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Acta Mathematica Scientia 2016年第6期36卷 1780-1792页

作者：魏利陈蕊 Ravi P.AGARWAL patricia yj wong School of Mathematics and Statistics Hebei University of Economics and Business Department of Mathematics Texas A&M University-Kingsville Department of Mathematics Faculty of ScienceKing Abdulaziz University School of Electrical and Electronic Engineering Nanyang Technological University

One parabolic p-Laplacian-like differential equation with mixed boundaries is au/at in the corresponding studies is replaced by a（au/at）, studied in this paper, where the item au/at which makes it more general. The sufficient condition of the existence and uniqueness of non-trivial solution in L2（O, T; L2 （Ω）） is presented by employing the techniques of splitting the boundary problems into operator equation. Compared to the corresponding work, the restrictions imposed on the equation are weaken and the proof technique is simplified. It can be regarded as the extension and complement of the previous work.

关键词： maximal monotone operator Caratheodory'conditions subdifferential p-Laplacian-tike equation nontrivial solution

Development of An ICR Mouse Bioassay for Toxicity Evaluation in Neurotoxic Poisoning Toxins-Contaminated Shellfish

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Biomedical and Environmental Sciences 2013年第5期26卷 346-364页

作者： wong Chun Kwan HUNG patricia KAM Kai Man Biotoxin Laboratory Microbiology DivisionPublic Health Laboratory Services BranchCentre for Health ProtectionDepartment of HealthShek Kip MeiKowloon

Objective To develop an ICR （female） mouse bioassay （MBA） for toxicity confirmation and evaluation of neurotoxins （brevetoxins）-contaminated shellfish. Methods Brevetoxins （BTX-B） as a causative agent of neurotoxic shellfish poisoning （NSP） under different shellfish matrices were intraperitoneally injected at different doses into mice to study their toxic effects and to differentiate the range of lethal and sublethal dosages. Their sensitivity and specificity were analyzed with 2 competitive ELISA kits for quantitative determination of standard BTX-B and dihydroBTX-B under different shellfish matrix-diluent combinations. Detection rates of MBA and two antibody-based assays for BTX-B from field NSP-positive shellfish samples were compared. Results BTX-B could be detected in shellfish tissues at concentration of 50-400 μg/100 g under shellfish matrix-Tween-saline media, which were appropriate to identify toxic shellfish at or above the regulatory limit （80 μg/100 g shellfish tissues）. The LD 50 identified was 455 g/kg for BTX-B under general shellfish matrices （excluding oyster matrices） dissolved in Tween-saline. The presence of shellfish matrices, of oyster matrices in particular, retarded the occurrence of death and toxicity presentation in mice. Two antibody-based assays, even in the presence of different shellfish matrix-diluent combinations, showed acceptable results in quantifying BTX-B and dihydroBTX-B well below the regulatory limit. Conclusion The two ELISA analyses agree favorably （correlation coefficient, r 0.96; Student＇s t-tests, P〉0.05） with the developed bioassay.

关键词： Antibody-based assay Brevetoxin ICR female mice LD 50 Mouse bioassay Neurotoxic shellfish poisoning

On Systems of Boundary Value Problems for Differential Inclusions

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Acta Mathematica Sinica,English Series 2007年第3期23卷 549-556页

作者： Lynn ERBE Christopher C.TISDELL patricia J.Y.wong Department of Mathematics The University of Nebraska-LincolnLincolnNE 68588-0130USA School of Mathematics and Statistics The University of New South WalesSydney 2052Australia School of Electrical and Electronic Engineering Nanyang Technological University50 Nanyan9 AvenueSingapore 639798Singapore

Herein we consider the existence of solutions to second-order, two-point boundary value problems （BVPs） for systems of ordinary differential inclusions. Some new Bernstein-Nagumo conditions are presented that ensure a priori bounds on the derivative of solutions to the differential inclusion. These a priori bound results are then applied, in conjunction with appropriate topological methods, to prove some new existence theorems for solutions to systems of BVPs for differential inclusions. The new conditions allow of the treatment of systems of BVPs without growth restrictions.

