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Safety of tirofiban and dual antiplatelet therapy in treating intracranial aneurysms

2015年

作者： Blaise pascal[]

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Stroke & Vascular Neurology 2019年第1期4卷 36-42页

作者： Edgar A Samaniego Emilee Gibson Daichi Nakagawa Santiago Ortega-Gutierrez Mario Zanaty Jorge A Roa pascal Jabbour David M Hasan Department of Neurology Neurosurgery and RadiologyUniversity of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurology University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurosurgery University of Iowa Hospitals and ClinicsIowa CityIowaUSA Department of Neurosurgery Thomas Jefferson UniversityPhiladelphiaPennsylvaniaUSA

Background Endovascular treatment of intracranial aneurysms usually involves stent-assisted coiling(SAC)and flow *** IIb/IIIa inhibitors such as tirofiban and dual antiplatelet therapy(DAPT)are required to prevent thromboembolic complications *** sought to determine the safety of tirofiban and DAPT in these *** We conducted a retrospective analysis of our database for patients with intracranial aneurysms who underwent SAC or flow *** tirofiban-DAPT protocol used is *** regarding duration of infusion,placement of external ventricular devices(EVDs),complications,haemoglobin levels and platelet count before and 24 hours after antiplatelet therapy were collected and *** One-hundred and forty-one patients with 148 aneurysms/procedures were included.110 aneurysms were treated acutely and 38 *** and major haemorrhagic events were recognised in 20%(30/148)*** 5(3.4%)intracerebral haemorrhages were symptomatic:3 cortical/SAH and 2 *** average blood volume in symptomatic haemorrhages was 24.8 cc versus 5.42 cc in asymptomatic haemorrhages(p=0.002).The rate of EVD-related haemorrhages was 15.7%(19/121)and only 2(1.7%)were *** haemorrhagic events occurred in ruptured aneurysms(90.1%,p=0.01).No significant change in platelet count or haemoglobin levels before and 24 hours after administration of tirofiban and DAPT was *** administration of heparin did not increase haemorrhagic *** The use of the GP IIb/IIIa inhibitors tirofiban and DAPT in this series was *** and DAPT did not affect platelet count or haemoglobin levels and did not increase rate of symptomatic haemorrhages or thromboembolic complications.

关键词： aneurysm intracranial infusion

Evolution of a Holocene banner bank controlled by morphodynamics and structural setting of a macrotidal coast: Saint-Brieuc Bay (NW-Europe)

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Geoscience Frontiers 2021年第5期12卷 166-181页

作者： Kalil Traoréa David Menier Erwan Gensac pascal Le Roy Clément Lambert Paul Bessin Kevin Pedoja Anne Duperret Romain Le Gall Laboratoire Géoscience Océan UMR 6538CNRSUniversitéBretagne SudCampus de Tohannic56000 VannesFrance Laboratoire Géoscience Océan UMR 6538CNRSIUEMUniversitéBretagne Occidentale29280 PlouzanéFrance Laboratoire de Planétologie et Géodynamique UMR 6112CNRSLe Mans UniversitéAvenue Olivier Messiaen72085 Le Mans CEDEX 9France Laboratoire Morphodynamique Continentale et Côtière UMR 6143CNRSUniversitéCaen Normandiecampus 12-4Rue des Tilleuls14000 Caen cedexFrance Laboratoire Ondes et Milieux Complexes UMR 6294CNRSUniversitéLe Havre Normandie53 rue de PronyCS8054076058 Le Havre cedexFrance

The morphology and internal structure of the Horaine Bank(Bay of Saint-Brieuc,NW France)are described based on multibeam echosounder and high-resolution seismic datasets coupled with vibro-core *** Horaine Bank shows large-scale bedforms in the lee of a submerged rocky shoal,which allowed defining it as a Banner *** internal structure of the sandbank reveals four seismic units(U1-U4)on a Cambrian basement(U0).The basal unit U1 is interpreted as reworked lowstand fluvial sediments those infilled micro incised valleys during a rise in sea *** unit is overlain by paleo-coastal barrier sand-spit(U2)whose development was controlled by swell in the context of a rapid rise in sea *** successive prograding unit(U3)is interpreted as flooding deposits in continuity with unit *** unit U4 is characterized by oblique reflectors oriented in two opposite *** last unit,dated post 3500 yr BP,corresponds to migrating dunes superimposed on the bank and observable in the high-resolution bathymetric *** strong correlation between tidal currents and the apparent clockwise migration of dune crests suggests the presence of a tidal gyre controlling the present-day dynamics of most of the Horaine bank *** study proposes a new model for the construction of banner banks characterized by the gradual transition of a sand spit to a banner bank during marine transgression and ensuing hydrodynamic variability.

