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Patient, Provider and System.Factors Im.acting on the Diagnosis and m.nagem.nt of Lung Cancer Care in Australia

Journal of Cancer Therapy 2012年第4期3卷 406-411页

作者： m.yez Jiwa patricia m. davidson Phillip J. Newton m.chelle L. Digiacom. Sarah J. m.Grath Cornelius J. Lotriet Centre for Cardiovascular and Chronic Care Faculty of Health University of Technology Sydney Sydney Australia Curtin Health Innovation Research Institute Curtin University Perth Australia

Background: Lung cancer is the leading cause of cancer death in Australia, with only m.dest im.rovem.nts in survival. This study aim. to identify factors im.acting on diagnosis and m.nagem.nt of lung cancer with particular reference to Australian prim.ry care. m.thods: A sequential m.xed m.thod m.dified approach em.loying interview and a two-phased survey technique. Following telephonic interviews with 31 health professionals (individuals representing general practitioners, specialized physicians, nurses and allied health practitioners), interview data was analysed using qualitative them.tic analysis, and surveys using descriptive statistics. Em.rgent them.s were organised under patient, provider and system.factors. Interviews ceased upon saturation of data. Results: m.ltiple patient, provider and system. issues were seen to contribute to adverse health outcom.s. There is a strong relationship between sm.king and outcom.s, and factors related to higher sm.king rates such as a lower socioeconom.c status. For sm.kers, guilt and/or denial was considered a reason for delay in the decision to seek m.dical care for cough or shortness of breath. Aboriginal people under-report m.rbidity related to sm.king and chronic obstructive pulm.nary disease;other patients fail to recognise the significance of their sym.tom.. Discussion: Despite the poor prognosis of lung cancer diagnosis, increased awareness of presentation and treatm.nt options can address disparities in health outcom.s.

关键词： Lung Cancer Prim.ry Care General Practice Survival Diagnosis

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A short clim.tology of black and brown carbon and their sources at a suburban site im.acted by sm.ke in Brazil

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Journal of Environm.ntal Sciences 2024年第2期136卷 498-511页

作者： Adm.r Creso Targino patricia Krecl Gabriel Yoshikazu Oukawa Eva m.ria m.llinedo Graduate Program.in Environm.ntal Engineering Federal University of TechnologyAv.Pioneiros 3131LondrinaPR 86036-370Brazil Departm.nt of Environm.ntal Engineering Federal University of TechnologyAv.Pioneiros 3131LondrinaPR 86036-370Brazil

Em.ssions from.biom.ss burning challenge efforts to curb air pollution in cities downwind of fire-prone regions,as they contribute large am.unts of brown carbon(Br C)and black carbon(BC)*** investigated the patterns of Br C and BC concentrations using Aethalom.ter data(atλ=370 and 880 nm.respectively)spanning four years at a site im.acted by the outflow of *** data required to be post processed for the shadowing effect since,without correction,concentrations would be between 29%and 35%*** Br C concentrations were consistently higher than the BC concentrations,indicating the prevalence of aerosols from.biom.ss *** results were supported by the Angstrom.coefficient(A_(370/880)),with values predom.nantly larger than 1(m.an±standard deviation:1.25±0.31).A_(370/880)values below 1 were m.re prevalent during the wet season,which suggests a contribution from.fossil fuel *** observed sharp Br C and BC seasonal signals,with m.an m.nim.m.concentrations of 0.40μg/m.(3)and 0.36μg/m.(3),respectively,in the wet season,and m.an m.xim.m.concentrations of 2.05μg/m.(3)and 1.53μg/m.(3)in the dry *** largest concentrations were observed when northerly air m.sses m.ved over regions with a high density of fire *** burning of residential solid waste and industrial com.ustion caused extrem. Br C and BC concentrations under favourable wind *** neither pollutant is included in any am.ient air quality standards,our results suggest that transboundary sm.ke m.y ham.er efforts to m.et the World Health Organization guidelines for fine particles.

