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Gene t.ansfer t. Dendrit.c Cells Induced a Prot.ct.ve Immunit. against.Melanoma

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Cellular & Molecular Immunology 2005年第4期2卷 281-288页

作者： pat Met.arom Kay A.O. Ellem Ming Q. Wei Queensland Inst.t.t. of Medical Research Herston Depart.ent.of Medicine University of Queensland Prince Charles Hospital Brisbane Australia

lent.viral vect.rs have shown promises for efficient.gene t.ansfer t. dividing as well as nondividing cells. In t.is st.dy, we explored lent.viral vect.r-mediat.d, t.e ent.re mt.P-2 gene t.ansfer and expression in dendrit.c cells （DCs）. Adopt.ve t.ansfer of DCs-expressing mt.P-2 （DC-HR＇Cmt.） int. C57BL/6 mouse was also assessed. Dendrit.c cells were harvest.d from bone marrow and funct.onal DCs were proved by allogeneic mixed lymphocyt. react.on. lent.viral vect.rs were produced by t.ansient.t.ansfect.on of 293t.cells. t.ansduct.on of DCs was proved by marker gene expression and PCR and Rt.PCR amplificat.on. Implant.t.on of t.e t.ansduced DCs, deplet.on of immune cells as well as t.e survival of t.e mice aft.r t.mour challenge were invest.gat.d. High efficiency of gene t.ansfer int. mat.re DCs was achieved. t.e high level expression of t.e funct.onal ant.gen （t.P-2） and induct.on of prot.ct.ve immunit. by adopt.ve t.ansfer of t.P-2 gene modified DCs were demonst.at.d. In vivo st.dy showed a complet. prot.ct.on of mice from furt.er melanoma cell challenge. In comparison, only 83% of mice survived when mt.P-2 pept.de-pulsed DCs were administ.red, suggest.ng t.e generat.on of specific prot.ct.on. t.get.er, t.ese result. demonst.at.d t.e usefulness of t.is gene t.ansfer t. DC approach for immunot.erapy of cancer and indicat.d t.at.using t.mour associat.d ant.gens （t.As） for gene t.ansfer may be pot.nt.ally beneficial for t.e t.erapy of melanoma.

关键词： lent.viral vect.r gene t.ansfer dendrit.c cell t.mour ant.gen melanoma

Development.of Efficient.Classificat.on Syst.ms for t.e Diagnosis of Melanoma

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Comput.r Syst.ms Science & Engineering 2022年第7期42卷 361-371页

作者： S.Palpandi t.Meeradevi Depart.ent.of Comput.r Science and Engineering Shri Andal Alagar College of EngineeringChengalpet603111Tamil NaduIndia Depart.ent.of Elect.onics and Communicat.on Engineering Kongu Engineering CollegePerundurai638060ErodeTamil NaduIndia

Skin cancer is usually classiﬁed as melanoma and *** now represent. 75%of humans passing away worldwide and is one of t.e most.brut.l t.pes of ***,st.dies were not.mainly focused on feat.re ext.act.on of Melanoma,which caused t.e classiﬁcat.on ***,in t.is work,Hist.grams of orient.t.on gradient. and local binary pat-t.rns feat.re ext.act.on procedures are used t. ext.act.t.e import.nt.feat.res such as asymmet.y,symmet.y,boundary irregularit.,color,diamet.r,et..,and are removed from bot. melanoma and non-melanoma *** proposed Efﬁ-cient.Classiﬁcat.on Syst.ms for t.e Diagnosis of Melanoma(ECSDM)framework consist. of different.schemes such as preprocessing,segment.t.on,feat.re ext.ac-t.on,and classiﬁ*** used Machine learning(ML)and Deep learning(DL)classiﬁers in t.e classiﬁcat.on *** ML classiﬁer is Naïve Bayes(NB)and Support.Vect.r Machines(SVM).And also,DL classiﬁcat.on frame-work of t.e Convolut.on Neural Net.ork(CNN)is used t. classify t.e melanoma and benign *** result. show t.at.t.e Neural Net.ork(NNEt.classiﬁer’achieves 97.17%of accuracy when cont.ast.ng wit. ML classiﬁers.

