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World Journa. of Ga.troenterology 2013年第48期19卷 9209-9215页

作者： Rica.do Robles Fra.cisco Sánchez-Bueno Pa.lo Ra.írez Roberto Brusa.in pascual Pa.rilla Depa.tment of Surgery a.d Liver a.d Pa.crea. tra.spla.ta.ion Virgen de la Arrixaca Clinic and University Hospital E-30120 Murcia Spain

The most a.propria.e trea.ment for Kla.skin tumor(KT)with a.cura.ive intention is multimoda. thera.y ba.ed on a.hieving resection with tumour-free ma.gins(R0resections)combined with other types of neoa.juva.t or a.juva.t trea.ment(the most importa.t fa.tor a.fecting KT surviva. is the possibility of R0 resections,a.hieving 5-yea. surviva. ra.e of 40%-50%).Thirty to forty percent of pa.ients with KT a.e inopera.le a.d present a.5-yea. surviva. ra.e of 0%.In irresecta.le non-dissemina.ed KT pa.ients,using liver tra.spla.ta.ion without neoa.juva.t trea.ment,the 5-yea. surviva. ra.e increa.e to 38%,rea.hing 50%surviva. in ea.ly sta.e.In selected ca.es,with liver tra.spla.ta.ion a.d neoa.juva.t trea.ment(chemothera.y a.d ra.iothera.y),the a.tua.ia. surviva. ra.e is 65%a. 5 yea.s a.d 59%a. 10 yea.s.In conclusion,correct sta.ing,neoa.juva.t trea.ment,living donor a.d priority on the liver tra.spla.t wa.ting list ma. lea. to improved results.

关键词： Kla.skin tumour Chola.gioca.cinoma Liver tra.spla.ta.ion Liver surgery Prima.y sclerosing chola.gitis

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木薯在菲律宾饲料工业中的应用

国外畜牧学（猪与禽） 2001年第4期21卷 56-59页

作者： Ba.ilisa.pascual-Rea. 美国大豆协会菲律宾办事处

前言配合饲料生产中最大的成本项目是能料饲料和蛋白质饲料,两者分别占配合饲料成本的50～60%和20～25%.在商品饲料生产中,最常用于猪日粮的能料饲料原料是谷物,比如玉米、小麦、高粱和大麦,以及一些植物油和动物脂肪.豆粕,由于其优良... 详细信息

前言配合饲料生产中最大的成本项目是能料饲料和蛋白质饲料,两者分别占配合饲料成本的50～60%和20～25%.在商品饲料生产中,最常用于猪日粮的能料饲料原料是谷物,比如玉米、小麦、高粱和大麦,以及一些植物油和动物脂肪.豆粕,由于其优良的营养价值,则是应用最广的蛋白质源.

关键词：木薯菲律宾饲料工业应用

High-pressure scheelite-type polymorph of SmCrO_4: synthesis, structura. cha.a.teriza.ion a.d ma.netic properties

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Journa. of Ra.e Ea.ths 2010年第6期28卷 936-939页

作者： Regino Sáez-Puche Ma.moud Ga.a. Ra.ie Julio Romero de Pa. José-Ma.uel Ga.la.do-a.ores Esteba. Climent pascual Depa.tment of Inorga.ic Chemistry Faculty of Chemical Sciences Complutense University of Madrid Ciudad Universitaria

The new scheelite form of SmCrO4 oxide wa. obta.ned by hea.ing the zircon-type SmCrO4 oxide a. 4 GPa.a.d 803 K. X-ra. diffra.tion revea.ed tha. this scheelite SmCrO4 pha.e crysta.lized with tetra.ona. symmetry, S.G. I41/a.a.d la.tice pa.a.eters: a.0.50776(3) nm a.d c=1.15606(2) nm. This structura. pha.e tra.sition from zircon to scheelite involved a.decrea.ing of a.ound 10% in the unit cell volume. a.though the Cr-O a.d Sm-O dista.ces did not cha.ge very much in both zircon a.d scheelite polymorphs, the cha.ges occurred in the bond a.gles were rema.ka.le tha. a.pea. to support the proposed reconstructive model to expla.n this structura. zircon-scheelite pha.e tra.sition. Ma.netic susceptibility a.d ma.netiza.ion mea.urements revea.ed tha. the scheelite SmCrO4 oxide beha.ed a. a.tiferroma.netic ma.eria., where the Sm3+ a.d Cr5+ were simulta.eously ordered. The estima.ed Néel tempera.ure, TN, wa. 16 K a.d the critica. field a. 12 K a.socia.ed with the meta.a.netic tra.sition wa. 3.2 T.

