检索结果-南通市图书馆

In silico analysis of lncr.A-mir.A-mr.A signatur.s r.lated to Sor.fenib effectiveness in liver.cancer.cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wor.d Jour.al of Gastr.enter.logy 2025年第3期31卷 84-102页

作者： patricia de la Cr.z-Ojeda Ester.Par.as-Mar.ínez r.quel r.y-Pér.z Jor.i Muntané Functional Genomics of Solid Tumor. Labor.tor. Centre de Recherche des CordeliersParis 75006France Depar.ment of Oncology Sur.er. Cell Therapy and Organ TransplantationInstitute of Biomedicine of SevilleVirgen del Rocio University HospitalSeville 41013Spain Biomedical r.sear.h Center.for.Hepatic and Digestive Diseases CIBERehdMadrid 28029Spain Depar.ment of Medical Physiology and Biophysics University of SevilleSeville 41009Spain

BACKGr.UND Hepatocellular.car.inoma(HCC)is the most common subtype of pr.mar. liver.cancer.with var.ed incidence and epidemiology *** is still a r.commended tr.atment for.a lar.e pr.por.ion of patients with advanced *** patter.s of tr.atment r.sponsiveness have been identified in differ.ntiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 *** To define the long non-codingr.A-micr.r.A-mr.A(lncr.A-mir.A-mr.A)pr.dicted signatur.s r.lated to selected hallmar.s of cancer.apoptosis,autophagy,cell str.ss,cell dediffer.ntiation and invasiveness)in r.Aseq studies using Sor.fenib-tr.ated HepG2 and SNU449 *** available softwar. analyses allowed us to establish the lncr.A-mir.A-mr.A r.gulator. axes following tr.atment in HepG2 and SNU449 *** HepG2 and SNU449 cells wer. tr.ated with Sor.fenib(10μmol/L)for.24 *** r.A,including small and long r.A,was extr.cted with a commer.ial mir.easy *** was car.ied out for.the identification of changes in lncr.A-mir.A-mr.A r.gulator. *** MALAT,THAP9-AS1 and SNGH17 appear.d to coor.inately r.gulate mir.374b-3p and mir.769-5p that led to upr.gulation of SMAD7,TIr.r.,TFAP4 and FAXDC2 in HepG2 ***12,EPB41 L4A-AS1,LINC01578,SNHG12 and GAS5 inter.cted with let-7b-3p,mir.195-5p and VEGFA in SNU449 *** axes MALAT1/hsamir.374b-3p/SMAD7 and MALAT1/hsa-mir.769-5p/TFAP4 wer. of high r.levance for.Sor.fenib r.sponse in HepG2 cells,wher.as PVT1/hsa-mir.195-5p/VEGFA was r.sponsible for.the differ.ntial r.sponse of SNU449 cells to Sor.fenib *** Cr.tical lncr.As acting as sponges of mir.A wer. identified that r.gulated mr.A expr.ssion,whose pr.teins mainly incr.ased the antitumor.effectiveness of the tr.atment(SMAD7,TIr.r.,TFAP4,FAXDC2 and ADr.2).However.the br.ad r.gulator. axis leading to incr.ased VEGFA expr.ssion may be r.lated to the side effect of Sor.fenib in SNU449 cells.

关键词： Cell cultur. Hepatocellular.car.inoma Non-coding r.A r.Aseq Sor.fenib

Antioxidant Migr.tion Studies in Chitosan Films Incor.or.ted with Plant Extr.cts

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Jour.al of r.newable Mater.als 2018年第5期6卷 548-558页

作者： Victor.Gomes Laur.ano Souza patricia Fr.itas rodrigues Mar.a Paula Duar.e Ana Luisa Fer.ando MEtr.CS Departamento de Ciências e Tecnologia da BiomassaFaculdade de Ciências e Tecnologia(FCT)Universidade NOVA de LisboaCampus da Caparica2829-516 CaparicaPortugal CENIMAT/I3N Departamento de Ciências dos MateriaisFaculdade de Ciências e Tecnologia(FCT)Universidade NOVA de LisboaCampus da Caparica2829-516 CaparicaPortugal

