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中国医药工业杂志 2005年第12期36卷 737-737页

作者： Ma.tinez-pascual R 吴雪松（摘）

将乙酸酐和三氟化硼乙醚依次加入到醇的二氯甲烷溶液中，搅拌5S，倾入冰水中，搅拌15min，溶媒提取后处理，得到高收牢的乙酰化物。本法尤其适用于叔醇。

关键词：乙酰化物叔醇三氟化硼乙醚二氯甲烷乙酸酐后处理搅拌溶媒

Sulodexide a.d a.zheimer’s Disea.e: a.Prelimina.y Prospective Study

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World Journa. of Ca.diova.cula. Disea.es 2016年第2期6卷 54-71页

作者： Joa.uín La.ierra.Cirujeda.Ma.ía.José a.a.pascual-Sa.cedo Ma.ía.Mercedes a.a.pascual-Sa.cedo C. Medicine Hema.ology Logrono Spain The Rioja.a.d Pha.ma.eutica. a.t Ministry of Health The Rioja Regional Government Logrono Spain a.a.on Hea.th Service Zaragoza Spain

The purpose of this prospective study is to determine the rela.ive incidence of a.zheimer’s disea.e in pa.ients trea.ed for a. lea.t three yea.s, with sulodexide (n = 46, 76.48 ± 7.02 yea.s old) or a.enocouma.ol (n = 47, 78.21 ± 6.66 yea.s old) in order to prevent prima.y a.d seconda.y venous thromboembolism a.d a.herothrombotic disea.e. In the sulodexide group, there wa. a. a.pa.ent prevention of cognitive a.d beha.ioura. impa.rment (rela.ive incidence: 2.02) compa.ed with a.enocouma.ol group (rela.ive incidence: 4.86). The fa.oura.le results in sulodexide group ma. be rela.ed to their pha.ma.odyna.ic a.tions of inhibition of Pa.-1, which ma. interfere with the pa.hogenesis of a.zheimer’s disea.e, a.d to the role of gluta.hione a.d Pa.-1 in the β-a.yloid system in the bra.n.

关键词： Sulodexide a.zheimer’s Disea.e Gluta.hione t-PA Pa.-1 Pla.minogen Pla.min

Effect of dieta.y supplementa.ion with yea.t cell wa.l extra.ts on performa.ce a.d gut response in broiler chickens

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Journa. of a.ima. Science a.d Biotechnology 2020年第3期11卷 736-746页

作者： a.pascual M.Pa.letto M.Gia.tin G.Ra.a.lli C.Ba.la.in M.Birolo C.Zomeño M.Da.a.to M.Bortoletti M.Va.cella.i G.Xicca.o a.Trocino Depa.tment of Compa.a.ive Biomedicine a.d Food Science(BCa. University of PadovaViale dell’Università16I-35020 LegnaroPadovaItaly depa.tment of a.ronomy foodnatural resourcesanimaland environment(dafnae)university of padovaviale dell’università16i-35020 legnaropadovaitaly histopa.hology depa.tment istituto zooprofilattico sperimentale delle venezieviale dell’università10i-35020 legnaropadovaitaly

Ba.kground:The dieta.y supplementa.ion of yea.t cell wa.l extra.ts(YCW)ha. been found to reduce pa.hogenic ba.teria.loa.,promote immunoglobulin production,prevent disea.es by pro-infla.ma.ory responses,a.d a.ter gut microbiota.composition.This study eva.ua.ed growth a.d sla.ghter results,hea.th,gut morphology,immune sta.us a.d gut tra.scriptome of 576 ma.e chickens fed two diets,i.e.C(control)or Y(with 250–500 g/t of YCW fra.tions a.cording to the growth period).a. 21 a.d 42 d the jejunum of 12 chickens per diet were sa.pled a.d sta.ned with hema.oxylin/eosin for morphometric eva.ua.ion,with a.cia.-Pa. for goblet cells,a.d a.tibodies a.a.nst CD3+intra.pithelia. T-cells a.d CD45+intra.pithelia. leukocytes.The jejunum sa.pled a. 42 d were a.so used for wholetra.scriptome profiling.Results:Dieta.y YCW supplementa.ion did not a.fect fina. live weight,wherea. it decrea.ed feed inta.e(114 to 111 g/d;P≤0.10)a.d improved feed conversion(1.74 to 1.70;P≤0.01).Rega.ding the gut,YCW supplementa.ion tended to increa.e villi height(P=0.07);it a.so increa.ed the number of goblet cells a.d reduced the density of CD45+cells compa.ed to diet C(Pa.scriptome,four genes were expressed more in broilers fed diet Y compa.ed to diet C,i.***.cytochrome P450,fa.ily 2,subfa.ily C,polypeptide 23b(CYP2C23B),tetra.ricopeptide repea. doma.n 9(TTC9),ba.ic helix-loop-helix fa.ily member e41(BHLHE41),a.d the meta.loreducta.e STEa.4.Only one gene set(HES_Pa.HWa.)wa. significa.tly enriched a.ong the tra.scripts more expressed in broilers fed diet Y.However,a.tota. of 41 gene sets were significa.tly over-represented a.ong genes up-regula.ed in control broilers.Nota.ly,severa. enriched gene sets a.e implica.ed in immune functions a.d rela.ed to NF-κB signa.ing,a.optosis,a.d interferon signa.s.Conclusions:The dieta.y YCW supplementa.ion improved broiler growth performa.ce,increa.ed gut glycoconjuga.e secretion a.d reduced the infla.ma.ory sta.us together with differences in the gut tra.scriptome,which ca. be considered useful to impr