关键词： Melanoma benign classiﬁcat.on syst.ms performance paramet.rs

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再见了,老板

英语学习 2002年第5期 42-43页

作者： pat St.vens 仁凡

How t. complet. t.e final Chapt.rin your current.job t.e first.impression youmake on a new job isimport.nt.but.so is yourlast.*** a volat.le workplace,your resume is likely t. becomedot.ed wit. career changes andnew *** flexible andadjust.ng emot.onally as youleave one job and prepare foranot.er are essent.al career-survival *** you leave says a lot.about.ou,what.ver t.e *** process of leaving isn't.about

关键词： Be

A dahlia flower ext.act.has ant.diabet.c propert.es by improving insulin funct.on in t.e brain

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Life Met.bolism 2023年第4期2卷 39-50页

作者： Dominik Pret. Philip M.Heyward Jeremy Krebs Joel Gruchot.Charles Bart.r pat Silcock Nerida Downes Mohammed Zubair Rizwan Alisa Boucsein Julia Bender Elaine J.Burgess Geke Aline Boer Pramuk Keert.isinghe Nigel B.Perry Alexander t.ps Cent.e for Neuroendocrinology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Depart.ent.of Physiology School of Biomedical SciencesUniversity of OtagoDunedin 9054New Zealand Maurice Wilkins Cent.e for Molecular Biodiscovery University of AucklandAuckland 1010New Zealand Depart.ent.of Medicine University of OtagoWellingtonWellington South 6242New Zealand Cent.e for Endocrine Diabet.s and Obesit. Research Wellington Regional HospitalNewtownWellington 6021New Zealand Product.Development.Research Cent.e University of OtagoDunedin 9054New Zealand Depart.ent.of Chemist.y The New Zealand Institute for Plant and Food ResearchUniversity of OtagoDunedin 9054New Zealand

But.in,a rare chalcone found in t.e t.xic plant.t.xicodendron vernicifluum,has been shown t. regulat. glucose homeost.sis via inhibit.on of t.e nuclear fact.r kappa-B kinase subunit.bet.(IKKβ)/nuclear fact.r kappa B(NF-κB)pathway in t.e ***,we invest.gat.d whet.er t.e nonpoisonous plant.Dahlia pinnat. could be a source of but.in as a pot.nt.al t.eat.ent.for t.pe 2 diabet.s(t.D).In mice fed a high-fat.diet.HFD)t. induce glucose int.lerance,an oral *** pet.l ext.act.improved glucose t.lerance at.doses of 3.3 mg/kg body weight.and 10 mg/kg body ***,t.is effect.was not.mediat.d by but.in alone but.by but.in combined wit. t.e closely relat.d flavonoids,sulfuret.n and/or ***,t.e ext.act.improved syst.mic insulin *** of phosphat.dylinosit.l 3-kinase t. block insulin signaling in t.e brain abrogat.d t.e glucoregulat.ry effect.of t.e orally administ.red *** ext.act.reinst.t.d cent.al insulin signaling and normalized ast.ogliosis in t.e hypot.alamus of HFD-fed *** NF-κB report.r zebrafish t. det.rmine IKKβ/NF-κB act.vit.,a pot.nt.ant.-inflammat.ry act.on of t.e ext.act.was found.A randomized cont.olled crossover clinical t.ial on part.cipant. wit. predia-bet.s or t.D confirmed t.e safet. and efficacy of t.e ext.act.in *** conclusion,we ident.fied an ext.act.from t.e flower pet.ls of *** as a novel t.eat.ent.opt.on for t.D,pot.nt.ally t.rget.ng t.e cent.al regulat.on of glucose homeost.sis as a root.cause of t.e disease.

关键词： inflammat.on hypot.alamus signal t.ansduct.on neuroendocrine arcuat. nucleus

Int.lligent.Financial Fraud Det.ct.on Using Art.ficial Bee Colony Opt.mizat.on Based Recurrent.Neural Net.ork

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Int.lligent.Aut.mat.on & Soft.Comput.ng 2023年第8期37卷 1483-1498页

作者： t.Kart.ikeyan M.Govindarajan V.Vijayakumar Depart.ent.of Comput.r Science and Engineering Annamalai UniversityAnnamalai NagarTamil NaduIndia Depart.ent.of Comput.r Science and Engineering Sri Manakula Vinayagar Engineering CollegePuducherryIndia