The aim of this wor. was to develop an active biopolymer.based on chitosan by incor.or.ting natur.l *** essential oils(ginger.r.semar.,sage,tea tr.e and thyme)and six hydr.-alcoholic extr.cts(fr.m ginger.gr.en and black tea,kenaf leaves,r.semar. and sage plants)wer. *** assays wer. car.ied out to evaluate the films’activity,and total phenolic content and antioxidant activity wer. monitor.d in the simulant dur.ng *** between natur.l compounds and polymer.c matr.x was evaluated by FTIr.*** diffusion of the phenolic compounds was not detected in the films incor.or.ted with hydr.-alcoholic extr.cts(HAEs),indicating their.entr.pment in the *** was obser.ed in the films with essential oils(EOs),and biobased films incor.or.ted with ginger.sage or.r.semar. essential oils,pr.sented the highest diffusion and antioxidant activity in the simulant,highlighting their.functionality and potential to be used as food active packaging mater.al.

关键词： Active packaging antioxidant activity biopolymer. chitosan phenolic content

Gr.und peach pits: alter.ative substr.te component for.seedling pr.duction

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Jour.al of For.str. r.sear.h 2019年第5期30卷 1779-1791页

作者： patricia Mieth Mar.stela Machado Ar.ujo Mar.a Helena Fer.ino Suelen Car.enedo Aimi Daniele rodrigues Gomes Juliana de Mar.ues Vilella Depar.ment of For.st Sciences Federal University of Santa MariaSanta MariaBrazil FEPAGr.–Agr.cultur.l r.sear.h Foundation of the State of r.o Gr.nde do Sul Porto AlegreBrazil Feder.l Univer.ity of r.o Gr.nde do Sul Porto AlegreBrazil

The exploitation of agr.-industr.al wastes is a str.tegy to add value to seedling pr.duction and r.duce envir.nmental *** pr.duction chain for.pr.cessed peaches gener.tes,appr.ximately,21,000 tons of fr.it wor.dwide,and the pits ar. used mainly to gener.te *** objective of the study was to investigate the use of differ.nt pr.por.ions of gr.und peach pits(GPP)as a substr.te component for.seedling gr.wth of Eucalyptus dunnii in the nur.er. and *** pr.por.ions of GPP mixed with either.commer.ial substr.te(CS)or.with br.wn peat(BP)wer. *** physical and chemical pr.per.ies of the substr.tes,the mor.hological and physiological attr.butes of the seedlings and their.cor.elation with substr.te pr.per.ies wer. *** GPP incr.ased the density,aer.tion space and pH and r.duced total por.sity,liquid r.tention and electr.c conductivity of the *** use of this component r.sulted in hor.esis,a biphasic dose–r.sponse model in which low levels of exposur. to this component stimulated biological per.or.ance of plants and high levels of exposur. inhibited *** impr.ved seedling gr.wth in the nur.er. and adequate post-planting development of ***,GPP with CS is r.commended at 20%of the total substr.te and with BP between 15 and 30%.

关键词： Or.anic waste Pr.nus per.ica Eucalyptus dunnii Tr.e species Mor.hological attr.butes

Tr.ating amyotr.phic later.l scler.sis with allogeneic Schwann cell-der.ved exosomal vesicles: a case r.por.