关键词： scheelite-type structure zircon-type structure high pressure synthesis a.tiferroma.netic beha.iour meta.a.netic tra.sition ra.e ea.ths

额部纤维化脱发与毛发扁平苔藓的比较:一项临床病理学研究

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世界核心医学期刊文摘（皮肤病学分册） 2006年第6期2卷 54-55页

作者： Poblet E. Jiménez F. pascual a. Piqué E. 张路坤 Ca.le a.gel Guimer2 Las Palmas de Gran Canaria 35003 Spain Dr.

Ba.kground: Fronta. fibrosing a.opecia.(FFa. is a. a.quired sca.ring a.opecia.currently considered a.clinica. va.ia.t of lichen pla.opila.is (LPP). Our purpose wa. to exa.ine the clinicopa.hologica. fea.ures of FFa. In a.dition, we investiga.ed the simila.ities a.d differences between FFa.a.d LPP. Methods: Biopsies from the sca.p lesions of eight pa.ients with FFa.a.d eight pa.ients with LPP were microscopica.ly a.a.yzed. Two ca.es of FFa.a.d four ca.es of LPP were studied using direct immunofluorescence. Results: In spite of the completely different clinica. cha.a.teristics of FFa.a.d LPP pa.ients, the histopa.hologica. findings for the two entities were simila.. Common microscopic findings for both FFa.a.d LPP included a. infla.ma.ory lymphocytic infiltra.e involving the isthmus a.d infundibulum of the ha.r follicles, the presence of a.optotic cells in the externa. root shea.h, a.d a.concentric fibrosis surrounding the ha.r follicles tha. resulted in their destruction with subsequent sca.ring a.opecia. Biopsies ta.en from FFa.pa.ients showed less follicula. infla.ma.ion a.d more a.optotic cells tha. those from LPP pa.ients. In some ca.es of LPP, the infla.ma.ory infiltra.e involved the interfollicula. epidermis, a.finding never present in our FFa.ca.es. Direct immunofluorescence wa. nega.ive in the two ca.es of FFa.studied a.d showed deposits of immunoglobulins a.d/or complement in two of the four LPP ca.es exa.ined. Conclusions: The cha.a.teristic findings for FFa.were more prominent a.optosis a.d less infla.ma.ion tha. found in LPP, a.ong with spa.ed interfollicula. epidermis. FFa.ca.es showed a.ra.her cha.a.teristic histopa.hologica. pa.tern, a.though we could not find a.y clea.-cut histologica. differences between FFa.a.d LPP.

关键词：扁平苔藓临床变异纤维化病理学研究脱发毛发额部免疫荧光检测组织病理学临床病理学特征

Bispecific sigma.1 receptor a.ta.onism a.d mu-opioid receptor pa.tia. a.onism:WLB-73502,a. a.a.gesic with improved effica.y a.d sa.ety profile compa.ed to strong opioids

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a.ta.Pha.ma.eutica.Sinica.B 2023年第1期13卷 82-99页

作者： a.ba.Vida.-Torres Begoña.Fernández-Pa.tor Mónica.Ga.cía.Eva.a.et a.na.Ca.ot Ja.ier Burgueño Xa.ier Monroy Bertra.d a.bel Xa.ier Codony Luz Romero Rosa.ía.pascual Ma.ia.Teresa.Sera.ini Gregorio Encina.Ca.men a.ma.sa.Da.iel Za.a.illo Ma.uel Merlos JoséMiguel Vela WeLa. Ba.celona Parc Cientific de BarcelonaBarcelona 08028Spain

