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Improving intermittent androgen deprivation therapy： lessons learned from basic and translational research

Asian Journal of Andrology 2014年第4期16卷 505-510页

作者： Rahul A Parikh Laura E pascal Benjamin J Davieses Zhou Wang Division of Hematology/OncologyUniversity of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA. Department of Urology University of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA. Department of Pharmacology and Chemical Biology University of Pittsburgh School of Medicine Hillman Cancer Centre University of Pittsburgh Medical Center Pittsburgh Pennsylvania USA.

Intermittent androgen deprivation therapy （IADT） is an alternative to continuous androgen deprivation therapy （ADT） in prostate cancer patients with nonmetastatic disease. ADT is associated with numerous side effects such as hot flashes, sexual dysfunction, anemia, fatigue, loss of muscle mass, osteoporosis, metabolic syndrome and premature cardiovascular disease. IADT was developed with the intention of improving the quality of life and to delay progression of prostate cancer to castration resistance. The benefits of slightly improved quality of life by IADT compared to ADT were demonstrated in multiple clinical trials. IADT was noted to be noninferior to ADT in patients with biochemical recurrence of prostate cancer but in studies performed in patients with metastatic prostate cancer, the results were inconclusive. Our recent studies suggested that the administration of 5 alpha-reductase inhibitors during the off-cycle of IADT can significantly prolong the survival of mice bearing androgen-sensitive prostate tumors when off-cycle duration was short. This review discusses the survival benefit of 5 alpha-reductase inhibition in IADT in animal models and the potential translation of this finding into clinic.

关键词： 5 alpha-reductase inhibitor androgen-responsive genes intermittent androgen deprivation therapy (IADT) prostatecancer testosterone

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Study on the Immobilization of Laccase and Its Application to the Removal of Dyes from Industrial Effluents

Study on the Immobilization of Laccase and Its Application t...

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作者： Habimana pascal 河北工业大学

学位级别：硕士

在工业应用中大量使用染料产生的废水,对人类健康和水环境造成了严重的影响。漆酶作为一种绿色生物催化剂,可对工业废水中的染料/有毒化学物质进行降解。然而漆酶的分子结构很容易受到外界环境的影响,而且游离的漆酶不可重复用、稳定性... 详细信息