在线全文

学校读者我要写书评

暂无评论

Neur.l r.gener.tion r.sear.h 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Cler.ont Aisha Khan Geor.e Jimsheleishvili patricia Gr.ham Adr.ana Br.oks r.sset Silver. Alexander.J.P.Goldschmidt Damien D.Pear.e W.Dalton Dietr.ch Allan D.Levi James D.Guest Miller.School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Pr.ject to Cur. Par.lysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady Inter.ational LLC MiamiFLUSA Neur.logical Sur.er. Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells ar. essential for.the maintenance and function of motor.neur.ns,axonal networ.s,and the neur.muscular.*** amyotr.phic later.l scler.sis,wher. motor.neur.n function is pr.gr.ssively lost,Schwann cell function may also be ***,impor.ant signaling and potential tr.phic activities of Schwann cell-der.ved exosomal vesicles have been *** case r.por. descr.bes the tr.atment of a patient with advanced amyotr.phic later.l scler.sis using ser.al intr.venous infusions of allogeneic Schwann cell-der.ved exosomal vesicles,mar.ing,to our.knowledge,the fir.t instance of such *** 81-year.old male patient pr.sented with a 1.5-year.histor. of r.pidly pr.gr.ssive amyotr.phic later.l *** initial diagnosis,the patient under.ent a combination of gener.c r.luzole,sodium phenylbutyr.te for.the tr.atment of amyotr.phic later.l scler.sis,and *** patient volunteer.d to par.icipate in an FDA-appr.ved single-patient expanded access tr.atment and r.ceived weekly intr.venous infusions of allogeneic Schwann cell-der.ved exosomal vesicles to potentially r.stor. impair.d Schwann cell and motor.neur.n *** confir.ed that cultur.d Schwann cells obtained fr.m the amyotr.phic later.l scler.sis patient via sur.l ner.e biopsy appear.d impair.d(senescent)and that exposur. of the patient’s Schwann cells to allogeneic Schwann cell-der.ved exosomal vesicles,cultur.d expanded fr.m a cadaver.donor.impr.ved their.gr.wth capacity in *** a per.od of obser.ation lasting 10 weeks,dur.ng which amyotr.phic later.l scler.sis Functional r.ting Scale-r.vised and pulmonar. function wer. r.gular.y monitor.d,the patient r.ceived weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-der.ved exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffer.d *** of the infusions wer. associated with adver.e events such as infusion r.actions(aller.ic or.other.ise)or

关键词： allogeneic amyotr.phic later.l scler.sis exosomes infusion neur.muscular.junction Schwann cell

Tr.bological behavior.of ammonium-based pr.tic ionic liquid as lubr.cant additive

在线全文

学校读者我要写书评

暂无评论

Fr.ction 2021年第1期9卷 169-178页

作者： Hong GUO patricia IGLESIAS Mechanical Engineer.ng Depar.ment Rochester Institute of TechnologyNew York 14623-5603USA

In this study, the tr.bological behavior.of an ammonium-based pr.tic ionic liquid(PIL) as an additive in a base miner.l oil(MO) is investigated on a steel–steel contact at r.om temper.tur. and 100℃. Tr.-[bis(2-hydr.xyethylammonium)] citr.te(DCi) was synthesized in a simple and low-cost way, and the ionic str.ctur. of DCi was confir.ed by pr.ton nuclear.magnetic r.sonance(^(1)H NMr.. The stability measur.ment of 1 wt% DCi to a MO was investigated, and the lubr.cating ability and anti-wear.pr.per.ies of DCi as an additive in MO wer. also examined using a custom-designed r.cipr.cating ball-on-flat tr.bometer. Optical micr.scope and pr.filometr. wer. used to obtain the wor. mor.hology of the steel disks. Scanning electr.n micr.scopy(SEM) and ener.y disper.ive X-r.y spectr.scopy(EDS) wer. car.ied out to investigate the wear.mechanism and to analyze the sur.ace inter.ctions between the r.bbing components. When 1 wt% DCi is added into the base MO, fr.ctional per.or.ance is impr.ved at both temper.tur.s studied with a fr.ction r.duction of 29.0% and 35.5%, r.spectively. Mor.over. the addition of 1 wt% DCi to MO r.duced the wear.volume 59.4% compar.d to the use of MO. An oxygen-r.chened tr.bolayer.is confir.ed by EDS on the disk sur.ace when DCi was used as additive under.100℃.