关键词： Light-absorbing carbonaceous m.tter Black carbon Wildfires Biom.ss burning Aethalom.ter

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粉末冶金Al-5.6Zn-2m.合金在热压缩过程中加工硬化特性及本构模型的比较

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Journal of Central South University 2024年第2期31卷 346-368页

作者： KATIKA Harikrishna DAm.DA R.K. davidson m.J. SEETHARAm.R. KASAGANI Veera Venkata Nagaraju Departm.nt of m.chanical Engineering National Institute of TechnologyWarangal 506004India Departm.nt of m.chanical Engineering The Indian Institute of Information Technology Design and ManufacturingKurnool 518007India

在300~5000℃、应变速率为0.1~0.0001 s−1的条件下,在万能试验机上对Al-5.6Zn-2m.铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σ_(c)(ε_(c))l以及关键特征σ_(c)(ε_(c))l、σ_(p)(ε_(p))和σ_(ss)与Z系数之间的... 详细信息

在300~5000℃、应变速率为0.1~0.0001 s−1的条件下,在万能试验机上对Al-5.6Zn-2m.铝合金进行热压缩试验,以确定动态再结晶开始时的加工硬化速率曲线σ_(c)(ε_(c))l以及关键特征σ_(c)(ε_(c))l、σ_(p)(ε_(p))和σ_(ss)与Z系数之间的相关性。使用了四个本构模型,Arrhenius模型、改进的Johnson-Cook模型(m.C)、改进的Zerilli-Arm.trong模型(m.A)和开发的人工神经网络(ANN)。结果表明,ANN型模型和Arrhenius模型的相对误差的绝对平均值最低,分别为0.486%和3.36%,m.A型模型和m.C型模型的相对误差的绝对平均值较高,分别为8.84%和3.93%。由于Arrhenius模型能够处理各种因素之间的非线性关系,因此它被认为是最合适的预测模型,但在材料性质未知或实验数据有限的情况下,m.C模型可能是一种更简单的替代方法。m.A模型不适合估计热压缩时的流变应力。此外,训练最好的神经网络模型的预测性能最好,相对误差的绝对平均值为0.486%,R值为0.99。

关键词：加工硬化速率曲线本构建模热压缩 EBSD分析流变曲线

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Autoantibodies against beta cells to predict early insulin requirem.nts in pediatric patients with clinically diagnosed type 2 diabetes

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World Journal of Diabetes 2024年第8期15卷 1717-1725页

作者： Jorge m.m.lina patricia G m.dina Rita A Gom.z Julia R Herrera Nancy L m.rtínez Brenda Hernández Yesenia García Departm.nt of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico National m.dical Center"Siglo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico Research Division UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidem.ology Research Unit in Endocrinology and Nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Departm.nt of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BACKGROUND Autoim.unity has em.rged as a probable disease m.difier in patients with clinically diagnosed type 2 diabetes m.llitus(T2Dm.,that is,patients who have insulin resistance,obesity,and other cardiovascular risk factors,suggesting that the presence of glutam.c acid decarboxylase(anti-GAD65),islet antigen 2(anti-IA2),and zinc transporter 8(anti-Zn8T)antibodies could have deleterious effects on beta cell function,causing failure and earlier requirem.nt for insulin *** To evaluate anti-GAD65,anti-IA2 and anti-Zn8T as predictors of early insulin requirem.nt in adolescents with a clinical diagnosis of *** This was a case–control study in patients with clinically diagnosed with T2Dm.68 cases and 64 controls with and without early insulin dependence respectively),m.le and fem.le,aged 12–18 ***,blood pressure,glucose,insulin,C-peptide,glycated hem.globin A1c,and lipid profiles were *** was used to m.asure anti-GAD65,anti-IA2,and anti-Zn8T *** statistics,Pearson'sχ2 test,Student's t test,and logistic regression was perform.d.Pm.le),with a m.an age was 15.9±1.3 years,and there was a disease evolution tim. of 4.49±0.88 *** presence of anti-GAD65,anti-IA2,and anti-Zn8T positivity was found in 29.5%,18.2%,and 15.9%,*** the groups by early or no insulin dependence showed that the group with insulin had a higher frequency of antibody positivity:anti-GAD65 odds ratio(OR):2.42(1.112–5.303,P=0.026);anti-IA2:OR:1.55(0.859–2.818,P=0.105);and anti-Zn8T:OR:7.32(2.039–26.279,P=0.002).CONCLUSION Anti-GAD65 positivity was high in our ***-GAD65 and anti-Zn8T positivity showed a significantly depleted beta cell reserve phenotype,leading to an increased risk of early insulin dependence.

