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Early tacrolimus exposure does not impact long-term outcomes after liver transplantation

World Journal of Hepatology 2021年第3期13卷 362-374页

作者： Mikel Gastaca patricia Ruiz Javier Bustamante Lorea Martinez-Indart Alberto Ventoso JoséRamón Fernandez Ibone Palomares Mikel Prieto Milagros Testillano patricia salvador Maria Senosiain Maria Jesus Suárez Andres Valdivieso Department of HPB Surgery and Liver Transplantation Unit Hospital Universitario CrucesBilbao 48903Spain Department of Hepatology Unit Hospital Universitario CrucesBilbao 48903Spain Department of Bioinformatics and Statistics Platform Biocruces Bizkaia Health Research InstituteHospital Universitario CrucesBilbao 48903Spain

BACKGROUND Tacrolimus trough levels(TTL)during the first weeks after liver transplantation(LT)have been related with long-term renal function and hepatocellular carcinoma ***,the significance of trough levels of tacrolimus during the early post-transplant period for the long-term outcome is under debate AIM To evaluate the effect of TTL during the first month on the long-term outcomes after *** One hundred fifty-five LT recipients treated de novo with once-daily tacrolimus were retrospectively *** with repeated LT or combined transplantation were excluded as well as those who presented renal dysfunction prior to transplantation and/or those who needed induction *** were classified into 2 groups according to their mean TTL within the first month after transplantation:≤10(n=98)and>10 ng/mL(n=57).Multivariate analyses were performed to assess risk factors for patient *** Mean levels within the first month post-transplant were 7.4±1.7 and 12.6±2.2 ng/mL in the≤10 and>10 groups,*** age was higher in the high TTL group 62.9±16.8 years vs 45.7±17.5 years(P=0.002)whilst mycophenolate-mofetil was more frequently used in the low TTL group 32.7%vs 15.8%(P=0.02).Recipient features were generally similar across *** a median follow-up of 52.8 mo(range 2.8-81.1),no significant differences were observed in:Mean estimated glomerular filtration rate(P=0.69),hepatocellular carcinoma recurrence(P=0.44),de novo tumors(P=0.77),new-onset diabetes(P=0.13),or biopsy-proven acute rejection rate(12.2%and 8.8%,respectively;P=0.50).Eighteen patients died during the follow-up and were evenly distributed across groups(P=0.83).Five-year patient survival was 90.5%and 84.9%,respectively(P=0.44),while 5-year graft survival was 88.2%and 80.8%,respectively(P=0.42).Early TTL was not an independent factor for patient mortality in multivariate *** Differences in tacrolimus levels restricted to the fi

关键词： Liver transplantation Tacrolimus levels Prolonged released tacrolimus Oncedaily tacrolimus Renal function Survival Outcomes

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Seismic hazard analysis for central-western Argentina

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Geodesy and Geodynamics 2018年第1期9卷 25-33页

作者： salvador Daniel Gregori Rodolfo Christiansen Instituto Geofísico Sismológico Volponi Nacional de San Juan(National University of San Juan)San JuanArgentina CONICET(National Scientific and Technical Research Council) San JuanArgentina

In this study, we present a PSHA（Probabilistic Seismic Hazard Analysis） for the city of San Juan, which is located in the central-western region of Argentina（30°S-35.5°S; 66.5°W-71°W）. In addition to crustal earthquakes provided by catalogues, recent paleoseismological and neotectonic investigations have permitted to consider events which occurred during the last 400 *** seismogenic sources that could cause damages to the studied site corresponding to Precordillera,Western Sierras Pampeanas, Basement of the Cuyana Basin and Cordillera Principal were *** on the evaluation of the contribution of these sources,maximum moment magnitudes above 7.5（Mw） are *** values of SA（spectral acceleration）（0.2 and 1 s periods） and PGA（peak ground acceleration） were found in the city of San Juan, which suggests that it is located in a zone of high seismic ***, the obtained SA spectra were compared with the seismic-resistant construction standards of Argentina INPRES-CIRSOC 103 [1]. Results suggest that for the city of San Juan and for a return period of475 years, it covers the seismic requirements of the structures.