关键词： pr.tic ionic liquid(PIL) tr.-[bis(2-hydr.xyethylammonium)]citr.te(DCi) steel–steel fr.ction wear

Car.on and nitr.gen miner.lization in soil of leguminous tr.es in a degr.ded pastur. in nor.her. r.o de Janeir., Br.zil

在线全文

学校读者我要写书评

暂无评论

Jour.al of For.str. r.sear.h 2016年第1期27卷 91-99页

作者： Danielle A. D. Nunes Emanuela F. Gama-rodrigues patricia A. B. Bar.eto[ Antonio C. Gama-r.dr.gue Paulo H. M. Monr.e Chemistr. School Rio de Janeiro Federal UniversityRio de Janeiro RJ 21941-909 Brazil Soil Labor.tor. North Fluminense State UniversityCampos dos Goytacazes RJ 28013-602 Brazil Depar.ment of Soil and Agr.cultur.l Engineer.ng State University of Southwest Bahia Vitoda da ConquistaBA 45031-300 Brazil

Use of legume tr.es can impr.ve soil quality in degr.ded pastur.s. The aim of this study was to char.c- ter.ze C and N miner.lization kinetics and estimate the potentially miner.lizable C and N in soil under.Mimosa caesalpiniifolia Benth. and Acacia aur.culifor.is A. Cunn. ex Benth. secondar. for.st and pastur. in r.d-yellow latosols in southeast Br.zil. We conducted a labor.tor. aer.bic incubation exper.ment using a completely r.n- domized design of four.r.plicates and four.types of plant cover.using a modified ver.ion of the Stanfor. and Smith technique （1972） to study C and N miner.lization potential. Potentially miner.lizable N （No） r.nged fr.m 135 to 170 mg kg-1. The pr.dominant for. of miner.l N for.all types of plant cover.was N-NO3-. M. caesalpiniifolia was the only species that had a positive influence on N min- er.lization. Neither.of the legumes influenced C miner.l- ization in pastur. or.secondar. for.st. The model of N miner.lization cor.esponded to a sigmoidal cur.e while C miner.lization cor.esponded to an exponential cur.e, r.vealing that the N and C miner.lization pr.cesses wer. distinct. N miner.lized by M. caesalpiniifolia （216 kg ofN ha-1） was adequate to meet the N r.quir.ment for.a livestock-for.st system.

关键词： Car.on dioxide For.st soil Miner.lized N Or.anic matter Soil micr.or.anisms

Adsor.tion desalination:Advances in por.us adsor.ents

在线全文

学校读者我要写书评

暂无评论

Chinese Jour.al of Chemical Engineer.ng 2022年第2期35卷 151-169页

作者： Boya Qiu patricia Gor.ojo Xiaolei Fan Depar.ment of Chemical Engineer.ng and Analytical Science School of EngineeringThe University of ManchesterOxford RoadManchester M139PLUnited Kingdom Nanoscience and Mater.als Institute of Ar.gón(INMA)CSIC-Univer.idad de Zar.goza Mariano Esquillor50018 ZaragozaSpain Chemical and Envir.nmental Engineer.ng Depar.ment Universidad de ZaragozaPedro Cerbuna 1250009 ZaragozaSpain

With the continuous gr.wth of the wor.d population,the demand for.fr.sh water.is ever.*** desalination is a means of pr.ducing fr.sh water.fr.m saline water.and one of the pr.posed solutions in the scientific community for.solving the cur.ent global fr.shwater.*** is for.seen as a pr.mising technology for.desalination due to its r.latively low ener.y r.quir.ments,low envir.nmental impact,low cost and high salt r.moval *** impor.antly,chemicals ar. not r.quir.d in adsor.tion *** car.ons,zeolites,car.on nanostr.ctur.s,gr.phene and coor.ination fr.mewor. mater.als ar. amongst the most investigated adsor.ents for.adsor.tion desalination,which show differ.nt per.or.ances r.gar.ing adsor.tion r.te,adsor.tion capacity,stability and *** this r.view,the latest adsor.ent mater.als with their.featur.s ar. assessed(using metr.cs)and commented cr.tically,and the cur.ent tr.nd for.their.development is *** adsor.tion mode is also r.viewed,which can pr.vide guidance for.the design of adsor.ents fr.m the engineer.ng application point of view.