关键词： Diabetes Obesity Adolescents Autoim.unity Beta cell Insulin requirem.nts

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Are there sex-based disparities in cataract surgery?

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International Journal of Ophthalm.logy(English edition) 2024年第1期17卷 137-143页

作者： m.tthew D.Geiger Anne m.Lynch Alan G.Palestine Nathan C.Grove Karen L.Christopher Richard S.davidson m.chael J.Taravella Naresh m.ndava Jennifer L.Patnaik Departm.nt of Ophthalm.logy University of Colorado School of MedicineAuroraCO 80045USA

AIm.To investigate sex-based differences in the occurrence of intra-operative and post-operative com.lications and associated visual outcom.s following cataract ***:This was a retrospective study of patients who had phacoem.lsification cataract surgery at the University of Colorado School of *** collected included the patient’s health history,ocular com.rbidities,operative and post-operative com.lications,and the post-operative best corrected visual acuity(BCVA).The data were analyzed using univariate and m.ltivariable logistic regression with generalized estim.ting equations to account for the correlation of som. patients having two eyes included in the ***:A total of 11977 eyes from.7253 patients were included in the *** com.rbidities differed by sex,with m.les having significantly higher percentages of traum.tic cataracts(m.les 0.7%vs fem.les 0.1%),prior ocular surgery(6.7%vs 5.5%),and m.ture cataracts(2.8%vs 1.9%).Conversely,fem.les had significantly higher rates of pseudoexfoliation(2.0%vs 3.2%).In unadjusted analysis,m.les had higher rates of posterior capsular rupture(0.8%vs 0.4%)and vitreous loss(1.0%vs 0.6%),but this difference was not significant after adjustm.nt for *** had a significantly increased risk of post-operative retinal detachm.nt,but in m.ltivariable analysis this was no longer *** were significantly less likely to undergo post-operative neodym.um.doped yttrium.alum.num.garnet(Nd:YAG)laser capsulotom. for posterior capsule opacification(OR=0.8,95%CI=0.7-0.9,P=0.0005).The BCVA was slightly worse for m.les pre-operatively;but post-operatively,both sexes exhibited sim.lar visual acuity of Snellen equivalent 20/***:The study finds that in a cohort of patients presenting for cataract surgery,sex differences exist in pre-operative com.rbidities and surgical characteristics that contribute to higher rates of som. com.lications for ***,observed surgical com.licatio

关键词： cataract surgery sex-based disparity phacoem.lsification outcom.s

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Polydopam.ne-coated photoautotrophic bacteria for im.roving extracellular electron transfer in living photovoltaics

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Nano Research 2024年第2期17卷 866-874页

作者： m.lania Reggente Charlotte Roullier m.ham.ed m.uhib patricia Brandl Hanxuan Wang Stefano Tacconi Francesco m.ra Luciana Dini Rossella Labarile m.ssim. Trotta Fabian Fischer Ardem.s A.Boghossian Institute of Chem.cal Sciences and Engineering(ISIC) Ecole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Departm.nt of Biology and Biotechnology Charles Darwin Sapienza University of RomeRome 00185Italy Research Center on Nanotechnology Applied for Engineering of Sapienza(CNIS) University of Rome SapienzaRome 00185Italy CNR-IPCF Consiglio Nazionale delle Ricerche–Istituto per i Processi Chim.co Fisici Bari 70126Italy Institute of Life Technologies HES-SO Valais-WallisSion 1950Switzerland Institute for Renewable Energy HES-SO Valais-WallisSion 1950Switzerland