Opioids a.e the most effective pa.nkillers,but their benefit-risk ba.a.ce often hinder their thera.eutic use.WLB-73502 is a.dua.,bispecific compound tha. binds sigma.1(S1R)a.d mu-opioid(MOR)receptors.WLB-73502 is a. a.ta.onist a. the S1R.It beha.ed a. a.pa.tia. MOR a.onist a. the G-protein pa.hwa. a.d produced no/unsignifica.tβ-a.restin-2 recruitment,thus demonstra.ing low intrinsic effica.y on MOR a. both signa.ling pa.hwa.s.Despite its pa.tia. MOR a.onism,WLB-73502exerted full a.tinociceptive effica.y,with potency superior to morphine a.d simila. to oxycodone a.a.nst nociceptive,infla.ma.ory a.d osteoa.thritis pa.n,a.d superior to both morphine a.d oxycodone a.a.nst neuropa.hic pa.n.WLB-73502 crosses the blood-bra.n ba.rier a.d binds bra.n S1R a.d MOR to a. extent consistent with its a.tinociceptive effect.Contra.y to morphine a.d oxycodone,tolera.ce to its a.tinociceptive effect did not develop a.ter repea.ed 4-week a.ministra.ion.a.so,contra.y to opioid compa.a.ors,WLB-73502 did not inhibit ga.trointestina. tra.sit or respira.ory function in ra.s a. doses inducing full effica.y,a.d it wa. devoid of proemetic effect(retching a.d vomiting)in ferrets a. potentia.ly effective doses.WLB-73502 benefits from its biva.ent S1R a.ta.onist a.d pa.tia. MOR a.onist na.ure to provide a. improved a.tinociceptive a.d sa.ety profile respect to strong opioid thera.y.

关键词： WLB-73502 Sigma.1 receptor Mu-opioid receptor Bia.ed a.onist a.a.gesic a.tivity Chronic pa.n Neuropa.hic pa.n Sa.ety

利扎曲坦对急性偏头痛患者生产能力和生活质量的影响:一项工作现场研究

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世界核心医学期刊文摘（神经病学分册） 2005年第11期1卷 26-27页

作者： Linez M.J.a. Lpez a. pascual a.M. 邓剑平 Dr. Hospita. Clnico Universita.io de Va.encia Universidad de Valencia Department of Neurology Valencia Spain

Objective. -To eva.ua.e the impa.t of trea.ment with riza.ripta. 10 mg on jobs a.d qua.ity of life of pa.ients with migra.ne. Methods. -Prospective, open-la.el study a. 27 work sites of 20 compa.ies representing diverse la.or sectors in Spa.n. Eligible pa.ients a.cording Interna.iona. Hea.a.he Society (IHS) criteria.were recruited for the study by on-site physicia.s a.d instructed to trea. modera.e or severe migra.ne a.ta.ks with one ta.let of riza.ripta. 10 mg. They were a.ked to complete the study questionna.res (ML-96, SF-36) a. ba.eline, a.d then 3 months la.er. Results. -a.tota. of 259 pa.ients (83 men a.d 176 women) of a.mea. a.e of 39 (ra.ge 18 to 61 yea.s) completed the study. Only 7%ha. ta.en tripta.s before for trea.ment of their migra.ne a.ta.ks. a.ter 3 months of riza.ripta. thera.y, the use of medica. services wa. significa.tly lower a.d a.l tested doma.ns of qua.ity of life ha. improved (P a.senteeism a.d da.s worked during migra.ne a.ta.ks a.so fell significa.tly during 3 months of riza.ripta. thera.y a. compa.ed with the 3 months before the study (P a. reflected in the significa.t decrea.es in lost workda. equiva.ents (decrea.e from 3.32 to 1.21 da.s; P a.d a.so in the tota. number of workda.s lost (decrea.e from 5.16 to 1.82 da.s; P a.ients described the effica.y of ora. riza.ripta. a. excellent or very good (62%), a.d 89%preferred it over their usua. medica.ions for a.ute trea.ment of migra.ne a.ta.ks. Conclusion. -For this employed popula.ion of pa.ients with migra.ne, trea.ment with riza.ripta. significa.tly improved pa.a.eters mea.uring direct medica. costs, work a.d productivity, a.d hea.th-rela.ed qua.ity of life. In a.corda.ce with these findings, direct a.d indirect costs rela.ed to migra.ne could be substa.tia.ly reduced by ga.hering deta.led informa.ion a.out the na.ure of hea.a.he, elimina.ing triggering fa.tors, a.d instituting effective trea.ment of migra.ne a.ta.ks.

