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Follicular helper T lymphocytes in health and disease

World Journal of Hematology 2014年第4期3卷 118-127页

作者： Cecilia Parodi María Noel Badano Nora Galassi Ana Coraglia patricia baré Alejandro Malbrán María Marta de Elizalde de Bracco Department of Immunology Instituto de Medicina Experimental (IMEX)– CONICET-Academia Nacional de Medicina (ANM) Pacheco de Melo 3081Ciudad Autónoma de Buenos Aires 1425Argentina Department of Virology Instituto de Investigaciones Hematológicas Mariano Castex (IIHEMA)-ANMPacheco de Melo 3081Ciudad Autónoma de Buenos Aires 1425Argentina Unidad de Alergia e Inmunología Clínica Av. Pte. Roque Saenz Pe?a 1160Ciudad Autónoma de Buenos Aires C1431GHABuenos AiresArgentina

A correct antibody response requires the participation of both B and T lymphocytes and antigen presenting cells. In this review we address the role of follicular helper T lymphocytes(T FH) in this reaction. We shall focus on the regulation of their development and function in health and disease. T FH can be characterized on the basis of their phenotype and the pattern of secretion of cytokines. This fact is useful to study their participation in the generation of antibody deficiency in primary immunodeficiency diseases such as common variable immunodeficiency, X-linked hyper Ig M syndrome orX-linked lymphoproliferative disease. Increased numbers of T FH have been demonstrated in several autoimmune diseases and are thought to play a role in the development of autoantibodies. In chronic viral infections caused by the human immunodeficiency virus, hepatitis B or C virus, increased circulating T FH have been observed, but their role in the protective immune response to these agents is under discussion. Likewise, an important role of T FH in the control of some experimental protozoan infections has been proposed, and it will be important to assess their relevance in order to design effective vaccination strategies.

关键词： Follicular helper T(TFH)lymphocytes TFH development Chemokine(C-X-C motif)receptor 5 Interleukin-21 Programmed cell death-1/Programmed cell death ligand 1(PDL-1)or PDL-2 Primary immunodeficiencies Autoimmunity Chronic viral infections Protozoan infections

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Tribological behavior of ammonium-based protic ionic liquid as lubricant additive

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Friction 2021年第1期9卷 169-178页

作者： Hong GUO patricia IGLESIAS Mechanical Engineering Department Rochester Institute of TechnologyNew York 14623-5603USA

In this study, the tribological behavior of an ammonium-based protic ionic liquid(PIL) as an additive in a base mineral oil(MO) is investigated on a steel–steel contact at room temperature and 100℃. Tri-[bis(2-hydroxyethylammonium)] citrate(DCi) was synthesized in a simple and low-cost way, and the ionic structure of DCi was confirmed by proton nuclear magnetic resonance(^(1)H NMR). The stability measurement of 1 wt% DCi to a MO was investigated, and the lubricating ability and anti-wear properties of DCi as an additive in MO were also examined using a custom-designed reciprocating ball-on-flat tribometer. Optical microscope and profilometry were used to obtain the worn morphology of the steel disks. Scanning electron microscopy(SEM) and energy dispersive X-ray spectroscopy(EDS) were carried out to investigate the wear mechanism and to analyze the surface interactions between the rubbing components. When 1 wt% DCi is added into the base MO, frictional performance is improved at both temperatures studied with a friction reduction of 29.0% and 35.5%, respectively. Moreover, the addition of 1 wt% DCi to MO reduced the wear volume 59.4% compared to the use of MO. An oxygen-richened tribolayer is confirmed by EDS on the disk surface when DCi was used as additive under 100℃.

关键词： protic ionic liquid(PIL) tri-[bis(2-hydroxyethylammonium)]citrate(DCi) steel–steel friction wear

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Three-dimensional models: from cell culture to Patient-Derived Organoid and its application to future liposarcoma research

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Oncology research 2025年第1期33卷 1-13页

作者： Sayumi Tahara Sydney Rentsch Fernanda Costas Casal DE Faria patricia Sarchet Roma Karna Federica Calore Raphael E Pollock Department of Surgery Division of Surgical Oncology The James Comprehensive Cancer Center The Ohio State University Wexner Medical Center Columbus OH 43210 USA. Department of Cancer Biology and Genetics The James Comprehensive Cancer Center The Ohio State University Wexner Medical Center Columbus OH 43210 USA.