在工业应用中大量使用染料产生的废水,对人类健康和水环境造成了严重的影响。漆酶作为一种绿色生物催化剂,可对工业废水中的染料/有毒化学物质进行降解。然而漆酶的分子结构很容易受到外界环境的影响,而且游离的漆酶不可重复用、稳定性差、成本高、难分离。为了解决这些问题,选用合适的载体对酶分子进行固定化是有效的策略之一。磁性核壳介孔氧化硅和金属有机骨架材料具有孔径可调、毒性低、化学稳定性高、比表面积大等优势,是固定化酶的理想载体。本研究以磁性介孔氧化硅纳米花(SiO@FeOnanoflowers)、介孔氧化硅包覆的磁性多壁碳纳米管(FeO-MWCNTs@SiO)和ZIF-8包覆的多壁碳纳米管(ZIF-8@MWCNTs)为载体,分别采用共价结合法和吸附法固定漆酶。考察了固定化漆酶的制备条件、稳定性及催化性能,并与游离漆酶进行了比较。最后,研究了固定化酶和游离漆酶对偶氮染料的脱色效果。本研究主要包括以下三个方面:(1)以十六烷基三甲基溴化胺(CTAB)为模板剂,FeO为磁核,正硅酸乙酯(TEOS)为硅源,合成了SiO@FeO磁性介孔氧化硅纳米花。在550 C下煅烧5 h去除模板剂。所得了SiO@FeO的比表面积、孔体积和孔径分别为518.252 m/g,0.502 cm/g和5.9nm。采用戊二醛为交联剂将漆酶固定在SiO@FeO纳米花上,制备固定化漆酶(Laccase-GA-SiO@FeO)。研究发现,65 C和p H 4.0为Laccase-GA-SiO@FeO的最适温度和最适p H。Laccase-GA-SiO@FeO的p H、热、贮存和机械稳定性均比游离酶好。重复使用10次后,Laccase-GA-SiO@FeO活性仍能维持原有活性的83%。此外,对于酸性红88、铬黑T和活性黑5,Laccase-GA-SiO@FeO的脱色率分别为97%、98.3%和51%,均高于游离酶,有利于工业应用。(2)以CTAB为模板剂,FeO-MWCNTs为基体材料,TEOS为硅源,合成了FeO-MWCNTs@SiO纳米复合材料。采用离子交换法去除模板剂CTAB。氮气吸附-脱附等温线显示,FeO-MWCNTs@SiO纳米复合材料的比表面积为428.1 m/g,介孔孔径为11.47 nm。用戊二醛作为交联剂将漆酶固定在FeO-MWCNTs@SiO中,得到一种稳定的固定化酶Laccase-GA-FeO-MWCNTs@SiO。研究发现,Laccase-GA-FeO-MWCNTs@SiO的最适温度和p H分别为60°C和3.0。与游离漆酶相比,Laccase-GA-FeO-MWCNTs@SiO在p H、热、贮存和机械稳定性方面均有所提高。重复使用10次后,固定化漆酶仍能保持原有活性的87%。研究了酶对酸性红88、铬黑T和活性黑5的脱色作用,固定化漆酶的脱色率分别为98%、99%和66%,均高于游离酶。(3)以FeO-MWCNTs@SiO纳米复合材料为模板,采用金属亲和吸附法制备了ZIF-8包覆的多壁碳纳米管(ZIF-8@MWCNTs)纳米复合材料。结果表明,所制备的ZIF-8@MWCNTs纳米复合材料的比表面积为328.778 m/g,孔体积为0.714 cm/g,平均孔径为4.149 nm。Laccase@ZIF-8@MWCNTs的最适温度和最适p H分别为60C和p H 3.0。与游离酶相比,固定化酶在p H、热、贮存和操作稳定性等方面都有所提高。重复使用10次后,Laccase@ZIF-8@MWCNTs仍然保留了68%的初始酶活。对酸性红88和铬黑T的脱色方面,固定化漆酶的脱色率分别达95.6%和97.4%,均高于游离酶。

关键词：染料脱色硅基纳米复合材料固定化酶漆酶金属-有机框架材料

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Analysis of the sensitivity to pressure and temperature of a membrane based SAW sensor

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International Journal of Smart and Nano Materials 2017年第2期8卷 95-109页

作者： Hugo Chambon pascal Nicolay Gudrun Bruckner Ayech Benjeddou Microsystems Technologies Carinthian Tech ResearchCTR AGVillachAustria Sorbonne Universités Universitéde Technologie de CompiègneCNRSUMR 7337 ROBERVALCentre de Recherche RoyallieuCompiègneFrance SUPMECA Saint OuenFrance

This paper presents a FEM analysis of a membrane-based Surface Acoustic Wave(SAW)*** sensor is a 2.45GHz Reflective Delay Line(R-DL)based on Lithium Niobate(LiNbO_(3)).As the wave propagation time is much smaller than the typical time constant of the phenomena to be monitored(deformation,temperature change etc.),the analysis can be performed in three successive ***,a static FEM study of the complete sensor(housing included)is carried out,to compute the temperature,stress and strain fields generated in the sensitive area by the measured parameters(pressure,temperature,etc.).Then,a dynamic electro-mechanical study of the R-DL is *** simulation takes the previously computed fields into account,which makes it possible to compute the sensor sensitivity to the measured *** model takes advantage of the periodicity of the components of the R-DL to compute phenomenological parameters(Coupling-of-Mode parameters),which can later on be used to compute the electrical response of the sensor(step 3).In this paper,we focus on the first two *** COM parameters are extracted,under simultaneous thermal and mechanical ***,the sensor sensitivity is obtained from the evolution of the velocity,under various stress configurations.