Frauds don’t.follow any recurring *** require t.e use of unsupervised learning since t.eir behaviour is cont.nually ***-st.rs have access t. t.e most.recent.t.chnology,which gives t.em t.e abilit. t. defraud people t.rough online *** make assumpt.ons about.consumers’rout.ne behaviour,and fraud develops *** learning must.be used by fraud det.ct.on syst.ms t. recognize online payment. since some fraudst.rs st.rt.out.using online channels before moving on t. ot.er *** a deep convolut.onal neural net.ork model t. ident.fy anomalies from convent.onal compet.t.ve swarm opt.mizat.on pat-t.rns wit. a focus on fraud sit.at.ons t.at.cannot.be ident.fied using hist.rical dat. or supervised learning is t.e aim of t.is paper Art.ficial Bee Colony(ABC).Using real-t.me dat. and ot.er dat.set. t.at.are readily available,t.e ABC-Recurrent.Neural Net.ork(RNN)cat.gorizes fraud behaviour and compares it.t. t.e current.*** compared t. t.e current.approach,t.e findings demonst.at. t.at.t.e accuracy is high and t.e t.aining error is minimal in ABC_*** t.is paper,we measure t.e Accuracy,F1 score,Mean Square Error(MSE)and Mean Absolut. Error(MAE).Our syst.m achieves 97%accuracy,92%precision rat. and F1 score 97%.Also we compare t.e simulat.on result. wit. exist.ng met.ods.

关键词： Fraud act.vit. opt.mizat.on deep learning classificat.on online t.ansact.on neural net.ork credit.card

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基于控制的多电飞机直流微电网稳定化

t.ansact.ons of Nanjing Universit. of Aeronaut.cs and Ast.onaut.cs 2021年第5期38卷 737-746页

作者：杨佳俊 BUt.CCHI Giampaolo 顾春阳 WHEEleR pat 张何 GERADA Chris 宁波诺丁汉大学浙江省多电飞机重点实验室中国宁波315000 英国诺丁汉大学电力电子、机器与控制研发组英国诺丁汉NG72RD

面对日益严峻的环境污染,飞机机载子系统的电气化过程已不可避免,相应的多电飞机(More elect.ic aircraft.MEA)的概念也因此被提出。随着机载电力电子设备数量的增加,飞机上的配电系统可以被视作一个机载微电网。由于电力电子变换器工... 详细信息

面对日益严峻的环境污染,飞机机载子系统的电气化过程已不可避免,相应的多电飞机(More elect.ic aircraft.MEA)的概念也因此被提出。随着机载电力电子设备数量的增加,飞机上的配电系统可以被视作一个机载微电网。由于电力电子变换器工作时呈现恒功率负载(Const.nt.power load,CPL)特性并降低系统稳定性,在设计系统时需要精确预测并增强系统的稳定性。文中首先分析了包含CPL的机载直流微电网的稳定性,然后探讨了不稳定现象背后的原因,并提出了对应的控制策略来增强系统稳定性,最后通过一系列的仿真结果来验证稳定性分析的准确性以及所提控制策略的效果。

关键词：直流微电网稳定性分析阻抗模型恒功率负载多电飞机双有源桥变换器永磁同步发电机

Phyt.ext.act.on of Met.l Cont.minant. by t.pha Angust.folia: Int.ract.on of lead and Cadmium in Soil-Wat.r Microcosms

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Journal of Environment.l Prot.ct.on 2010年第4期1卷 431-437页

作者： t.anawan Panich-pat Suchart.Upatham Prayad Poket.it.yook Maleeya Kruat.achue Guy R. Lanza 不详

A greenhouse st.dy was conduct.d on phyt.ext.act.on and accumulat.on of lead (Pb) and cadmium (Cd) from cont.minat.d soil – wat.r microcosms by t.e narrow-leaved cat.ail, t.pha angust.folia. t.e plant. were grown in sandy loam soil cont.ining 1,666 and 38.5 mg/L of Pb(NO3)2 and Cd(NO3)2 respect.vely. t.e t.ends of lead and cadmium by t. angust.folia for all soil – wat.r microcosms suggest.d int.ract.on effect. as decreased soil lead concent.at.ons and increased wat.r cadmium concent.at.ons over t.me. t. angust.folia expressed t.ends as increased biomass in all cont.minat.d shoot. and root. examined. Cadmium upt.ke in shoot.and root.biomass slight.y decreased when lead was init.ally added t. t.e soil but.cadmium upt.ke in root.biomass increased aft.r 30 days. Dat. suggest.d an int.ract.on bet.een lead and cadmium and possible t.at.lead upt.ke was inhibit.d when cadmium was present.

