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Preoperative serum cortisone levels are associated with cognition in preschool‑aged children with tetralogy of Fallot after corrective surgery:new evidence from human populations and mice

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World Journal of Pediatrics 2024年第2期20卷 173-184页

作者： Si-Yu Ma Yu-Ting Liu Yue-Shuang Cun Qiang Wang Ming-Cui Fu Ke-De Wu Xin-Yu Cai Shu-Ting Cheng Nishant patel Min Da Liang Hu Zhuoga Deqin Xue-Jun Kang Ming Yang Xu-Ming Mo Department of Cardiothoracic Surgery Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China Department of Radiology Children’s Hospital of Nanjing Medical University72 Guangzhou RoadNanjing 210008China Key Laboratory of Child Development and Learning Science Research Center For Learning ScienceSchool of Biological Sciences&Medical EngineeringMinistry of EducationSoutheast UniversityNanjing 210096China Medical School of Nanjing University Nanjing 210093China

Background Tetralogy of Fallot(TOF)is the most common cyanotic congenital heart *** with TOF would be confronted with neurological impairment across their *** study aimed to identify the risk factors for cerebral morphology changes and cognition in postoperative preschool-aged children with *** We used mass spectrometry(MS)technology to assess the levels of serum metabolites,Wechsler preschool and primary scale of intelligence-Fourth edition(WPPSI-Ⅳ)index scores to evaluate neurodevelopmental levels and multimodal magnetic resonance imaging(MRI)to detect cortical morphological *** Multiple linear regression showed that preoperative levels of serum cortisone were positively correlated with the gyrification index of the left inferior parietal gyrus in children with TOF and negatively related to their lower visual spaces index and nonverbal ***,preoperative SpO_(2) was negatively correlated with levels of serum cortisone after adjusting for all ***,after intervening levels of cortisone in chronic hypoxic model mice,total brain volumes were reduced at both postnatal(P)11.5 and P30 *** Our results suggest that preoperative serum cortisone levels could be used as a biomarker of neurodevelopmental impairment in children with *** study findings emphasized that preoperative levels of cortisone could influence cerebral development and cognition abilities in children with TOF.

关键词： Cognition Cortisone MRI Neurodevelopment Tetralogy of Fallot

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海藻养殖场助力碳捕捉行业发展

科技纵览 2024年第1期 40-41页

作者： Prachi patel 不详

2023年1月,研究人员首次在菲律宾宿务市附近的水域部署了一个撒有海藻种子的巨大环状网,并用辐条状的绳索和管子将其支撑展开。每天傍晚,安装在浮动平台上的曲柄会将网拉到水面以下25米,让海藻暴露在更凉爽、营养更丰富的水中。黎明时,... 详细信息

2023年1月,研究人员首次在菲律宾宿务市附近的水域部署了一个撒有海藻种子的巨大环状网,并用辐条状的绳索和管子将其支撑展开。每天傍晚,安装在浮动平台上的曲柄会将网拉到水面以下25米,让海藻暴露在更凉爽、营养更丰富的水中。黎明时,曲柄会将网拉回水面,吸收阳光和二氧化碳。

关键词：浮动平台环状网二氧化碳碳捕捉海藻助力曲柄养殖场

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提取锂的方法将更快、更加环保

科技纵览 2024年第1期 7-9页

作者： Prachi patel 不详

安第斯山脉位于阿根廷、玻利维亚和智利的边界,这里浩瀚的白色盐沼绵延数千公里,下面的盐水蕴藏的锂占全球总量的58%。几十年来,生产商提取锂的方法一直是将水抽取到地面并使其蒸发提纯,直至可滤出锂盐。该过程需要12到18个月,会留下成... 详细信息

安第斯山脉位于阿根廷、玻利维亚和智利的边界,这里浩瀚的白色盐沼绵延数千公里,下面的盐水蕴藏的锂占全球总量的58%。几十年来,生产商提取锂的方法一直是将水抽取到地面并使其蒸发提纯,直至可滤出锂盐。该过程需要12到18个月,会留下成堆的含有其他金属的废弃物,此外还会蒸发近200万升当地的水资源,给本土社区带来危害。

关键词：玻利维亚废弃物水资源阿根廷锂生产商

Lean body mass index is a marker of advanced tumor features in patients with hepatocellular carcinoma

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World Journal of Hepatology 2024年第3期16卷 393-404页

作者： Andrew Scott deLemos Jing Zhao Milin patel Banks Kooken Karan Mathur Hieu Minh Nguyen Areej Mazhar Maggie McCarter Heather Burney Carla Kettler Naga Chalasani Samer Gawrieh Department of Medicine Atrium HealthCharlotteNC 28204United States Center for Outcomes Research and Evaluation Atrium HealthCharlotteNC 28204United States Department of Medicine Indiana University School of MedicineIndianapolisIN 46202United States Center for Health System Sciences(CHASSIS) Atrium HealthCharlotteNC 28204United States Department of Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States Department of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisIN 46202United States Department of Gastroenterology and Hepatology Indiana University School of MedicineIndianapolisIN 46202United States