关键词： boundary value problem, systems of differential inclusions, existence of solutions a priori bounds Bernstein-Nagumo condition

Nitric Oxide： A Multitasked Signaling Gas in Plants

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Molecular Plant 2015年第4期8卷 506-520页

作者： patricia Domingos Ana Margarida Prado Aloysius wong Christoph Gehring Jose A. Feijo Instituto Gulbenkian de Ciencia P-2780-156 Oeiras Portugal Division of Biological and Environmental Sciences and Engineering 4700 King Abdullah University of Science and Technology Thuwa123955-6900 Kingdom of Saudi Arabia Department of Cell Biology and Molecular Genetics University of Maryland 0118 BioScience Research Building College Park MD 20742-5815 USA

Nitric oxide （NO） is a gaseous reactive oxygen species （ROS） that has evolved as a signaling hormone in many physiological processes in animals. In plants it has been demonstrated to be a crucial regulator of development, acting as a signaling molecule present at each step of the plant life cycle. NO has also been implicated as a signal in biotic and abiotic responses of plants to the environment. Remarkably, despite this plethora of effects and functional relationships, the fundamental knowledge of NO production, sensing, and transduction in plants remains largely unknown or inadequately characterized. In this review we cover the current understanding of NO production, perception, and action in different physiological sce- narios. We especially address the issues of enzymatic and chemical generation of NO in plants, NO sensing and downstream signaling, namely the putative cGMP and Ca^2＋ pathways, ion-channel activity modulation, gene expression regulation, and the interface with other ROS, which can have a profound effect on both NO accumulation and function. We also focus on the importance of NO in cell-cell communication during developmental processes and sexual reproduction, namely in pollen tube guidance and embryo sac fertilization, pathogen defense, and responses to abiotic stress.

关键词： nitric oxide (NO) reactive oxygen species (ROS) plant sexual reproduction cell communication pollen

Features of Ciguatera Fish Poisoning Cases in Hong Kong 2004-2007

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Biomedical and Environmental Sciences 2008年第6期21卷 521-527页

作者： CHUN-KWAN wong patricia HUNG KELLIE L. H. LEE TINA MOK THOMAS CHUNG KAI-MAN KAM Biotoxin Laboratory Public Health Laboratory Services Branch Centre for Health Protection Department of Health Shek Kip Mei Kowloon Food and Environmental Hygiene Department Queensway Government Offices

Ohjective To review the clinical features and laboratory investigations of ciguatera patients in Hong Kong between 2004 and 2007 in order to show the timely sampling of implicated fish from ciguatera victims and application of validated mouse bioassay for confirming suspected clinical cases of ciguatera. Methods Diagnosis of the ciguatera victims was based on history of coral fish consumption and clinical presentations stated in official guidelines for clinical diagnosis of ciguatera fish poisoning in Hong Kong. Food remnants of coral fish samples were collected swiftly from ciguatera victims between 2004 and 2007 for ciguatoxins （CTXs） analysis. Results Major clinical symptoms in ciguatera patients included gastrointestinal and neurological effects including limb numbness and diarrhoea, which developed at 0.5 to 15 hours after consumption of fish. In most cases, neurological symptoms were more common than gastrointestinal symptoms. A broad range of attack rate （10%-100%） was observed in each ciguatera outbreak. Validated mouse bioassay on ether extracts of the food remnant samples confirmed that all were CTXs-positive （〈0.5 - 4.3 MU/20 mg ether extract） and directly linked to the corresponding ciguatera cases. Conclusion Consistency between clinical and laboratory analysis for ciguatera poisoning illustrates the application of laboratory mouse bioassay in a timely fashion for confirming ciguatera poisoning cases and implementing effective public health measures. With further improvement in laboratory techniques, features of ciguatera fish poisoning cases can be better defined, Further studies are needed to determine the risk of each class of CTXs （Pacific-, Indian- and Caribbean-CTXs） in Hong Kong.

关键词： Ciguatera poisoning Ciguatoxin Food remnants Hong Kong Mouse bioassay

Feasibility of gallbladder preservation during robotic left hepatectomy:A retrospective comparative study

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第3期5卷 100-105页

作者： Kit-Fai Lee Andrew KY.Fung Hon-Ting Lok Janet WC.Kung Eugene yj.Lo Charing CN.Chong John wong Kelvin KC.Ng Division of Hepatobiliary and Pancreatic Surgery Department of SurgeryPrince of Wales HospitalThe Chinese University of Hong KongHong KongChina