关键词：偏头痛患者现场研究头痛发作曲坦类药物生活质量国际头痛协会直接医疗费用自然病史间接费用急性发作

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MTS 1500型自动化金属液处理站

MTS 1500型自动化金属液处理站

膝关节剥脱性骨软骨炎松动骨软骨块活力的研究

第21届重庆市铸造年会

作者： Jun pascual 薛跃腾 P Ca.eil R Simon 福士科铸造材料(中国)有限公司福士科(德国)有限公司

为应对日趋激烈的竞争,铝铸造厂大多采用降低废品率和减少资源浪费来提高高品质铸件的产量和生产率。为能在安全的工作环境下提高金属出品率必须做到:①生产出符合标准、安全

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中国矫形外科杂志 2010年第21期18卷 1775-1775页

作者：吴波孙磊 pascual-Ga.ridoC Ta.oira. MusclolDL 第88医院全军骨科中心山东泰安271000

本研究目的为明确膝关节剥脱性骨软骨炎中松动骨软骨块内软骨组织是否存在活性。研究对象为5例经外科治疗的膝关节剥脱性骨软骨炎病例,所有病例均接受了关节镜下松动骨软骨块复位、固定治疗。

关键词：膝关节剥脱性骨软骨炎骨块松动软骨组织外科治疗固定治疗关节镜病例

在健康受试者与患者非运动皮质区进行rTMS的安全性

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 26-27页

作者： Ma.hii K. Cohen D. Ra.os-Esteba.ez C. pascual-Leone a. 袁海峰(译) 不详 Center for Noninva.ive Bra.n Stimula.ion Department of Neurology Harvard Medical School 330 Brookline Avenue Boston MA 02215 United States

Objective: rTMS is increa.ingly being used for stimula.ion to non-motor a.ea., but a.a.la.le sa.ety guidelines a.e derived from experience with motor cortex rTMS. We reviewed the litera.ure a.d our own da.a.to a.sess the sa.ety of rTMS to non-motor a.ea.. Methods: We reviewed for a.verse effects a.l a.ticles published from Ja.ua.y 1998 to December 2003 tha. a.plied rTMS to non-motor a.ea., a.d a.a.yzed da.a.from our own studies from Ja.ua.y 1997 to December 2003. Results: a.verse effects were infrequent a.d genera.ly mild. Hea.a.he wa. the most common, occurring in 23%of the subjects a.d more frequent with fronta. rTMS. More serious a.verse effects were ra.e a.d consisted of two seizures a.d four insta.ces of psychotic symptoms induced by rTMS to the dorsola.era. prefronta. cortex in pa.ients with depression. Conclusions: Overa.l, a. currently a.plied rTMS to non-motor a.ea. a.pea.s to be sa.e with few, genera.ly mild a.verse effects. In future studies, we recommend systema.ic reporting of a.verse effects a.d ca.eful documenta.ion of ma.hine type, coils used, a.d a.tua. intensity a. a.function of ma.imum stimula.or output. Phosphene threshold might be used to index stimula.i on intensity when rTMS is a.plied to the visua. cortex, a.d resea.ch should be directed to identifying other indexes of intensity for TMS to other non-motor a.ea.. Significa.ce: rTMS under the present guidelines is sa.e, with minima. a.verse effects, when a.plied to non-motor a.ea..

关键词： rTMS 患者实施健康受试者运动区安全性皮质区安全指南刺激强度副作用研究资料