关键词： SAW sensor Piezoelectric FEM Pressure Temperature

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A New Basal Neoceratopsian Dinosaur from the Middle Cretaceous of Jilin Province,China

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Acta Geologica Sinica(English Edition) 2009年第2期83卷 200-206页

作者： JIN Liyong CHEN Jun ZAN Shuqin pascal GODEFROIT Jilin University Museum Chaoyang Campus Jilin 130026 China The Geological Museum of China Beijing 100034 China Department of Palaeontology Royal Belgian Institute of Natural Sciences Belgium

A new basal neoceratopsian dinosaur, Helioceratops brachygnathus gen. et sp. nov., is described from the Quantou Formation （late Early Cretaceous or early Late Cretaceous） in the Liufangzi locality （Jilin province, China）. Helioceratops differs from other basal neoceratopsians with its deep dentary ramus, its steeply-inclined ventral predentary facet, its heterogeneous dentary crowns, and by the denticles and secondary ridges asymmetrically distributed on either side of the primary ridge on its dentary teeth. Along with Auroraceratops and Yamaceratops, Helioceratops represents one of the most derived non-coronosaurian neoceratopsians. The palaeogeographical distribution of basal neoceratopsians appears limited to northern China and southern Mongolia in the current state of our knowledge. It is therefore probable that this region constituted the birthplace for more advanced, Late Cretaceous Coronosanria.

关键词： Dinosauria Neoceratopsia Middle Cretaceous Quantou Formation Jilin province

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Self-formation of hexagonal nanotemplates for growth of pyramidal quantum dots by metalorganic vapor phase epitaxy on patterned substrates

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Nano Research 2016年第11期9卷 3279-3290页

作者： Alessandro Surrente Romain Carron pascal Gallo Alok Rudra Benjamin Dwir Eli Kapon Laboratory of Physics of Nanostructures Ecole Polytechnique Federale de Lausanne CH- 1015 Lausanne Switzerland

We demonstrate the self-formation of hexagonal nanotemplates on GaAs （111）B substrates patterned with arrays of inverted tetrahedral pyramids during metal-organic vapor phase epitaxy and its role in producing high-symmetry, site-controlled quantum dots （QDs）. By combining atomic force microscopy measurements on progressively thicker GaAs epitaxial layers with kinetic Monte Carlo growth simulations, we demonstrate self-maintained symmetry elevation of the QD formation sites from three-fold to six-fold symmetry. This symmetry elevation stems from adatom fluxes directed towards the high-curvature sites of the template, resulting in the formation of a fully three-dimensional hexagonal template after the deposition of relatively thin GaAs layers. We identified the growth conditions for consistently achieving a hexagonal pyramid bottom, which are useful for producing high-symmetry QDs for efficient generation of entangled photons.

关键词： metalorganic vapor phaseepitax kinetic Monte Carlosimulations epitaxial growth onpatterned substrates symmetry elevation adatom diffusion

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High-throughput volumetric adaptive optical imaging using compressed time-reversal matrix

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Light(Science & Applications) 2022年第1期11卷 114-126页

作者： Hojun Lee Seokchan Yoon pascal Loohuis Jin Hee Hong Sungsam Kang Wonshik Choi Center for Molecular Spectroscopy and Dynamics Institute for Basic ScienceSeoul 02841Korea Department of Physics Korea UniversitySeoul 02841Korea Department of Applied Mathematics University of TwenteDrienerlolaan 57522 NB EnschedeNetherlands Achmea Holding BV Handelsweg 23707 NH ZeistNetherlands

Deep-tissue optical imaging suffers from the reduction of resolving power due to tissue-induced optical aberrations and multiple scattering *** matrix approaches recording the maps of backscattered waves for all the possible orthogonal input channels have provided formidable solutions for removing severe aberrations and recovering the ideal diffraction-limited spatial resolution without relying on fluorescence labeling and guide ***,measuring the full input–output response of the tissue specimen is time-consuming,making the real-time image acquisition ***,we present the use of a time-reversal matrix,instead of the reflection matrix,for fast high-resolution volumetric imaging of a mouse *** time-reversal matrix reduces two-way problem to one-way problem,which effectively relieves the requirement for the coverage of input *** a newly developed aberration correction algorithm designed for the time-reversal matrix,we demonstrated the correction of complex aberrations using as small as 2%of the complete basis while maintaining the image reconstruction fidelity comparable to the fully sampled reflection *** to nearly 100-fold reduction in the matrix recording time,we could achieve real-time aberration-correction imaging for a field of view of 40×40µm^(2)(176×176 pixels)at a frame rate of 80 ***,we demonstrated high-throughput volumetric adaptive optical imaging of a mouse brain by recording a volume of 128×128×125µm^(3)(568×568×125 voxels)in 3.58 s,correcting tissue aberrations at each and every 1µm depth section,and visualizing myelinated axons with a lateral resolution of 0.45µm and an axial resolution of 2µm.