关键词： Probabilistic seismic hazard analysis Seismic-resistant construction standards Seismic sources Visual cumulative method

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Steroid-refractory ulcerative colitis and associated primary sclerosing cholangitis treated with infliximab

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World Journal of Gastroenterology 2013年第4期19卷 590-593页

作者： Ileana Duca patricia Ramírez de la Piscina Silvia Estrada Rosario Calderón Katerina Spicakova Leire Urtasun Carlos Marra-López salvador Zabaleta Raquel Bengoa María Asunción Marcaide Francisco García-Campos Service of Gastroenterology Hospital Universitario de álava-Sede TxagorritxuUniversidad del País VascoE-01009 Vitoria-GasteizSpain

Primary sclerosing cholangitis is an infrequent extraintestinal manifestation of ulcerative *** to bile ducts is irreversible and medical therapies to prevent progression of the disease are usually *** describe a patient with long-standing ulcerative colitis,which was refractory to corticosteroid therapy who developed primary sclerosing cholangitis(biochemical stage Ⅱ/Ⅳ) in the course of his *** with infliximab(5 mg/kg as an induction dose followed by maintenance doses every two months) was indicated because of steroid-dependent disease associated to primary sclerosing cholangitis as well as sacroiliitis and uveitis and previous episode of severe azathioprinerelated hepatic *** present,after two years of follow-up,the patient is asymptomatic with normal liver tests and complete resumption of daily life *** case draws attention to the usefulness of antitumor necrosis factor-alpha therapy for the management of primary sclerosing cholangitis as extraintestinal manifestation of inflammatory bowel disease.

关键词： Ulcerative colitis Infliximab Monoclonal antibodies Sclerosing cholangitis Bile duct diseases Tumor necrosis factor-alpha

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Analysis of the Meteorological Variables for Puebla City 2011-2012 Applying the Modeling Ion-Wavelets in a Hypothetical Manner

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Atmospheric and Climate Sciences 2013年第4期3卷 450-458页

作者： Rogelio Ramos-Aguilar patricia Máximo-Romero Blanca Susana Soto-Cruz salvador Alcántara-Iniesta José Guillermo Pérez-Luna Engineering School Benemérita Universidad Autónoma de Puebla Puebla México Research Center of Semiconductor Devices Benemérita Universidad Autónoma de Puebla Puebla México

This work presents the results of the analysis of meteorological variables applying the modeling Ion-Wavelets in a hypothetical manner. In this case the Morlet wavelet transform is used, which is the result of a huge number of researches made in the80’s and applied to various physical phenomena derived from natural chaotic processes;the data were processed using the phenomenon “El Nino” and CO2 (Carbon dioxide) due to the fact that these are the meteorological phenomena which best adapt to our object of study correlating with distribution of Gauss and Morlet during the study period in the Puebla Valley.

关键词： Wavelets Gauss Morlet Variables Model

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Geostatistical Analysis of the Colorada and Quimichule Canyons Located in Popocatépetl Volcano (Mexico) for the Prevention of Natural Disasters

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International Journal of Geosciences 2016年第5期7卷 701-715页

作者： Rogelio Ramos-Aguilar patricia Máximo-Romero Blanca Susana Soto-Cruz salvador Alcántara-Iniesta María de la Cruz Vázquez-García Engineering School Benemérita Universidad Autónoma de Puebla Puebla México Research Center of Semiconductor Devices Benemérita Universidad Autónoma de Puebla Puebla México Bufete in Telecommunications and Systems Engineering México City México

This paper aims to contribute to the prevention of natural disasters and generate a complement to other similar studies. The Popocatépetl volcano has showed significant and constant activity since 1994. The Colorada and Quimichule canyons are located within its geologic structure;due to their topographic features, ejected volcanic material and torrential rains in the past recent years, they put nearby communities at risk. This work presents a geostatistical analysis to obtain the gravity acceleration, slope by the distance-elevation relation, height-gravity and the fluid force on the canyons. The conversion of UTM to geographical coordinates was made with the use of the program Traninv applying the ITRF2008 epoch 2010.0 Datum and the 14 Zone;the local gravity was calculated with the use of International Organization of Legal Metrology (OIML) and the statistical analysis was obtained with the use of the Geostatistical Environmental Assessment. The structural modeling was performed using Surfer, and the spending and force were calculated using hydrological models. The correlation analysis concluded that Quimichule has the greatest gravity and that it would transport lahars faster. Mapping, geomorphological and statistical techniques and models were applied in accordance with the study to obtain the results presented here.

关键词： Natural Disasters Geostatistical Force Acceleration Gravity

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Blue LED as a new treatment to vaginal stenosis due pelvic radiotherapy:Two case reports

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World Journal of Clinical Cases 2021年第23期9卷 6839-6845页

作者： Daniela Barros Cecília Alvares Teresa Alencar Priscila Baqueiro Augusto Marianno Rafael Alves Juliana Lenzi Laura Ferreira Rezende patricia Lordelo Oncology Department Hospital Santa IzabelSalvador 40290-000Brazil Pelvic Floor Care Center(CAAP)and Postgraduate Bahiana School of Medicine and Public HealthSalvador 40290-000Brazil Oncology Department NOB/Grupo OncoclinicasSalvador 40290-000Brazil Pelvic Floor Care Center(CAAP) University Center of the Associated Teaching FacultiesCampinas 40000000Brazil Physiotherapy Instituto Patrícia Lordelo-IPLSalvador 40290-000Brazil

