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生物技术世界 2010年第2期7卷 55-57页

作者： pascale Cossart（编译）洪浩舟

它在细胞质中穿棱留下一条长长的聚合肌动蛋白尾巴，变化一下RNA结构便能激活大量的毒力因子？并将RNA转录物的密码子隐藏在错误的DNA链上，利斯塔氏菌谱写着自己的生存法则。

关键词：细菌肌动蛋白毒力因子 DNA链 RNA 细胞质密码子转录物

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药物的分配技术：设计、使用与安全

气雾剂通讯 2012年第4期 17-20页

作者： pascale Gauthier 金安琪(译)

概述现如今，设计在我们的日常生活中几乎无所不在。合理的设计能让药物更准确地为患者使用。兼备技术与效率的药物分配技术将令药物的使用更为安全：保证药物分析实验的准确性和可重复性．提高配方的存储安全性。本文将提到各种药品规... 详细信息

概述现如今，设计在我们的日常生活中几乎无所不在。合理的设计能让药物更准确地为患者使用。兼备技术与效率的药物分配技术将令药物的使用更为安全：保证药物分析实验的准确性和可重复性．提高配方的存储安全性。本文将提到各种药品规格的演化，并对新配方的未来前景做出展望。

关键词：安全性药物设计技术分配可重复性分析实验新配方

Uterine Artery Embolization for a Safe Surgical Abortion in Human Very High-Order Multifetal Pregnancy: A Case Report

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Open Journal of Obstetrics and Gynecology 2015年第13期5卷 735-739页

作者： Federica Brosio Mizar Paragona Sabrina Pizzulo pascale Riu Daniela Valeriani Giovanna Scassellati Sforzolini Patrizia Logoteta Vittorio Unfer Department of Obstetrics and Gynecology San Camillo Forlanini Hospital Rome Italy Department of Cardiological Science San Camillo Forlanini Hospital Rome Italy AGUNCO Obstetrics and Gynecology Centre Rome Italy

In the last few decades, the use of ovarian stimulation with follicle stimulating hormone (FSH) or clomiphene citrate (CC) increases the percentage of multiple pregnancies. The presence of many follicles can lead to the risk of higher-order multiple pregnancy and ovarian high stimulation syndrome (OHSS). This is correlated to a significant increase in morbidity and mortality maternal and/or fetal rate. For this reason, sometime therapeutic measures are necessary to preserve woman’s health. We describe the case of a surgical abortion using a transcatheter arterial embolization (TAE), a minimally invasive, safe and effective procedure to preserve the patients.

关键词： Multiple Pregnancies Transcatheter Arterial Embolization Abortion Pelvic Hemorrhage

Optimized Antiretroviral Therapy with Darunavir/Ritonavir, Etravirine and/or Raltegarvir: A Salvage Therapy Option in HIV-1 Infected Patients with Long-Term Therapeutic Failures, about 23 Cases

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World Journal of AIDS 2012年第4期2卷 300-305页

作者： Vincent Guiyedi Olivier Mounoury Soraya Boucherit pascale Longuet CBrunet-Francois Eric Kendjo JLEcobichon Madeleine Okome-Nkoumou Catherine Leport FRaffi Laboratoire de Recherche en Pathologie Infectieuse Universite Diderot-ParisParisFrance Service des Maladies Infectieuses et Tropicales CHU Xavier BICHATAPHPParisFrance Departement de Maladies Infectieuses et Tropicales Faculte de Medecine de LibrevilleUniversite des Sciences de la SanteLibrevilleGabon Service des Maladies Infectieuses et Tropicales Hotel DieuCHU NantesFrance Centre Nationale de Reference du Paludisme UPMCInVSParisFrance Department of Parasitology In-stitute of Tropical MedicineUniversity of TubingenTubingenGermany.