关键词： matrix correction recording

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High-magnification observation of seminiferous tubules through the tunica albuginea by two-photon laser scanning microscopy

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Asian Journal of Andrology 2011年第5期13卷 774-776页

作者： Vincent Achard pascal Weber Georges Mercier Marie-Pierre Blanchard Laboratoire d＇Histologie-Cytologie Faculte de Medecine secteur Timone Universite de la Mediterranee Marseille 13385 France Centre d＇Assistance Medicale a la Procreation AP-HM Conception Marseille 13385 France CNRS - IBDML - UMR6216 Service Imagerie - Case 907 Faculte des Sciences de Luminy Marseille 13288 France and Centre de Microscopie et Imagerie IFR Jean Roche Universite de la Mediterranee Marseille 13916 France

Testicular sperm extraction is widely used in the treatment of male infertility in cases of non-obstructive azoospermia. Identifying spermatogenetic foci within the testes is critical for testicular sperm extraction. Two-photon laser scanning microscopy （TPLSM） is an autofluorescence-based microscopy technique that allows observation at a cellular level in the depth of fresh living tissues and does not require any histological processing （fixation or staining）. The wavelengths previously used have shown no phototoxicity on sperm. We used TPLSM to detect spermatogenetic foci in fresh mouse testicular parenchyma without disrupting the tunica albuginea. Fresh surgically retrieved testes were observed using TPLSM within 1 h after extraction. Contralateral testes for each animal were observed using standard histology. Using TPLSM we were able to observe and measure the diameter of seminiferous tubules through the tunica albuginea, similar to the histological control. Structures within epithelial tubules were also observed, although their nature has yet to be identified. TPLSM is a real-time microscopy technique that could detect spermatogenetic foci.

关键词： seminiferous epithelium spermatogenesis

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m^(6)A Profile Dynamics Indicates Regulation of Oyster Development by m^(6)A-RNA Epitranscriptomes

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Genomics, Proteomics & Bioinformatics 2023年第4期21卷 742-755页

作者： Lorane Le Franc Bruno Petton pascal Favrel Guillaume Rivière Laboratoire de Biologie des Organismes et des Ecosyste`mes Aquatiques(BOREA) Muséum d’Histoire NaturelleSorbonne UniversitéUniversitéde Caen NormandieUniversitédes AntillesCNRS UMR 8067IRD14032 CaenFrance Ifremer Laboratoire des Sciences de l’Environnement MarinUMR 6539 CNRS/UBO/IRD/IfremerCentre Bretagne29280 PlouzanéFrance

The N6-methylation of RNA adenosines(N6-methyladenosine,m^(6)A)is an important regulator of gene expression with critical implications in vertebrate and insect ***,the developmental significance of epitranscriptomes in lophotrochozoan organisms remains *** methylated RNA immunoprecipitation sequencing(MeRIP-seq),we generated transcriptome-wide m^(6)A-RNA methylomes covering the entire development of the oyster from oocytes to *** RNA classes display specific m^(6)A signatures,with messenger RNAs(mRNAs)and long non-coding RNAs(lncRNAs)exhibiting distinct profiles and being highly methylated compared to transposable element(TE)*** are dynamic and correspond to the chronological steps of development(cleavage,gastrulation,organogenesis,and metamorphosis),with minimal mRNA and lncRNA methylation at the morula stage followed by a global *** m^(6)A levels are correlated with transcript levels,and shifts in methylation profiles correspond to expression *** methylated transcripts cluster according to embryo-larval stages and bear the corresponding developmental functions(cell division,signal transduction,morphogenesis,and cell differentiation).The m^(6)A level of TE transcripts is also regulated and peaks during the *** demonstrate that m^(6)A-RNA methylomes are dynamic and associated with gene expression regulation during oyster *** putative epitranscriptome implication in the cleavage,maternal-to-zygotic transition,and cell differentiation in a lophotrochozoan model brings new insights into the control and evolution of developmental processes.