BACKGROUND Obesity is an independent risk factor for the development of hepatocellular carcinoma(HCC)and may influence its ***,after diagnosis of HCC,like other malignancies,the obesity paradox may exist where higher body mass index(BMI)may in fact confer a survival *** is frequently observed in patients with advanced HCC and cirrhosis,who often present late with advanced tumor features and cancer related weight *** To explore the relationship between BMI and survival in patients with cirrhosis and *** This is a retrospective cohort study of over 2500 patients diagnosed with HCC between 2009-2019 at two United States academic medical *** and tumor characteristics were extracted manually from medical records of each institutions'cancer *** were stratified according to BMI classes:30 kg/m^(2)(obese).Patient and tumor characteristics were compared according to BMI *** performed an overall survival analysis using Kaplan Meier by the three BMI classes and after adjusting for Milan criteria.A multivariable Cox regression model was then used to assess known risk factors for survival in patients with cirrhosis and *** A total of 2548 patients with HCC were included in the analysis of which 11.2%(n=286)were classified as *** three main BMI categories:Lean(n=754),overweight(n=861),and obese(n=933)represented 29.6%,33.8%,and 36.6%of the total population *** each BMI class,the non-cirrhotic patients accounted for 15%(n=100),12%(n=94),and 11%(n=92),*** patients with a BMI<18.5 kg/m^(2)(n=52)were included in the lean *** the obese cohort,42%(n=396)had a BMI≥35 kg/m^(2).Out of 2262 patients with cirrhosis and HCC,654(29%)were lean,767(34%)were overweight,and 841(37%)were *** three BMI classes did not differ by age,MELD,or Child-Pugh *** hepatitis C was the dominant etiology in lea

关键词： Hepatocellular carcinoma Cirrhosis Obesity Body mass index class Sarcopenia Chronic hepatitis C

生成式人工智能“瘦身”,进入便携消费电子产品

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科技纵览 2024年第2期 7-9页

作者： Prachi patel 不详

消费电子产品技术瞄准各种大型语言模型,笔记本电脑是滩头阵地。下一代亲密聊天机器人将在不需要连接互联网的情况下,以光速在个人笔记本电脑上运行。这至少是英特尔首席执行官帕特·格尔辛格(Pat Gelsinger)在2023年英特尔创新峰会上... 详细信息

消费电子产品技术瞄准各种大型语言模型,笔记本电脑是滩头阵地。下一代亲密聊天机器人将在不需要连接互联网的情况下,以光速在个人笔记本电脑上运行。这至少是英特尔首席执行官帕特·格尔辛格(Pat Gelsinger)在2023年英特尔创新峰会上提出的愿景。格尔辛格通过在台上演示,宣布“人工智能个人电脑”的问世,该个人电脑可仅依靠用户手上的硬件,加速运行不断增多的各种人工智能任务。

关键词：消费电子产品笔记本电脑人工智能个人电脑聊天机器人语言模型英特尔互联网

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从实际出发

科技纵览 2024年第3期 50-51页

作者： tom Coughlin IEEE

如果问IEEE的长期会员们为什么一直保留IEEE会籍,您将得到许多不同的答案。对我来说,IEEE是一个由专业技术人士组成的社区,他们会互相帮助以掌握最新动态,发展有价值的专业技能,并共同努力为今天和未来几代人创造一个更美好的世界。IEE... 详细信息

如果问IEEE的长期会员们为什么一直保留IEEE会籍,您将得到许多不同的答案。对我来说,IEEE是一个由专业技术人士组成的社区,他们会互相帮助以掌握最新动态,发展有价值的专业技能,并共同努力为今天和未来几代人创造一个更美好的世界。IEEE为会员提供了诸多福利和资源。会员从中获得价值的产品可能会有所不同,具体取决于他们生活和职业生涯中的经历。

关键词：从实际出发 IEEE 专业技能职业生涯最新动态会员价值

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地热公司为旧聚变技术注入新动能

科技纵览 2024年第6期 11-13页

作者： tom Clynes 不详

用于引导等离子体的微波束也可以熔化地壳。地壳上层10千米内的部分蕴藏着大量地热资源,但目前用地热资源生产的电力仅占全球电力的0.3%。长期以来,这种颇有前景的能源一直因异乎寻常的挑战而受到限制,因为只有达到足够的钻井深度才能... 详细信息

用于引导等离子体的微波束也可以熔化地壳。地壳上层10千米内的部分蕴藏着大量地热资源,但目前用地热资源生产的电力仅占全球电力的0.3%。长期以来,这种颇有前景的能源一直因异乎寻常的挑战而受到限制,因为只有达到足够的钻井深度才能获取地表下的高温热能。

关键词：地热资源钻井深度等离子体技术注入

Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaemic lesions at 1 month: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam Longting Lin Christina Lam Carlos Garcia-Esperon Yash Gawarikar Ronak patel Matthew Lee-Archer Andrew Wong Michael Roizman Amanda Gilligan Andrew Lee Kee Meng Tan Susan Day Christopher Levi Stephen M Davis Mark Parsons Bernard Yan Melbourne Brain Centre at Royal Melbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Department of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Department of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Department of Neurology Northern Hospital EppingEppingVictoriaAustralia Department of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of Medicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Department of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of Medicine and Public Health AdelaideSouth AustraliaAustralia Department of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Department of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optimal time to commence anticoagulation in patients with atrial fibrillation(AF)after ischaemic stroke or transient ischaemic attack(TIA)is unclear,with guidelines differing in recommendations.A limitation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted imaging ischaemic *** aimed to quantify silent ischaemic lesions and haemorrhages on MRI at 1month in patients commenced on early(5mL,regardless of anticoagulation *** Commencing anticoagulation<4days after stroke or TIA is associated with fewer ischaemic lesions at 1month in AF *** is no increased rate of haemorrhage with early *** results suggest that early anticoagulation after mild-to-moderate acute ischaemic stroke associated w

关键词： patients lesions ischaemic

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扩大IEEE的影响力

科技纵览 2024年第6期 52-53页

作者： tom Coughlin IEEE

在3月份的主席专栏中,我探讨了IEEE需要留住更多年轻会员,扩大与行业的密切联系。我确定的工作重点还包括扩大组织与公众的广泛联系。我想让人们知道我们是谁、都做些什么。

关键词： IEEE 影响力密切联系