Objectives: The aims of this study was to analyze the immuno-virologic response after optimised background antiretroviral therapy (OBT) associated to new active antiretroviral treatment (ART) in HIV-1 infected patients with chronic virologic failure. Methods: We conducted a descriptive analysis of the immuno-virologic responses in HIV-1 adult infected patients: 1) harbouring multiple therapeutic failures with ART;2) with no virologic response obtained over 10 years (1997-2008);and 3) treated with OBT combined with new drugs including at least 1 of the 3 active ART among darunavir/ritonavir, etravirine and raltegravir;4) observed between month 0 (M0), before new ART to month 12 (M12) after new ART initialisation. Results: Twenty three patients were included in the study. After OBT, the proportion of patients with undetectable viral load was significantly higher at M6 and M12 than M0 (86% and 73% versus 0%, p = 0.03, respectively). At the same period, the median HIV viral load decreased significantly in 19/23 (83%) patients from 4.3 to 1.69log10 HIV-1 RNA copies/ml (p 3 [0 - 604] to 449/mm3 [130 - 964] between M0 and M12 (p 3 decreased from 57% to 23% (p = 0.02). Tolerability was good and no death was recorded during the 12-month' follow-up. Conclusions: These results show that the combination of OBT with the new ART can offer a salvage therapy in patients presenting a long-term history of virologic failures.

关键词： Darunavir/Ritonavir Etravirine Raltegravir HIV-1

A Ground Penetrating Radar and Electrical Resistivity Tomography Prospection for Detecting Sterile Bodies in the Phosphatic Bearing of Sidi Chennane(Morocco)

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International Journal of Geosciences 2011年第4期2卷 406-413页

作者： Nora El Assel Azzouz Kchikach Teresa Teixido Jose Antonio Pena Mohammed Jaffal Roger Guerin pascale Lutz Es-Said Jourani Mbarek Amaghzaz Equipe de Recherche E2G Universite Cadi AyyadMarrakechMorocco Laboratorio de Geofisica Aplicada Instituto Andaluz de GeofisicaUniversidad de GranadaSpain Universite Pierre et Marie Curie-Paris UMR 7619 SisypheParisFrance Institut Polytechnique LaSalle Beauvais Department GeosciencesBeauvaiFrance Groupe Office Cherifien des Phosphates(OCP) KhouribgaMorocco

In Sidi Chennane deposits (Morocco), the phosphatic series is composed of regular interbedded phosphatic and marly limestone layers. Exploitation of the phosphate in these deposits collides frequently with problems bound to the existence, in this series, of sterile bodies qualified as derangements. They cause two kinds of problems: 1) as they are hard, compact and masked by a Quaternary cover, they disturb the exploitation in some yards and give bad reserve calculation;2) even the use of wells and mechanical boreholes did not evidence their delimitation. Our study shows that these bodies can be detected and delimited using ground penetrating radar and electrical resistivity tomography methods. It is based on the acquisition and the interpretation of series tests using these methods carried out above visible sterile bodies in a trench of exploitation in order to have geologically valid information. The article concerns to the analysis of the results and of the proceeding for a possible large geophysics survey.

关键词： Phosphatic Series Sterile Bodies Geophysical Prospecting GPR and ERT Methods

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苏云金杆菌防治储烟害虫研究进展

烟草科技 2003年第6期36卷 24-27页

作者： Michel Blanc pascale Kaelin Ferruccio Gadani 王颖

在所有为害贮存烟草并能造成严重损失的昆虫种类中 ,烟草甲虫Lasiodermaserricorne(F .)和烟草粉螟Ephestiaelutella(H¨ubner)是原烟及加工后烟草的 2种主要害虫。收获后烟草害虫的防治主要通过消毒、害虫监测以及磷化氢熏蒸来实现 ,... 详细信息

在所有为害贮存烟草并能造成严重损失的昆虫种类中 ,烟草甲虫Lasiodermaserricorne(F .)和烟草粉螟Ephestiaelutella(H¨ubner)是原烟及加工后烟草的 2种主要害虫。收获后烟草害虫的防治主要通过消毒、害虫监测以及磷化氢熏蒸来实现 ,而储烟害虫已对磷化氢产生抗药性 ,并已有防治失败的实例报道 ,而熏蒸也越来越受到相关法规的制约。一些生物防治剂如苏云金杆菌Bacillusthuringiensis(Bt) ,因对环境无害而有可能替代化学防治。Bt是一种细菌 ,在芽孢形成阶段能够产生杀虫晶体蛋白。Bt用作植食性害虫的生防制剂已有 4 0多年的历史。Bt产生的杀虫晶体蛋白对几个目的昆虫具有特有的生物活性 ,可对昆虫的取食产生影响。我们实验室进行了广泛的研究并在世界范围内开展了调查 ,对仓储烟草中的Bt进行评价 ,现已证实了以前的研究结果 ,即Bt是自然发生的叶面微生物群落中的一部分。已从烟草上分离出几个Bt菌株并进行了特征描述 (DNA和蛋白质图谱 )。已通过胃毒的方法对所分离的菌株以及 2个商业产品对烟草甲幼虫的杀虫活性进行了测定。在长达 30个月的贮存期内 ,对已调制烟叶上的Bt孢子及其晶体蛋白的稳定性进行了分析。Bt处理过的烟叶制成卷烟样品评吸后 ,处理与对照卷烟无显著性差异。尽管在规定的时间及剂量情?