关键词： Sand banks Banner bank Holocene climate Geomorphology Sea level rise Tidal gyre

散射光彩色数字全息光学系统及波面重建算法研究

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物理学报 2010年第7期59卷 4646-4655页

作者：李俊昌彭祖杰 Tankam Patrice Picart pascal 昆明理工大学理学院昆明650093 LAUM CNRSUniversite du MaineAv. O. Messiaen72085 LE MANSFrance ENSIM-ecole Nationale Superieure d' Ingenieurs du Mans rue Aristote 72085 LE MANS France

令物体表面为散射面,参考光及重建光为球面波,详细研究了离轴数字全息物光场重建平面的光波场.导出物光、共轭物光及零级衍射光分布与光学系统参数的关系.根据彩色数字全息的特点,提出抑制零级衍射干扰的光学系统设计方法,并且对一种能... 详细信息

令物体表面为散射面,参考光及重建光为球面波,详细研究了离轴数字全息物光场重建平面的光波场.导出物光、共轭物光及零级衍射光分布与光学系统参数的关系.根据彩色数字全息的特点,提出抑制零级衍射干扰的光学系统设计方法,并且对一种能够避免插值误差的波面重建算法进行了优化研究,给出了相应的实验证明.

关键词：全息技术彩色数字全息波前重建零级衍射干扰

Construction of Coherence Identity in Sports： The Case of the ＂Grand Raid＂ Running Race in Nature of Reunion Island

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Sociology Study 2011年第2期1卷 115-120页

作者： pascal Duret Muriel Augustini The University of La Reunion France

Sportsmen who engage in sports in open natural settings are not always coherent in their behaviors towards environment; in fact, they seldom are. From survey made on a sport event the ＂Grand Raid 2010＂, a foot race in mountains of Reunion Island, the authors discover that these sportsmen are not the good activists fighting for a green planet that they imagine they are. The authors try to explain the disparity between the perception that they have of themselves and the reality of their practices.

关键词： Nature sports environmentalist identity coherence

Switching Regimes in Economics: The Contraction Mapping and the ω-Limit Set

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Applied Mathematics 2019年第7期10卷 513-520页

作者： pascal Stiefenhofer Peter Giesl Department of Mathematics University of Sussex Falmer East Sussex UK Brighton Business School University of Brighton Brighton UK

This paper considers a dynamical system defined by a set of ordinary autonomous differential equations with discontinuous right-hand side. Such systems typically appear in economic modelling where there are two or more regimes with a switching between them. Switching between regimes may be a consequence of market forces or deliberately forced in form of policy implementation. Stiefenhofer and Giesl [1] introduce such a model. The purpose of this paper is to show that a metric function defined between two adjacent trajectories contracts in forward time leading to exponentially asymptotically stability of (non)smooth periodic orbits. Hence, we define a local contraction function and distribute it over the smooth and nonsmooth parts of the periodic orbits. The paper shows exponentially asymptotical stability of a periodic orbit using a contraction property of the distance function between two adjacent nonsmooth trajectories over the entire periodic orbit. Moreover it is shown that the ω-limit set of the (non)smooth periodic orbit for two adjacent initial conditions is the same.

关键词： Non-Smooth Periodic Orbit Differential Equation Contraction Mapping Economic Regimes Non-Smooth Dynamical System

On the Setup of a Test Bench for Predicting Laminar-to-Turbulent Transition on a Flat Plate

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Journal of Energy and Power Engineering 2016年第7期10卷 411-424页

作者： pascal Bader Wolfgang Sanz Institute for Thermal Turbomachinery and Machine Dynamics Graz University of Technology Inffeldgasse 25/A Graz 801 O Austria

At turbomachinery relevant flow conditions the boundary layers are often transitional with laminar-to-turbulent transition occurring. The characteristics of the main flow can depend highly on the state of the boundary layer. Therefore it can be vitally important for the designer to understand the process of laminar-to-turbulent transition and to determine the position and length of the transitional region. In this paper the flow over a flat plate is experimentally studied in order to investigate and better understand transitional flow. Preston tube measurements as well as a thermographic camera system were performed for two different inlet velocities in order to determine the position of the transitional zone. The results of the experiment are compared to numerical flow solutions using a common transition model to determine its capability. The simulation has been performed with the two commercial codes CFX and Fluent by Ansys and an in-house code called LINARS. As a result of this study, a better understanding of the experimental and numerical methods for determining transition shall be given.