关键词： RNA methylation Transcription Embryo Metamorphosis Evo-devo

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Identification of Potential Zinc Deficiency Responsive Genes and Regulatory Pathways in Rice by Weighted Gene Co-expression Network Analysis

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Rice science 2022年第6期29卷 545-558页

作者： Blaise pascal MUVUNYI LU Xiang ZHAN Junhui HE Sang YE Guoyou CAAS-IRRI Joint Laboratory for Genomics-Assisted Germplasm Enhancement Agricultural Genomics Institute in ShenzhenChinese Academy of Agricultural Sciences(CAAS)Shenzhen 518120China Rice Breeding Innovations Platform International Rice Research Institute(IRRI)Metro Manila 1301the Philippines

Zinc(Zn)malnutrition is a major public health *** biofortification of Zn in rice grain can alleviate global Zn ***,elucidating the genetic mechanisms regulating Zn deprivation response in rice is essential to identify elite genes useful for breeding high grain Zn rice ***,a meta-analysis of previous RNA-Seq studies involving Zn deficient conditions was conducted using the weighted gene co-expression network analysis(WGCNA)and other in silico prediction tools to identify modules(denoting cluster of genes with related expression pattern)of co-expressed genes,modular genes which are conserved differentially expressed genes(DEGs)across independent RNA-Seq studies,and the molecular pathways of the conserved modular *** identified 16 modules of co-expressed ***-eight and five modular DEGs were conserved in leaf and crown,and root tissues across two independent RNA-Seq *** enrichment analysis showed that 24 of the 28 conserved modular DEGs from leaf and crown tissues significantly up-regulated 2 Kyoto Encyclopedia of Genes and Genomes(KEGG)pathways and 15 Gene Ontology(GO)terms,including the substrate-specific transmembrane transporter and the small molecule metabolic ***,the well-studied transcription factors(OsWOX11 and OsbHLH120),protein kinase(OsCDPK20 and OsMPK17),and miRNAs(OSA-MIR397A and OSA-MIR397B)were predicted to target some of the identified conserved modular *** of the 24 conserved and up-regulated modular DEGs,19 were yet to be experimentally validated as Zn deficiency responsive *** from this study provide a comprehensive insight on the molecular mechanisms of Zn deficiency response and may facilitate gene and pathway prioritization for improving Zn use efficiency and Zn biofortification in rice.

关键词： rice biofortification zinc deficiency gene expression weighted gene co-expression network analysis

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Frequency-Diversified Space-Efficient Radiating Surface Using Convolved Electric and Magnetic Currents for Highly Dense Multiband Antenna-Frontend Integration

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Electromagnetic Science 2024年第1期2卷 63-76页

作者： Amirhossein Askarian pascal Burasa Ke Wu Department of Electrical Engineering Poly-Grames Research CenterPolytechnique MontrealQC H3T1J4Canada

We propose and investigate a methodology based on convolved electric and magnetic currents for the generation of multi-band responses over a space-shared radiating ***,a single wideband antenna operation principle based on inter-leaved dipole and slot modes is studied and analyzed using full-wave simulations followed by a qualitative time domain ***,a 2×2 dual-band radiating unit is conceived and developed by closely arranging single wideband *** this case,multimode resonances are generated in a lower frequency band by a proper convolving and coupling of the magnetic and electric currents realized in the gaps between the antennas and on the surface of the antennas,*** methodology can be deployed repeatedly to build up a self-scalable topology by reusing the electromagnetically(EM)connected radiating surfaces and gaps be-tween the radiating *** to the efficient reuse of the electromagnetic region for the development of multiband radiation,a high aperture-reuse efficiency is ***,as a proof of concept,a 2×4 dual-band array operating in Ku-and Ka-bands is devel-oped and fabricated by a linear arrangement of the two developed radiating *** measurement results show that the proposed antenna array provides impedance and gain bandwidths of 30%and 25.4%in the Ku-band and 10.65%and 8.52%in the Ka-band,respectively.

关键词： Aperture-shared array Aperture-reused efficiency Antenna-frontend integration Dual-band antenna Magneto-electric dipole antenna Multi-mode resonance Multi-band array Multi-functional antenna Wideband antenna array

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