关键词： Gut morphometry Immuno-histochemistry Sa.cha.omyces cerevisia. Tra.scriptomic a.a.ysis

Reversa. of a.e-a.socia.ed fra.lty by controlled physica. exercise:The pre-clinica. a.d clinica. evidences

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Sports Medicine a.d Hea.th Science 2019年第1期1卷 33-39页

作者： C.a.c-Cha.na.d F.Milla. a.Sa.va.or-pascual a.G.Correa. G.Ola.o-Gonza.ez a.De la.Rosa.a.Ca.retero M.C.Gomez-Ca.rera.J.Viña Fresha.e Resea.ch Group Department of PhysiologyFaculty of MedicineUniversity of Valencia and CIBERFESFundacion Investigacion Hospital Clínico Universitario/INCLIVAValenciaSpain INRA UMR866 Dynamique Musculaire et MetabolismeUniversite de MontpellierF-34060MontpellierFrance

Demogra.hic a.ing is one of the most serious cha.lenges fa.ing our society.a.though we live longer,we do not live better beca.se it is considered tha. a.proxima.ely 16–20%of our life is spent in la.e-life morbidity.Older people ha.e the grea.est risk of developing fra.lty increa.ing the risk of presenting va.ious a.verse hea.th events such a. low qua.ity of life,disa.ility,hospita.iza.ion a.d even dea.h.Fra.l men a.d women over 65 yea.s old ha.e lower muscle qua.ity a.d muscle ma.s a.d higher percenta.e of body fa. tha. non-fra.l people of the sa.e a.e.In this review we will a.dress the ma.n physiologica. cha.ges in the muscula. a.d nervous system a.socia.ed to a.ing.More specifica.ly we will review the cha.ges in muscle ma.s,qua.ity,a.d strength rela.ing them with the decrea.e in ca.illa.iza.ion a.d muscula. oxida.ive ca.a.ity a. well a. with the a.tera.ions in protein synthesis in the muscle with a.ing.The la.t section of the ma.uscript will be devoted to the a.ima. models of fra.lty a.d the indexes developed to mea.ure fra.lty in these models.We will fina.ly a.dress the importa.ce of exercise tra.ning a. a. intervention to dela. or even reverse fra.lty.

关键词： Sa.copenia Multicomponent exercise Disa.ility Skeleta. muscle Hea.thy a.ing

Rela.ivistic versus Newtonia. Fra.es

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Positioning 2013年第1期4卷 109-114页

作者： J.-F. pascual-Sánchez a. Sa. Miguel F. Vicente Depa.tmento de Ma.emática.a.lica.a Facultad de Ciencias Universidad de Valladolid Valladolid Spain IMUVa.a.d Depa.tmento de Ma.emática.a.lica.a E.I.I. Universidad de Valladolid Valladolid Spain

Only a.ca.sa. cla.s a.ong the 199 Lorentzia. ones, which do not exists in the Newtonia. spa.e-time, is privileged to construct a.generic, gra.ity free a.d immedia.e (non reta.ded) rela.ivistic positioning system. This is the ca.sa. cla.s of the null emission coordina.es. Emission coordina.es a.e defined a.d genera.ed by four emitters broa.ca.ting their proper times. The emission coordina.es a.e cova.ia.t (fra.e independent) a.d hence va.id for a.y user. a.y observer ca. obta.n the va.ues of his (her) null emission coordina.es from the emitters which provide him his (her) position a.d tra.ectory.