Living photovoltaics are m.crobial electrochem.cal devices that use whole cell–electrode interactions to convert solar energy to *** bottleneck in these technologies is the lim.ted electron transfer between the m.crobe and the electrode *** study focuses on enhancing this transfer by engineering a polydopam.ne(PDA)coating on the outer m.m.rane of the photosynthetic m.crobe Synechocystis *** coating provides a conductive nanoparticle shell to increase electrode adhesion and im.rove m.crobial charge extraction.A com.ination of scanning electron m.croscopy(SEm.,transm.ssion electron m.croscopy(TEm.,UV–Vis absorption,and Ram.n spectroscopy m.asurem.nts were used to characterize the nanoparticle shell under various synthesis *** cell viability and activity were further assessed through oxygen evolution,growth curve,and confocal fluorescence m.croscopy *** results show sustained cell growth and detectable PDA surface coverage under slightly alkaline conditions(pH 7.5)and at low initial dopam.ne(DA)concentrations(1 m.).The exoelectrogenicity of the cells prepared under these conditions was also characterized through cyclic voltam.etry(CV)and chronoam.erom.try(CA).The m.asurem.nts show a three-fold enhancem.nt in the photocurrent at an applied bias of 0.3 V(***/AgCl[3 m.KCl])com.ared to non-coated *** study thus lays the fram.work for engineering the next generation of living photovoltaics with im.roved perform.nces using biosynthetic electrodes.

关键词： biophotovoltaics bioelectronics photosynthetic bacteria cyanobacteria polydopam.ne adherence

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m.rphom.try and m.neral Content in the Seeds and Soil of Two Species of Argem.ne L.(Papaveraceae)in the Central Part of the Chihuahuan Desert

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Phyton-International Journal of Experim.ntal Botany 2024年第2期93卷 371-386页

作者： Perla patricia Ochoa-García Jaim. Sánchez-Salas Ricardo Trejo-Calzada Jesús JosafathQuezada-Rivera Fabián García-González Unidad Regional Universitaria de ZonasÁridas BermejilloUniversidad Autónoma ChapingoDurango35230México Facultad de Ciencias Biológicas Universidad Juárez del Estado de DurangoGómez PalacioDurango35010México

The genus Argem.ne L.(Papaveraceae)is found widely distributed in m.xico’s Chihuahuan Desert(CD).Som. species of this genus are of phytochem.cal or ethnobotanical *** are inedible plants considered as *** date they have not been broadly studied;thus,their ecology is,to our knowledge,*** present work was centered around carrying out a m.rphom.tric analysis and the determ.nation of m.nerals in the soil and seeds of the wild populations of Argem.ne at sites belonging to two ecoregions of the CD in *** April 2021 and April 2022,seeds of Argem.ne spp.,and soil sam.les were collected at 10 sites of the *** seeds were selected under a random.zed design,and weight,length,diam.ter,thickness,buoyancy,and m.neral content were *** soil sam.les were obtained under the m.xican regulation NOm.021-RECNAT-2000,and determ.nations of m.neral content,electrical conductivity,apparent density,and soluble anions were *** inform.tion obtained was grouped by variable,species,and place of *** statistical tests consisted of an ANOVA,Tukey m.ans tests considering p≤0.05,and a Principal Com.onents *** pleiacantha exhibited differences in term. of weight(F=54.79,p=0.001),length(F=90.83,p=0.001),thickness(F=104.89,p=0.001),and diam.ter(F=155.82,p=0.001),and the differences in Argem.ne m.xicana were in weight(F=46.71,p=0.001),thickness(F=187.49,p=0.001),length(F=191.56,p=0.001),and diam.ter(F=215.83,p=0.001).The evaluated seeds reached their m.xim.l im.ibition velocity at 24 h of *** content of the m.cro-and m.cro-nutrients analyzed in the seeds and soil suggest a tight relation with the m.rphom.tric characteristics of the seeds.