BACKGROUND Currently,the advancement cancer treatment technology improves overall survival,however,adverse events are still a challenge for health *** syndrome of menopause and vaginal stenosis are conditions that impact the quality of life of patients undergoing *** present two such cases in patients with previous cervical and endometrial *** conditions were handled with an innovative method using an energy-based device with blue light emitting diode for concomitant vaginal and vulvar *** impact in clinical findings,cytologic changes,and referred symptoms were *** SUMMARY One patient diagnosed with vaginal severe vaginal stenosis with previous cervix cancer treatment and other patient diagnosed with mild stenosis with severe dyspareunia and recent endometrium cancer treatment were considered for vulvovaginal treatment with weekly blue led device and closely evaluated with repeated validated questionnaires and cytological *** This innovative technique showed an improvement in all areas of the examiner's criteria,the cytological criteria,and most bothered symptoms.

关键词： Radiotherapy Atrophic vaginitis Vaginal diseases Laser therapy Semiconductor diode lasers Nonhormonal vaginal therapy Case report

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Mobility after Heart Surgery： What Are Influential Factors？

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Journal of Pharmacy and Pharmacology 2018年第4期6卷 429-435页

作者： Gabriela Lago Rosier Gleide Gllcia Gama Lordello Marcela Araujo de Moura Larissa Santana Correia Luana Lais Silva Polte Giulliano Gardenghi Luis Claudio Correia patricia Alcantara Doval de Carvalho Viana Escola Bahiana de Medicina e Saude Publica Salvador 40290-000 Brasil Hospital ENCORE Goias 74930-390 Brasil

Objective： To analyze postoperative mobility after cardiac surgery. Methods： Observational study in patients, aged 〉 18 years, undergoing myocardial revascularization and/or valvular heart surgery, hospitalized in a Brazil hospital. The data collection took place between April 2016 and March 2017. On admission to the ward, patients received a calibrated pedometer. They were asked to use the device during five consecutive days, yet only three days of full use were analyzed. Results： Analyzed were data of 87 individuals with mean age of 58.70 ~ 12.59 years, 52 （59.8%） of them were males. Regarding surgery, 53 （60.9%） underwent myocardial revascularization. The median number of steps was 738 （185-1,557）, which showed a weak and inverse correlation with the length of stay in the intensive care unit （r = -0.3/p = 0.02）, however, it was not statistically significant when related to clinical and surgical data. Male patients had a better mobility when compared to patients of the female sex （p = 0.04）. Conclusions： Individuals who had a longer stay in the intensive care unit, as well as females, had a lower mobility in the ward. The mobility did not show a relation with intra- and postoperative factors.

关键词： Cardiac surgery physiotherapy ambulation.

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Outcomes of critically ill cancer patients with Acinetobacter baumannii infection

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World Journal of Critical Care Medicine 2015年第3期4卷 258-264页

作者： Silvio A ?amendys-Silva Paulina Correa-García Francisco J García-Guillén María O González-Herrera Américo Pérez-Alonso Julia Texcocano-Becerra Angel Herrera-Gómez patricia Cornejo-Juárez Abelardo Meneses-García Department of Critical Care Medicine Instituto Nacional de Cancerología Department of Critical Care Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Division of Education and Research Hospital de la Mujer Department of Infectious Diseases Instituto Nacional de Cancerología

AIM: To describe the intensive care unit(ICU) outcomes of critically ill cancer patients with Acinetobacter baumannii(AB) ***: This was an observational study that included 23 consecutive cancer patients who acquired AB infections during their stay at ICU of the National Cancer Institute of Mexico(INCan), located in Mexico City. Data collection took place between January 2011, and December 2012. Patients who had AB infections before ICU admission, and infections that occurred during the first 2 d of ICU stay were excluded. Data were obtained by reviewing the electronic health record of each patient. This investigation was approved by the Scientific and Ethics Committees at INCan. Because of its observational nature, informed consent of the patients was not ***: Throughout the study period, a total of 494 critically ill patients with cancer were admitted to the ICU of the INCan, 23(4.6%) of whom developed AB infections. Sixteen(60.9%) of these patients had hematologic malignancies. Most frequent reasons for ICU admission were severe sepsis or septic shock(56.2%) and postoperative care(21.7%). The respiratory tract was the most frequent site of AB infection(91.3%). The most common organ dysfunction observed in our group of patients were the respiratory(100%), cardiovascular(100%), hepatic(73.9%) and renal dysfunction(65.2%). The ICU mortality of patients with 3 or less organ system dysfunctions was 11.7%(2/17) compared with 66.6%(4/6) for the group of patients with 4 or more organ system dysfunctions(P = 0.021). Multivariate analysis identified blood lactate levels(BLL) as the only variable independently associated with inICU death(OR = 2.59, 95%CI: 1.04-6.43, P = 0.040). ICU and hospital mortality rates were 26.1% and 43.5%, ***: The mortality rate in critically ill patients with both HM, and AB infections who are admitted to the ICU is high. The variable most associated with increased mortality was a BLL ≥ 2.6 mmol/L in