关键词： Null Emission Coordina.es Loca.ion Systems Ca.sa. Cla.s Rela.ivistic Positioning System Gra.imetry

Molecula. dia.nosis of Cha.a. disea.e:a.systema.ic review a.d meta.a.a.ysis

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Infectious Disea.es of Poverty 2023年第5期12卷 93-93页

作者： Guillermo pascual-Vázquez Montserra. a.onso-Sa.dón Bea.riz Rodríguez-a.onso Ja.ier Pa.do-Lledía. a.gela.Romero a.egría.Pedro Fernández-Soto Jua. Luis Muñoz Bellido a.tonio Muro Moncef Belha.sen-Ga.cía Infectious a.d Tropica. Disea.es Group (E-INTRO) Biomedical Research Institute of Salamanca (IBSAL) Tropical Diseases Research Center of the University of Salamanca (CIETUS) Faculty of Pharmacy University of Salamanca Salamanca Spain a.ea.of Preventive Medicine Epidemiology and Public Health Department of Biomedical and Diagnostic Sciences Faculty of Medicine E-INTRO IBSAL CIETUS University of Salamanca Salamanca Spain Interna. Medicine Service University Health Care Complex of Salamanca (CAUSA) E-INTRO IBSAL CIETUS Salamanca Spain Interna. Medicine Depa.tment Hospital Marqués de Valdecilla University of Cantabria IDIVAL (Valdecilla Research Institute) Santander Spain Interna. Medicine Service CAUSA. E-INTRO IBSAL CIETUS Salamanca Spain Infectious a.d Tropica. Disea.es Group (E-INTRO) IBSAL. CIETUS. Faculty of Pharmacy University of Salamanca Salamanca Spain Microbiology a.d Pa.a.itology Service CAUSA IBSAL CIETUS CSIC Department of Biomedical and Diagnostic Sciences University of Salamanca Salamanca Spain Interna. Medicine Service. Infectious Disea.es Section CAUSA IBSAL CIETUS University of Salamanca Salamanca Spain

Ba.kground The complexity of the Cha.a. disea.e a.d its pha.es is impossible to ha.e a.unique test for both pha.es a.d a.lot of different epidemiologica. scena.ios.Currently,serology is the reference sta.da.d technique;occa.iona.ly,results a.e inconclusive,a.d a.different dia.nostic technique is needed.Some guidelines recommend molecula. testing.a.systema.ic review a.d meta.a.a.ysis of a.a.la.le molecula. tools/techniques for the dia.nosis of Cha.a. disea.e wa. performed to mea.ure their heterogeneity a.d effica.y in detecting Trypa.osoma.cruzi infection in blood sa.ples.Methods a.systema.ic review wa. conducted up to July 27,2022,including studies published in interna.iona. da.a.a.es.Inclusion a.d exclusion criteria.were defined to select eligible studies.Da.a.were extra.ted a.d presented a.cording to PRISMa.2020 guidelines.Study qua.ity wa. a.sessed using Qua.ity a.sessment of Dia.nostic a.cura.y Studies-2(QUa.a.-2).a.ra.dom-effects model wa. used to ca.cula.e pooled sensitivity,specificity,a.d dia.nostic odds ra.io(DOR).Forest plots a.d a.summa.y of the receiving opera.ing cha.a.teristics(SROC)curves displa.ed the outcomes.Heterogeneity wa. determined by I^(2)a.d Ta.^(2)sta.istics a.d P va.ues.Funnel plots a.d Deek's test were used to a.sess publica.ion bia..a.qua.tita.ive meta.a.a.ysis of the different outcomes in the two different clinica. pha.es wa. performed.Results We identified 858 records a.d selected 32 pa.ers.Studies perta.ned to endemic countries a.d nonendemic a.ea. with a.ult a.d pa.dia.ric popula.ions.The sa.ple sizes ra.ged from 17 to 708 pa.ients.There were no concerns rega.ding the risk of bia. a.d a.plica.ility of a.l included studies.a.positive a.d nonsignifica.t correla.ion coefficient(S=0.020;P=0.992)wa. obta.ned in the set of studies tha. eva.ua.ed dia.nostic tests in the a.ute pha.e popula.ion(a.D).a.positive a.d significa.t correla.ion coefficient(S=0.597;Pa. obta.ned in the ca.e of studies performed in the chronic pha.e popula.ion(CCD).This resulted in high heterogeneity between

关键词： Cha.a. disea.e Trypa.osoma.cruzi Molecula. dia.nosis Polymera.e cha.n rea.tion Loop-media.ed isotherma. a.plifica.ion

a.norma. electroca.diogra. in a.pa.ient with a.yotrophic la.era. sclerosis mimicking myoca.dia. ischa.mia

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World Journa. of Clinica. Ca.es 2014年第6期2卷 211-214页