关键词：贮存烟草苏云金杆菌防治害虫生物防治剂烟草甲

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乳牙,随它去吗?

父母必读 2004年第17期 48-48页

作者： pascale Gares

每天,你的孩子都会露出小牙齿开心地笑!为了让他保持住这种开心的大笑,你需要鼓励并帮助他发现刷牙的乐趣。不要以乳牙反正要换为借口。就对乳牙抱一种随它去的态度!保护好小乳牙,这一点非常重要。因为乳牙会影响到宝宝身体的健康,以及... 详细信息

每天,你的孩子都会露出小牙齿开心地笑!为了让他保持住这种开心的大笑,你需要鼓励并帮助他发现刷牙的乐趣。不要以乳牙反正要换为借口。就对乳牙抱一种随它去的态度!保护好小乳牙,这一点非常重要。因为乳牙会影响到宝宝身体的健康,以及未来恒牙的健康。

关键词：乳牙牙齿牙膏

The Delivery of Grand Multiparas in a Semi-Rural Setting: A Cross-Sectional Descriptive Study at the Ayos Locality of Cameroon

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Open Journal of Obstetrics and Gynecology 2023年第1期13卷 74-81页

作者： Serge Robert Nyada Cliford E. Ebong Véronique Mboua Christiane Nsahlai pascale Mpono Emenguele Michelle Mendoua Junie Metogo Isidore Tompeen Cyrile Claude Noa Ndoua Centre Hospitalier de Recherche et d’Application en Chirurgie Endoscopique et Reproduction Humaine Paul et Chantal Biya (CHRACERH) Yaoundé Cameroon Faculty of Medicine and Biomedical Sciences University of Yaoundé I Yaoundé Cameroon Central Hospital of Yaoundé Yaoundé Cameroon University Teaching Hospital Yaoundé Yaoundé Cameroon Faculty of Health Sciences University of Buea Buea Cameroon Gynaeco-Obstetric and Pediatric Hospital Yaoundé Yaoundé Cameroon

Introduction: Grand multiparity is a known risk factor for maternal and fetal complications. Materials and Methods: We carried out a cross-sectional descriptive study on the delivery of grand multiparas at the maternity of the regional hospital annex of Ayos, a semi-rural locality in the Center region of Cameroon. The study covered the period from January 2012 through December 2020, and the objective was to assess the frequency, the determinants and the outcome of delivery in grand multiparas. Results: We recorded 1384 deliveries and enrolled 137 cases of delivery of grand multiparas. This gives a frequency of grand multipara delivery of 9.89%. The mean age of the women was 34.96 ± 4.45 years. Married parturients accounted for 65% of the cases and 16.8% were HIV positive. Delivery occurred at term in 89.9%. In 35.8%, no antenatal consultation was done. The use of the partograph during labor was reported in 11.7%. Per vaginal delivery was noted in 88.3%, emergency cesarean in 10.2% and elective cesarean in 1.5%. The most frequent maternal complications included post-partum hemorrhage (19.9%), genital tract tears (12.4%), endometritis (9.5%) and surgical wound infection (8.7%). No maternal death was recorded. The mean birth weight of the newborns was 3336.8 ± 550 g. Fetal complications were mostly represented by neonatal infection (20.1%), perinatal death (7.9%) and neonatal asphyxia (9.5%). Conclusion: The frequency of grand multiparous delivery in the semi-rural locality of Ayos, Cameroon, was 9.89%. The mean age of parturients was 38.96 years and the proportion of vaginal delivery was 88.3%.

关键词： Grand Multipara Delivery Semi Rural Cameroon

评世界贸易组织“8月30日体系”的执行——以无国界医生运用加拿大药物可及法案为例

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评世界贸易组织“8月30日体系”的执行——以无国界医生运用加拿...