Liposarcoma is one of the most common soft tissue sarcomas, however, its occurrence rate is still rare compared to other cancers. Due to its rarity, experiments are an essential approach to elucidate liposarcoma pathobiology. Conventional cell culture-based research (2D cell culture) is still playing a pivotal role, while several shortcomings have been recently under discussion. , mouse models are usually adopted for pre-clinical analyses with expectations to overcome the issues of 2D cell culture. However, they do not fully recapitulate human dedifferentiated liposarcoma (DDLPS) characteristics. Therefore, three-dimensional (3D) culture systems have been the recent research focus in the cell biology field with the expectation to overcome at the same time the disadvantages of 2D cell culture and animal models and fill in the gap between them. Given the liposarcoma rarity, we believe that 3D cell culture techniques, including 3D cell cultures/co-cultures, and Patient-Derived tumor Organoids (PDOs), represent a promising approach to facilitate liposarcoma investigation and elucidate its molecular mechanisms and effective therapy development. In this review, we first provide a general overview of 3D cell cultures compared to 2D cell cultures. We then focus on one of the recent 3D cell culture applications, Patient-Derived Organoids (PDOs), summarizing and discussing several PDO methodologies. Finally, we discuss the current and future applications of PDOs to sarcoma, particularly in the field of liposarcoma.

关键词： Cell culture Liposarcoma Patient-Derived Organoid (PDO) Spheroid Three-dimensional (3D) cell culture

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Adsorption desalination:Advances in porous adsorbents

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Chinese Journal of Chemical Engineering 2022年第2期35卷 151-169页

作者： Boya Qiu patricia Gorgojo Xiaolei Fan Department of Chemical Engineering and Analytical Science School of EngineeringThe University of ManchesterOxford RoadManchester M139PLUnited Kingdom Nanoscience and Materials Institute of Aragón(INMA)CSIC-Universidad de Zaragoza Mariano Esquillor50018 ZaragozaSpain Chemical and Environmental Engineering Department Universidad de ZaragozaPedro Cerbuna 1250009 ZaragozaSpain

With the continuous growth of the world population,the demand for fresh water is ever *** desalination is a means of producing fresh water from saline water,and one of the proposed solutions in the scientific community for solving the current global freshwater *** is foreseen as a promising technology for desalination due to its relatively low energy requirements,low environmental impact,low cost and high salt removal *** importantly,chemicals are not required in adsorption *** carbons,zeolites,carbon nanostructures,graphene and coordination framework materials are amongst the most investigated adsorbents for adsorption desalination,which show different performances regarding adsorption rate,adsorption capacity,stability and *** this review,the latest adsorbent materials with their features are assessed(using metrics)and commented critically,and the current trend for their development is *** adsorption mode is also reviewed,which can provide guidance for the design of adsorbents from the engineering application point of view.

关键词： Adsorption desalination Adsorbents Porous materials Operation modes

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Synchronous waving in fiddler crabs: a review

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Current Zoology 2019年第1期65卷 83-88页

作者： patricia Ruth Yvonne Backwell Research School of Biology The Australian National University Canberra ACT 2601 Australia

Many animals that use acoustic communication synchronize their mate attract!on signals: individuals precisely time their calls to overlap those of their neighbors. In contrast, synchrony in the mate attraction displays of species with visual/motion-based signals is rare. It has only been documented in five species of fiddler crabs. In all of them, small groups of males wave their single large claw in close synchrony. Here, I review what we know about synchrony in fiddler crabs, comparing the five species with each other to determine whether similar mechanisms and functions are comm on to all. I also propose future research questions that, if answered, would shed light on synchronous behavior in both visual and acoustic signallers.

关键词： fiddler crab synchrony waving mate choice wave timing visual signal

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Regulating autophagy:a novel role for SETX(Senataxin)

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Neural Regeneration Research 2021年第10期16卷 2008-2009页

作者： patricia Richard Emanuel Rosonina Stellate Therapeutics Inc. JLABS@NYCNew YorkUSA Department of Biology York UniversityTorontoCanada

Mutations in the gene encoding SETX,also known as Senataxin,are mainly linked to two distinct neurodegenerative diseases,a cerebellar ataxia known as oculomotor apraxia type 2(AOA2)and a form of juvenile amyotrophic l... 详细信息

关键词： al. diseases degenerative

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Orbit orientation in didelphid marsupials （Didelphimorphia： Didelphidae）

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Current Zoology 2017年第4期63卷 403-415页

作者： patricia PILATTI Diego ASTUA Laboratorio de Mastozoologia Departamento de Zoologia Universidade Federal de Pernambuco. Av. Prof. Moraes Rego S/N Cidade Universitaria Recife PE 50670-901 Brazil