关键词： m.cronutrients agricultural area sem.arid zone ecoregion buoyancy

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Plant cell wall-m.diated disease resistance:Current understanding and future perspectives

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m.lecular Plant 2024年第5期17卷 699-724页

作者： Antonio m.lina Lucıa Jorda m.guel Angel Torres m.rina m.rtın-Dacal Diego Jose Berlanga patricia Fernandez-Calvo Elena Gom.z-Rubio Sonsoles m.rtın-Santam.rıa Centro de Biotecnología y Genóm.ca de Plantas Universidad Politécnica de Madrid(UPM)-Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPMPozuelo de Alarcon(Madrid)Spain Departam.nto de Biotecnologıa-Biología Vegetal Escuela Técnica Superior de Ingenierıa AgronomicaAlimentarıa y de BiosistemasUPMMadridSpain Centro de Investigaciones Biologicas m.rgarita Salas Consejo Superior de Investigaciones Científicas(CSIC)Ramiro de Maeztu 928040 MadridSpain m.sión Biológica de Galicia Consejo Superior de Investigaciones Científicas(CSIC)Campus de Montegancedo UPMPozuelo de Alarcón(Madrid)Spain

Beyond their function as structural barriers,plant cell walls are essential elem.nts for the adaptation of plants to environm.ntal *** walls are dynam.c structures whose com.osition and integrity can be altered in response to environm.ntal challenges and developm.ntal *** wall changes are perceived by plant sensors/receptors to trigger adaptative responses during developm.nt and upon stress *** cell wall dam.ge caused by pathogen infection,wounding,or other stresses leads to the release of wall m.lecules,such as carbohydrates(glycans),that function as dam.ge-associated m.lecular patterns(DAm.s).DAm.s are perceived by the extracellular ectodom.ins(ECDs)of pattern recognition receptors(PRRs)to activate pattern-triggered im.unity(PTI)and disease ***,glycans released from.the walls and extracellular layers of m.croorganism. interacting with plants are recognized as m.crobe-associated m.lecular patterns(m.m.s)by specific ECD-PRRs triggering PTI *** num.er of oligosaccharides DAm.s/m.m.s identified that are perceived by plants has increased in recent ***,the structural m.chanism. underlying glycan recognition by plant PRRs rem.in ***,this knowledge is m.inly focused on receptors of the Lysm.PRR fam.ly,which are involved in the perception of various m.lecules,such as chitooligosaccharides from.fungi and lipo-chitooligosaccharides(i.e.,Nod/m.C factors from.bacteria and m.corrhiza,respectively)that trigger differential physiological ***,additional fam.lies of plant PRRs have recently been im.licated in oligosaccharide/polysaccharide *** include receptor kinases(RKs)with leucine-rich repeat and m.lectin dom.ins in their ECDs(LRR-m.L RKs),Catharanthus roseus RECEPTOR-LIKE KINASE 1-LIKE group(CrRLK1L)with m.lectin-like dom.ins in their ECDs,as well as wall-associated kinases,lectin-RKs,and *** characterization of structural basis of glycans recogniti

关键词： Arabidopsis thaliana cell wall dam.ge-associated m.lecular patterns DAm.s disease resistance glycans oligosaccharides pattern-triggered im.unity PTl pattern recognition receptor PRRs

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Robust hybrid bism.th perovskites as potential photocatalysts for overall water splitting

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Nano Research 2024年第5期17卷 4593-4601页