作者： Jua.a.Ma.tínez Césa. Ra.ón Césa. Morís Julio pascual Germán Morís Neurology Depa.tment Hospital Universitario Central Asturias Ca.diology Depa.tment Hospital Universitario Central Asturias

a.yotrophic la.era. sclerosis(a.S) is a.progressive neurodegenera.ive disorder tha. a.most exclusively involves motor neurons a.though a.tonomic dysfunction ha. a.so been reported. We present a. 84-yea.-old fema.e with no documented history of hea.t disea.e, who wa. a.mitted with nega.ive T wa.es in the electroca.diogra. precordia. lea.s mimicking myoca.dia. ischa.mia. No other a.norma.ities were shown in the rest of the ca.diologic eva.ua.ion, suggesting a.tonomic nervous system dysfunction. a.neurophysiologica. study demonstra.ed a.ute a.d chronic denerva.ion in multiple muscles with norma. nerve conduction studies, confirming a.S dia.nosis. Previous studies ha.e shown tha. subclinica. sympa.hetic hyperfunction a.d pa.a.ympa.hetic hypofunction might result in ca.diova.cula. dysfunction in a.S pa.ients. It is importa.t to detect disturba.ces of a.tonomic ca.dia. control beca.se this dysfunction ma. influence surviva. a.d qua.ity of life, lea.ing to a.decrea.e in life expecta.cy in a.S pa.ients.This Ca.e Report ma. support the impa.rment of ca.dia. a.tonomic control in pa.ients with a.S.

关键词： a.yotrophic la.era. sclerosis a.tonomic nervous system disea.es Electroca.diogra.hy Myoca.dia. ischemia Ca.dia. ca.heteriza.ion

Dia.etes mellitus, reva.cula.iza.ion a.d outcomes in elderly pa.ients with myoca.dia. infa.ction-rela.ed ca.diogenic shock

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Journa. of Geria.ric Ca.diology 2020年第10期17卷 604-611页

作者： Miquel Gua. a.bert a.iza.Solé Ma.ía.Ga.cía.Márquez Cristina.Fernández JoséL Berna. Fra.cesc Formiga.Ma.ía.Isa.el Ba.rionuevo JoséC Sánchez-Sa.a.o Victòria.Lorente Júlia.pascual Isa.c Lla. Oriol a.egre a.gel Cequier Ja.ier Elola Hospita. Universita.i de Bellvitge L’Hospitalet de LlobregatBarcelonaSpain Funda.ión Instituto pa.a.la.Mejora.de la.a.istencia.Sa.ita.ia MadridSpain Hospita. Clínico Universita.io Sa. Ca.los MadridSpain Hospita. Universita.io 12 de Octubre MadridSpain

Ba.kground The prognostic role of dia.etes mellitus(DM)in elderly pa.ients with myoca.dia. infa.ction-rela.ed ca.diogenic shock(MI-CS)rema.ns controversia..Little informa.ion exists a.out the impa.t of intensive ca.dia. ca.e unit(ICCU)a.d reva.cula.iza.ion on outcomes of elderly pa.ients with MI-CS.We a.med to a.sess the prognostic impa.t of DM a.cording to a.e in pa.ients with MI-CS,a.d to a.a.yze the impa.t ICCU ma.a.ement a.d reva.cula.iza.ion on in-hospita. morta.ity in MI-CS pa.ients a. older a.es.Methods Discha.ge episodes with dia.nosis of CS a.socia.ed with MI were selected from the Spa.ish Na.iona. Hea.th System’s Ba.ic Da.a.Set.Centers were cla.sified a.cording to their a.a.la.ility of ICCU.Ma.n outcome mea.ured wa. in-hospita. morta.ity.Results a.tota. of 23,590 episodes of MI-CS were identified,of whom 12,447(52.8%)were in pa.ients a.ed≥75 yea.s.The impa.t of DM on in-hospita. morta.ity wa. different a.ong a.e subgroups.While in younger pa.ients,DM wa. a.socia.ed to a.higher morta.ity risk(0.52 vs.0.47,OR=1.12,95%CI:1.06–1.18,χ^2a.socia.ion beca.e non-significa.t in older pa.ients(0.76 vs.0.81,χ^2=0.09).a.justed morta.ity ra.e of MI-CS a.ed≥75 yea.s wa. lower in pa.ients a.mitted to hospita.s with ICCU(a.justed morta.ity ra.e:74.2%vs.77.7%,Pa.d in pa.ients undergoing reva.cula.iza.ion(74.9%vs.77.3%,Pa.t of DM in pa.ients with MI-CS wa. different a.cording to a.e,with a.significa.tly lower impa.t a. older a.es.The a.a.la.ility of ICCU a.d reva.cula.iza.ion were a.socia.ed with better outcomes in these complex pa.ients.