Objective:Traditionally,gallbladder is routinely removed during left hepatectomy even if there is no gallbladder ***,adverse consequence after cholecystectomy,though rare,still occa-sionally *** study aims to evaluate the feasibility of gallbladder preservation during robotic left ***:All consecutive robotic left hepatectomy cases between December 2010 and January 2022 in Prince of Wales Hospital,the Chinese University of Hong Kong were retrieved from a prospectively collected *** gallbladder was preserved by moving the liver transection line just away from the gallbladder *** were divided into two groups:gallbladder preservation(GBP)and non-gallbladder preservation(NGBP).Operative results and long-term outcomes were compared between these two ***:There were 11 cases in the GBP group and 25 cases in the NGBP *** two groups were comparable in terms of the patient demographics and disease *** was no operative *** was no difference between the two groups in operative time(GBP 270 min *** 332 min,p=0.132),blood loss(GBP 50 mL *** 150 mL,p=0.115)or complication rate(GBP 27.3%*** 24.0%,p>0.999).There was also no difference in 5-year overall *** the GBP group,no patient developed specific symptoms or complications related to the preserved ***-up ultrasound or computed tomography revealed a normal appearance of the preserved gallbladders except in one patient who developed a 3-mm gallbladder *** the other hand,one(4%)patient in the NGBP group developed troublesome diarrhoea after ***:Gallbladder preservation is safe and feasible during robotic left *** preserved gallbladder does not lead to any symptoms,while postcholecystectomy diarrhoea can be avoided.

关键词： Robotic left hepatectomy Gallbladder preservation Cholecystectomy

具混合边界的双曲微分方程在L^p(0,T;W^(1,p)(?))空间中的研究（英文）

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数学杂志 2017年第3期37卷 598-612页

作者：魏利 RAVI P.AGARWAL patricia J.Y.wong 河北经贸大学数学与统计学学院河北石家庄050061 Department of Mathematics Texas A&M University-Kingsville Department of Mathematics Faculty of ScienceKing Abdulaziz University School of Electrical and Electronic Engineering Nanyang Technological University

本文研究了一类具混合边界的一般形式的双曲微分方程.利用分裂方程和Neumann边界条件的方法,借助于定义非线性算子,并利用Reich关于极大单调算子值域几乎相等的结论检验所定义算子具备某些性质的技巧,获得了双曲边值问题在L^p(0,T;W^(1,... 详细信息

本文研究了一类具混合边界的一般形式的双曲微分方程.利用分裂方程和Neumann边界条件的方法,借助于定义非线性算子,并利用Reich关于极大单调算子值域几乎相等的结论检验所定义算子具备某些性质的技巧,获得了双曲边值问题在L^p(0,T;W^(1,p)(?))空间中存在唯一解的结果.基于双曲方程中的主项是非线性的,所以本文应用了新的证明技巧,推广和补充了以往的相关工作.

关键词：严格单调算子次微分迹算子值域几乎相等双曲方程

RELATIONSHIP BETWEEN TV VIEWING, PHYSICAL ACTIVITY, AND OBESITY OF SCHOOLCHILDREN IN HONG KONG

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RELATIONSHIP BETWEEN TV VIEWING, PHYSICAL ACTIVITY, AND OBES...

第4届全国青年体育科学学术会议

作者： Stephen H.S.wong FACSM patricia L.Y. LEUNG The Department of Sports Science and Physical Education The Department of Sports Science and Physical Education The Department of Sports Science and Physical Education

＜正＞PURPOSE: To assess the time Hong Kong primary schoolchildren spend on watching television and physical activity, as well as the correlation between television viewing time, physical activity participation and ch...

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东方美学的继承与发展

现代装饰（家居） 2012年第8期 129-137页

作者： Seung-Yong Song patricia wong Danya TakeHome Design KARIMOKU NEW STANDARD

亚洲设计,作为全球设计中日益成熟的力量,有着不容忽视的地位。以日本设计为例,这个集合了东方传统美学的"禅"意与静态美学的设计力量,甚至可以与荷兰设计相媲美。日本设计界不仅拥有如草间弥生、川保久玲等注重强烈始觉效果的设计怪才... 详细信息

亚洲设计,作为全球设计中日益成熟的力量,有着不容忽视的地位。以日本设计为例,这个集合了东方传统美学的"禅"意与静态美学的设计力量,甚至可以与荷兰设计相媲美。日本设计界不仅拥有如草间弥生、川保久玲等注重强烈始觉效果的设计怪才,也有像吉冈德仁这样享誉世界的重量级设计师。而韩国、台湾、香港的设计师力量也不容忽视,包括亚洲其他国家,如菲律宾的家具设计师Kenneth Cobonpue,他与他的作品更是名扬海内外。

关键词：家具设计师荷兰设计设计力量弥生东方美学始觉德仁维登时尚魅力室内设计专业

wong's Essentials of Pediatric Nursing

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