关键词： Boundary layer transition computational fluid dynamics Preston tube thermographic camera flat plate boundary layers.

Synthesis and Characterization of New Chiral Monoanionic [ON] Ancillary Phenolate Ligands

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International Journal of Organic Chemistry 2014年第3期4卷 182-188页

作者： pascal Binda Leslie Glover Department of Chemistry and Forensic Science Savannah State University Savannah GA USA Science Division Southern Wesleyan University Central SC USA

Three new chiral monoanionic [ON] ancillary phenolate ligands with varying pendant arms have been synthesized in moderate to high yields (50% - 85%) via Mannich-type condensation reaction of chiral substituted phenol, formaldehyde and (+)-bis-[(R)-1-phenylethyl]amine. These new organic compounds were fully characterized via nuclear magnetic resonance spectroscopy (1H and 13C) and elemental analysis. The newly synthesized ligands are suitable candidates for metal-catalyzed ring-opening of lactones and asymmetric catalysis.

关键词： Phenolate Ligands Mannich Condensation Reaction Ring-Opening Polymerization of Lactones

Totally laparoscopic trans-hiatal gastroesophagectomy for benign diseases of the esophago-gastric junction

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World Journal of Gastroenterology 2007年第2期13卷 285-288页

作者： Jean-Louis Dulucq pascal Wintringer Ahmad Mahajna Department of Abdominal Surgery Institute of Laparoscopic Surgery Maison de Santé Protestante Bagatelle Hospital Route de Toulouse 203 Talence-Bordeaux 33401 France

AIM： To prospectively present our initial experience with totally laparoscopic transhiatal esophagogastrectomies for benign diseases of the cardia and distal esophagus. METHODS： Laparoscopic gastric mobilization and tubularization combined with transhiatal esophageal dissection and intrathoradc esophagogastric anastomosis accomplished by a circular stapler was done in 3 patients. There were 2 females and 1 male patient with a mean age of 73 ± 5 years. RESULTS： Two patients were operated on due to benign stromal tumor of the cardia and one patient had severe oesophageal peptic stenosis. Mean blood loss was 47 ± 15 mL and mean operating time was 130 ± 10 rain. There were no cases that required conversion to laparotomy. All patients were extubated immediately after surgery. Soft diet intake and ambulation times were 5.1 ± 0.4 d and 2.6 ±0.6 d, respectively. There were no intraoperative and postoperative complications and there were no perioperative deaths. The average length of hospital stay was 9.3 ± 3 d. All procedures were curative and all resected margins were tumor free. The mean number of retrieved lymph nodes was 18 ±8. CONCLUSION： Laparoscopic transhiatal esophagogastrectomy for benign lesions has good effects and proves feasible and safe.

关键词： Esophagogastrectomy Transhiatal resection Cardial tumor Laparoscopy Stromal tumor

Arabidopsis NRTI.1 Is a Bidirectional Transporter Involved in Root-to-Shoot Nitrate Translocation

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Molecular Plant 2013年第6期6卷 1984-1987页

作者： Sophie Léran[a], Stéphane Mu?os[a],[b], Chantal Brachet[a], pascal Tillard[a], Alain Gojon[a] Beno?t Lacombe[a], [a] Laboratoire de Biochimie et Physiologie Moléculaire des Plantes Institut de Biologie Intégrative des Plantes ‘Claude Grignon’UMR CNRS/INRA/SupAgro/UM2 Place Viala 34060 Montpellier cedex France.

Dear Editor, In most plants, nitrogen （N） is acquired by roots in the form of nitrate （NO3-）. In many species, NO3- is not assimi- lated in the roots, but is secreted into the xylem sap for translocation to the shoot, where it enters the cells to be metabolized and/or stored in the vacuoles. Several plasma membrane transporters involved in NO3- influx into the cell have been identified in Arabidopsis （Wang et ai., 2012）, especially in the roots where members of the NPF （NRTI/PTR Family, L^ran et al., 2013） and NRT2 transporter families are predominantiy implicated. Concerning efflux to the xylem sap, only one transporter, NPF7.3/NRT1.5, has been shown to be involved. However, physiological characterization of npf7.31nrtl.5 knockout mutant plants demonstrated that other transporter（s） is （are） also contributing to xylem Ioad- inq of NO^- （Lin et al., 2008）.

关键词： ARABIDOPSIS PLANT translocation NITRATES