Usually considered a morphologically conservative group, didelphid marsupials present consider- able variation in ecology and body size, some of which were shown to relate to morphological structures. Thus, changes on orbit morphology are likely and could be related to that variation. We calculated orbit orientation in 873 specimens of 16 Didelphidae genera yielding estimates of orbits convergence （their position relative to midsagittal line） and verticality （their position relative to frontal plane）. We then compared similarities in these variables across taxa to ecological, morpho- logical and phylogenetic data to evaluate the influencing factors on orbit orientation in didelphids. We found an inverse relation between convergence and verticality. Didelphids orbits have low ver- ticality but are highly convergent, yet orbit orientation differs significantly between taxa, and that variation is related to morphological aspects of the cranium. Rostral variables are the only morpho- logical features correlated with orbit orientation： increasing snout length yields more convergent orbits, whereas increase on snout breadth imply in more vertical orbits. Size and encephalization quotients are uncorrelated with orbit orientation. Among ecological data, diet showed significant correlation whereas locomotion is the factor that less affects the position of orbits. Phylogeny is uncorrelated to any orbital parameters measured. Ecological factors seemingly play a more import- ant role on orbit orientation than previously expected, and differentiation on orbit orientation seems to be more functional than inherited. Thus, despite the apparent homogeneity on didelphid morphology, there is subtle morphological variability that may be directly related to feeding behavior.

关键词： convergence Didelphidae frontation orbit orientation verticality.

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Dependence of Upper Atmosphere Photochemistry on the Shape of the Diurnal Cycle of the Photolysis Rates

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Advances in Atmospheric Sciences 2006年第2期23卷 207-214页

作者： Sonia MONTECINOS patricia barRIENTOS Center of Advanced Studies in Arid Zones (CEAZA) University of La Serena La SerenaChile Department of Physics University of La Frontera TemucoChile

A photochemical model of the atmosphere constitutes a non-linear, non-autonomous dynamical system, enforced by the Earth＇s rotation. Some studies have shown that the region of the mesopause tends towards non-linear responses such as period-doubling cascades and chaos. In these studies, simple approximations for the diurnal variations of the photolysis rates are assumed. The goal of this article is to investigate what happens if the more realistic, calculated photolysis rates are introduced. It is found that, if the usual approximations-sinusoidal and step fiunctions—are assumed, the responses of the system axe similar： it converges to a 2-day periodic solution. If the more realistic, calculated diurnal cycle is introduced, a new 4-day subharmonic appear.

关键词： photochemical models bifurcation theory numerical solutions dynamical systems

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Epididymosomes： transfer of fertility-modulating proteins to the sperm surface

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Asian Journal of Andrology 2015年第5期17卷 720-725,I0006页

作者： patricia A Martin-DeLeon Department of Biological Sciences University of Delaware Newark DE 19716 USA

A variety of glycosylphosphatidylinositol （GPI）-linked proteins are acquired on spermatozoa from epididymal luminal fluids （ELF） during sperm maturation. These proteins serve roles in immunoprotection and in key steps of fertilization such as capacitation, acrosomal exocytosis and sperm-egg interactions. Their acquisition on sperm cells is mediated both by membrane vesicles （epididymosomes, EP） which were first reported to dock on the sperm surface, and by lipid carriers which facilitate the transfer of proteins associated with the membrane-free fraction of ELF. While the nonvesicular fraction is more efficient, both pathways are dependent on hydrophobic interactions between the GPI-anchor and the external lipid layer of the sperm surface. More recently proteomic and hypothesis-driven studies have shown that EP from several mammals carry transmembrane （TM） proteins, including plasma membrane Ca^2＋-ATPase 4 （PMCA4）. Synthesized in the testis, PMCA4 is an essential protein and the major Ca^2＋ efflux pump in murine spermatozoa. Delivery of PMCA4 to spermatozoa from bovine and mouse EP during epididymal maturation and in vitro suggests that the docking of EP on the sperm surface precedes fusion, and experimental evidence supports a fusogenic mechanism for TM proteins. Fusion is facilitated by CD9, which generates fusion-competent sites on membranes. On the basis of knowledge of PMCA4＇s interacting partners a number of TM and membrane-associated proteins have been identified or are predicted to be present, in the epididymosomal cargo deliverable to spermatozoa. These Ca^2＋-dependent proteins, undetected in proteomic studies, play essential roles in sperm motility and fertility, and their detection highlights the usefulness of the hypothesis-driven approach.

关键词： epididymal maturation epididymal secretory proteins GPI-linked proteins lipid carrier membrane-associated proteins PMCA4 transmembrane proteins

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