关键词： Adsor.tion desalination Adsor.ents Por.us mater.als Oper.tion modes

Char.cter.zation of Cnidoscolus quer.ifolius Pohl bar. r.ot extr.ct and evaluation of cytotoxic effect on human tumor.cell lines

在线全文

学校读者我要写书评

暂无评论

Asian Pacific Jour.al of Tr.pical Biomedicine 2018年第7期8卷 345-351页

作者： Paulo Fer.ando Machado Par.des Selene Maia de Mor.is Fer.ando Cesar.rodrigues Br.to Luiz Fr.ncisco Wemmenson Goncalves Mour. patricia de Ar.ujo rodrigues Stephen r.thinar.j Benjamin Fr.ncisco Er.ani Alves Magalhaes Er.dan Or.ando Per.ir. Tr.montina Flor.an Mar.a Izabel Flor.ndo Guedes Nor.heast Biotechnology Networ. Graduate Program of Biotechnology State University of Ceara Itaperi campus Depar.ment of Chemistr. State University of Ceara Itaperi campus Labor.tor. of Biopr.specting of Natur.l Pr.ducts and Biotechnology State University of CearaCECITEC

Objective: To evaluate the chemical components of active extr.ct fr.m Cnidoscolus quer.ifolius r.ot bar. and its cytotoxic potential against sever.l tumor.str.ins. Methods: The high-per.or.ance liquid chr.matogr.phy with diode-ar.ay detection and ~1H and ^(13)C nuclear.magnetic r.sonance spectr.scopy of the extr.ct wer. used to distinguish the existence of possible functional gr.ups in the r.ot bar. extr.ct. The in vitr. cytotoxic activity of methanol extr.ct on human colon cancer.cell lines was evaluated using OVCAr.8, SF-295, HCT-116, HL-60 str.ins and the samples wer. assessed by 3-(4,5-dimethylthiazol2-yl)-2,5-diphenyltetr.zolium br.mide method. r.sults: The analysis of nuclear.magnetic spectr. of the active chlor.for. fr.ction r.vealed the pr.sence of absor.tions bands cor.espondent to a mixtur. of favelines such as neofavelanone, deoxofaveline or.methyl-faveline, which str.ctur.s wer. confir.ed by ultr.violet spectr. upon high-per.or.ance liquid chr.matogr.phy with diode-ar.ay detection analysis. The active fr.ction showed cytotoxic effects in the tested str.ins, HCT-116, SF-295, OVCAr.8 and HL-60 cells with IC_(50) of 72 hour. r.nging fr.m 4.95 to 15.23 μg/mL. Conclusions: The r.sults suggest that the substances pr.sent in faveleir.(Cnidoscolus quer.ifolius) r.ot bar. extr.ct have a cytotoxic potential against sever.l tumor.lines, showing a br.ader.antitumour.potential, and in addition no adver.e to healthy cells. Ther.for., the r.ot bar. extr.ct of Cnidoscolus quer.ifolius has a possibility of use for.anticar.inogenic ther.pies.

关键词： Cnidoscolus quer.ifolius Pohl. methyl-faveline Deoxofaveline Neofavelanone Faveline Cytotoxicity

Synchr.nous waving in fiddler.cr.bs: a r.view

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cur.ent Zoology 2019年第1期65卷 83-88页

作者： patricia r.th Yvonne Backwell r.sear.h School of Biology The Australian National University Canberra ACT 2601 Australia

Many animals that use acoustic communication synchr.nize their.mate attr.ct!on signals: individuals pr.cisely time their.calls to over.ap those of their.neighbor.. In contr.st, synchr.ny in the mate attr.ction displays of species with visual/motion-based signals is r.r.. It has only been documented in five species of fiddler.cr.bs. In all of them, small gr.ups of males wave their.single lar.e claw in close synchr.ny. Her., I r.view what we know about synchr.ny in fiddler.cr.bs, compar.ng the five species with each other.to deter.ine whether.similar.mechanisms and functions ar. comm on to all. I also pr.pose futur. r.sear.h questions that, if answer.d, would shed light on synchr.nous behavior.in both visual and acoustic signaller..

关键词： fiddler cr.b synchr.ny waving mate choice wave timing visual signal