association between treatment modality and OS,adjusting for potential *** A total of 21951 patients with metastatic colorectal cancer were included in the analysis,of which 2358 were MSI-H,and 19593 were MSI-L/*** the MSI-H cohort,immunotherapy treatment(n=142)was associated with a significantly improved median OS compared to chemotherapy(n=860).After adjusting for potential confounders,immunotherapy treatment remained significantly associated with better OS in the MSI-H cohort[adjusted hazard ratio(aHR):0.57,95%confidence interval(95%CI):0.43-0.77,P<0.001].In the MSS cohort,no significant difference in median OS was observed between immunotherapy treatment and chemotherapy(aHR:0.94,95%CI:0.69-1.29,P=0.715).CONCLUSION In this population-based study using the NCDB,immunotherapy treatment was associated with significantly improved OS compared to chemotherapy in patients with MSI-H metastatic colorectal cancer,but not in those with MSI-L/MSS metastatic colorectal *** studies are warranted to determine the optimal therapeu

关键词： Immunotherapy Chemotherapy Metastatic colorectal cancer Microsatellite instability National cancer database

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The Influence of Biomass Cokes on the Microstructure and Thermal Shock Resistance of MgO-C Refractories

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China's Refractories 2024年第3期33卷 9-14页

作者： patrick GEHRE Magzhan KAPESSOV Stefan GUHL Martin GRÄBNER Christos G.ANEZIRIS Institute of Ceramics Refractories and Composite MaterialsTU Bergakademie FreibergFreiberg 09599Germany Institute of Energy Process Engineering and Chemical Engineering TU Bergakademie FreibergFreiberg 09599Germany

In this study,biomass cokes from sunflower seed hull(SFSH)and wood pellets(WP)were added to a MgO-C batch(3 mass%C)to replace 1.1 mass%of *** hardening and carbonizing the samples,the influence of the biomass cokes on the microstructure and thermal shock resistance was *** replacement of flaky graphite by carbonized WP and SFSH reduced the bulk density and increased the apparent porosity after pressing and carbonization,but the degree was only *** was confirmed by SEM investigations,where the biomass-coke containing samples exhibited a microstructure with a higher amount of pores between the fine MgO *** thermal shock resistance of the porous wood pellet coke containing MgO-C is at the same level as the reference sample but not superior to it.

关键词： MgO-C carbon biomass microstructure thermal shock

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High formability Mg-Zn-Gd wire facilitates ACL reconstruction via its swift degradation to accelerate intra-tunnel endochondral ossification

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Journal of Magnesium and Alloys 2024年第1期12卷 295-315页

作者： Xuan He Ye Li Hongwei Miao Jiankun Xu Michael Tim-yun Ong Chenmin Wang Lizhen Zheng Jiali Wang Le Huang Haiyue Zu Zhi Yao Jie Mi Bingyang Dai Xu Li patrick Shu-hang Yung Guangyin Yuan Ling Qin Musculoskeletal Research Laboratory of Department of Orthopaedics&Traumatology and Innovative Orthopaedic Biomaterial and Drug Translational Research Laboratory of Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongHong KongChina National Engineering Research Center of Light Alloy Net Forming School of Materials Science&EngineeringShanghai Jiao Tong UniversityShanghaiChina Department of Orthopaedics and Traumatology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina Orthopaedic Department Peking University Third HospitalBeijingChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong KongChina

After reconstructing the anterior cruciate ligament(ACL),unsatisfactory bone tendon interface healing may often induce tunnel enlargement at the early healing *** good biological features and high formability,Magnesium-Zinc-Gadolinium(ZG21)wires are developed to bunch the tendon graft for matching the bone tunnel during ***,tensile strength,degradation,and cytotoxicity of ZG21 wire are *** rabbit model is used for assessing the biological effects of ZG21 wire by Micro-CT,histology,and mechanical *** SEM/EDS,immunochemistry,and in vitro assessments are performed to investigate the underlying *** tests demonstrate the high formability of ZG21 wire as surgical ***-CT shows ZG21 wire degradation accelerates tunnel bone formation,and histologically with earlier and more fibrocartilage regeneration at the healing *** mechanical test shows higher ultimate load in the ZG21 *** SEM/EDS presents ZG21 wire degradation triggered calcium phosphate(Ca-P)*** results demonstrate upregulation of Wnt3a,BMP2,and VEGF at the early phase and TGFβ3 and Type II collagen at the late phase of *** vitro tests also confirmed the Ca-P in the metal extract could elevate the expression of Wnt3a,βcatenin,ocn and opn to stimulate *** vivo tests of clinical samples indicated suturing with ZG21 wire did not weaken the ultimate loading of human tendon *** conclusion,the ZG21 wire is feasible for tendon graft *** degradation products accelerated intra-tunnel endochondral ossification at the early healing stage and therefore enhanced bone-tendon interface healing in ACL reconstruction.

关键词： Magnesium wire ACL reconstruction Magnesium alloy Biomaterials Endochondral ossification

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