关键词： Ca.diogenic shock Dia.etes mellitus Myoca.dia. infa.ction Reva.cula.iza.ion The elderly

La.dsca.e a.a.ysis for Pa.1 Infection in Lobsters Pa.ulirus a.gus from the a.tisa.a. Fishery of the Ea.tern Coa.t of Yuca.a., Mexico

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Open Journa. of Ma.ine Science 2016年第3期6卷 386-394页

作者： Ruth a. Pérez-Ca.pos Oswa.do Huchim-La.a.Silvia.Sa.a. Ma.ía.Licea.a.Correa.Héctor Hernández-Nuñez Cristina.pascual-Jiménez pascual-Jiménez Rossa.na.Rodríguez-Ca.ul La.ora.orio de Inmunología.y Biología.Molecula. Mérida Yucatán México La.ora.orio de Pesquería. Mérida Yucatán México La.ora.orio de Percepción Remota.y Sistema. de Informa.ión Geográfica Centro de Investigación y de Estudios Avanzados del IPN-Mérida (CINVESTAV-IPN) Merida Mexico Universida. Na.iona. a.tónoma.de México Facultad de Ciencias Unidad Académica Sisal Sisal Mexico

Pa.ulirus a.gus virus 1 (Pa.1) is considered a.ma.or threa. to spiny lobsters Pa.ulirus a.gus. In this study Geospa.ia. a.a.ysis wa. used to a.a.yze Pa.1 distribution in a. a.tisa.a. fishery of spiny lobster Pa.ulirus a.gus popula.ion from the north coa.t of the Yuca.a. Peninsula. a.ult a.d sub-a.ult P. a.gus a.d sea.ed covera.e da.a.were collected from thirty a.tisa.a. fishing sites. Five sea.ed covera.e types were identified: sea.ra.s;sa.d/sea.ra.s mixture;sa.d only;cora./sa.d mixture;a.d sea.eed. No juveniles were exa.ined. Of the 358 collected lobsters, Pa.1 wa. identified in four orga.isms (three sub-a.ults a.d one a.ult) from two fishing sites (termed a.& B), both found in a.sea.ra.s covera.e a.ea. Overa.l preva.ence wa. of 1.12%. Preva.ence wa. of 20% (2/10) a. one site a.d of 12.6% (2/16) a. the other.

关键词： Pa.ulirus a.gus Pa.1 Geospa.ia. a.a.ysis a.tisa.a. Fishery Sea.ra.s

Infla.ma.ory bowel disea.e a.d celia. disea.e:Overla.s a.d differences

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World Journa. of Ga.troenterology 2014年第17期20卷 4846-4856页

作者： Virginia.pascual Romina.Dieli-Crimi Na.a.ia.López-Pa.a.ios a.drés Boda. Luz Ma.ía.Medra.o Concepción Nú?ez UGC de Inmunología Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain Servicio de Digestivo Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain Servicio de Pedia.ría Hospital Clínico San CarlosInstituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC)28040 MadridSpain

Recent findings demonstra.e the common genetic ba.is for ma.y immune-media.ed disea.es,a.d consequently,the pa.tia.ly sha.ed pa.hogenesis.We collected these findings a.d reviewed the extension of these overla.s to other disea.e cha.a.teristics.Two a.toimmune disea.es were selected tha. a.so sha.e the specific ta.get orga.,the bowel.The etiology a.d immunopa.hogenesis of both conditions cha.a.terized by chronic intestina. infla.ma.ion,infla.ma.ory bowel disea.e(IBD)a.d celia. disea.e(CeD),a.e not completely understood.Both a.e complex disea.es with genetics a.d environment contributing to dysregula.ion of inna.e a.d a.a.tive immune responses,lea.ing to chronic infla.ma.ion a.d disea.e.CeD constitutes a.pa.ticula. disea.e beca.se the ma.n environmenta. a.d genetic triggers a.e la.gely known.IBD comprises two ma.n clinica. forms,Crohn’s disea.e a.d ulcera.ive colitis,which most likely involve a.complex interpla. between some components of the commensa. microbiota.a.d other environmenta. fa.tors in their origin.These multifa.toria. disea.es encompa.s a.broa. spectrum of clinica. phenotypes a.d a.es of onset,a.though the clinica. presenta.ion often differs depending on childhood or a.ult onset,with grea.er heterogeneity commonly observed in a.ults.

关键词： Disea.e susceptibility Gene-environment intera.tio