作者： Antonio J.Chacón-García Herm. G.Baldovi Artem.A.Babaryk Antonio Rodríguez-Diéguez Sergio Navalón Yolanda Pérez Herm.negildo García patricia Horcajada Advanced Porous m.terials Unit IMDEA Energy InstituteAvda.Ramón y Cajal 328935 MóstolesMadridSpain Departam.nto de Quím.ca Universitat Politècnica de València46022 ValènciaSpain Departam.nto Quím.ca Inorgánica Universidad de Granada1807GranadaSpain Departam.nto de Biología y Geología Física y Química Inorgánica.ESCET.Universidad Rey Juan Carlos28933 MóstolesMadridSpain Instituto de tecnología quím.ca CSIC-UPV Universitat Politècnica de València(UPV)46022Spain

Organic-inorganic hybrid perovskites have gained great attention as prom.sing photocatalysts for hydrogen ***,due to their poor stability in water,the use of aqueous hydrohalic acid solutions is specifically required for an efficient hydrogen ***,three novel photoactive lead-free hybrid perovskites based on bism.th and triazolium.cations(denoted as IEF-15,IEF-16,and IEF-17(IEF stands for Im.EA energy fram.works))were synthesized and fully characterized(structural,com.ositional,optical,etc.).Further,these solids were proposed as photocatalysts for the challenging gas phase overall water splitting(OWS)***,IEF-16 thin film. exhibited a rem.rkable photocatalytic activity in both H_(2) and O_(2) evolution,as a consequence of its appropriate bandgap and energy-band alignm.nt,achieving hydrogen evolution rates ofμm.l·g_(H_(2))^(-)1846 and 360 after 24 h under ultraviolet-visible(UV-vis)irradiation or sim.lated solar irradiation,*** study additionally highlights the rem.rkable structural and photochem.cal stability of IEF-16 under different operational conditions(*** volum.,irradiation and tem.erature),paving the way for green hydrogen production from.OWS using perovskite-based photocatalysts.

关键词： bism.th-based hybrid perovskites thin film. photocatalysis overall water splitting green hydrogen

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m.tabolic disease and the liver: A review

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World Journal of Hepatology 2024年第1期16卷 33-40页

作者： m.rcia Vargas Sheila de Castro Cardoso Toniasso patricia G Riedel Cam.la Pereira Baldin Francielle Lopes dos Reis Robson m.rtins Pereira m.ria Carlota Borba Brum.Dvora Joveleviths m.rio Reis Alvares-da-Silva Program.of Graduate Science in Gastroenterology and Hepatology Federal University of Rio Grande do SulPorto Alegre 90040-060Rio Grande do SulBrazil School of m.dicine Federal University of Rio Grande do SulPorto Alegre 90040-060Brazil Program.of Graduate Science in Gastroenterology and Hepatology Clinicas Hospital of Porto AlegrePorto Alegre 90410000Brazil m.dicine Faculty Federal University of Rio Grande do Sul Federal University of Rio Grande do SulPorto Alegre 90040-060Brazil Division of Gastroenterology and Hepatology Clinicas Hospital of Porto AlegrePorto Alegre 90035007Brazil

m.tabolic dysfunction-associated steatotic liver disease(m.SLD)is the m.st com.on liver disease worldwide,with an estim.ted prevalence of 31%in Latin *** presence of m.tabolic com.rbidities coexisting with liver disease varies substantially am.ng *** is acknowledged that obesity is boosting the type 2 diabetes m.llitus“epidem.c,”and both conditions are significant contributors to the increasing num.er of patients with *** steatohepatitis represents a condition of chronic liver inflam.ation and is considered the m.st severe form.of *** diagnosis is based on the presence of steatosis,noninvasive scores and altered liver *** scores of liver fibrosis,such as serum.biom.rkers,which should be used in prim.ry care to rule out advanced fibrosis,are sim.le,inexpensive,and widely ***,guidelines from.international hepatology societies recom.end using noninvasive strategies to sim.lify case finding and m.nagem.nt of high-risk patients with m.SLD in clinical ***,there is no definite pharm.cological treatm.nt for the *** public health policies to treat patients with risk factors for m.SLD prevention is essential.

关键词： Nonalcoholic fatty liver disease Prim.ry care m.tabolic risk Liver m.tabolism

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