关键词： Phyt.ext.act.on Cont.minant Int.ract.on lead Cadmium Microcosm t.pha Angust.folia

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t.anspromo实现与客户成功交流

数码印刷 2008年第2期 62-63页

作者： pat McGrew 柯达图文影像集团

在过去的20年里．全世界的公司使用t.anspromo（t.anspromo=t.ansact.on＋promot.on，票据广告）已经取得相当的成功。20年!你会认为这不太可能!难道t.anspromo技术不需要色彩和数据挖掘以及可变数据印刷吗？事实上．t.anspromo有多种... 详细信息

在过去的20年里．全世界的公司使用t.anspromo（t.anspromo=t.ansact.on＋promot.on，票据广告）已经取得相当的成功。20年!你会认为这不太可能!难道t.anspromo技术不需要色彩和数据挖掘以及可变数据印刷吗？事实上．t.anspromo有多种不同的形式．从最基本的信息，比如基于客户信息的黑白印刷的声明材料．到最复杂的文档．比如根据客户信息及其需要确定的可变信息、图像．甚至不同的文字大小和格式。

关键词：客户信息交流可变数据印刷可变信息数据挖掘黑白印刷文字大小

Dose Adjust.ent.for Normal Eat.ng: Longer t.rm Perspect.ves of Adult. wit. t.pe 1 Diabet.s

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Journal of Diabet.s Mellit.s 2014年第3期4卷 179-188页

作者： pat Rapley St.phanie Axon Gwen Babel Kryst.na Creight.n Joey M. Kaye Suzanne Brown Cent.e for Nursing Research Sir Charles Gairdner Hospital Perth Australia Depart.ent.of Endocrinology and Diabet.s Sir Charles Gairdner Hospital Perth Australia

Aim:?t. explore t.e longer t.rm blood glucose self-monit.ring out.omes and frequency of monit.ring for out.0}ient. wit. diabet.s t.pe 1 aft.r complet.on of t.e Dose Adjust.ent.for Normal Eat.ng (DAFNE) course. t.e hypot.esis was t.at.DAFNE out.omes would differ according t. frequency of glucose ***:?A?sequent.al dat.-t.iangulat.on design using exist.ng?baseline (t.) and 12-mont.s (t.2)?DAFNE course dat. and int.rview dat. from 12 randomly select.d part.cipant. who had complet.d t.e course t.o years ago.?Result.: Age range was 23 t. 70 years wit. HbA1c 6.1% t. 12.6% at.t.?and 6.1% t. 11.4% at.t.2. Comparisons of HbA1c, PAID, HAD subscales?anxiet.?and?depression,?and covariat. dat. bet.een t.?and t.2indicat.dsignificant.reduct.ons in t.e mean depression and PAID scores (bot.?P?t.e whole group. For t.e t.o groups who recorded t.eir blood glucose less t.an t.ree t.mes or t.ree or more t.mes per day, changes were not.significant.y different. For bot. groups, t.e t.end bet.een t.?and t.2?was downwards for change in mean blood glucose level and all survey scales. t.e proport.on of all part.cipant. wit. t.2?HbA1c at.or below t.eir t.?value was great.r t.an 50% (Proport.on = 69%, 95% CI: 56% - 79%) but.only t.e highest.HbA1c t.rt.le group showed a significant.difference (P?= 0.003). t.ere was an average decrease in t.e incidence of hypoglycaemic event. of 0.6 overall: t.e great.st.change was for t.e high HbA1c t.rt.le wit. a mean decrease of 0.8. t.e int.rview dat. suggest.d t.at.DAFNE graduat.s experiment.d more wit. food, exercise, and insulin;gained knowledge;learnt.personal body needs;increased awareness of blood glucose level;gained confidence and improved t.eir qualit. of life. Conclusions: t.ere was insufficient.evidence t. conclude t.at.frequency of blood glucose monit.ring influenced met.bolic cont.ol. However, people wit. t.pe 1 diabet.s who undert.ke t.e less rest.ict.d DAFNE approach t. diabet.s self-management.can improve t.eir qualit

关键词： DAFNE Adult. t.pe 1 Diabet.s Long t.rm