关键词： Outcomes Cancer patients Acinetobacter baumannii Intensive care Critical care

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Mexican Guidelines for the Diagnosis and Treatment of Chronic Myeloid Leukaemia

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Journal of Cancer Therapy 2013年第3期4卷 747-764页

作者： Eduardo Cervera Federico Godínez Rosa Sosa Ramón Rivas Carlos Best Juan Hernández Adrián Morales Hugo Zurita Ivette Carrasco Jorge Cruz álvaro Aguayo José Espinoza Juan Labardini Luis Valero Judith Cruz Diana Arcos Diego Limón Omar López-Navarro Daniela Gordillo-Bastidas Myrna Candelaria Francisco Torres Juan Kassack Oscar de Jesús Pérez Ramírez Jorge Aquino Guillermo Díaz Mariela Cardiel Margarita Rodríguez patricia Montoya Juan Contreras María Chávez Sandra Chávez David Gómez Olga Cantú Jorge Duque Luis Pita Eduardo Lobato Julio López Antonio López Pedro González Jorge Cortés Haematology and Oncology Department National Institute of Medical and Nutrition Sciences “Dr. Salvador Zubirán” Mexico City Mexico Haematology Deparment from Hospital Juárez Mexico City Mexico Haematology Department Blood Bank and Unit of Aphaeresis General Hospital of Culiacán Health Ministry Culiacán Mexico Haematology Department Bone Marrow Transplant and Blood Bank from Hospital Regional de Alta Especialidad “Dr. Juan Graham Casassus” Villahermosa Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico Haematology Department Cancerology National Institute (INCan) Mexico City Mexico 2Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Haematology Department Centenario Hospital Miguel Hidalgo Health Ministry Aguascalientes Mexico Haematology Department General Hospital of Sonora State Sonora Mexico Haematology Department Hospital Universitario UANL Monterrey Mexico Haematology Haematology Service Hospital General Regional SSG León Mexico Haematology Head of Haematology Service School of Medicine Autonomous University of San Luis Potosí San Luis Potosí Mexico Haematology Hospital “Aranda de la Parra” León Mexico Haematology Hospital General de Especialidades Campeche Mexico Haematology Hospital General de México Mexico City Mexico Haematology Hospital General de Occidente SSA Guadalajara Mexico Haematology Hospital Regional de Alta Especialidad de Oaxaca Oaxaca Mexico Haematology Mérida Clinic Yucatán Mexico Haematology Oncology Unit SSEP Puebla Mexico Hospital Betania Puebla Mexico Hospital of the Poblano Child Puebla Mexico Internal Medicine Haematology Hospital ISSSTECALI Tijuana Mexico Leukaemias Clinic at ISSEMyM Toluca Mexico Leukemia Department MD Anderson Cancer Center Houston Mexico Los Mochis General Hospital Sinaloa Mexico Renaissance Clinic Morelia Mexico State Council for AIDS Prevention and Control Chihuahua Mexico Universidad Autónoma de Yucatán Mérida Mexico

Background: This document includes recommendations and guidelines issued by a group of Mexican researchers and specialists gathered in the First National Colloquium for the Diagnosis and Management of Chronic Myeloid Leukaemia (CML) by initiative of Instituto Nacional de Cancerología and with the support of the Leukaemia Department of the MD Anderson Cancer Center. Mexico lacks of updated information taken from its own reality on the diagnosis and treatment of CML and other haematological disorders;besides, there are no national guidelines. Aim: To publish a consensus document with guidelines for the management of CML adjusted to the national environment and overall characteristics. Method: The participants answered a DELPHI questionnaire about the overall aspects of the disease, aiming to target controversial topics, discuss them in the colloquium, and to agree on the best ones. After those meetings, a final document was drawn up. Results: The group presents recommendations for definition, diagnosis, prognosis, monitoring, and treatment of CML in Mexico. Conclusions: Having consensus guidelines for the clinical management of CML in our country will enable the consensual practice of Mexican specialists regarding the clinical approach to CML, as well as optimize the resources which allow the rational planning of the medical care strategies.

关键词： Chronic Myeloid Leukaemia Management Guidelines Diagnosis Treatment.

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